Download or read book Piecing Together the Plasmodium Falciparum Genome Puzzle written by Maggie S. Schlarman and published by . This book was released on 2011 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is still a significant problem around the world and, thus, better control methods are in great need. A key stage in the Plasmodium life cycle is the sporozoite because it exhibits dual infectivity in both the mosquito vector and vertebrate host and, therefore, is a promising target for discovering effective ways of controlling malaria. The P. falciparum genes, PFE0565w and PF11_0394, were chosen as candidates for study based on data available on PlasmoDB, the Plasmodium database, indicating that they are expressed both at the transcriptional and protein levels in sporozoites and likely encode putative surface proteins. Transcripts of both PFE0565w and PF11_0394 are present in both mosquito and vertebrate host life cycle stages, but both of their proteins are specific to salivary gland sporozoites as shown by immunofluorescent assays and/or GFP-trafficking studies. Functional studies for PFE0565w are currently in progress to determine if it may play a role in parasite development and/or invasion of host tissues. Because PFE0565w and PF11_0394 do not have homology with any human proteins, they could be targets for new drugs and/or vaccines. Lastly, in addition to studies conducted with P. falciparum, a preliminary comparative study between the P. berghei orthologs of PFE0565w and PF11_0394, PBANKA_111090 and PBANKA_091050, respectively, was conducted.

Download or read book Saving Lives Buying Time written by Institute of Medicine and published by National Academies Press. This book was released on 2004-09-09 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.

Download or read book Laboratory Animal Medicine written by Lynn C. Anderson and published by Elsevier. This book was released on 2015-07-04 with total page 1727 pages. Available in PDF, EPUB and Kindle. Book excerpt: Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals. Organized by species for in-depth understanding of biology, health, and best care of animals Features the inclusion of chinchillas, quail, and zebra finches as animal models Offers guidance on program and employee management Covers regulations, policies, and laws for laboratory animal management worldwide

Download or read book Trapping and the Detection Control and Regulation of Tephritid Fruit Flies written by Todd Shelly and published by Springer. This book was released on 2014-10-06 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on four broad topics related to trapping of agriculturally important tephritid fruit flies, namely i) lures and traps, ii) invasion biology and detection of infestations, iii) attract and kill systems, and iv) trade regulations and risk assessment. This comprehensive structure progresses from the biological interaction between insect and lures/traps to the area-wide use of trapping systems to the utilization and impact of trapping data on international trade. The chapters include accounts of earlier research but are not simply compendia and instead evaluate past and current work as a tool for critical analysis and proposal of productive avenues for future work. At present there is no book available that deals with fruit fly trapping in such a broad context. Our book fills this gap and serves as a global reference for both those interested in fruit flies specifically as well as anyone dealing with the threat of invasive agricultural insects in general.

Download or read book Parasite Infections From Experimental Models to Natural Systems written by Toni Aebischer and published by Frontiers Media SA. This book was released on 2018-07-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eukaryotic parasites (including parasitic protozoans, worms and arthropods) are more complex and heterogeneous organisms than pathogenic bacteria and viruses. This notion implies different evolutionary strategies of host exploitation. Typically, parasites establish long-term infections and induce relatively little mortality, as they often limit pathological changes by modulating host cells and downregulating adverse immune responses. Their pattern of distribution tends to be endemic rather than epidemic. Despite these seemingly benign traits, parasites usually cause substantial chronic morbidity, thus constituting an enormous socioeconomic burden in humans, particularly in resource poor countries, and in livestock worldwide. Parasite-induced fitness costs are an evolutionary force that can shape populations and contribute to species diversity. Therefore, a thorough understanding of parasites and parasitic diseases requires detailed knowledge of the respective biochemical, molecular and immunological aspects as well as of population genetics, epidemiology and ecology. This Research Topic (RT) bridges disciplines to connect molecular, immunological and wildlife aspects of parasitic infections. The RT puts emphases on four groups of parasites: Plasmodium, Toxoplasma, Giardia and intestinal helminths. Co-infections are also covered by the RT as they represent the most common form of parasite infections in wildlife and domestic animal populations. Within the four types of parasites the following topics are addressed: (1) Experimental models: hypothesis testing, translation and limits. (2) Critical appraisal of experimental models. (3) Natural systems: Technological advances for investigations in natural parasite-host systems and studies in natural systems. (4) The urgent need for better models and methods in natural parasite systems. Hence, the RT covers and illustrate by the means of four main parasitic infections the parasite-host system at the molecular, cellular and organismic level.

Download or read book The Ten Thousand Year Fever written by Loretta A Cormier and published by Routledge. This book was released on 2016-06-16 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of the oldest recorded diseases in human history, and its 10,000-year relationship to primates can teach us why it will be one of the most serious threats to humanity in the 21st century. In this pathbreaking book Loretta Cormier integrates a wide range of data from molecular biology, ethnoprimatology, epidemiology, ecology, anthropology, and other fields to reveal the intimate relationships between culture and environment that shape the trajectory of a parasite. She argues against the entrenched distinction between human and non-human malarias, using ethnoprimatology to develop a new understanding of cross-species exchange. She also shows how current human-environment interactions, including deforestation and development, create the potential for new forms of malaria to threaten human populations. This book is a model of interdisciplinary integration that will be essential reading in fields from anthropology and biology to public health.

Download or read book World Malaria Report 2015 written by World Health Organization and published by World Health Organization. This book was released on 2016-01-30 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Malaria Report 2015assesses global malaria disease trends and changes in the coverage and financing of malaria control programs between 2000 and 2015. It also summarizes progress towards international targets, and provides regional and country profiles that summarize trends in each WHO region and each country with malaria. The report is produced with the help of WHO regional and country offices, ministries of health in endemic countries, and a broad range of other partners. The data presented are assembled from the 96 countries and territories with ongoing malaria transmission, and a further five countries that have recently eliminated malaria. Most data are those reported for 2014 and 2015, although in some cases projections have been made into 2015, to assess progress towards targets for 2015.

Download or read book Skin and Arthropod Vectors written by Nathalie Boulanger and published by Academic Press. This book was released on 2018-01-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods. Offers the only compilation of research focusing on both the skin interface and arthropod vectors, with contributions from international experts Advances research in the effort toward generating more effective diagnostic tools and vaccines focusing on the skin interface Can also serve as supplemental material for dermatology lectures or specialized lectures on medical entomology and skin immunity

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book The Secret Life of Germs written by Philip M. Tierno and published by Simon and Schuster. This book was released on 2004-01-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traces the history of germs, discussing how germs have been viewed and treated throughout time and explains why germs now pose an even greater risk to mankind than ever before.

Download or read book Cellular and Molecular Basis in Parasitic Diseases Control Research Trends written by Qingfeng Zhang and published by Frontiers Media SA. This book was released on 2022-05-04 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Evolution written by Roderick D.M. Page and published by John Wiley & Sons. This book was released on 2009-07-14 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility.

Download or read book A Life Decoded written by J. Craig Venter and published by Penguin. This book was released on 2007-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The triumphant memoir of the man behind one of the greatest feats in scientific history Of all the scientific achievements of the past century, perhaps none can match the deciphering of the human genetic code, both for its technical brilliance and for its implications for our future. In A Life Decoded, J. Craig Venter traces his rise from an uninspired student to one of the most fascinating and controversial figures in science today. Here, Venter relates the unparalleled drama of the quest to decode the human genome?a goal he predicted he could achieve years earlier and more cheaply than the government-sponsored Human Genome Project, and one that he fulfilled in 2001. A thrilling story of detection, A Life Decoded is also a revealing, and often troubling, look at how science is practiced today.

Download or read book The Things They Carried written by Tim O'Brien and published by HarperCollins. This book was released on 2009-10-13 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: A classic work of American literature that has not stopped changing minds and lives since it burst onto the literary scene, The Things They Carried is a ground-breaking meditation on war, memory, imagination, and the redemptive power of storytelling. The Things They Carried depicts the men of Alpha Company: Jimmy Cross, Henry Dobbins, Rat Kiley, Mitchell Sanders, Norman Bowker, Kiowa, and the character Tim O’Brien, who has survived his tour in Vietnam to become a father and writer at the age of forty-three. Taught everywhere—from high school classrooms to graduate seminars in creative writing—it has become required reading for any American and continues to challenge readers in their perceptions of fact and fiction, war and peace, courage and fear and longing. The Things They Carried won France's prestigious Prix du Meilleur Livre Etranger and the Chicago Tribune Heartland Prize; it was also a finalist for the Pulitzer Prize and the National Book Critics Circle Award.

Download or read book New Scientist and Science Journal written by and published by . This book was released on 1997 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Companion to Biological Anthropology written by Clark Spencer Larsen and published by John Wiley & Sons. This book was released on 2010-02-22 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extensive overview of the rapidly growing field of biologicalanthropology; chapters are written by leading scholars who havethemselves played a major role in shaping the direction and scopeof the discipline. Extensive overview of the rapidly growing field of biologicalanthropology Larsen has created a who’s who of biologicalanthropology, with contributions from the leadingauthorities in the field Contributing authors have played a major role in shaping thedirection and scope of the topics they write about Offers discussions of current issues, controversies, and futuredirections within the area Presents coverage of the many recent innovations anddiscoveries that are transforming the subject

Download or read book Genomes 3 written by Terence A. Brown and published by Garland Science. This book was released on 2007 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: The VitalBook e-book version of Genomes 3 is only available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815341383 Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3is the latest edition of this pioneering textbook. Updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics. Genomes 3 builds on the achievements of the previous two editions by putting genomes, rather than genes, at the centre of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.