Download or read book PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS I written by Dr. Trilochan Satapathy and published by JEC PUBLICATION. This book was released on with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sciences of pharmacology and toxicology are strongly intertwined. The former focuses on how medications function in live beings, while the latter focuses on the bad effects of drugs and chemicals and how to treat them. Both fields are concerned with the behaviour of drugs and chemicals in living organisms. This book provides a detailed illustration of the most important concepts that are involved in pharmacology and the medical sciences that are related to it. The title opens with a discussion of the historical elements of drug creation, including up-to-date information about Nobel Laureates in pharmacology and toxicology and the key discoveries they made. Following this, it conducts an analysis of the fundamental concepts of pharmacology, including pharmacokinetics and pharmacodynamics, as well as providing comprehensive information on drug transporters and interactions. The subsequent chapters of the book are dedicated to covering a comprehensive assortment of subjects that provide vital knowledge on the fundamental principles of pharmacology and the manner in which these concepts are used for the clinical treatment of disorders.

Download or read book Pharmacological Screening Methods and Toxicology written by A Srinivasa Rao and published by . This book was released on 2016 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Book covers all steps of drug discovery like lead synthesis, preclinical studies, FDA requirements and clinical studies and also about High Throughput Screening. It also covers about all aspects about experimental animals.

Download or read book Pharmacological Screening Methods Toxicology written by Avanapu Srinivasa Srinivasa Rao and published by . This book was released on 2021-11 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Screening Methods in Pharmacology written by Robert Turner and published by Elsevier. This book was released on 2013-10-22 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Screening Methods in Pharmacology, Volume II is a collection of papers that presents practical techniques and information on the selection of a screening program for a particular pharmacological activity. The book contains the most reliable, simplest, and the most preferred screening methods in pharmacology. The text presents screening methods for alpha and beta Adrenergic blocking agents; compounds for antianginal activity; topical products for excessive eccrine sweating; antidepressant agents; and agents with analgesic and analgesic antagonist activity. Pharmacologists, pharmacists, researchers, and physicians will find this book a good source of information.

Download or read book Introduction to Toxicological Screening Methods and Good Laboratory Practice written by Saravana Babu Chidambaram and published by Springer Nature. This book was released on 2022-02-11 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.

Download or read book Screening Methods in Pharmacology written by Robert Arnold Turner and published by . This book was released on 1971 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book PHARMACOLOGICAL AND TOXICOLOGICAL SCREENING METHODS II written by Dr. Trilochan Satapathy and published by JEC PUBLICATION. This book was released on with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete handbook on toxicology covers basic principles, regulatory criteria, and sophisticated methods for understanding and assuring the safety of varied chemicals in the following pages. Introduction to toxicology, "Toxicology Fundamentals and Regulatory Guidelines," covers broad overviews, mechanistic toxicology, regulatory frameworks, and descriptive toxicology. Focus is on OECD, ICH, EPA, and Schedule Y regulatory criteria, as well as the history and importance of Good Laboratory Practise (GLP) in drug development. As the book explores "Types of Toxicity Studies and Test Item Characterization," it examines acute, sub-acute, chronic, and particular acute investigations, including oral, cutaneous, and inhalational toxicity studies. Test item characterisation procedures are carefully explained, emphasising their importance in regulatory compliance and toxicity evaluation. This leads to "Advanced Toxicology Studies," which covers reproductive toxicology, genotoxicity, and in vivo carcinogenicity. These investigations provide a thorough view of possible dangers and evaluate drug safety. The book then discusses "IND Enabling Studies and Safety Pharmacology," which covers the necessary research for IND applications. Exploring regulatory settings, corporate views, and safety pharmacology in drug development provides a complete knowledge of experimental substance safety. The third part, "Toxicokinetic and Alternatives to Animal Testing," emphasises toxicokinetic assessment and discusses new methods. Following the evolution of safety assessment practises, these options are investigated for ethical and regulatory consequences. Students, researchers, and professionals traversing toxicology's difficult landscape may find this book invaluable. Its extensive coverage, from basic concepts to sophisticated approaches, makes it an important tool for protecting humans and ecosystems in the dynamic pharmaceuticals and beyond industries.

Download or read book Text Book of Pharmacological and Toxicological Screening Methods I written by Prabha Manjari and published by . This book was released on 2024-05-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Screening Methods in Pharmacology written by Robert A. Turner and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Text Book of Pharmacological and Toxicological Screening Methods II written by Swetlana and published by . This book was released on 2024-06-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Screening Methods in Pharmacology written by Robert A. Turner and published by . This book was released on 1979 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Screening Methods in Pharmacology written by N. S. Parmar and published by Alpha Science International, Limited. This book was released on 2006 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Screening Methods in Pharmacology provides an up to-date and concise account of in vivo methods used in the pharmacological screening of important categories of clinically useful drugs. It also encompasses the basic principles of animal experimentation and current advances leading to the use of transgenic animals, combinatorial chemistry, high throughout screening, pharmacogenomics, proteomics and array technology. The methods used for the detection of pharmacological effects of potential drugs on the CNS, CVS, endocrines, respiratory tract and immunomodulation have been described in adequate details with cross references for further studies and comprehension. The book is expected to be extremely useful for postgraduates in pharmacology from all disciplines and for the scientists engaged in the drug discovery research programmes.

Download or read book Drug Screening Methods written by Suresh Kumar Gupta and published by Anshan Pub. This book was released on 2005 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery and development is a challenging, expensive and time consuming field of research, requiring contributions from chemists, pharmacologists, toxicologists, clinicians, and practitioners. The ultimate goal is to generate a safe and biologically active drug which can stall, or even reverse, the pathological events that cause the disease condition. But in the search for the drug a host of tests and trials must be applied to evaluate the efficiency and safety of the newly developed molecule in the biological system. These trials or "screening methods" are critical. On their basis, the new molecule either becomes accepted for usage, or is discarded forever. Advances in drug research have forced the need for quicker, more automated screening methods, using molecular techniques applied in vitro, in vivo and in clinical systems. Researchers need to know the latest developments outside their own speciality. With this book, Professor Gupta has brought together in one coherent volume the most up to date developments of consolidated screening methods for biological systems. By paying attention to the practical techniques used in academia and the commercial pharmaceutical industry, "Drug Screening Methods" will enjoy a broad readership, serving both the professional community and the student of pharmacology.

Download or read book Screening Methods in Pharmacology written by Robert Turner and published by Elsevier. This book was released on 2013-10-22 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Screening Methods in Pharmacology focuses on the methods for screening substances for pharmacological activities and discussions of organization of screening programs. The manuscript first offers information on the biochemistry of the nervous system and organization of screening, as well as mechanisms of drug effects within the autonomic system; mechanisms within the parasympathetic and symphatetic systems; and neuropharmacological tests in blind screening. The book also takes a look at general and quantal responses. The publication reviews depressants of the central nervous system and ataractic (tranquillizing, neuroleptic) agents. Topics include natatory exhaustion, motor deficit, righting reflex, pentylenetetrazol (metrazol) antagonism, head-withdrawal reflex, and avoidance of electrical shock. The book also ponders on analgesics and oxytoxic, antiserotonin, and anti-inflammatory agents. Discussions focus on narcotic and nonnarcotic analgesics, erythema, inhibition of ascites, and pleural fluid. The manuscript is a valuable reference for readers interested in the screening methods in pharmacology.

Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Download or read book Screening Methods in Pharmacology written by Rao Muralidhar and published by . This book was released on 2023-03-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the essential topics related to drug discovery and development, with a particular focus on the care, handling, and breeding techniques of laboratory animals, toxicity testing, and screening methods for pharmacological activity. Designed for M.Pharm Pharmacology and B.Pharm students, as well as anyone involved in drug discovery and development, this book covers the following topics: Care, handling, and breeding techniques of laboratory animals, along with alternative methods to animal studies OECD guidelines and the determination of LD50, acute, sub-acute, and chronic toxicity studies Organization of screening for pharmacological activity of new substances, with a particular emphasis on the evaluation of antipsychotics, antiepileptics, and antidepressants Screening methods for anti-diabetic, antiulcer, CHF, and anti-hypertensive drugs, as well as screening methods for anti-inflammatory, analgesics, and antipyretic drugs Throughout the book, the importance of preclinical studies in drug development and the role of screening methods in identifying potential drug candidates are emphasized. The ethical considerations related to animal experimentation are also discussed in detail. This book is a valuable resource for anyone involved in drug discovery and development, providing a comprehensive overview of the essential topics related to pharmacology.

Download or read book Guidelines and Screening Methods of Pharmacology written by Surendra H Bodakhe and published by Pharmamed Press. This book was released on 2021-02 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery is the process by which new molecules are discovered and now a days everybody is becoming aware of its level of importance especially in this era of COVID 19, which creates a possible anticipation of an increment in the demand for books related to screening methods of pharmacology. Pharmacological screening of drugs is a sequential testing of new chemical entities or extracts from biological material in isolated organs followed by test in whole experimental animals. Screening Methods in Pharmacology focuses on the methods for screening of moieties for pharmacological activities and discussions for organization of screening programs. This book envelops a descriptive approach detailed about CPCSEA, OECD and ICH guidelines that must be followed during screening of new drug moieties. It also provides a brief idea about bioassay and research methodology along with various experimental animal screening models for different diseases. This book shall serve as a reference guide for students of Pharmacy and life sciences graduates. Salient Features: 1. Beneficial for Pharmacy and life science graduates and research scholars. 2. Provides various experimental animal screening models for different diseases. 3. Gives special guidelines for animal use during experimental protocols. 4. Provides brief description about Bioassay