Download or read book Perinatal Brain Damage written by Jonathan S. Wigglesworth and published by . This book was released on 1986-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Haemorrhage Ischaemia and the Perinatal Brain written by Karen E. Pape and published by Lippincott Williams & Wilkins. This book was released on 1979 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haemorrhage, Ischaemia and the Perinatal Brain focuses on an area of major importance in perinatal medicine. The authors, who have both made significant contributions to the subject of cerebral haemorrhage in the newborn, put forward many new and unpublished ideas throughout this monograph. By presenting a synopsis of current knowledge on all aspects of the haemorrhagic and ischaemic lesions affecting the newborn brain, they aim to provide the clinician with a logical basis for management of these devastating conditions and attempts at their prevention. The influence of altered cerebral circulatory physiology on the developing vasculature is emphasized as the key to understanding the patterns of pathology that occur at different gestational ages. A feature of the book is the chapter on vascular anatomy of the developing brain, which contains extensive new and original work illustrated in colour. Cerebral circulatory physiology, birth trauma, ischaemic lesions of the preterm and term brain damage all receive coverage, in addition to a comprehensive series of chapters on intraventricular haemorrhage. Sections on clinical management are illustrated by radiographs and CT scans from the Department of Radiology, Hospital for Sick Children, Toronto, and there are original line drawings by the authors throughout the book. Although intended primarily for the paediatrician, this book should also be of particular interest to pathologists, obstetricians and all whose work is concerned with perinatal care.
Download or read book Birth Trauma and Perinatal Brain Damage written by Vasily Vasilievich Vlasyuk and published by Springer. This book was released on 2018-11-03 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on traumatic birth injuries, predominantly of the skull and brain, as well as hemorrhagic and ischemic disorders of cerebral circulation in fetuses and newborns, providing information on each condition’s classification, incidence, etiology and pathogenesis, pathomorphology, clinic, diagnostics, prognosis, and complications. It discusses the configuration (molding) of the head, venous congestion, displacements of cranial bones, ruptures of the cerebellar tentorium during labor, and the compression of the skull and brain damage caused by obstetric operations and asynclitic insertion of the head, while also describing the importance of the periosteal stagnation of the skull to assess the delivery and explanation of tentorium tears. Intracranial hemorrhages are considered in detail, taking into account the role of the traumatic factor in their occurrence and hypoxic-ischemic brain lesions (periventricular leukomalacia, selective neuronal necrosis, multicystic encephalomalacia, etc.). Lastly, it offers the world’s first explanation of why tentorium tears occur most frequently in the left half, providing an original classification of damaged tentoria, subarachnoid and intraventricular hemorrhages, and the degree of configuration of the head in childbirth. Given the depth and breadth of its coverage, the book offers an essential resource for neonatologists, obstetricians-gynecologists, perinatologists, pediatric neurologists, pathologists, pediatricians, forensic experts and neuroimaging professionals.
Download or read book Perinatal Brain Damage written by Luca A. Ramenghi and published by John Libbey Eurotext. This book was released on 2008 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on a highly successful conference dedicated to Perinatal brain damage: from pathogenesis to neuroprotection. Neonatologists, paediatricians, paediatric neurologists, obstetricians, basic researchers involved in neurosciences, as well as rehabilitation professionals, will be interested by this publication. The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic work-up and treatment. The most authoritative basic researchers, clinicians, and specialists in the field of neuroimaging, provide chapters on recent clinical advances. A subject of particular importance is the neurological vulnerability of the preterm infant, which also touches on ethical aspects of the care of high-risk preterm babies and those born from multiple pregnancies. A particularly original section focuses on cerebral white matter and the many issues related to this crucial part of the developing brain. Experts also deal with cerebral visual impairment, motor development, cognitive function, and the mechanisms underlying the neuronal plasticity of the infant's brain. Concepts of neuroprotection are also outlined, based on pharmacological agents tested on experimental animals and the best drugs used to treat neonatal convulsions.
Download or read book Experimental and Clinical Approaches in the Pursuit of Novel Therapeutic Strategies for Perinatal Brain Injury and its Neurological Sequelae written by Changlian Zhu and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fetal and Neonatal Brain Injury written by David K. Stevenson and published by Cambridge University Press. This book was released on 2003-02-06 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this is a comprehensive survey of fetal and neonatal brain injury arising from hypoxia, ischemia or other causes. The volume spans a broad range of areas from epidemiology and pathogenesis, through to clinical manifestations and obstetric care, and then on to diagnosis, long-term outcomes, and medico-legal aspects. An important theme running throughout is to highlight scientific and clinical advances that have a role to play in minimising risk, improving clinical care and outcomes.
Download or read book Cell Therapy for Perinatal Brain Injury written by Haruo Shintaku and published by Springer. This book was released on 2018-03-01 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.
Download or read book Neural Plasticity and Cognitive Development written by Joan Stiles and published by OUP USA. This book was released on 2012-05-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title addresses fundamental questions about human brain development through the study of children with early occurring focal brain injury.
Download or read book Perinatal Events and Brain Damage in Surviving Children written by Fred Kubli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decision making in modem obstetrics and perinatology is con trolled by a variety of different factors, but there is little doubt that in industrialized countries one of the most powerful single factors is the concern and fear of causing permanent brain damage in the unborn and newborn. The dramatic increase in the rates of abdom inal deliveries in many parts of the world is certainly rooted to a substantial part in the ~bstetrician's concern not so much about possible perinatal death, but more so about permanent brain dam age in surviving children. This trend has been accelerated by the increasing number of litigations in connection with brain damage observed in many societies. This problem itself has many aspects, but it seems evident that litigation - justified or unjustified - is one modem expression of the human and social tragedy inflicted on individuals and families by the birth of a brain-damaged child. The medical, social, and human importance of the problem is in sharp contrast to the relative lack of scientific knowledge avail able. This became very clear when the National Institutes of Health published the excellent review in 1985 on "Prenatal and Perinatal Factors Associated with Brain Disorders" and its editor, J. M.
Download or read book Fetal and Neonatal Brain Injury written by David K. Stevenson and published by Cambridge University Press. This book was released on 2009-06-18 with total page 1638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. New material includes pregnancy-induced hypertension, HELLP syndrome and chronic hypertension, complications of multiple gestation, neurogenic disorders of the brain, neonatal stroke and much more. An expanded, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.
Download or read book The Newborn Brain written by Hugo Lagercrantz and published by Cambridge University Press. This book was released on 2010-01-07 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.
Download or read book Pathology of Perinatal Brain Injury written by Lucy Balian Rorke and published by . This book was released on 1982 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neural Plasticity and Cognitive Development written by Joan Stiles and published by Oxford University Press. This book was released on 2012-05-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of modern neurobiological methods over the last three decades has provided overwhelming evidence that it is the interaction of genetic factors and the experience of the individual that guides and supports brain development. Brains do not develop normally in the absence of critical genetic signaling, and they do not develop normally in the absence of essential environmental input. The key to understanding the origins and emergence of both the brain and behavior lies in understanding how inherited and environmental factors are engaged in the dynamic and interactive processes that define and direct development of the neurobehavioral system. Neural Plasticity and Cognitive Development focuses on children who suffered focal brain insult (typically stroke) in the pre- or perinatal period which provides a model for exploring the dynamic nature of early brain and cognitive development. In most, though not all, of the cases considered, the injuries affect substantial portions of one cerebral hemisphere, resulting in patterns of neural damage that would compromise cognitive ability in adults. However, longitudinal behavioral studies of this population of children have revealed only mild cognitive deficits, and preliminary data from functional brain imaging studies suggest that alternative patterns of functional organization emerge in the wake of early injury. Neural Plasticity and Cognitive Development posits that the capacity for adaptation is not the result of early insult. Rather, it reflects normal developmental processes which are both dynamic and adaptive operating against a backdrop of serious perturbation of the neural substrate.
Download or read book Perinatal Brain Damage Repair and Neurological Sequelae written by Rodrigo Martinez Mariño and published by . This book was released on 1995 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Perinatal Neuropathology written by Mirna Lechpammer and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "1 Clinical history, clinical correlations with placental pathology and prematurity The initial steps in the process of perinatal nervous system evaluation, namely the planning of the optimal approach and choice of samples to be obtained, are driven by the clinical context. Of key importance are the following data: a. Gestational age at time of demise (if stillborn); or gestational age and postnatal age (if liveborn), for comparison with normative standards of development (see Appendix); b. State of maternal health (age, parity, pre-existing medical conditions or ones appearing during gestation or around the time of delivery, exposure to medications/toxins/infections), and of health of siblings or other family members: - Concerns for inherited (i.e., genetic) conditions, metabolic disorders, congenital infections, etc., may indicate the need for special testing; c. Details of prenatal course, including any imaging, amniocentesis, or monitoring: - Prenatal imaging modalities most commonly consist of transabdominal ultrasonography, generally done at the time of the first prenatal visit (to confirm pregnancy) or more usually in the mid-second-trimester for detection of fetal or placental anomalies"--
Download or read book Neonatal Pain written by Giuseppe Buonocore and published by Springer Science & Business Media. This book was released on 2008-02-13 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book dealing with fetal pain and its consequences and with pain in premature babies. The volume gives an overview of the current knowledge in this field. An international team of renowned specialists evaluates neonatal and fetal pain from the different points of view, and possible consequences of pain – even psychological – on the brain. This book will be an invaluable resource for professionals and for post-graduate students in all disciplines.
Download or read book Aspects of Praematurity and Dysmaturity written by J.H.P. Jonxis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of the foeto-placental unit as an integrated endocrine organ has been defined recently by many in vivo studies at the 17th- 20th week of gestation. A functioning foeto-placental unit is necessary for most of the increased oestrogen production of pregnancy and for the provision of glucocorticoids and aldosterone to the foetus. Neither the foetus nor the placenta alone have the necessary enzyme systems for the synthesis of these groups of steroids. However, when the foetus and placenta function as a unit, all of the enzyme systems are present for the synthesis of these steroids from circulating cholesterol. The placenta, but not the mid-gestation foetal adrenal, can synthesize physiologically significant amounts of pregnenolone from circulating cholesterol. Part of the pregnenolone is converted to progesterone in the placenta by the 3~-HSD system (absent in the foetus). The progesterone is transferred to the foetus where it is transformed by C-II, C-17, C-18 and C-21 hydroxylases (all absent in the placenta) to cortisol, corticosterone and aldosterone. Pregnenolone transferred from the placenta to the foetus undergoes 171X-hydroxylation, side chain splitting and sulfurylation (absent in the placenta) and is converted to DHAS. The DHAS may undergo 161X-hydroxylation (absent in the placenta) in the foetal liver and be transported to the placenta as 161X-OH-DHAS. There it is subjected to a neutral steroid sulfatase (absent in the foetus) and is converted to oestriol by action of the 3~-HSD system and the aromatizing enzyme system.
