Download or read book Peptide Bionanomaterials written by Mohamed A. Elsawy and published by Springer Nature. This book was released on 2023-08-28 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular self-assembly has been exploited by nature for developing the higher functional macromolecular structures of both the genome and proteome. Inspired by nature, there has been a surge of research, in the last two decades, for the molecular engineering of peptide-based self-assembling nanostructures, adopting the bottom-up design approach. This book gives the reader an overview on the design rules for de novo self-assembling peptide and reviews the diverse range of bioinspired peptide nanostructures such as β-sheet and β-hairpin, α-helical and coiled coil, self-assembling short peptides and peptidomimetics, collagen-based and elastin-like peptides, silk peptides, peptide amphiphiles, peptides co-polymers and others. The book also covers the wide variety of responsive and functional biomaterials that have been innovated based on those nanostructures for various applications ranging from tissue engineering, therapeutics and drug delivery to antimicrobial nanomaterials and biosensors. Finally, the book also discusses the peptide bionanomaterials global market and the future of the emerging industry. Chapter “Characterization of Peptide-Based Nanomaterials” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Physicochemical Characterization of Bionanomaterials written by Justin Stanley Plaut and published by . This book was released on 2021 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the first section of this dissertation, work involving the characterization of membrane-bound bioparticles is presented. Atomic force microscopy (AFM) is preeminent among techniques to characterize the morphological and nanomechanical properties of membrane-bound bioparticles, including extracellular vesicles, platelets, and liposomes. However, due to the sensitivity of the measurements and the fragility of the materials, there are significant challenges that must be overcome for the acquisition of accurate and high-quality data. A variety of commonly encountered issues, such as sample- or probe-related artifacts, are presented along methodological considerations to surpass such challenges. Extracellular vesicles are particularly difficult to characterize by AFM due to their diminutive size, on the order of tens to hundreds of nm, which results in a multitude of sample-specific artifacts. A study applying these methodological considerations to the quantitative, nanomechanical AFM characterization of matrix vesicles (MVs) is presented. MVs, a class of extracellular vesicles involved in physiological and pathological mineralization processes, are approximately 150 nm in diameter and are secreted from mineralization-competent cells, including chondrocytes, osteoblasts, and odontoblasts. These vesicles contain transporters and enzymatic payloads that enable sequestration of calcium cations and inorganic phosphate within the vesicle lumen to form calcium-phosphate minerals, which condense into semi-crystalline hydroxyapatite. AFM, with other physicochemical techniques, was used to measure the physical properties of MVs in both mineralizing and non-mineralizing conditions, which provided new insight into the structure and function of these membrane-bound bioparticles. In future work, MVs or synthetic MV could foreseeably be applied to the treatment of degenerative bone diseases and stronger linkages between pathological processes and MVs can be established. In the second section of this dissertation, work involving designed peptide biomaterials is presented. Oligopeptides, short polymers of amino acids, have a diverse set of naturally occurring chemical functionalities that can be harnessed to develop functional, shape-defined bionanomaterials. Solid-phase peptide synthesis (SPPS) enables the manufacture of peptides of arbitrary sequence and expands the natural chemical functionality through the inclusion of rare or synthetic amino acids, terminal capping, and other modifications. Three studies using N-terminal fluorenylmethyloxycarbonyl (Fmoc)-modified peptides are presented. Fmoc is an aromatic, polycyclic group that promotes peptide self-assembly through [pi]-[pi] stacking and contributes to the formation of hydrophobic pockets within which guest molecules, including diagnostic or therapeutic agents, can be loaded. Since Fmoc is a standard N-terminal protecting for SPPS, it presents as a no-cost modification for which inclusion reduces the complexity of the peptide synthesis. In each study, AFM was used to characterize the morphology of the peptide bionanomaterials. In the first study, a series of cell-penetrating triblock peptides, composed of a Fmoc-Fx hydrophobic block, a RADARADA amphiphilic block, and terminated with the HIV TAT 48-59 sequence, was developed. By varying the number of N-terminal phenylalanine residues, nanodrills of different morphologies and secondary structures were produced. An assembly model was developed with support by simulations in silico. The nanodrills were demonstrated to be effective vehicles for the enhanced intracellular delivery of hydrophobic molecules. In future work, the lessons learned from this study can help guide the design of simpler and more effective supramolecular delivery vehicles. In the second study, a series of triblock peptides, composed of an Fmoc-F assembly block, a permutated K,F,E amphiphilic block, and an R-G-D-amide cell-binding functional block, were developed through rational design and sequence permutation to identify a peptide suited for hydrogelation, P3. Since hydrogels produced from this peptide exhibit spontaneous gelation at 37oC, molecular-loading capability, and delayed drug release, P3 shows promise as an injectable hydrogel for drug or antigen delivery. Ongoing work will rigorously investigate the in situ hydrogelation and delivery functionality of these hydrogels. In the third study, a label-free protease sensor was developed by exchanging the functional block of P3 for the recognition site (AAN/G) for legumain, a cancer-associated protease, and a solubilizing unit (EEGSGEE). Upon cleavage of the peptide by legumain, the liberated Fmoc-FKFEAAN peptide self-assembles into [beta]-sheeted nanoplatelets that can be stained with thioflavin T for fluorescent signal amplification. The performance of the resulting label-free protease assay was then optimized in both buffer and human plasma. This assay can be adapted, in principle, to any protease of interest by changing the recognition sequence. Ultimately, this simple, inexpensive, and highly adaptable technology shows promise as a diagnostic assay for disease-associated protease biomarkers. In future work, more elaborate detection schemes, such as multiplexing of protease detection, or an adaptation to intracellular or cell-surface protease detection could be implemented. Ultimately, the distinct applications of the peptides in these studies serve as an illustration of the diverse structural and functional properties achievable with designed peptide bionanomaterials.

Download or read book Fundamentals of Bionanomaterials written by Ahmed Barhoum and published by Elsevier. This book was released on 2022-01-26 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bionanomaterials are molecular materials composed partially or completely of biological molecules, key biological structures, such as proteins, enzymes, viruses, DNA, biopolymers as well as metal, metal oxides, and carbon nanomaterials with characteristic bioactivity. Bionanomaterials have drawn much attention for their use in a wide range of industrial applications from scaffolds, dental implants, drug delivery, dialysis, biobatteries, biofuel cells, air purification, and water treatment. Therefore, the intensive current research in this area is driven towards the designing and functionalization of bionanomaterials for industrial applications. Fundamentals of Bionanomaterials covers the fundamental aspects, experimental setup, synthesis, properties, and characterization of the different types of bionanomaterial. It discusses the different structure and unique properties of bionanomaterials that can be obtained by modifying their morphology and composition, highlighting a wide range of fabrication techniques of bionanomaterials and critical processing parameters. This is an important reference source for all those seeking to gain a solid understanding of the characterization, properties and processing a variety of bionanomaterial classes. - Explains the major properties and characterization techniques for a range of bionanomaterial classes - Discusses the commercialization of different types of bionanomaterials for a variety of industry sectors - Highlights the challenges and interdisciplinary perspective of bionanomaterials in science, biology, engineering, medicine, and technology, incorporating both fundamentals and applications

Download or read book Biological and Bio inspired Nanomaterials written by Sarah Perrett and published by Springer Nature. This book was released on 2019-11-11 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes naturally occurring and designed bio-inspired molecular building blocks assembled into nanoscale structures. It covers a fascinating array of biomimetic and bioinspired materials, including inorganic nanozymes, structures formed by DNA origami, a wide range of peptide and protein-based nanomaterials, as well as their applications in diagnostics and therapeutics. The book elucidates the mechanism of assembly of these materials and characterisation of their mechanical and physico-chemical properties which inspires readers not only to exploit the potential applications of nanomaterials, but also to understand their potential risks and benefits. It will be of interest to a broad audience of students and researchers spanning the disciplines of biology, chemistry, engineering, materials science, and physics.

Download or read book Bionanotechnology Emerging Applications of Bionanomaterials written by Ahmed Barhoum and published by Elsevier. This book was released on 2022-05-29 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bionanotechnology: Emerging Applications of Bionanomaterials highlights a wide range of industrial applications using bionanotechnologies, with biomedical applications prominent amongst these, including drug delivery, tissue engineering, wound healing, medical implants, medical diagnostics and therapy. Other key areas include energy harvesting and storage, water/waste treatment, papermaking, textiles, construction industry, automotive, aerospace. This book is a valuable resource for all those seeking to gain a fundamental understanding of how bionanomaterials are used in a variety of industry sectors. Bionanomaterials are molecular materials composed partially or completely of biological molecules - such as proteins, enzymes, viruses, DNA and biopolymers - as well as metal, metal oxides, and carbon nanomaterials. Bionanomaterials have drawn much attention for their use in a wide range of industrial applications, including scaffolds, dental implants, drug delivery, dialysis, biobatteries, biofuel cells, air purification, and water treatment. - Assesses which bionanomaterial types are particularly suited to particular application areas - Shows how bionanomaterials are being used for biotechnology, biomedicine, energy production, energy storage, and environmental remediation applications - Highlights the challenges and interdisciplinary perspectives of bionanomaterials in science, biology, engineering, medicine, and technology, incorporating both fundamentals and applications

Download or read book Theranostic Bionanomaterials written by Wenguo Cui and published by Elsevier. This book was released on 2019-05-01 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theranostic Bionanomaterials is an invaluable study of recent advances and trends in the development and application of functional bionanomaterials for theranostic applications. This book describes the design and characterization of nanomaterials which exhibit distinctive physical, chemical and biological properties and discusses how these functional nanomaterials enable the precise manipulation of architectural, physical and biochemical cell microenvironments in vitro. In addition, it covers how they can act as the carriers of diagnostic or therapeutic agents, thus providing new pathways or strategies for disease diagnosis and treatment. Specific chapters discuss protein delivery, drug delivery, tissue regeneration, bioimaging, biodetection, and much more. This book will be a critical resource for those involved in cutting-edge research in theranostics bionanomaterial. - Focuses on nanofabrication methods of bionanomaterials - Reviews the application of bionanomaterials, with a focus on drug delivery and diagnosis - Describes the design and characterization of nanomaterials which exhibit distinctive physical, chemical and biological properties

Download or read book Self Assembled Bio Nanomaterials written by Gang Wei and published by MDPI. This book was released on 2020-03-25 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomolecular self-assembly provides a green, facile, and highly effective method to synthesize various functional nanomaterials that have exhibited considerable potential in the fields of nanotechnology, materials science, biomedicine, tissue engineering, food science, energy storage, and environmental science. In this collection of articles, we presented recent advance in the synthesis, characterization, and applications of self-assembled bio-nanomaterials. In a comprehensive review article, the controlled self-assembly of biomolecules including DNA, protein, peptide, enzymes, virus, and biopolymers via internal interactions and external simulations is introduced and discussed in detail. In other research articles, the self-assembly of DNA, protein, peptide, bio-drugs, liquid crystal polycarbonates, and diblock copolymers to various biomimetic/bioinspired nanomaterials and their potential applications in nanopatterning, sensors/biosensors, drug delivery, anti-parasite, and water purification are demonstrated.

Download or read book Bionanotechnology Towards Green Energy written by Shubha Dwivedi and published by CRC Press. This book was released on 2023-03-20 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bionanotechnology Towards Green Energy explains the role of bionanotechnology in the next generation technologies of green energy from an interdisciplinary and sustainability perspective. Chapters cover different roles of bionanotechnology such as applications of bio-nano enabled materials/coatings, scaling-up of green energy production, design and synthesis of bio-inspired nanomaterials and their applications, bio-nanofluid-based photovoltaic thermal systems, the use of bio-templated and biomimetic materials, and so forth. It focuses on waste-to-energy conversion and fixing intricate environmental issues. Key features: Provides detailed coverage of green energy production through bionanotechnological intervention Reviews future research needs in bionanotechnology in the green energy sector and scientific challenges in the mitigation of energy crises Deals with cutting-edge research on microbial synergism in biohydrogen production and storage Discusses the fabrication of bio-nano/hybrid electrode materials for supercapacitors and energy storage devices Includes extensive illustrations, case studies, summary tables, and up-to-date references This book is aimed at researchers and professionals in bionanotechnology, energy sciences, and environmental engineering.

Download or read book Sustainable Nanomaterials for Biosystems Engineering written by Junaid Ahmad Malik and published by CRC Press. This book was released on 2023-05-04 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume explores the integration of bionanomaterials and sustainable resources for the development of new and emerging sustainable processes. It highlights the concept of essential bionanomaterials derived from sustainable resources with examples of interdisciplinary methodologies and research that highlight the reuse of biomass waste as well as the proper usage of green technologies. The volume considers the most recent trends, challenges, and applications in bionanomaterials derived from sustainable sources in energy production and environmental mitigation. The book looks at state-of-the-art trends in the use of bionanomaterials for renewable energy such as in production of solar energy, for energy harvesting, and for energy conversion and storage. Chapters consider the application of bionanomaterials for the development of improved optical and electrical biosensors. The volume goes on to address the promising use of bionanomaterials for environmental remediation, such as for recovering heavy metals, radioactive metals, and other pollutants from wastewater, from river water, from soils, etc. Other topics include the use of sustainable nanomaterials in the food industry, in the biomedical field, in ecological research, and more.

Download or read book Bionanotechnology written by V. Renugopalakrishnan and published by Springer Science & Business Media. This book was released on 2006-10-12 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bionanotechnology is the key integrative technology of the 21st century and aims to use the knowledge, gathered from the natural construction of cellular systems, for the advancement of science and engineering. Investigating the topology and communication processes of cell parts can lead to invention of novel biological devices with exciting applications. Though microscale to nanoscale research offers an excellent space for the development of futuristic technologies, a number of challenges must be overcome. Due to paucity of a dedicated literature on the protein based nanodevices we bring you this monograph that combines collective research works of scientists probing into this fascinating universe of bionanotechnology. The monograph has been written with an aim of surveying engineering design principles of biomolecular nanodevices, prototype nanodevices based on redox proteins, bacteriorhodopsins and natural fibers, and touching upon the future developments in the field.

Download or read book Nanobiotechnology for Bioremediation written by Charles Oluwaseun Adetunji and published by Elsevier. This book was released on 2023-06-16 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiotechnology for Bioremediation: Fundamentals and Mechanisms provides detailed information on nanomaterial applications for the bioremediation of a heavily contaminated environment. Relevant information is provided on the application of nanofibers, nanoscale zero-valent iron (nZVI), nanocomposites, and carbon nanotubes to rejuvenate the environment from different pollutants, such as heavy metals, chlorinated compounds, organic compounds, polyaromatic hydrocarbon, and hydrocarbons. The book also explores the application of nanomaterials as a sustainable green solution that helps prevent various high levels of contamination in the environment. Each chapter addresses the application of nanomaterials as a sustainable tool for managing innumerable environmental challenges. This helps readers translate their research findings into sustainable innovations to resolve their immediate environmental challenges. - Provides information on nanomaterial utilization for bioremediation of soil and water heavily polluted with pesticides and heavy metals - Outlines novel nanomaterials that could serve as adsorbents, especially in managing heavy metal–polluted wastewater - Explores nanomaterial applications derived from microorganisms via immobilizing or through novel remediating microbial enzymes

Download or read book Peptide Materials written by Carlos Aleman and published by John Wiley & Sons. This book was released on 2013-03-29 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications. Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including: Properties of peptide scaffolds in solution and on solid substrates Nanostructures, peptide assembly, and peptide nanostructure design Soft spherical structures obtained from amphiphilic peptides and peptide-polymer hybrids Functionalization of carbon nanotubes with peptides Adsorption of peptides on metal and oxide surfaces Peptide applications including tissue engineering, molecular switches, peptide drugs and drug delivery Peptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.

Download or read book Advances in Bionanomaterials II written by Stefano Piotto and published by Springer Nature. This book was released on 2020-05-29 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials. The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29–October 3, 2019, on an MSC cruise ship navigating the Mediterranean Sea. It particularly highlights Horizon 2020 projects, covering topics such as novel synthetic strategies for nanomaterials, the implementation of bio- and smart materials for pharmacological and medical purposes, as well as environmental applications. Intended for a broad audience of academics and professionals, it offers a comprehensive and timely snapshot of the field of biomaterials. In addition to a set of innovative theories together with the necessary practical tools for their implementation, it also addresses the current challenges in the field, fostering new discussions and possible future collaborations between diverse groups.

Download or read book Bio Inspired Nanotechnology written by Marc R. Knecht and published by Springer Science & Business Media. This book was released on 2014-04-12 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the use of bio-inspired and biomimetic methods for the fabrication and activation of nanomaterials. This includes studies concerning the binding of the biomolecules to the surface of inorganic structures, structure/function relationships of the final materials and extensive discussions on the final applications of such biomimetic materials in unique applications including energy harvesting/storage, biomedical diagnostics and materials assembly.

Download or read book Bionanomaterials for Biosensors Drug Delivery and Medical Applications written by Won-Chun Oh and published by CRC Press. This book was released on 2023-12-13 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers advances in nanostructured materials across a variety of biomedical applications as the field evolves from development of prototype devices to real-world implementation. It provides an in-depth look at the current state of the art in oxide nanostructures, carbon nanostructures, and 2D material fabrication and highlights the most important biomedical applications and devices of nanomaterials, including drug delivery, medical imaging, gene therapy, biosensors, and diagnostics. FEATURES Presents the findings of cutting-edge research activities in the field of nanomaterials, with a particular emphasis on biological and pharmaceutical applications Details finished and ongoing toxicity evaluations of emerging nanomaterials Offers a multidisciplinary perspective This book is recommended for senior undergraduate and graduate students, professionals, and researchers working in the fields of bioengineering, materials science and engineering, and biotechnology.

Download or read book Functional Bionanomaterials written by Devarajan Thangadurai and published by Springer Nature. This book was released on 2020-07-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the application of nanotechnology in medicine and drug delivery, including diagnosis and therapy. Nanomedicine can contribute to the development of a personalized medicine both for diagnosis and therapy. By interacting with biological molecules at nanoscale level, nanotechnology opens up an immense field of research and applications. Interactions between artificial molecular assemblies or nanodevices and biomolecules can be understood both in the extracellular medium and inside human cells. Operating at nanoscale allows exploitation of physical properties different from those observed at microscale, such as the volume to surface area ratio. A number of clinical applications of nanobiotechnology, such as disease diagnosis, target-specific drug delivery, and molecular imaging are being investigated. Some promising new products are also undergoing clinical trials. Such advanced applications of this approach to biological systems will undoubtedly transform the foundations of diagnosis, treatment, and prevention of disease in the future. Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested each year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013. As the nanomedicine industry continues to grow, it is expected to have a significant impact on the global economy. This book provides clear, colorful and simple illustrations, tables, and case studies to clearly convey the content to a general audience and reader. This book also discusses the development of nanobiomaterials from biogenic (biological sources) systems for healthcare and disease therapies. This book, therefore, is useful for researchers and academicians in the fields of nanotechnology, medicine, nano-biotechnology and pharmacology.

Download or read book Bio nanoimaging written by Vladimir N Uversky and published by Academic Press. This book was released on 2013-11-05 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. - Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs - Includes over 200 color images to illustrate the power of various nanoimaging technologies - Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine