Download or read book Penalized Maximum Likelihood Methods in Emission Tomography written by Jeffrey A. Zahnen and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: Positron emission tomography (or PET) has been utilized for years in medical diagnosis. The PET reconstruction problem consists of recovering the image from the data gathered by the detectors in the machine. Penalized maximum likelihood techniques allow for the recovery of the image with a smoothing term to improve the image. Previous methods using this technique forced the use of a weak penalty term in order to gain convergence. Using a new method, this restriction is removed while retaining convergence. In addition, the method is extended to the problem of recovering multiple PET images along with a vector describing the motion between the images.

Download or read book Maximum Penalized Likelihood Estimation written by P.P.B. Eggermont and published by Springer Science & Business Media. This book was released on 2001-06-21 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with parametric and nonparametric density estimation from the maximum (penalized) likelihood point of view, including estimation under constraints. The focal points are existence and uniqueness of the estimators, almost sure convergence rates for the L1 error, and data-driven smoothing parameter selection methods, including their practical performance. The reader will gain insight into technical tools from probability theory and applied mathematics.

Download or read book Maximum Penalized Likelihood Estimation written by P.P.B. Eggermont and published by Springer Nature. This book was released on 2020-12-15 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with parametric and nonparametric density estimation from the maximum (penalized) likelihood point of view, including estimation under constraints. The focal points are existence and uniqueness of the estimators, almost sure convergence rates for the L1 error, and data-driven smoothing parameter selection methods, including their practical performance. The reader will gain insight into technical tools from probability theory and applied mathematics.

Download or read book Penalized Maximum likelihood PET Image Reconstruction for Lesion Detection written by Li Yang and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Detecting cancerous lesions is one major clinical application of positron emission tomography (PET). Statistical reconstruction methods based on the penalized maximum-likelihood (PML) principle have been developed to improve image quality such as spatial resolution, noise variance, contrast-to-noise ratio, etc. However, these technical metrics do not necessarily reflect the performance of a specific clinical task. In this dissertation, we focus on a task-specific metric to evaluate image quality and optimize PML reconstruction for lesion detection through penalty design, resolution modeling, and dynamic imaging. To assess lesion detectability in 3D images, we develop a multiview channelized Hotelling observer (mvCHO) to mimic the condition where a human observer examines three orthogonal views of a 3D image for detecting lesions. We derive simplified theoretical expressions that allow fast prediction of lesion detectability based on the mvCHO in PML reconstruction. The theoretical results are then applied to guide the design of a shift-variant quadratic penalty function in PML reconstruction to maximize lesion detectability in fully 3D PET. The proposed method is evaluated using computer-based Monte Carlo simulations as well as clinical patient data with superimposed lesions. The second focus of this dissertation is to improve lesion detection through resolution modeling (RM). Incorporating resolution modeling within reconstruction has been shown to improve spatial resolution and tumor contrast, by modeling resolution degrading phenomena such as positron range, inter-crystal scatter and photon non-collinearity. Here we extend our theoretical analysis of the PML reconstruction to quantitatively evaluate the effect of image-space RM on detection performance. We then propose a task-based resolution modeling in PML reconstruction and validate it using computer-based Monte Carlo simulations as well as real data. Furthermore, we extend our theoretical analysis of static PET reconstruction to dynamic PET. We study both the conventional indirect reconstruction and direct reconstruction for Patlak parametric image estimation. In the indirect reconstruction, Patlak parametric images are generated by reconstructing a sequence of dynamic PET images first and then performing Patlak analysis on the time activity curves (TACs) pixel-by-pixel. In the direct reconstruction, Patlak parametric images are estimated directly from raw sinogram data by incorporating the Patlak model into the image reconstruction procedure. The PML reconstruction is used in both the indirect and direct reconstruction methods. Simplified analytical expressions for evaluating lesion detectability on Patlak parametric images have been derived and applied to optimize the regularization parameter value for lesion detection. The proposed method is validated using computer-based Monte Carlo simulations. Good agreements between the theoretical predictions and the Monte Carlo results are observed. Both theoretical predictions and Monte Carlo simulation results show the benefit of the indirect and direct methods under optimized regularization parameters in dynamic PET reconstruction for lesion detection, when compared with the conventional static PET reconstruction.

Download or read book Improved Penalized Likelihood Reconstruction of Anatomically Correlated Emission Computed Tomography Data written by Stephen Robert Titus and published by . This book was released on 1996 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Emission Tomography written by Miles N. Wernick and published by Elsevier. This book was released on 2004-12-07 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging. *Contains thorough tutorial treatments, coupled with coverage of advanced topics *Three of the four holders of the prestigious Institute of Electrical and Electronics Engineers Medical Imaging Scientist Award are chapter contributors *Include color artwork

Download or read book Positron Emission Tomography written by Dale L. Bailey and published by Springer Science & Business Media. This book was released on 2006-07-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)

Download or read book Proceedings of the International Conference on Recent Cognizance in Wireless Communication Image Processing written by Nitin Afzalpulkar and published by Springer. This book was released on 2016-04-28 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the proceedings of the International Conference on Recent Cognizance in Wireless Communication & Image Processing. It brings together content from academicians, researchers, and industry experts in areas of Wireless Communication and Image Processing. The volume provides a snapshot of current progress in computational creativity and a glimpse of future possibilities. The proceedings include two kinds of paper submissions: (i) regular papers addressing foundation issues, describing original research on creative systems development and modeling; and (ii) position papers describing work-in-progress or research directions for computational creativity. This work will be useful to professionals and researchers working in the core areas of wireless communications and image processing.

Download or read book Quantitative Analysis in Nuclear Medicine Imaging written by Habib Zaidi and published by Springer Science & Business Media. This book was released on 2006-07-11 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a review of image analysis techniques as they are applied in the field of diagnostic and therapeutic nuclear medicine. Driven in part by the remarkable sophistication of nuclear medicine instrumentation and - crease in computing power and its ready and inexpensive availability, this is a relatively new yet rapidly expanding field. Likewise, although the use of nuclear imaging for diagnosis and therapy has origins dating back almost to the pioneering work of Dr G. de Hevesy, quantitative imaging has only recently emerged as a promising approach for diagnosis and therapy of many diseases. An effort has, therefore, been made to place the reviews provided in this book in a broader context. The effort to do this is reflected by the inclusion of introductory chapters that address basic principles of nuclear medicine instrumentation and dual-modality imaging, followed by overview of issues that are closely related to quantitative nuclear imaging and its potential role in diagnostic and therapeutic applications. A brief overview of each chapter is provided below. Chapter 1 presents a general overview of nuclear medicine imaging physics and instrumentation including planar scintigraphy, single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Nowadays, patients’ diagnosis and therapy is rarely done without the use of imaging technology. As such, imaging considerations are incorporated in almost every chapter of the book. The development of dual-modality - aging systems is an emerging research field, which is addressed in chapter 2.

Download or read book Handbook of Mathematical Methods in Imaging written by Otmar Scherzer and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 1626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Mathematical Methods in Imaging provides a comprehensive treatment of the mathematical techniques used in imaging science. The material is grouped into two central themes, namely, Inverse Problems (Algorithmic Reconstruction) and Signal and Image Processing. Each section within the themes covers applications (modeling), mathematics, numerical methods (using a case example) and open questions. Written by experts in the area, the presentation is mathematically rigorous. The entries are cross-referenced for easy navigation through connected topics. Available in both print and electronic forms, the handbook is enhanced by more than 150 illustrations and an extended bibliography. It will benefit students, scientists and researchers in applied mathematics. Engineers and computer scientists working in imaging will also find this handbook useful.

Download or read book Physics of PET and SPECT Imaging written by Magnus Dahlbom and published by CRC Press. This book was released on 2017-02-17 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.

Download or read book Basic Science of PET Imaging written by Magdy M. Khalil and published by Springer. This book was released on 2016-11-07 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.

Download or read book Computer Vision and Mathematical Methods in Medical and Biomedical Image Analysis written by Milan Sonka and published by Springer Science & Business Media. This book was released on 2004-09-20 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical imaging and medical image analysisare rapidly developing. While m- ical imaging has already become a standard of modern medical care, medical image analysis is still mostly performed visually and qualitatively. The ev- increasing volume of acquired data makes it impossible to utilize them in full. Equally important, the visual approaches to medical image analysis are known to su?er from a lack of reproducibility. A signi?cant researche?ort is devoted to developing algorithms for processing the wealth of data available and extracting the relevant information in a computerized and quantitative fashion. Medical imaging and image analysis are interdisciplinary areas combining electrical, computer, and biomedical engineering; computer science; mathem- ics; physics; statistics; biology; medicine; and other ?elds. Medical imaging and computer vision, interestingly enough, have developed and continue developing somewhat independently. Nevertheless, bringing them together promises to b- e?t both of these ?elds. We were enthusiastic when the organizers of the 2004 European Conference on Computer Vision (ECCV) allowed us to organize a satellite workshop devoted to medical image analysis.

Download or read book Pattern Theory written by Ulf Grenander and published by Oxford University Press. This book was released on 2007 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pattern Theory provides a comprehensive and accessible overview of the modern challenges in signal, data, and pattern analysis in speech recognition, computational linguistics, image analysis and computer vision. Aimed at graduate students in biomedical engineering, mathematics, computer science, and electrical engineering with a good background in mathematics and probability, the text includes numerous exercises and an extensive bibliography. Additional resources including extended proofs, selected solutions and examples are available on a companion website. The book commences with a short overview of pattern theory and the basics of statistics and estimation theory. Chapters 3-6 discuss the role of representation of patterns via condition structure. Chapters 7 and 8 examine the second central component of pattern theory: groups of geometric transformation applied to the representation of geometric objects. Chapter 9 moves into probabilistic structures in the continuum, studying random processes and random fields indexed over subsets of Rn. Chapters 10 and 11 continue with transformations and patterns indexed over the continuum. Chapters 12-14 extend from the pure representations of shapes to the Bayes estimation of shapes and their parametric representation. Chapters 15 and 16 study the estimation of infinite dimensional shape in the newly emergent field of Computational Anatomy. Finally, Chapters 17 and 18 look at inference, exploring random sampling approaches for estimation of model order and parametric representing of shapes.

Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

Download or read book Information Processing in Medical Imaging written by James Duncan and published by Springer Science & Business Media. This book was released on 1997-05-21 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 15th International Conference on Information Processing in Medical Imaging, IPMI'97, held in Poultney, Vermont, USA, in June 1997. The 27 revised full papers presented were selected from a total of 96 submissions; also included are 31 poster presentations. The book is divided into topical sections on shape models and matching, novel imaging methods, segmentation, image quality and statistical character of measured data, registration/mapping, statistical models in functional neuroimaging, and MR analysis and processing.

Download or read book Codes Curves and Signals written by Alexander Vardy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Codes, Curves, and Signals: Common Threads in Communications is a collection of seventeen contributions from leading researchers in communications. The book provides a representative cross-section of cutting edge contemporary research in the fields of algebraic curves and the associated decoding algorithms, the use of signal processing techniques in coding theory, and the application of information-theoretic methods in communications and signal processing. The book is organized into three parts: Curves and Codes, Codes and Signals, and Signals and Information. Codes, Curves, and Signals: Common Threads in Communications is a tribute to the broad and profound influence of Richard E. Blahut on the fields of algebraic coding, information theory, and digital signal processing. All the contributors have individually and collectively dedicated their work to R. E. Blahut. Codes, Curves, and Signals: Common Threads in Communications is an excellent reference for researchers and professionals.