Download or read book Pathway of Progress written by David Weller Bowman and published by . This book was released on 1951 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell and molecular signaling and transport pathways involved in growth factor control of synaptic development and function written by Akira Yoshii and published by Frontiers Media SA. This book was released on 2015-08-31 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain derived neurotophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) signaling has been extensively studied for its roles in the central nervous system (CNS) ranging from cell survival, axonal and dendritic growth and synapse formation. Intracellular signaling pathways triggered by BDNF activate gene transcription, translation, post-translational functions, trafficking of key synaptic proteins, and synaptic release mechanism. BDNF-TrkB signaling mediates long-lasting activity-modulated synaptic changes on excitatory and inhibitory neurons and plays significant roles in circuit development and modulation. Furthermore, this pathway is critical for learning, memory, sensory processing and other cognitive functions, and is implicated in neurological and psychiatric diseases. In addition to BDNF, more recent studies have identified new “growth” factors that play important roles in the development, maturation and maintenance and modulation of synaptic function. However, details of the cytoplamic signaling systems downstream of these synaptogenic factors are often less understood than conventional neurotophin signaling. This e-Book has collected original studies and review articles that present cellular and molecular mechanisms concerning activity-dependent synapse formation and their implications for behavior and brain disorders. It is our hope that readers will perceive this volume as a showcase for diversity and complexity of synaptogenic growth factors, and will stimulate further studies in this field.

Download or read book Pathway to a Professorship written by Donald E. Hattin and published by AuthorHouse. This book was released on 2014-01-21 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: As an undergraduate student at UMass Don Hattin recorded in detail events which colored each day with the trials and triumphs of academic life. He recounts the low cost of attending college, fun and facts about dormitory life, seemingly endless drudgery of homework, unfounded fear of earning poor grades, and classes of great interest versus those without redeeming characteristics or content. Don describes the antics of dormitory life, which leave the reader wondering how and when studying was done. Don shares treasured memories of work in the College Store, where many humorous events occurred, and lively association with faculty and students in the Geology Department, where genuine camaraderie accompanied work in the classroom, laboratory and field. As a T.A. at the University of Kansas, Don discovered the joy of teaching and field work. His master’s thesis research on Cretaceous-age rocks was prompted by a future member of the National Academy of Science, leading initially to both fun and temporary futility of work on the Kansas prairie. At the doctoral level, Don was mentored by a world-famous paleontologist who was intimidating in the office but a mellow field geologist. Just once, Don challenged his mentor on identification of a fossil, and won! During this interval, a key geology faculty member departed, resulting in Don’s appointment as Instructor to teach two courses, thus enabling Don to gain skills needed when assuming a professional role. While interviewing in Ohio for a full time teaching position, Don received a call from the geology chairman at Indiana University, where a short visit resulted in offer of an Assistant Professorship. Don’s acceptance let to a career-long association with that institution.

Download or read book Signaling Pathways in Liver Diseases written by Pierre-Alain Clavien and published by Springer Science & Business Media. This book was released on 2005 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo surgery obliges liver surgeons and hepatologists to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate more research that can lead to more exchanges between the laboratory, the clinical ward and the operating room.

Download or read book Green Development written by Rocky Mountain Institute and published by John Wiley & Sons. This book was released on 1998 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Green Development is good for business. Tenants, owners, purchasers, and brokers are all becoming more sophisticated and are realizing the financial and social benefits of green product." --Gerald Hines, Chairman of Hines. Environmentally responsible real estate development makes dollars and sense. Green Development describes an exciting new field in which environmental considerations are viewed as opportunities to create fundamentally better buildings and communities--more comfortable, more efficient, more appealing, and ultimately more profitable. If you're a developer, architect, planner, contractor, lender, or city official, this book speaks your language. Every stage of the development process is examined in detail: market research, site planning, design, approvals, financing, construction, marketing, and occupancy. Also included are lists of project statistics and contacts, books and other information sources, and development strategies. Based on 80 case studies drawn from Rocky Mountain Institute's extensive worldwide research and consulting work, Green Development distills proven procedures and practical lessons that work in the real world.

Download or read book Publication written by and published by . This book was released on 1994 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights to Improve Oncologic Therapies written by Alma D. Campos-Parra and published by Frontiers Media SA. This book was released on 2021-08-26 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Common Pathways Linking Neurodegenerative Diseases The Role of Inflammation written by Grzegorz Kreiner and published by Frontiers Media SA. This book was released on 2021-11-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book P38 Signaling Pathway written by Ana Cuenda and published by MDPI. This book was released on 2021-09-02 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.

Download or read book Targeting the Wnt Pathway in Cancer written by Kathleen H. Goss and published by Springer Science & Business Media. This book was released on 2011-01-25 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

Download or read book Reprogramming Microbial Metabolic Pathways written by Xiaoyuan Wang and published by Springer Science & Business Media. This book was released on 2012-10-20 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering has been developed over the past 20 years to become an important tool for rational engineering of microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of metabolites in microorganisms. The overall goal is to achieve a better understanding of metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation.

Download or read book Signaling Pathways in Cancer Pathogenesis and Therapy written by David A. Frank and published by Springer Science & Business Media. This book was released on 2011-11-12 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis. In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion, metastasis, and angiogenesis. Thus, understanding the mechanisms by which signaling pathways become subverted in a cancer cell can provide insight into critical events in cancer pathogenesis. Furthermore, as our ability to target specific molecular interactions advances, we now have the ability to design small molecules, protein therapeutics, and other forms of targeted therapies. By focusing on the specific molecular abnormalities in a cancer cell, these agents hold the potential to be much more effective and much less toxic than current cytotoxic therapies.

Download or read book Molecular Signalling and Pathways Editor s Picks 2021 written by Jean-Marc Taymans and published by Frontiers Media SA. This book was released on 2021-07-29 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Base Excision Repair Pathway written by Kishor K. Bhakat and published by Springer Nature. This book was released on 2023-09-14 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides a comprehensive set of experimental protocols and useful strategies to examine the repair of damaged bases via the Base Excision Repair (BER) pathway in vitro and in cells. Beginning with multiple molecular and cellular techniques to examine the excision of damaged bases from double-stranded DNA or DNA wrapped in a nucleosome, the book continues with sections covering procedures to detect and quantify the damaged bases, protein DNA crosslinks, and double-strand breaks, experimental procedures to identify DNA repair protein interactome by conventional tandem affinity purification followed by mass spectroscopy analysis, as well as the analysis of genome-wide binding of DNA repair proteins and copy number variations of the DNA damage response gene in tumors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Base Excision Repair Pathway: Methods and Protocols serves as a valuable resource for novices and experts trying to examine the repair of various types of DNA lesions in vitro and in cell by the distinct set of proteins in the BER pathway.

Download or read book Targeting Cellular Signalling Pathways in Lung Diseases written by Kamal Dua and published by Springer Nature. This book was released on 2021-07-02 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively reviews and provides detailed insight into the cellular and molecular signalling mechanisms involved in pathophysiology of various respiratory diseases, towards developing effective therapeutic strategies in the management and treatment of lung disease. It also covers promising advances in the field of therapeutics that could lead to novel clinical therapies capable of preventing or reversing the disease features including novel strategies for targeting chronic lung diseases using advanced drug delivery systems. Importantly, the book examines the significance and relevance of the plant extracts and their constituents with therapeutic efficiencies against lung diseases. As such, the book offers a blend of translational, biological, chemical, and drug delivery aspects relevant to respiratory diseases, thus, offering a valuable resource for pulmonologists and translational researchers working in the field of pulmonary biology and respiratory medicine.

Download or read book Repurposed Drugs Targeting Cancer Signaling Pathways Dissecting New Mechanisms of Action Through in vitro and in vivo Analyses written by Alma D. Campos-Parra and published by Frontiers Media SA. This book was released on 2021-11-29 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Illinois Services Directory written by and published by . This book was released on 1990 with total page 1568 pages. Available in PDF, EPUB and Kindle. Book excerpt: