Download or read book Parkinson s Diva written by Maria De Leon and published by . This book was released on 2015-06-29 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease affects all sides of you: your inside, your outside, and your "right" side-that is, the side where you feel positive, balanced, and beautiful. How do you find that edge when you're not feeling very sharp at all? Parkinson's Diva is a personal and professional accounting of a young Parkinson's doctor's experience with the disease in all realms of her life . . . from doctor, caregiver, and ultimately as a young Parkinson's patient herself. Not only does Dr. Maria De Leon cover important basics of PD and research-based data, she also shares the personal concerns and gender-specific battles that young women who live with the disease must face. She encourages all of us to be empowered through education, self-awareness, and faith. This book is about embracing your own style and grace in your journey with PD . . . as Maria says "summoning your inner diva.""
Download or read book Parkinson s Diva written by Maria De Leon and published by Thewordverve Incorporated. This book was released on 2019-07-12 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed specifically for women with Parkinson's disease, this delightfully illustrated guided journal offers fun activities and a place to document the hopes and struggles that go along a Parkinson's diagnosis. Be inspired through this workbook and let your Inner Diva shine!
Download or read book Self management support to handle everyday life with Parkinson s disease written by Carina Hellqvist and published by Linköping University Electronic Press. This book was released on 2020-04-27 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background: Being diagnosed with Parkinson´s disease (PD) is a life-altering experience. The long-term condition requires continuous adjustments to the everyday life not only of the person affected, but also for care partners. There is still insufficient knowledge on how best to support this process of acceptance and adjustment to encourage self-management. Aims: The aim of this thesis is to enhance the knowledge and understanding of self-management for persons with PD (PwPD) and their care partners. Furthermore, to investigate whether the self-management intervention Swedish National Parkinson School can be used as a tool to support self-management, and how nurses specialised in the care of persons with Parkinson´s disease can tailor their support to encourage self-management in everyday life. Method and design: Both qualitative and quantitative designs and methods were used in the three studies included in this thesis. Participants included a total of 209 persons. Of these, 127 were persons with PD and 75 were care partners. Participants with PD were largely in the middle stages of the disease. The time since diagnosis ranged from less than one year to over 20 years, and most participants had lived with the disease for around five years. Participants were cared for at five separate outpatient clinics, both geriatric and neurological, in three county and two university hospitals across Sweden. Data collection included observations, interviews, self-reported questionnaires and audio-recordings of the National Parkinson School in clinical care. The overall results of this thesis were obtained using a qualitative approach, where the results of the three studies were analysed using qualitative thematic analysis as described by Braun and Clarke (2006). Results: In combining the results of the separate studies through thematic analysis three distinct but interrelated themes were evident. These described the processes and efforts of persons to accept, manage and adjust to everyday life with PD. The theme “A changed reality” involves participants´ descriptions of how life changed after the diagnosis of PD. For many this was a shock, and both the person affected and their care partners experienced a variety of emotions such as anger, denial and hopelessness. It changed their personal identities, their perception of themselves as individuals and as a couple. They worried about what the future would hold, and the uncertainty was hard to accept and handle. One strategy for processing and beginning to acknowledge the new situation involved speaking openly about the diagnosis. The second theme “Finding a new path”, involves a description of how, after accepting or at least acknowledging, their new reality, participants started to find ways of managing the impact of PD on everyday life, incorporating it into their current life and identity. Many felt new knowledge was needed and turned to books and websites on PD. An intervention which was appreciated in terms of providing tools for self-observation and self-knowledge was the Swedish National Parkinson School. Participants later used these techniques to communicate and observe symptoms and healthcare needs. Being an active participant in life and performing activities such as physical exercise or other activities they enjoyed were also used as a strategy to feel satisfaction in life. Participants frequently worked out self-care and compensatory strategies to handle everyday tasks. Another strategy they found comforting and helpful involved retaining a positive mind-set and believing that a good future lay ahead. In the third category “The companions”, the participants described self-management in everyday life as a task they performed together. Management of PD was considered the shared responsibility of the person affected and the care partner, but was also influenced by others such as family members and close friends. The Swedish National Parkinson School provided knowledge as a form of common ground for the person affected and the care partner. During the Swedish National Parkinson School, the social interaction involved in exchanging experiences and feeling support from others in the same situation was considered helpful and was much appreciated. Conclusions: Management of PD in everyday life involves both the person affected and the care partner. After the initial emotional reactions, alongside feelings of lost identity and an altered life, persons started to look to the future and were ready to find ways of handling the changed conditions of their everyday lives. Persons with PD and their care partners were now willing to learn more about PD and to find tools and strategies to help them manage its impact on their everyday lives. During this phase, they appreciated the support of the Swedish National Parkinson School intervention. In the intervention, they would meet others in the same situation to find support and exchange experiences. They also turn to healthcare for support in the process of self-management in everyday life. Nurses working specifically to support PwPD and their CP will need to tailor support taking into account the disease trajectory as well as the psychological processes involved in accepting and adjusting to PD to best fit the unique needs and wishes of every person with PD and their care partner.
Download or read book Apomorphine in Parkinson s Disease written by Per Odin and published by . This book was released on 2005 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apomorphine in Parkinson's Disease provides a thorough and comprehensive review of apomorphine, one of the oldest drugs still in clinical use that recently has received renewed attention due to its efficacy in the treatment of advanced Parkinson's disease.Apomorphine in Parkinson's Disease covers the history of the drug, its pharmacology and clinical use in Parkinson's disease, practical tips and recommendations for its use, as well as a discussion of health economic aspects of its use. The efficacy of apomorphine is also contrasted to that of other recent approaches to the treatment of advanced Parkinson's disease, most notably neurosurgical interventions.The primary audience of Apomorphine in Parkinson's Disease consists of physicians and nurses concerned with the management of patients suffering from advanced Parkinson's disease, but it will probably also be relevant for other health care professionals (including students and those practicing in related fields), researchers, teachers, administrators and decision makers with an interest in the field of Parkinson's disease and clinical neurology.
Download or read book Mary and Me written by Robyn Cotton and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Living and Laughing with Parkinson s written by and published by Memoirs Foundation. This book was released on 2011 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Anne Atkin endured many of the symptoms of Parkinson's for eight long, frustrating and painful years. When she was finally diagnosed with Parkinson's disease, her reaction was mixed. She was glad she finally knew the cause of her symptoms but she wasn't happy about the label that came with it. Anne made up her mind, she knew there were some fights she could never win but there would be many that she could, so she set about doing just that. Working on overcoming each challenge one by one, Anne trained her facial muscles to smile and when she succeeded she began to laugh again. With the help of others she set about using art as therapy... Anne has identified many of the challenges of people with Parkinson's. Dealing with them in a light hearted fashion, Anne shows ways in which loved ones will be better able to understand what changes are occurring..."--Back cover.
Download or read book The hiss of hope written by Meredith Oenning-Hodgson and published by Chiron Publications. This book was released on 2019-05-03 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s Disease;chronic illness;intimate autonomy;psychology;Jungian psychology From the initial port of a relating pattern with Parkinson’s Disease consisting of the usual fight, flight, freeze or the book’s new ‘fall’ structural methodology, the author takes off on a voyage harboring cryptic intimations about being “with” an illness, about a less ego accentuated interacting. This remarkable transmutation happens gradually. A re-molding takes place during the course of an eight year journey. The nucleus of this book is a descriptive narrative of this journey, of a voyage to the paradoxical space of an intimate autonomy. Even though THE HISS OF HOPE is about living with a chronic disease, the book does not dwell on a life of suffering and desperation, but rather, it also depicts the adventure leading to places, to encounters and to depths of experience that would not have been possible without first having been ambushed by Parkinson’s. Today’s Zeitgeist seems to be pregnant with dark and fearful hints of impending disasters. This book suggests an intimate autonomy as a culturally integrable relating pattern to cope with life in the first half of the 21st century. And with death. With a grateful nod to Parkinson’s Disease and its initial rupture of her life, the author concludes her book with a generous smile. The sparkle of the ‘before’ space links to the calm radiance of the ‘after’. And the sibilant hiss, reveals itself as a dynamic third between hope and no-hope: a concurrent unity of an intimate togetherness and an autonomous separateness. A beginning asserts itself at the end. Parkinson’s reacts with a wise and iconic grin.
Download or read book The Truth About Parkinson s Disease In Women written by Dr Lisa E Patterson and published by Independently Published. This book was released on 2024-03-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now you are about to embark on a transformative journey into the world of Parkinson's disease, where women's world take the center stage. In this book, you'll be seeing deep into the untold truths, unique challenges, and remarkable resilience of women living with Parkinson's disease. Discover the hidden complexities behind Parkinson's as we unravel its mysteries through the eyes of women facing this formidable foe. From the subtle tremors to the invisible battles within, this book sheds light on the often-overlooked nuances of Parkinson's in women. Through accessible insights, "The Truth About Parkinson's Disease In Women- The Brave Journey; Her Quiet Battle" will empower you to understand the intersection of gender and Parkinson's disease. Explore the genetic predispositions, hormonal influences, and socio-economic factors shaping women's journey with PD- The Parkinson's disease. This book is a celebration of the extraordinary courage and strength exhibited by women in the face of adversity. Each page is a testament to their resilience, determination, and unwavering spirit as they navigate the twists and turns of life with Parkinson's. Join us on a mission to raise awareness, advocate for equity, and inspire hope for a brighter future for women with Parkinson's disease. "The Truth About Parkinson's Disease In Women" is not just a book-it's a beacon of light, a source of empowerment, and a rallying cry for change. Whether you're a woman living with Parkinson's, a caregiver, a healthcare professional, or simply someone curious about women with Parkinson's, this book invites you to join the conversation, challenge perceptions, and embrace the power of resilience in the face of adversity. Together, let's shine a spotlight on the truth about Parkinson's disease in women and illuminate the path towards a world of understanding, support, and empowerment. You don't have to look any further.. Click NOW to purchase!
Download or read book Simple Dreams written by Linda Ronstadt and published by Simon and Schuster. This book was released on 2014-09-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes discography (page 203-225) and index.
Download or read book Cognition in Parkinson s Disease written by and published by Elsevier. This book was released on 2022-03-02 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognition in Parkinson's Disease, Volume 269 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cognition in Prodromal Parkinson’s disease, The epidemiology of cognitive function in Parkinson's disease, Real-life consequences of cognitive dysfunction in Parkinson’s disease, Animal models of cognition in Parkinson’s disease, Functional neuroanatomy of cognition in Parkinson’s disease, Neuroimaging approaches to cognition in Parkinson’s disease, Cognitive dysfunction and neuropsychiatric aspects of Parkinson’s disease, Neuropsychology of Parkinson’s disease, Cholinergic Systems, Attentional-Motor Integration, and Cognitive Control in Parkinson Disease, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Progress in Brain Research series Updated release includes the latest information on Cognition in Parkinson's Disease
Download or read book Neuropalliative Care written by Claire J. Creutzfeldt and published by Springer. This book was released on 2018-10-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide thoroughly covers all aspects of neuropalliative care, from symptom-specific considerations, to improving communication between clinicians, patients and families. Neuropalliative Care: A Guide to Improving the Lives of Patients and Families Affected by Neurologic Disease addresses clinical considerations for diseases such as dementia, multiple sclerosis, and severe acute brain injury, as well discussing the other challenges facing palliative care patients that are not currently sufficiently met under current models of care. This includes methods of effective communication, supporting the caregiver, how to make difficult treatment decisions in the face of uncertainty, managing grief, guilt and anger, and treating the pain itself. Written by leaders in the field of neuropalliative care, this book is an exceptional, well-rounded resource of neuropalliative care, serving as a reference for all clinicians caring for patients with neurological disease and their families: neurologists and palliative care specialists, physicians, nurses, chaplains, social workers, as well as trainees in these areas.
Download or read book A Soft Voice in a Noisy World written by Karl Robb and published by RobbWorks LLC. This book was released on 2012-11 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: A compilation of insights, practical tools and inspirational suggestions for improving mind-body connection and empowering healing.
Download or read book Cortico Subcortical Dynamics in Parkinson s Disease written by Kuei-Yuan Tseng and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The striatum is the principal input structure of the basal ganglia. Numerically, the great majority of neurons in the striatum are spiny projection neurons, which produce the inhibitory output of the striatum to the globus pallidum and substantia nigra. The major glutamatergic afferents to the striatum from the cerebral cortex make monosynaptic contact with spiny projection neurons. The dopaminergic afferents from the substantia nigra also synapse directly on the spiny projection neurons. Thus, the spiny projection neurons play a crucial role in the input–output operations of the striatum by integrating glutamatergic cortical inputs with dopaminergic inputs and producing the output to other basal ganglia nuclei. Anatomical observations made nearly 30 years ago suggested that inhibitory interactions among the spiny projection neurons of the striatum are very pr- able. Individual spiny projection neurons produce a local axonal plexus in the spheroidal space occupied by their own dendritic trees [1, 2]. Based on the GABAergic nature of these neurons and their synaptic contacts with other spiny neurons, several authors have proposed that the spiny projection neurons form a lateral inhibition type of neural network [3–5]. In the idealised concept of lateral inhibition, each output neuron makes inhibitory synaptic contact with its neighbours [5]. However, there are physical limitations set by the extent of axonal and dendritic trees, and the number of synaptic sites, which mean that lateral inhibition is limited to a local domain of inhibition.
Download or read book Peripheral Immunity in Parkinson s Disease Emerging Role and Novel Target for Therapeutics written by Cristoforo Comi and published by Frontiers Media SA. This book was released on 2019-12-23 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mitochondrial Mechanisms of Degeneration and Repair in Parkinson s Disease written by Lori M. Buhlman and published by Springer. This book was released on 2016-09-13 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Download or read book Biomarkers and Pathogenesis of Alpha Synuclein in Parkinson s Disease written by Pingyi Xu and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Levodopa pharmacokinetics from stomach to brain written by Maria Nord and published by Linköping University Electronic Press. This book was released on 2019-01-07 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.
