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Book Paradigm Changes Are Required in HIV Vaccine Research

Download or read book Paradigm Changes Are Required in HIV Vaccine Research written by Marc H. V. Van Regenmortel and published by Frontiers Media SA. This book was released on 2015-12-08 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his 1962 book "The Structure of Scientific Revolutions", Thomas Kuhn famously argued that researchers in every field of scientific enquiry always operate under a set of presuppositions known as paradigms that are rarely explicitly stated. In the field of HIV vaccine research, several prevailing paradigms led scientists for many years to pursue unfruitful lines of investigations that impeded significant progress. The uncritical acceptance of reigning paradigms makes scientists reluctant to abandon their mistaken assumptions even when they obtain results that are not consistent with the paradigms. The following five paradigms which disregard the degeneracy of the immune system were particularly harmful. 1) There is a primary and intrinsic epitope specific for each B cell receptor and for the corresponding monoclonal antibody. In reality, there is no single, intrinsic or "real" epitope for any antibody but only a diverse group of potential ligands. 2) Reactions with monoclonal antibodies are more specific than the combined reactivity of polyclonal antibodies. In reality, a polyclonal antiserum has greater specificity for a multiepitopic protein because different antibodies in the antiserum recognize separate epitopes on the same protein, giving rise to an additive specificity effect. By focusing vaccine design on single epitope-Mab pairs, the beneficial neutralizing synergy that occurs with polyclonal antibody responses is overlooked. 3) The HIV epitope identified by solving the crystallographic structure of a broadly neutralizing Mab – HIV Env complex should be able, when used as immunogen, to elicit antibodies endowed with the same neutralizing capacity as the Mab. Since every anti HIV bnMab is polyspecific, the single epitope identified in the complex is not necessarily the one that elicited the bnMab. Since hypermutated Mabs used in crystallographic studies differ from their germline-like receptor version present before somatic hypermutation, the identified epitope will not be an effective vaccine immunogen. 4) Effective vaccine immunogenicity can be predicted from the antigenic binding capacity of viral epitopes. Most fragments of a viral antigen can induce antibodies that react with the immunogen, but this is irrelevant for vaccination since these antibodies rarely recognize the cognate, intact antigen and even more rarely neutralize the infectivity of the viral pathogen that harbors the antigen. 5) The rational design of vaccine immunogens using reverse vaccinology is superior to the trial-and-error screening of vaccine candidates able to induce protective immunity. One epitope can be designed to increase its structural complementarity to one particular bnMab, but such antigen design is only masquerading as immunogen design because it is assumed that antigenic reactivity necessarily entails the immunogenic capacity to elicit neutralizing antibodies. When HIV Env epitopes, engineered to react with a bnMab are used to select from human donors rare memory B cells secreting bnAbs, this represents antigen design and not immunogen design. The aim of this Research Topic is to replace previous misleading paradigms by novel ones that better fit our current understanding of immunological specificity and will help HIV vaccine development.

Book Reassessing HIV Vaccine Design and Approaches

Download or read book Reassessing HIV Vaccine Design and Approaches written by Omar Bagasra and published by . This book was released on 2013 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we not have a vaccine for HIV? What are we doing wrong? Every HIV vaccine has failed so far, and public opinion is turning pessimistic against the scientific community. HIV vaccine efforts need a major shift in strategy. They require a better understanding of the immunological mechanisms that prevent African primates from getting AIDS. None of the 40 species of African primates, including chimpanzees and gorillas, get AIDS, even though all of them carry HIV-like viruses in their bodies. Why are they naturally vaccinated, while all of the man-made vaccines against HIV have failed miserably? This book offers intriguing new possibilities for the nature of human immunity, and the development of an effective AIDS vaccine. It is also a provocative treatise on the origin, evolution, and etiology of several forms of immune systems that is supported by a wealth of peer-reviewed scientific references. The compelling ideas presented in this study should have an important bearing on HIV vaccine development. It is a must read for anyone interested in the development of a safe AIDS vaccine, and for individuals interested in human immunity generally.

Book HIV AIDS  Immunochemistry  Reductionism and Vaccine Design

Download or read book HIV AIDS Immunochemistry Reductionism and Vaccine Design written by Marc H V Van Regenmortel and published by Springer Nature. This book was released on 2019-11-26 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.

Book HIV AIDS  New Insights for the Healthcare Professional  2013 Edition

Download or read book HIV AIDS New Insights for the Healthcare Professional 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 1112 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIV/AIDS: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built HIV/AIDS: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of HIV/AIDS: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Book Animal Experimentation  Working Towards a Paradigm Change

Download or read book Animal Experimentation Working Towards a Paradigm Change written by Kathrin Herrmann and published by BRILL. This book was released on 2019-04-30 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.

Book Medicinal Protein Engineering

Download or read book Medicinal Protein Engineering written by Yury E. Khudyakov and published by CRC Press. This book was released on 2008-12-01 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: An All-Inclusive Review of the Achievements and Trends in the Fast-Growing Protein Engineering Field From humble beginnings like making fire for mere survival, engineering now steadfastly penetrates all aspects of our lives and even life itself at the molecular level. Protein engineering is a molecular biological discipline focused on designing and

Book Immunology

    Book Details:
  • Author : Richard A. Goldsby
  • Publisher : Macmillan
  • Release : 2003
  • ISBN : 9780716749479
  • Pages : 662 pages

Download or read book Immunology written by Richard A. Goldsby and published by Macmillan. This book was released on 2003 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of the acclaimed bestseller, always praised for offering cutting edge material in the context of landmark experiments, in a student friendly format built on pedagogy not usually found in immunology texts.

Book A Guide to AIDS

    Book Details:
  • Author : Omar Bagasra
  • Publisher : CRC Press
  • Release : 2017-03-31
  • ISBN : 1315317265
  • Pages : 176 pages

Download or read book A Guide to AIDS written by Omar Bagasra and published by CRC Press. This book was released on 2017-03-31 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guide to AIDS is succinct review of HIV/AIDS from a human-interest perspective. Chapters focus on some of the common patterns and prevention of HIV transmission and debunks misconceptions about HIV and AIDS. Brief descriptions the human immune system and epidemiology of HIV are included. The cultural component of disease, treatment and living with AIDS is central to much of this guide intended to synthesize, explain and de-mystify HIV and AIDS.

Book Immunology and the Quest for an HIV Vaccine

Download or read book Immunology and the Quest for an HIV Vaccine written by Dr. Omar Bagasra, MD, PhD and Dr. Donald Gene Pace, PhD and published by Author House. This book was released on 2012-01-13 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: How many human immune systems are there? How old are they? Why is there no AIDS vaccine? Is a new approach needed? Why is public opinion growing skeptical of the scientific community after three decades of public awareness about HIV/AIDS? Consider answers to these puzzling questions. Learn from the decades of experience of two senior scholars: Dr. Omar Bagasra (an eminent molecular biologist, immunologist, and retrovirologist) and Dr. Donald Gene Pace (a highly published writer who examines public health policy). Explore intriguing new possibilities about human immunity, and the development of an effective AIDS vaccine. Read Immunology and the Quest for an HIV Vaccine. Benefit from an informed synthesis backed by a wealth of peer-reviewed scientific references. Review basic concepts of immunology, and stretch your perspective by contemplating this creative synthesis that provides a provocative treatise on the origin, evolution, and etiology of several forms of immune systems. Consider compelling ideas that will have an important bearing on HIV vaccine development. Enjoy this informative volume designed for anyone interested in the development of a safe AIDS vaccine, for anyone curious about present knowledge about human immunity, and for anyone yearning for a solution to the global pandemic that is AIDS.

Book Kuby Immunology

    Book Details:
  • Author : Thomas J. Kindt
  • Publisher : Macmillan
  • Release : 2007
  • ISBN : 9781429202114
  • Pages : 700 pages

Download or read book Kuby Immunology written by Thomas J. Kindt and published by Macmillan. This book was released on 2007 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally authored by the award winning author Janis Kuby, "Immunology" remains the best selling textbook for the undergraduate course. The first and only true textbook written by professors who teach the undergraduate course, it presents the most current concepts in an experimental context with clinical advances highlighted in boxes, supported by the kind of helpful pedagogical tools that other books do not provide.

Book HIV Associated Immune Activation and Persistent Inflammation

Download or read book HIV Associated Immune Activation and Persistent Inflammation written by Martin Hoenigl and published by Frontiers Media SA. This book was released on 2020-01-21 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2013

Download or read book Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2013 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 2012 with total page 1834 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Vaccine Design

    Book Details:
  • Author : Rino Rappuoli
  • Publisher : Caister Academic Press Limited
  • Release : 2011
  • ISBN : 9781904455745
  • Pages : 0 pages

Download or read book Vaccine Design written by Rino Rappuoli and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, expert international authors critically review the current cutting-edge research in vaccine design and development. Particular emphasis is given to new approaches and technologies.

Book Vaccines for Biodefense and Emerging and Neglected Diseases

Download or read book Vaccines for Biodefense and Emerging and Neglected Diseases written by Alan D.T. Barrett and published by Academic Press. This book was released on 2009-03-05 with total page 1519 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 20 years has seen a rapid increase in infectious diseases, particularly those that are termed "emerging diseases" such as SARS, "neglected diseases" such as malaria and those that are deemed biothreats such as anthrax. It is well-recognized that the most effective modality for preventing infectious diseases is vaccination. This book provides researchers with a better understanding of what is currently known about these diseases, including whether there is a vaccine available or under development. It also informs readers of the key issues in development of a vaccine for each disease. Provides a comprehensive treatise of the agents that are responsible for emerging and neglected diseases and those that can be used as biothreats Includes the processes such as the vaccine development pathway, vaccine manufacturing and regulatory issues that are critical to the generation of these vaccines to the marketplace Each chapter will include a map of the world showing where that particular disease is naturally found

Book Promoting Innovation  Productivity and Industrial Growth and Reducing Poverty

Download or read book Promoting Innovation Productivity and Industrial Growth and Reducing Poverty written by Maureen Mackintosh and published by Routledge. This book was released on 2021-04-26 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development and the ending of mass poverty require a massive increase in productive capabilities and production in developing countries. Some countries, notably in Asia, are achieving this. Yet ‘pro-poor’ aid policies, especially for the least developed countries, operate largely without reference to policy thinking on the promotion of innovation for productivity growth. Conversely, policy-makers and researchers on innovation and industrial policies tend to know little about the potential for social protection to support innovation and productivity improvement. This book aims to focus attention on this gulf between research on innovation and on poverty reduction and to identify some of its policy consequences; to set out some ways in which this gulf can be bridged, analytically and empirically; and to contribute to the creation of an agenda for further research and an understanding of the urgency of the implied rethinking. The first two chapters provide sustained arguments for embedding social policy thinking in much more ‘productivist’ frameworks of thought that focus on raising productivity and employment; and for identifying growth theories that can incorporate satisfactory understandings of innovation and employment upgrading. A set of chapters then tackle these broad themes in the context of health, addressing the interlinked issues of innovation, health inequity and associated impoverishment. The final set of chapters examines the challenge of creating industrial policies that generate both innovation and employment, using and going beyond concepts of systems of innovation.

Book AIDS

    Book Details:
  • Author : The aids2031 Consortium
  • Publisher : FT Press
  • Release : 2010-12-09
  • ISBN : 0132172925
  • Pages : 171 pages

Download or read book AIDS written by The aids2031 Consortium and published by FT Press. This book was released on 2010-12-09 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: AIDS is a continuing worldwide health crisis. Over 25,000,000 people have died from AIDS, and more than 33,000,000 are infected today. While treatments in the developed world have moved AIDS from a fatal to a chronic, highly expensive disease, it remains the sixth greatest cause of death globally and most of those infected in the developing world don't have access to treatments. Here, the AIDS 2031 Commission's experts report on the first 50 years of the AIDS pandemic: the 30 years that have passed since AIDS was first diagnosed, and the prospects and best plans to address the ongoing worldwide AIDS epidemic over the coming 20 years. The authors address the entire scope of the pandemic: basic science, public health, funding, treatment options, and social and societal impacts and review the full range of possible and recommended responses over the next two decades. They carefully assess the progress that has been made, and both persistent and emerging challenges. Written to be easily understandable by all readers, this book is the single best source of reliable information on where the pandemic stands today, where it's headed, and what can be done to create better outcomes between now and 2031.

Book Mandell  Douglas  and Bennett s Principles and Practice of Infectious Diseases E Book

Download or read book Mandell Douglas and Bennett s Principles and Practice of Infectious Diseases E Book written by John E. Bennett and published by Elsevier Health Sciences. This book was released on 2019-08-08 with total page 5208 pages. Available in PDF, EPUB and Kindle. Book excerpt: For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips. Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource. Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis. Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases. Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases. Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci. PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America. Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition.