Download or read book Overcoming Ovarian Cancer Chemoresistance written by Goli Samimi and published by Academic Press. This book was released on 2020-11-06 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Download or read book Overcoming Drug Resistance in Gynecologic Cancers written by and published by Academic Press. This book was released on 2021-08-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Download or read book A Guide to Survivorship for Women with Ovarian Cancer written by F. J. Montz and published by JHU Press. This book was released on 2005-03-14 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers women with ovarian cancer support and resources to help them deal with the physical and emotional impact of their disease.

Download or read book Ovarian Cancer written by Ethan D. and published by Shuttle Systems. This book was released on 2024-03-11 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ovarian Cancer: A Comprehensive Resource for Patients and Families" is a vital guide for anyone impacted by ovarian cancer. This book provides a thorough exploration of the disease, offering clarity and support through each stage, from initial diagnosis to treatment and beyond.Understanding Ovarian CancerThe journey begins with an introduction to ovarian cancer, including its epidemiology, types, and stages. Gain an understanding of the ovaries' role in the female reproductive system and how cancer affects these vital organs.Recognizing Risk Factors and Early DetectionLearn about the genetic and environmental risk factors associated with ovarian cancer and the importance of early detection. This book covers the challenges of early detection, screening methods, and the critical role of diagnostic testing.Navigating Diagnosis and TreatmentDelve into the diagnostic process, including understanding pathology reports and the role of biopsy. Explore comprehensive treatment options, from surgery to chemotherapy, radiotherapy, and the latest in targeted therapy and immunotherapy.Managing Side Effects and ComplicationsUnderstand and manage the side effects and complications associated with treatment, including pain management and coping with emotional and physical stress.Nutrition and Lifestyle during TreatmentDiscover the importance of nutrition and lifestyle changes during treatment, with practical advice on diet, exercise, and lifestyle modifications for optimal health.Psychological Impact and SupportFind guidance on coping with the emotional and psychological impacts of ovarian cancer. Learn about the importance of psychological support, counseling, and the role of community and support groups.Recurrence and Long-term ManagementAddress the challenges of recurrence and long-term management of ovarian cancer, including strategies for monitoring, follow-up care, and understanding recurrence.Advances in ResearchStay informed about the latest advances in ovarian cancer research, emerging treatments, and the future direction of care and clinical trials.Special Considerations in CareGain insights into special considerations for ovarian cancer care, including issues relevant to young women, fertility, and menopausal management post-treatment.Advocacy and AwarenessUnderstand the importance of raising awareness and advocacy for ovarian cancer. Discover support networks and resources available to empower patients and families."Ovarian Cancer: A Comprehensive Resource for Patients and Families" is an indispensable tool, offering comfort, clarity, and hope to those navigating the complexities of ovarian cancer. It is a comprehensive guide that not only provides medical information but also addresses the emotional and practical aspects of coping with the disease.

Download or read book Ovarian Cancer written by Omer Devaja and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.

Download or read book Treatment of Ovarian Cancer written by A. P. Bardos and published by Nova Publishers. This book was released on 2005 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume presents the latest research on therapies for ovarian cancer. Ovarian cancer is cancer that begins in the cells that constitute the ovaries, including surface epithelial cells, germ cells, and the sex cord-stromal cells. Cancer cells that metastasize from other organ sites to the ovary (most commonly breast or colon cancers) are not then considered ovarian cancer. According to the American Cancer Society, ovarian cancer accounts for 4 percent of all cancers among women and ranks fifth as a cause of their deaths from cancer. The American Cancer Society statistics for ovarian cancer estimate that there will be 25,400 new cases and 14,300 deaths in 2003. The death rate for this disease has not changed much in the last 50 years. Unfortunately, almost 70 percent of women with the common epithelial ovarian cancer are not diagnosed until the disease is advanced in stage -- i.e., has spread to the upper abdomen (stage III) or beyond (stage IV). The 5-year survival rate for these women is only 15 to 20 percent, whereas the 5-year survival rate for stage I disease patients approaches 90 percent and for stage II disease patients approaches 70 percent. Ovarian tumors are named according to the type of cells the tumor started from and whether the tumor is benign or cancerous. The three main types of ovarian tumors are: Epithelial Tumors, Germ Cell Tumors and Stromal Tumors.

Download or read book Ovarian Cancers written by Eric Pujade-Lauraine and published by Springer. This book was released on 2016-10-17 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the latest developments in the concepts and management of ovarian cancer. The new data presented throughout opens the way to radically different therapeutic approaches. Surgery remains the core of ovarian cancer treatment, but its ultimate goal and the standard surgical procedure have evolved, giving rise to the question of how to label expert centers for debulking surgery. Neo-adjuvant chemotherapy is becoming more popular and is also a new field for testing novel drug combinations. Over recent years, ovarian cancer management has embraced molecular biology. It is now more correct to talk about cancers of the ovary rather than ovarian cancer, since it is not a unique disease but several entities with different molecular drivers. The significant advances in drugs targeting the microenvironment or the tumor cell DNA repair mechanisms are presented in detail together with exciting future perspectives. All these advances would not have been possible without collaborative groups such as the GINECO group in France and their integration in wider clinical research networks at the European (ENGOT) and international (GCIG) level.

Download or read book Ovarian Cancers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.

Download or read book A Guide to Survivorship for Women Who Have Ovarian Cancer written by Robert E. Bristow and published by JHU Press. This book was released on 2015-10-30 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers detailed information on diagnosis and treatment of ovarian cancer, including surgery, chemotherapy, and radiation treatment. Information on genetic testing, nutrition, pain control, and dealing with loss are covered also. Personal testimonials are included as well.

Download or read book Surgery for Ovarian Cancer written by Robert E. Bristow and published by CRC Press. This book was released on 2019-02-21 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated and expanded, the third edition of Surgery for Ovarian Cancer focuses on essential techniques for the effective management of ovarian cancer. It reflects the most contemporary science and surgical applications for the management of patients with ovarian cancer and related peritoneal surface malignancies. This new edition takes a step-by-step approach and includes new intraoperative photographs and videos illustrating surgical procedures. It is principally devoted to the technical aspects of cytoreductive surgery, with chapters divided according to anatomic region. The chapters cover relevant anatomical considerations, surgical challenges specific to each region, and operative approaches and techniques favored by the authors. The list of contributing authors has been expanded from the previous edition and includes international and world-renowned experts from the fields of gynecologic oncology and surgical oncology. The topics of minimally invasive surgery, secondary cytoreduction, palliative surgery, and postoperative care are also covered in detail. New to the third edition are chapters on preoperative risk stratification, regional therapeutics and peritonectomy procedures, and quality assurance relating to ovarian cancer surgery. This comprehensive text is essential reading for all practitioners working with patients with ovarian cancers.

Download or read book Fast Facts Ovarian Cancer written by Christina Fotopoulou and published by Karger Medical and Scientific Publishers. This book was released on 2017-05-09 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: When it comes to detecting, diagnosing and treating women who have, or are suspected of having, ovarian cancer, there are significant opportunities for well-informed healthcare professionals to intervene in a meaningful way. 'Fast Facts: Ovarian Cancer' examines the areas that will have the biggest effect in clinical practice, including: • the evidence for and against screening • the valuable role of genetic testing in identifying at-risk women • if and when to operate • strategies to overcome platinum resistance • the impact of targeted therapies. From the tools that will help establish a swift diagnosis to the risks and benefits of palliative salvage surgery, this refreshingly readable resource captures the key knowledge that every busy healthcare professional needs in order to make better health decisions for patients with ovarian cancer. Contents: • Epidemiology and prevention • Pathophysiology and classification • Genetic testing • Diagnosis, staging and grading • Surgery • Chemotherapy • Recurrent ovarian cancer • Targeted therapies • Non-epithelial ovarian cancers • Follow-up and palliative surgery • Useful resources

Download or read book Novel players in the development of chemoresistance in ovarian cancer ovarian cancer stem cells non coding RNA and nuclear receptors written by Shahil Alam and published by OAE Publishing Inc.. This book was released on 2024-02-28 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ovarian cancer (OC) ranks as the fifth leading factor for female mortality globally, with a substantial burden of new cases and mortality recorded annually. Survival rates vary significantly based on the stage of diagnosis, with advanced stages posing significant challenges to treatment. OC is primarily categorized as epithelial, constituting approximately 90% of cases, and correct staging is essential for tailored treatment. The debulking followed by chemotherapy is the prevailing treatment, involving platinum-based drugs in combination with taxanes. However, the efficacy of chemotherapy is hindered by the development of chemoresistance, both acquired during treatment (acquired chemoresistance) and intrinsic to the patient (intrinsic chemoresistance). The emergence of chemoresistance leads to increased mortality rates, with many advanced patients experiencing disease relapse shortly after initial treatment. This review delves into the multifactorial nature of chemoresistance in OC, addressing mechanisms involving transport systems, apoptosis, DNA repair, and ovarian cancer stem cells (OCSCs). While previous research has identified genes associated with these mechanisms, the regulatory roles of non-coding RNA (ncRNA) and nuclear receptors in modulating gene expression to confer chemoresistance have remained poorly understood and underexplored. This comprehensive review aims to shed light on the genes linked to different chemoresistance mechanisms in OC and their intricate regulation by ncRNA and nuclear receptors. Specifically, we examine how these molecular players influence the chemoresistance mechanism. By exploring the interplay between these factors and gene expression regulation, this review seeks to provide a comprehensive mechanism driving chemoresistance in OC.

Download or read book Ovarian Cancer written by Ethan D. Anderson and published by . This book was released on 2024-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ovarian Cancer: A Comprehensive Resource for Patients and Families" is a vital guide for anyone impacted by ovarian cancer. This book provides a thorough exploration of the disease, offering clarity and support through each stage, from initial diagnosis to treatment and beyond. Understanding Ovarian Cancer The journey begins with an introduction to ovarian cancer, including its epidemiology, types, and stages. Gain an understanding of the ovaries' role in the female reproductive system and how cancer affects these vital organs. Recognizing Risk Factors and Early Detection Learn about the genetic and environmental risk factors associated with ovarian cancer and the importance of early detection. This book covers the challenges of early detection, screening methods, and the critical role of diagnostic testing. Navigating Diagnosis and Treatment Delve into the diagnostic process, including understanding pathology reports and the role of biopsy. Explore comprehensive treatment options, from surgery to chemotherapy, radiotherapy, and the latest in targeted therapy and immunotherapy. Managing Side Effects and Complications Understand and manage the side effects and complications associated with treatment, including pain management and coping with emotional and physical stress. Nutrition and Lifestyle during Treatment Discover the importance of nutrition and lifestyle changes during treatment, with practical advice on diet, exercise, and lifestyle modifications for optimal health. Psychological Impact and Support Find guidance on coping with the emotional and psychological impacts of ovarian cancer. Learn about the importance of psychological support, counseling, and the role of community and support groups. Recurrence and Long-term Management Address the challenges of recurrence and long-term management of ovarian cancer, including strategies for monitoring, follow-up care, and understanding recurrence. Advances in Research Stay informed about the latest advances in ovarian cancer research, emerging treatments, and the future direction of care and clinical trials. Special Considerations in Care Gain insights into special considerations for ovarian cancer care, including issues relevant to young women, fertility, and menopausal management post-treatment. Advocacy and Awareness Understand the importance of raising awareness and advocacy for ovarian cancer. Discover support networks and resources available to empower patients and families. "Ovarian Cancer: A Comprehensive Resource for Patients and Families" is an indispensable tool, offering comfort, clarity, and hope to those navigating the complexities of ovarian cancer. It is a comprehensive guide that not only provides medical information but also addresses the emotional and practical aspects of coping with the disease.

Download or read book Intraperitoneal Therapy for Ovarian Cancer written by David Alberts and published by Springer Science & Business Media. This book was released on 2010-08-24 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraperitoneal chemotherapy is increasingly being used as first-line treatment for ovarian cancer. Nevertheless, it is difficult for the oncologist to find a definitive text that documents both the fundamental methods required to optimize therapy and the up-to-date results of phase I, II, and III clinical trials. With this in mind, the editors of Intraperitoneal Chemotherapy have assembled a team of highly experienced clinicians and researchers to cover every aspect of the subject. The topics addressed include treatment principles, patient, drug, and catheter selection, administration guidelines, the role of hyperthermia, supportive care requirements, novel drugs, and the most recent results of clinical trials. This book will be an invaluable source of information for both practicing clinical oncologists and oncologists in training.

Download or read book Clinical Trials in Ovarian Cancer written by Christine S. Walsh and published by Rutgers University Press. This book was released on 2017-01-16 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: When a patient is diagnosed with a gynecological malignancy, she and her doctors must make urgent, high-risk decisions about her course of treatment. In selecting an appropriate plan of care, physicians must weigh the patient’s individual needs, the tumor’s specific characteristics, and the treatment’s potential side effects. Because there is no one-size-fits-all treatment solution, a plethora of clinical trials have been performed on ovarian cancer patients, but clinicians may struggle to keep up with this ever-growing body of research. Collecting and synthesizing research findings from a wide array of medical journal articles and book chapters, Clinical Trials in Ovarian Cancer provides physicians with an invaluable resource. Gynecologic oncologist Christine S. Walsh systematically outlines each of the seminal Phase III trials that have shaped the treatment of ovarian cancers, detailing the rationale for the trial, the patient population studied, treatment delivery methods, efficacy, toxicity, and trial conclusions. She provides a clear overview of established treatments, as well as still-controversial experimental approaches. The first book to organize this cutting-edge research into an easy-to-use reference, Clinical Trials in Ovarian Cancer should help medical personnel at all levels provide their patients with the highest standard of care.

Download or read book Cancer Cell Chemoresistance And Chemosensitization written by Ajaikumar B Kunnumakkara and published by World Scientific. This book was released on 2018-02-14 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemotherapy holds immense prospect. However, there is barely such comprehensive work available in scientific literature that explains how chemosensitization of cancer cells functions using different drug combinations and exhibit synergism. This book provides a detailed description of chemoresistance and chemosensitization, targets for chemosensitization and various approaches adapted in the process of chemosensitization. Furthermore, the book explicates the role of various chemosensitizers, both natural and synthetic in sensitizing cancer cells and also details the current research findings on chemosensitization of different cancer types in both pre-clinical and clinical settings.

Download or read book Cell and Molecular Biology of Ovarian Cancer written by Heide Schatten and published by Springer Nature. This book was released on with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: