Download or read book Opioids and Their Receptors written by Mariana Spetea and published by MDPI. This book was released on 2020-12-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
Download or read book Neurobiology of Alcohol Dependence written by Antonio Noronha and published by Elsevier. This book was released on 2014-05-02 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific advances have provided substantial information on the brain circuits and pathways relevant to various aspects of dependence. Neurobiology of Alcohol Dependence highlights the most recent data at the molecular, cellular, neurocircuitry, and behavioral levels, fostering an understanding how neuroplasticity and neuroadaptation occur, and how different neural pathways and neurocircuits contribute to dependence. - Highlights recent advances in understanding alcohol addiction from molecular, cellular, neurocircuitry, and behavioral levels - Integrates several emerging areas of research and discusses the application of novel research techniques to the understanding of alcohol dependence - Chapters authored by leaders in the field around the globe — the broadest, most expert coverage available
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Download or read book Regulatory Roles of Opioid Peptides written by Peter Illes and published by John Wiley & Sons. This book was released on 1988 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioactive Peptides written by John Oloche Onuh and published by CRC Press. This book was released on 2021-06-15 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive peptides have been receiving attention recently due to their applications as health-promoting agents. Derived from food proteins and other natural sources, they exhibit various beneficial effects such as preventing diseases or modulating physiological systems once absorbed. As the market for nutraceuticals and functional foods continues to expand, consumer interest has also grown and there are many common foods that have shown an abundance of bioactive peptides, including dairy products, cereal, legumes, meat, and numerous other sources. In this newest addition to the series Nutraceuticals: Basic Research and Clinical Applications, Bioactive Peptides: Production, Bioavailability, Health Potential, and Regulatory Issues provides a comprehensive review of the current state of knowledge in the field of food protein hydrolysates and bioactive peptides, their food sources, bioavailability, production, applications, functionalities, health potentials, and regulatory issues governing their use. Features Discusses different methodologies employed for scaling up bioactive peptides commercially Provides information on optimizing the production process Explains various bioactive properties exerted by different types of bioactive peptides Explores the application of metabolomics to the study of bioactive peptides With over 20 chapters written by established subject matter experts in their field, this book provides timely information and discusses the latest developments of bioactive peptides. It will be useful for researchers, academics, and industry experts, and can serve as an excellent resource for anyone interested in enhancing their knowledge in the field of bioactive peptides.
Download or read book Acupuncture Therapy for Neurological Diseases written by Ying Xia and published by Springer Science & Business Media. This book was released on 2010-09-08 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acupuncture therapy has been practiced in China and other Asian countries for more than two thousand years. Modern clinical research has confirmed the impressive therapeutic effect of acupuncture on numerous human ailments, such as controlling pain, nausea, and vomiting. However, the biological mechanisms of acupuncture are still under debate. In Traditional Chinese Medicine (TCM), the mechanism of acupuncture therapy is explained by a meridian model. According to this model, acupuncture is believed to treat the diseased organs by modulating two conditions known as Yin and Yang, which represent all the opposite principles that people find in the universe, both inside and outside the human body. Yin and Yang complement each other, and are subjected to changes between each other. The balance of Yin and Yang is thought to be maintained by Qi, an energy substance flowing constantly through the meridian, a network connecting all the organs of the body. The illness, according to this theory, is the temporary dominance of one principle over the other, owing to the blockade of the Qi from flowing through the meridian under certain circumstance. The axiom of “No stagnation, No pain” in TCM summarizes this concept. Thus, the goal of acupuncture treatment is to restore the balance of Yin and Yang conditions in the diseased organ(s). This theory has been considered to be useful to guide this ancient therapy, such as carrying out diagnosis, deciding on the principle, and selecting the acupoints.
Download or read book Endorphins in Mental Health Research written by Earl Usdin and published by Springer. This book was released on 2016-01-14 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Opioids in Non Cancer Pain written by Catherine F. Stannard and published by Oxford University Press. This book was released on 2013-03-21 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pocketbook summarizes the recent developments in this important and controversial aspect of pain management, looking at the benefits and adverse effects of opioids in non-cancer pain.
Download or read book An Introduction to Western Medical Acupuncture written by Adrian White and published by Elsevier Health Sciences. This book was released on 2018-04-18 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its 2nd edition, An Introduction to Western Medical Acupuncture provides a broad evidence-based approach to acupuncture when used as part of modern medicine. Illustrated throughout it gives the practitioner an essential guide for deciding where and how to treat conditions with acupuncture, and how to avoid known risks associated with it. Ultimately it provides the practitioner with a tool to develop safe and effective practice. For this edition the text has been revised, updated and extensively re-written. A new chapter brings together the understanding of how pain is recognised by the nervous system, and how acupuncture can influence these pathways. This is followed by six chapters providing detailed explanations of the effects and mechanisms of acupuncture, organised according to three recognised treatment approaches – needling to produce local changes, to generate effects at the level of the spinal segment, and to modify the overall function of the nervous system. The chapters on the evidence from research have been also updated. - An explanation of the various mechanisms of acupuncture linked to how they can best be activated by needling. - Learn the principles of treatment rather than any 'cook-book' approach. - Clear and objective discussion of the evidence for the effectiveness and the risks of acupuncture. - Thorough and detailed description of all aspects of clinical practice. - Reference section for quickly reminding the practitioner of the best approach to treating many problems.
Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Opioid Food Peptides written by Mohammad Raies Ul Haq and published by Springer Nature. This book was released on 2020-07-15 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest research on food-derived opioid peptides, particularly those derived from milk. It describes in detail the structure, classification and, more importantly, physiological functions of these peptides. Presenting an interesting overview of the opioid receptors and receptor ligands, it examines the absorption, transport and degradation of these opioid peptides. Further, it highlights the production of β-casomorphins from only one variant of β-casein and its biological activities, and explores the generation of αb‐lactorphin from bovine αb‐lactalbumin and βb‐lactorphin. The book also includes a section on the use of advanced biochemical and pharmacological techniques to analyze opioid peptides, discussing the extraction of protein from food sources, protein purification followed by SGID, filtration of peptides and analysis using analytical HPLC. Lastly, it offers insights into the significance of these peptides in the pharmaceutical industry and their potential role as therapeutic agents.This timely book is useful for researchers and students in the field of food sciences, dairy science, agriculture and pharmacology. It is also of interest to industry experts.
Download or read book The Neuroscience of Cocaine written by Victor R Preedy and published by Academic Press. This book was released on 2017-05-23 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine's neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse. - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Illustrated in full color - Provides unique full coverage of all aspects of cocaine and its related pathology - Provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms
Download or read book Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery written by Henry I. Mosberg and published by MDPI. This book was released on 2020-03-13 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.
Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
Download or read book Neuropsychopharmacology written by W.E. Jr. Bunney and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medications for Opioid Use Disorder Save Lives written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-06-16 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Download or read book Pharmacology of Opioid Peptides written by L F Tseong and published by CRC Press. This book was released on 1995-09-01 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is being published at a time when opioid receptors have recently been cloned. The structural characteristics of opioid receptors and the recent advances in their molecular cloning and expression are explicated. Connecting these cloned opioid receptors with the pharmacology of opioid receptor actions is of particular importance. The use of antisense oligodeoxynucleotides to opioid receptors to elucidate the neural mechanisms of opioid action is detailed. As analgesia is one of the most important clinical functions for opioids and opioid peptides, this book concentrates on the detailed mechanisms of action of opioids and opioid peptides for the production of analgesia. The significant pharmacologic actions of opioids and opioid peptides in gastrointestinal function, immune function, cardiovascular and respiratory regulation, addiction and the cellular mechanisms involved in tolerance and dependence of opioids are also described. The book will be of interest both to researchers investigating the neural mechanisms of the pharmacologic and physiologic functions of the endogenous opioid system and to clinicians who are involved in pain management and assessment.
