Download or read book On Multiplicity Adjustment in Bayesian Variable Selection and an Objective Bayesian Analysis of a Crossover Design written by Dandan Li and published by . This book was released on 2014 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiplicity is a common problem in multiple testing for both traditional and Bayesian approaches. The first part of this dissertation considers certain issues relating to multiplicity adjustment in the Bayesian approach. Scott and Berger (2010) explained how multiplicity adjustment is achieved in fully Bayesian approach for model selection by using a single prior on inclusion probability in terms of model prior odds ratio. We extend their work by studying the general properties of model prior odds ratio and using it to propose a measure to quantify the multiplicity adjustment induced by a prior in fully Bayesian framework. Simulation studies are performed to evaluate the proposed measure. Estimation and testing hypotheses about the treatment effects in a crossover design is interesting as it involves consideration whether the carryover effect is present or not. Presence or absence of carryover effect also may depend on the existence of treatment effect. In the second part of this dissertation, we consider a crossover design with normally distributed response variable, and use standard objective priors for estimation and model selection to estimate the treatment effect, and test hypothesis about it. The performance is evaluated by simulation studies through MSE and coverage probability of confidence interval. We apply the approach to a real data example and compare the numerical results with other frequentist and Bayesian approaches.
Download or read book A Bayesian Analysis of Crossover Designs and Carryover Effects written by Stacy Rachelle David and published by . This book was released on 1996 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Adjustment Uncertainty and Variable Selection in a Bayesian Context written by Andrew James Dennis Henrey and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Model Averaging (BMA) has previously been proposed as a solution to the variable selection problem when there is uncertainty about the true model in regression. Some recent research discusses the drawbacks; specifically, BMA can (and does) give biased parameter estimates in the presence of confounding. This is because BMA is optimized for prediction rather than parameter estimation. Though some newer research attempts to fix the issue of bias under confounding, none of the current algorithms handle either large data sets or survival outcomes. The Approximate Two-phase Bayesian Adjustment for Confounding (ATBAC) algorithm proposed in this paper does both, and we use it on a large medical cohort study called THIN (The Health Improvement Network) to estimate the effect of statins on risk of stroke. We use simulation and some analytical techniques to discuss two main topics in this paper. Firstly, we demonstrate the ability of ATBAC to perform unbiased parameter estimation on survival data while accounting for model uncertainty. Secondly, we discuss when it is, and isn't, helpful to use variable selection techniques in the first place, and find that in some large data sets variable selection for parameter estimation is unnecessary.
Download or read book Bayesian Networks written by Marco Scutari and published by CRC Press. This book was released on 2021-07-28 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains the material step-by-step starting from meaningful examples Steps detailed with R code in the spirit of reproducible research Real world data analyses from a Science paper reproduced and explained in detail Examples span a variety of fields across social and life sciences Overview of available software in and outside R
Download or read book Bayesian Networks in R written by Radhakrishnan Nagarajan and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Networks in R with Applications in Systems Biology is unique as it introduces the reader to the essential concepts in Bayesian network modeling and inference in conjunction with examples in the open-source statistical environment R. The level of sophistication is also gradually increased across the chapters with exercises and solutions for enhanced understanding for hands-on experimentation of the theory and concepts. The application focuses on systems biology with emphasis on modeling pathways and signaling mechanisms from high-throughput molecular data. Bayesian networks have proven to be especially useful abstractions in this regard. Their usefulness is especially exemplified by their ability to discover new associations in addition to validating known ones across the molecules of interest. It is also expected that the prevalence of publicly available high-throughput biological data sets may encourage the audience to explore investigating novel paradigms using the approaches presented in the book.
Download or read book Bayesian Models for Categorical Data written by Peter Congdon and published by John Wiley & Sons. This book was released on 2005-12-13 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of Bayesian methods for the analysis of data has grown substantially in areas as diverse as applied statistics, psychology, economics and medical science. Bayesian Methods for Categorical Data sets out to demystify modern Bayesian methods, making them accessible to students and researchers alike. Emphasizing the use of statistical computing and applied data analysis, this book provides a comprehensive introduction to Bayesian methods of categorical outcomes. * Reviews recent Bayesian methodology for categorical outcomes (binary, count and multinomial data). * Considers missing data models techniques and non-standard models (ZIP and negative binomial). * Evaluates time series and spatio-temporal models for discrete data. * Features discussion of univariate and multivariate techniques. * Provides a set of downloadable worked examples with documented WinBUGS code, available from an ftp site. The author's previous 2 bestselling titles provided a comprehensive introduction to the theory and application of Bayesian models. Bayesian Models for Categorical Data continues to build upon this foundation by developing their application to categorical, or discrete data - one of the most common types of data available. The author's clear and logical approach makes the book accessible to a wide range of students and practitioners, including those dealing with categorical data in medicine, sociology, psychology and epidemiology.
Download or read book Registries for Evaluating Patient Outcomes written by Agency for Healthcare Research and Quality/AHRQ and published by Government Printing Office. This book was released on 2014-04-01 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Download or read book Adaptive Design Theory and Implementation Using SAS and R written by Mark Chang and published by CRC Press. This book was released on 2014-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the
Download or read book Practical Aspects of Signal Detection in Pharmacovigilance written by Council for International Organizations of Medical Sciences (CIOMS) and published by Cioms. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years public expectations for rapid identification and prompt management of emerging drug safety issues have grown swiftly. Over a similar timeframe, the move from paper-based adverse event reporting systems to electronic capture and rapid transmission of data has resulted in the accrual of substantial datasets capable of complex analysis and querying by industry, regulators and other public health organizations. These two drivers have created a fertile environment for pharmacovigilance scientists, information technologists and statistical experts, working together, to deliver novel approaches to detect signals from these extensive and quickly growing datasets, and to manage them appropriately. In following this exciting story, this report looks at the practical consequences of these developments for pharmacovigilance practitioners. The report provides a comprehensive resource for those considering how to strengthen their pharmacovigilance systems and practices, and to give practical advice. But the report does not specify instant solutions. These will inevitably be situation specific and require careful consideration taking into account local needs. However, the CIOMS Working Group VIII is convinced that the combination of methods and a clear policy on the management of signals will strengthen current systems. Finally, in looking ahead, the report anticipates a number of ongoing developments, including techniques with wider applicability to other data forms than individual case reports. The ultimate test for pharmacovigilance systems is the demonstration of public health benefit and it is this test which signal detection methodologies need to meet if the expectations of all stakeholders are to be fulfilled.
Download or read book Medical Statistics from A to Z written by B. S. Everitt and published by Cambridge University Press. This book was released on 2006-12-21 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 'Abcissa' to 'Zygosity determination' - this accessible introduction to the terminology of medical statistics describes more than 1500 terms all clearly explained, illustrated and defined in non-technical language, without any mathematical formulae! With the majority of terms revised and updated and the addition of more than 100 brand new definitions, this new edition will enable medical students to quickly grasp the meaning of any of the statistical terms they encounter when reading the medical literature. Furthermore, annotated comments are used judiciously to warn the unwary of some of the common pitfalls that accompany some cherished biomedical statistical techniques. Wherever possible, the definitions are supplemented with a reference to further reading where the reader may gain a deeper insight, so whilst the definitions are easily disgestible, they also provide a stepping stone to a more sophisticated comprehension. Statistical terminology can be quite bewildering for clinicians: this guide will be a lifesaver.
Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.
Download or read book Common Errors in Statistics and How to Avoid Them written by Phillip I. Good and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the Second Edition "All statistics students and teachers will find in this book a friendly and intelligentguide to . . . applied statistics in practice." —Journal of Applied Statistics ". . . a very engaging and valuable book for all who use statistics in any setting." —CHOICE ". . . a concise guide to the basics of statistics, replete with examples . . . a valuablereference for more advanced statisticians as well." —MAA Reviews Now in its Third Edition, the highly readable Common Errors in Statistics (and How to Avoid Them) continues to serve as a thorough and straightforward discussion of basic statistical methods, presentations, approaches, and modeling techniques. Further enriched with new examples and counterexamples from the latest research as well as added coverage of relevant topics, this new edition of the benchmark book addresses popular mistakes often made in data collection and provides an indispensable guide to accurate statistical analysis and reporting. The authors' emphasis on careful practice, combined with a focus on the development of solutions, reveals the true value of statistics when applied correctly in any area of research. The Third Edition has been considerably expanded and revised to include: A new chapter on data quality assessment A new chapter on correlated data An expanded chapter on data analysis covering categorical and ordinal data, continuous measurements, and time-to-event data, including sections on factorial and crossover designs Revamped exercises with a stronger emphasis on solutions An extended chapter on report preparation New sections on factor analysis as well as Poisson and negative binomial regression Providing valuable, up-to-date information in the same user-friendly format as its predecessor, Common Errors in Statistics (and How to Avoid Them), Third Edition is an excellent book for students and professionals in industry, government, medicine, and the social sciences.
Download or read book Linear Regression Analysis written by Xin Yan and published by World Scientific. This book was released on 2009 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume presents in detail the fundamental theories of linear regression analysis and diagnosis, as well as the relevant statistical computing techniques so that readers are able to actually model the data using the techniques described in the book. This book is suitable for graduate students who are either majoring in statistics/biostatistics or using linear regression analysis substantially in their subject area." --Book Jacket.
Download or read book Ecological Inference written by Gary King and published by Cambridge University Press. This book was released on 2004-09-13 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing upon the recent explosion of research in the field, a diverse group of scholars surveys the latest strategies for solving ecological inference problems, the process of trying to infer individual behavior from aggregate data. The uncertainties and information lost in aggregation make ecological inference one of the most difficult areas of statistical inference, but these inferences are required in many academic fields, as well as by legislatures and the Courts in redistricting, marketing research by business, and policy analysis by governments. This wide-ranging collection of essays offers many fresh and important contributions to the study of ecological inference.
Download or read book Statistics with Confidence written by Douglas Altman and published by John Wiley & Sons. This book was released on 2013-06-03 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly popular introduction to confidence intervals has been thoroughly updated and expanded. It includes methods for using confidence intervals, with illustrative worked examples and extensive guidelines and checklists to help the novice.
Download or read book Modern Issues and Methods in Biostatistics written by Mark Chang and published by Springer Science & Business Media. This book was released on 2011-07-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Download or read book The Cambridge Handbook of Computing Education Research written by Sally A. Fincher and published by . This book was released on 2019-02-13 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an authoritative introduction to Computing Education research written by over 50 leading researchers from academia and the industry.
