Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 427 Skin Absorption In Vivo Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 428 Skin Absorption In Vitro Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 439 In Vitro Skin Irritation Reconstructed Human Epidermis Test Method written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 404 Acute Dermal Irritation Corrosion written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document for the Conduct of Skin Absorption Studies written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance document has been prepared to support technical aspects of the OECD skin absorption test guidelines. In particular is discusses the various aspects of in vivo vs. in vitro testing.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 411 Subchronic Dermal Toxicity 90 day Study written by OECD and published by OECD Publishing. This book was released on 1981-05-12 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 442D In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 435 In Vitro Membrane Barrier Test Method for Skin Corrosion written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to animal skin in situ.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 498 In vitro Phototoxicity Reconstructed Human Epidermis Phototoxicity test method written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin phototoxicity (photoirritation) is defined as an acute toxic response elicited by topically or systemically administered photoreactive chemicals after the exposure of the skin to environmental light. The in vitro reconstructed human epidermis phototoxicity test (RhE PT) is used to identify the phototoxic potential of a test chemical after topical application in reconstructed human epidermis (RhE) tissues in the presence and absence of simulated sunlight.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 402 Acute Dermal Toxicity written by OECD and published by OECD Publishing. This book was released on 2017-10-09 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 431 In vitro skin corrosion reconstructed human epidermis RHE test method written by OECD and published by OECD Publishing. This book was released on 2019-06-18 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using other existing information.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 442C In Chemico Skin Sensitisation Assays addressing the Adverse Outcome Pathway key event on covalent binding to proteins written by OECD and published by OECD Publishing. This book was released on 2015-02-05 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. It provides an in chemico procedure (Direct Peptide Reactivity Assay – DPRA) used for supporting the discrimination between skin sensitisers and non-sensitisers.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 417 Toxicokinetics written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 406 Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 1992-07-17 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance via intradermical injection and/or epidermical application. In this Test Guideline, the methods preferred over other are: the Guinea Pig Maximisation ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 430 In Vitro Skin Corrosion Transcutaneous Electrical Resistance Test Method TER written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal stratum corneum integrity and barrier function.

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 410 Repeated Dose Dermal Toxicity 21 28 day Study written by OECD and published by OECD Publishing. This book was released on 1981-05-12 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study relates to the analysis, via dermal application, of the health hazard of solid or liquid test substance. This method is composed of two tests: the main test and the limit test. This Test Guideline is intended for use with the adult rat ...

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 442E In Vitro Skin Sensitisation In Vitro Skin Sensitisation assays addressing the Key Event on activation of dendritic cells on the Adverse Outcome Pathway for Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This TG is proposed to address the activation of dendritic cells, which is one Key Event on the Adverse Outcome Pathway (AOP) for Skin Sensitisation. It provides four in vitro test methods addressing the same Key Event on the AOP: (i) the human cell Line Activation Test or h-CLAT method, (ii) the U937 Cell Line Activation Test or U-SENS, (iii) the Interleukin-8 Reporter Gene Assay or IL-8 Luc assay and (iv) the Genomic Allergen Rapid Detection for assessment of skin sensitisers (GARDTMskin). All of them are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. The test methods described in this TG either quantify the change in the expression of cell surface marker(s) CD54 and CD86, the cytokine IL-8, or a series of genes (genomic biomarker signature) that are associated with the process of activation of monocytes and DC following exposure to sensitisers.