Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) provides the current state-of-the-knowledge in the area of amphibian metamorphosis with the view to use amphibian metamorphosis as a model for the detection of chemicals affecting the thyroid axis in vertebrates.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of amphibian metamorphosis with the view to use amphibian metamorphosis as a model for the detection of chemicals affecting the thyroid axis in vertebrates.

Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Aquatic Testing Methods for Pesticides and Industrial Chemicals written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review paper is based on the compilation of more than 600 pelagic and benthic testing methods.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Hazard Classification Systems for Mixtures written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document focuses on the health and environmental hazards of mixtures.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification in OECD Member Countries of Substances and Mixtures which in contact with water release toxic gases written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review documents examines member country classification of substances and mixtures which in contact with water release toxic gases.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification in OECD Member Countries of Substances and Mixtures which cause Respiratory Tract Irritation and Corrosion written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review documents examines member country classification of substances and mixtures which cause respiratorytract irritation and corrosion.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification Systems for Substances which Pose an Aspiration Hazard written by OECD and published by OECD Publishing. This book was released on 2002-12-12 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review document examines member country classifications systems for substances which pose an aspiration hazard.

Download or read book OECD Guidelines for the Testing of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay XETA written by OECD and published by OECD Publishing. This book was released on 2019-06-18 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Hazard Classification Systems for Specific Target Organ Systemic Toxicity Following Single or Repeated Exposure in OECD Member Countries written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review document examines member country hazard classification systems for specific target organ systemic toxicity following single or repeated exposure.

Download or read book OECD Series on Testing and Assessment Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document on Aquatic Toxicity Testing of Difficult Substances and Mixtures written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document provides guidance for the testing of substances, and mixtures, classed as “difficult to test” for the purposes of determining their aquatic toxicity.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document on Reporting Summary Information on Environmental Occupational and Consumer Exposure written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document contains guidance for using the summary exposure information reporting formats, which were developed by the OECD Ad Hoc Group on Reporting Summary Exposure Information.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work.

Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document for the Development of OECD Guidelines for Testing of Chemicals written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Monograph describes in detail the process of Test Guideline development, including the structure of the Test Guidelines Programme, the responsibilities of those involved and the procedures which should be followed.