Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification in OECD Member Countries of Substances and Mixtures which cause Respiratory Tract Irritation and Corrosion written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review documents examines member country classification of substances and mixtures which cause respiratorytract irritation and corrosion.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification in OECD Member Countries of Substances and Mixtures which cause Respiratory Tract Irritation and Corrosion written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review documents examines member country classification of substances and mixtures which cause respiratorytract irritation and corrosion.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document for the Conduct of Skin Absorption Studies written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance document has been prepared to support technical aspects of the OECD skin absorption test guidelines. In particular is discusses the various aspects of in vivo vs. in vitro testing.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Paper on Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) provides the current state-of-the-knowledge in the area of amphibian metamorphosis with the view to use amphibian metamorphosis as a model for the detection of chemicals affecting the thyroid axis in vertebrates.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Detailed Review Document on Classification in OECD Member Countries of Substances and Mixtures which in contact with water release toxic gases written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review documents examines member country classification of substances and mixtures which in contact with water release toxic gases.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Descriptions of Selected Key Generic Terms used in Chemical Hazard Risk Assessment written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper presents internationally harmonised generic and technical terms used in chemical hazard/risk assessment which will help facilitate the mutual use and acceptance of the assessment of chemicals between countries.
Download or read book OECD Guidelines for the Testing of Chemicals OECD Series on Testing and Assessment Guidance Document on Reporting Summary Information on Environmental Occupational and Consumer Exposure written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document contains guidance for using the summary exposure information reporting formats, which were developed by the OECD Ad Hoc Group on Reporting Summary Exposure Information.
Download or read book OECD Series on Testing and Assessment Guidance on Grouping of Chemicals written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance document provides guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group, or category, rather than as individual chemicals.
Download or read book OECD Series on Testing and Assessment The Guidance Document for Using the OECD Q SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR Application Toolbox.
Download or read book OECD Series on Testing and Assessment Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies Supporting Test Guidelines 451 452 and 453 Second edition written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Download or read book OECD Series on Testing and Assessment Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations.
Download or read book OECD Series on Testing and Assessment Guidance Document on the Validation of Quantitative Structure Activity Relationship Q SAR Models written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document presents principles and helpful guides for validating (Q)SAR technology for a variety of applications.
Download or read book OECD Series on Testing and Assessment Guidance Document on the Honey Bee Apis Mellifera L Brood test Under Semi field Conditions written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The method described in this guidance document assesses the effects of plant protection products (PPPs), and has been validated using the active Fenoxycarb, which is known to act as an insect growth regulator (IGR), to the honey bee brood (Apis mellifera L.).
Download or read book OECD Series on Testing and Assessment Fish Toxicity Testing Framework written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Download or read book Principles of Toxicology Testing Second Edition written by Frank A Barile and published by CRC Press. This book was released on 2013-04-02 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, including absorption, distribution, metabolism, and elimination of toxins, including chemicals and drugs. The book then continues with animal (in vivo) and in vitro toxicology testing methods associated with toxicological analysis and preclinical drug development. As in the first edition, the book begins with an introduction into the fundamentals of toxicology (Section I) to prepare readers for the subsequent topics and continues through with a discussion of toxicokinetics and human risk assessment. This introductory material is useful in understanding the applications of toxicology testing. Section II describes the fundamental principles of toxicology testing in animals in greater detail. This section describes acute toxicity studies as well as subchronic and chronic studies performed on animals. Special emphasis is placed on study design and determination of classical indicators for acute and chronic testing, such as the LD50. The book examines other short- and long-term animal toxicity testing methodologies, including dermal, ocular, and reproductive toxicity testing. In addition, mutagenicity and carcinogenicity studies are also discussed in separate chapters. Section III introduces and discusses in vitro alternatives to animal toxicology tests. This section emphasizes cell culture methodology and cellular methods for acute systemic toxicity, target organ toxicity, and local toxicity. The contributors present the advantages and disadvantages of alternative methods. They also describe the use of high-throughput screening and its applications, the concepts of standardization and validation of in vitro techniques (especially large, organized validation efforts currently supported by US and EU regulatory agencies), and the theories supporting the development of in vitro methodologies. This second edition is a must-read for undergraduate and graduate toxicology students. Industrial and academic research centers will also find the text useful for establishing a toxicology testing laboratory.
Download or read book OECD Series on Testing and Assessment The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins written by OECD and published by OECD Publishing. This book was released on 2014-09-03 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies databases containing test results related to key events.
