Download or read book Translational Medicine written by Joy A. Cavagnaro and published by CRC Press. This book was released on 2021-11-26 with total page 952 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Download or read book Open Book written by Jessica Simpson and published by HarperCollins. This book was released on 2020-02-04 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The #1 New York Times Bestseller Jessica reveals for the first time her inner monologue and most intimate struggles. Guided by the journals she's kept since age fifteen, and brimming with her unique humor and down-to-earth humanity, Open Book is as inspiring as it is entertaining. This was supposed to be a very different book. Five years ago, Jessica Simpson was approached to write a motivational guide to living your best life. She walked away from the offer, and nobody understood why. The truth is that she didn’t want to lie. Jessica couldn’t be authentic with her readers if she wasn’t fully honest with herself first. Now America’s Sweetheart, preacher’s daughter, pop phenomenon, reality tv pioneer, and the billion-dollar fashion mogul invites readers on a remarkable journey, examining a life that blessed her with the compassion to help others, but also burdened her with an almost crippling need to please. Open Book is Jessica Simpson using her voice, heart, soul, and humor to share things she’s never shared before. First celebrated for her voice, she became one of the most talked-about women in the world, whether for music and fashion, her relationship struggles, or as a walking blonde joke. But now, instead of being talked about, Jessica is doing the talking. Her book shares the wisdom and inspirations she’s learned and shows the real woman behind all the pop-culture cliché’s — “chicken or fish,” “Daisy Duke,” "football jinx," “mom jeans,” “sexual napalm…” and more. Open Book is an opportunity to laugh and cry with a close friend, one that will inspire you to live your best, most authentic life, now that she is finally living hers.

Download or read book The Flower of Battle written by and published by . This book was released on 2018-07-12 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Flower of Battle is Colin Hatcher's translation of Fiore dei Liberi's art of combat from the early 15th century. The work included high-resolution images and English text laid out in the manner of the original.

Download or read book Modern Forms of Work written by Stefano Bellomo and published by Sapienza Università Editrice. This book was released on 2020-10-06 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collective volume “Modern Forms of Work. A European Comparative Study” evokes the intent to embody a reflection focused on modern labour law issues from a comparative perspective. A first set of essays contains national reports on modern forms of work. The second group contains some reflections regarding critical issues on digitalization, platforms and algorithms, analysing the different facets of the galaxy of digital work. The third group of essays flows into the section entitled “new balances and workers’ rights in the digital era”, a crucial topic in the debate. The complex of the writings, despite the diversity of approaches and methods, reveals the existence of a dense and inexhaustible dialogue between young scholars, at European and extra-European level. The analysis of new forms of work – the offspring of transnational processes of globalization and technologization – forms a fertile ground for experimenting a transnational dialogue on which young researchers can practice with excellent results, as this small volume confirms.

Download or read book Critical CALL Proceedings of the 2015 EUROCALL Conference Padova Italy written by Francesca Helm and published by Research-publishing.net. This book was released on 2015-12-02 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: The theme of the conference this year was Critical CALL, drawing inspiration from the work carried out in the broader field of Critical Applied Linguistics. The term ‘critical’ has many possible interpretations, and as Pennycook (2001) outlines, has many concerns. It was from these that we decided on the conference theme, in particular the notion that we should question the assumptions that lie at the basis of our praxis, ideas that have become ‘naturalized’ and are not called into question. Over 200 presentations were delivered in 68 different sessions, both in English and Italian, on topics related specifically to the theme and also more general CALL topics. 94 of these were submitted as extended papers and appear in this volume of proceedings.

Download or read book UNCITRAL Conciliation Rules written by United Nations Commission on International Trade Law and published by New York : United Nations. This book was released on 1981 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Format Age written by Jean K. Chalaby and published by John Wiley & Sons. This book was released on 2015-12-22 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few trends have had as much impact on television as formats have in recent years. Long confined to the fringes of the TV industry, they have risen to prominence since the late 1990s. Today, they are a global business with hundreds of programmes adapted across the world at any one time, from mundane game shows to blockbuster talent competitions, from factual entertainment to high-end drama. Based on exclusive industry access, this book provides an in-depth analysis of the complex world of the TV format from its origins to the present day. Chalaby delivers a comprehensive account of the TV format trading system and conceptualizes the global value chain that underpins it, unpicking the corporate strategies and power relations within. Using interviews with format creators, he uncovers the secrets behind the world’s most travelled formats, exploring their narrative structure and cultural meanings.

Download or read book Seneca the Elder and His Rediscovered Historiae ab initio bellorum civilium written by Maria Chiara Scappaticcio and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-06-08 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: The refreshed insights into early-imperial Roman historiography this book offers are linked to a recent discovery. In the spring of 2014, the binders of the archive of Robert Marichal were dusted off by the ERC funded project PLATINUM (ERC-StG 2014 n°636983) in response to Tiziano Dorandi’s recollections of a series of unpublished notes on Latin texts on papyrus. Among these was an in-progress edition of the Latin rolls from Herculaneum, together with Marichal’s intuition that one of them had to be ascribed to a certain ‘Annaeus Seneca’. PLATINUM followed the unpublished intuition by Robert Marichal as one path of investigation in its own research and work. Working on the Latin P.Herc. 1067 led to confirm Marichal’s intuitions and to go beyond it: P.Herc. 1067 is the only extant direct witness to Seneca the Elder’s Historiae. Bringing a new and important chapter of Latin literature arise out of a charred papyrus is significant. The present volume is made up of two complementary sections, each of which contains seven contributions. They are in close dialogue with each other, as looking at the same literary matter from several points of view yields undeniable advantages and represents an innovative and fruitful step in Latin literary criticism. These two sections express the two different but interlinked axes along which the contributions were developed. On one side, the focus is on the starting point of the debate, namely the discovery of the papyrus roll transmitting the Historiae of Seneca the Elder and how such a discovery can be integrated with prior knowledge about this historiographical work. On the other side, there is a broader view on early-imperial Roman historiography, to which the new perspectives opened by the rediscovery of Seneca the Elder’s Historiae greatly contribute.

Download or read book Between Utopia and Dystopia written by Hanan Yoran and published by Lexington Books. This book was released on 2010-04-19 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between Utopia and Dystopia offers a new interpretation of Erasmian humanism. It argues that Erasmian humanism created the identity of the universal and critical intellectual, but that this identity undermined the fundamental premises of humanist discourse. It closely reads several works of Erasmus and Thomas More, employing an interdisciplinary approach to the study of intellectual history, and adopting theoretical insights and methodological procedures from various disciplines.

Download or read book West Roman Vulgar Law written by Ernst Levy and published by . This book was released on 1951 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Machiavelli Islam and the East written by Lucio Biasiori and published by Springer. This book was released on 2017-10-28 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the first survey of the unexplored connections between Machiavelli’s work and the Islamic world, running from the Arabic roots of The Prince to its first translations into Ottoman Turkish and Arabic. It investigates comparative descriptions of non-European peoples, Renaissance representations of Muḥammad and the Ottoman military discipline, a Jesuit treatise in Persian for a Mughal emperor, peculiar readers from Brazil to India, and the parallel lives of Machiavelli and the bureaucrat Celālzāde Muṣṭafá. Ten distinguished scholars analyse the backgrounds, circulation and reception of Machiavelli’s writings, focusing on many aspects of the mutual exchange of political theories and grammars between East and West. A significant contribution to attempts by current scholarship to challenge any rigid separation within Eurasia, this volume restores a sense of the global spreading of books, ideas and men in the past.

Download or read book Mutuae Relationes Mutual Relationship written by Catholic Church. Congregatio pro Religiosis et Institutis Saecularibus and published by USCCB Publishing. This book was released on 2004 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Portuguese written by Milton M. Azevedo and published by Cambridge University Press. This book was released on 2005-01-13 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description

Download or read book Perspectives of Law and Culture on the End of life Legislations in France Germany India Italy and United Kingdom written by Stéphanie Rohlfing-Dijoux and published by Nomos Verlagsgesellschaft. This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Présentation de l'éditeur : "The interactions between law and culture in addressing the legal problems at the end of a life are currently being discussed in many countries. The discourse on this issue should be multidisciplinary, taking into account its legal, medical, ethical, philosophical and anthropological aspects. The concepts designed to manage the legal problems that occur when a life comes to an end are closely linked to the culture of each country. For this reason, countries with different cultural backgrounds have been selected for this comparative end-of-life study. In France, Germany and Italy, which have a continental legal system, the United Kingdom, which has a common law system, and India, the various religions and cultures exert an important influence on the modernisation of the legislation in this respect. The book deals with recent legislative changes and developments in the countries surveyed."

Download or read book The Divine Comedy written by Dante Alighieri and published by Princeton University Press. This book was released on 1989 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dante's classic is presented in the original Italian as well as in a new prose translation, and is accompanied by commentary on the poem's background and allegory.

Download or read book Give Them Lala written by Lala Kent and published by Simon and Schuster. This book was released on 2022-04-12 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Vanderpump Rules provocateur opens up about her rocky road to fame and sobriety in this collection of humorous and brutally honest essays"--

Download or read book The Ndrangheta and Sacra Corona Unita written by Nicoletta Serenata and published by Springer. This book was released on 2014-05-13 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers two lesser known but important members of the Italian Mafia: the ’Ndrangheta and the Sacra Corona Unita. Italian criminal organizations, in particular Mafia, are one of the most commonly researched organized crime groups, usually focusing on the Sicilian Mafia, Cosa Nostra, or the Neapolitan Mafia, Camorra. However, Italy has other two other Mafias, one in Apulia, Sacra Corona Unita, and the other in Calabria, ’Ndrangheta. Although an extensive literature is available on Cosa Nostra and Camorra, less is known about the other two organizations, particularly their operations in the United States. Territory is one of the most important elements in the Mafia because the criminal organization operates its signoria territoriale, controlling every illegal activity in its sphere of action. This territorial power goes beyond the Italian boundaries reaching the United States of America and other non-European countries, with the mere aim of developing their drug/weapon deals and money laundering businesses. Mafia, therefore, is not a uniquely Italian phenomenon as it might appear, but a worldwide phenomenon, affecting many societies and economies. This unique volume is its interest into a field as yet completely provides new information about the ’Ndrangheta and Sacra Corona Unita written by an interdisciplinary group of Italian scholars. It covers organizational, hierarchic, and operative aspects: that is, the role that they have in politics, in their own families, in business relations in Italy and abroad. It also highlights the particular role that Cosa Nostra and Camorra had in their development. This work will be of interest to criminology researchers studying organized crime, corruption, money laundering and trafficking, as well as researchers from related fields, such as political science, economics, and international relations.