Download or read book Model Rules of Professional Conduct written by American Bar Association. House of Delegates and published by American Bar Association. This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.

Download or read book The Nuclear Tipping Point written by Kurt M. Campbell and published by Rowman & Littlefield. This book was released on 2005-06-22 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than half a century after the advent of the nuclear age, is the world approaching a tipping point that will unleash an epidemic of nuclear proliferation? Today many of the building blocks of a nuclear arsenal—scientific and engineering expertise, precision machine tools, software, design information—are more readily available than ever before. The nuclear pretensions of so-called rogue states and terrorist organizations are much discussed. But how firm is the resolve of those countries that historically have chosen to forswear nuclear weapons? A combination of changes in the international environment could set off a domino effect, with countries scrambling to develop nuclear weapons so as not to be left behind—or to develop nuclear "hedge" capacities that would allow them to build nuclear arsenals relatively quickly, if necessary. Th e Nuclear Tipping Point examines the factors, both domestic and transnational, that shape nuclear policy. The authors, distinguished scholars and foreign policy practitioners with extensive government experience, develop a framework for understanding why certain countries may originally have decided to renounce nuclear weapons—and pinpoint some more recent country-specific factors that could give them cause to reconsider. Case studies of eight long-term stalwarts of the nonproliferation regime—Egypt, Germany, Japan, Saudi Arabia, South Korea, Syria, Turkey, and Taiwan—flesh out this framework and show how even these countries might be pushed over the edge of a nuclear tipping point. The authors offer prescriptions that would both prevent such countries from reconsidering their nuclear option and avert proliferation by others. The stakes are enormous and success is far from assured. To keep the tipping point beyond reach, the authors argue, the international community will have to act with unity, imagination, and strength, and Washington's leadership will be essential. Contributors include Leon Feurth, George Wash

Download or read book Structural Immunology written by Tengchuan Jin and published by Springer Nature. This book was released on 2019-10-18 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.

Download or read book Protein Dimerization and Oligomerization in Biology written by Jacqueline M. Matthews and published by Springer Science & Business Media. This book was released on 2012-09-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has a strong focus on homo-oligomerization, which is surprisingly common. However, protein function is so often linked to both homo- and hetero-oligomerization and many heterologous interactions likely evolved from homologous interaction, so this volume also covers many aspects of hetero-oligomerization.

Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Download or read book The Inflammasomes written by Isabelle Couillin and published by Springer Science & Business Media. This book was released on 2011-07-02 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

Download or read book Studies on Biomarkers and New Targets in Aging Research in Iran written by Paul C. Guest and published by Springer. This book was released on 2021-06-20 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Middle East is known as the cradle of civilization. It was the crossroads of ancient empires and the birthplace of major world religions. Today it is the center of many world issues due to its economic, religious and political importance. Although it has lagged behind many other regions of the world in medicinal research, this has increased dramatically in recent years with increasing numbers of relevant publications and the country of Iran has spearheaded this progress. Much of the research has focused on increasing our understanding of the aging process and attempting to identify biomarkers and natural products to improve the human healthspan. This book provides a comprehensive overview of the research conducted in the Middle East on the health benefits of curcumin, a phytochemical derived from the famous spice turmeric. Hundreds of studies have now been published describing the health benefits of this spice. The importance of this research is exemplified by poor data regarding health and longevity as only 0.08% of the population in Iran consists of individuals over 90 years of age. This is approximately 10 times lower than the percentage of this same age group in the United Kingdom and the United States of America and almost 20 times lower than that in Japan. This book presents a series of reviews and meta-studies describing research which has resulted in identification potential new biomarkers and drug targets for age-related disorders. All of the studies have focussed on the testing of curcumin and related products, which have already shown some promising leads in age-related conditions such as heart-disease, diabetes, cognitive impairment and cancer. The authors in this series come from different centers and cities of Iran, including Mashhad, Tehran, Isfahan, Ahvaz, Birjand, Quchan and Yazd, and many of the chapters feature collaborations with other countries of the Middle East and throughout the world, including Brazil, Italy, Mexico, Oman, Poland, Switzerland, the United Kingdom and the United States of America. This underscores the emergence of the Middle East into this arena of research. The book will be of high interest to scientific and clinical researchers in the subject of aging and age-related disease, and to physicians and pharmaceutical company scientists since it gives insights into the latest strategies, biomarkers and targets involved in the mechanism of action of curcumin to promote healthy aging. It will also provide important information on disease mechanisms related to age-related disorders, as each chapter will be presented in the context of specific chronic diseases.

Download or read book Uranium Enrichment and Nuclear Weapon Proliferation written by Allan S. Krass and published by Routledge. This book was released on 2020-11-20 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1983, this book presents both the technical and political information necessary to evaluate the emerging threat to world security posed by recent advances in uranium enrichment technology. Uranium enrichment has played a relatively quiet but important role in the history of efforts by a number of nations to acquire nuclear weapons and by a number of others to prevent the proliferation of nuclear weapons. For many years the uranium enrichment industry was dominated by a single method, gaseous diffusion, which was technically complex, extremely capital-intensive, and highly inefficient in its use of energy. As long as this remained true, only the richest and most technically advanced nations could afford to pursue the enrichment route to weapon acquisition. But during the 1970s this situation changed dramatically. Several new and far more accessible enrichment techniques were developed, stimulated largely by the anticipation of a rapidly growing demand for enrichment services by the world-wide nuclear power industry. This proliferation of new techniques, coupled with the subsequent contraction of the commercial market for enriched uranium, has created a situation in which uranium enrichment technology might well become the most important contributor to further nuclear weapon proliferation. Some of the issues addressed in this book are: A technical analysis of the most important enrichment techniques in a form that is relevant to analysis of proliferation risks; A detailed projection of the world demand for uranium enrichment services; A summary and critique of present institutional non-proliferation arrangements in the world enrichment industry, and An identification of the states most likely to pursue the enrichment route to acquisition of nuclear weapons.

Download or read book The Endocrinology of Parturition written by Roger Smith (Prof.) and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the processes by which we ourselves are born is arguably one of the greatest current challenges in clinical medicine. The prevention of preterm delivery, the cause of 70-80% of neonatal morbidity, has become a key area of research. 'The Endocrinology of Parturition' provides an encyclopedia of human parturition which charts the progress of this goal. ̈ In nineteen chapters of authoritative writing this volume covers a wide range of topics from the comparative endocrinology of mammalian parturition and the socio-economic impact of preterm delivery to the relative merits of current tocolytics. Hormonal actions involved in the process of parturition and the role of different hormones are discussed in detail. Several new approaches like the concept of parturition as a variant of inflammatory response or the role of the wide spectrum of known cytokines are introduced. This timely book in a highly dynamic research area is of special interest to birth-clinical obstetricians, endocrinologists and reproductive biologists as well as general practitioners involved in obstetrics.

Download or read book Encyclopedia of Medical Immunology written by Ian R. Mackay and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a broad appeal to microbiologists, immunologists, and infectious disease specialists, this four volume encyclopedia covers all autoimmune, tropical, and infectious diseases. Emphasis will also be placed on genetics, physiology, metabolism, pathogenesis and applied microbiology. Under the leadership of some of the most world renowned names in the field, the encyclopedia will bring together an outstanding collection of contributions by top scientists in a variety of fields. Volumes 1-3: Diseases will be divided by the 11 main sections of the body, namely Integumentary, Skeletal, Respiratory, Digestive, Urinary, and Reproductive. For some of the autoimmune disease, more then one system will be involved but the delineation serves to broadly break down the diseases into systems. Volume 4 will cover the vaccines for said diseases and future prospects will be offered by leaders in industry and academia. Volume 4 will also be broken down into all the body systems, as in the other two volumes. For each vaccine, for each disease, and in each system the following will be included: • A list of the vaccines currently available along with a list of the companies that manufacture them • Molecular Immunology of the Vaccine • Type of Immunity involved in protection • Mode of Vaccination for each vaccine; repeated boosters and length of immunological memory • Commercial production of vaccines • Storage of vaccines • Standardization and Control of Vaccines • WHO programs and World-Wide Disease Eradication Programs based upon Vaccines.

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Download or read book Dento Oro Craniofacial Anomalies and Genetics written by Agnes Bloch-Zupan and published by Elsevier. This book was released on 2012-03-21 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research. Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format

Download or read book Protein Kinase mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Functional Selectivity of G Protein Coupled Receptor Ligands written by Kim Neve and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile. Functional selectivity has profound implications for drug development, for chemical biology, and for the design of experiments to characterize receptor function. In Functional Selectivity of G Protein-Coupled Receptors expert neuroscientists and pharmacologists review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon. This exciting, comprehensive, and future-oriented volume includes chapters that focus on theoretical and mechanistic aspects of functional selectivity and that cut across subfamilies of GPCRs. Additional chapters focus on subfamilies of therapeutically relevant receptors where there is considerable evidence of ligand functional selectivity. Accessible and authoritative, Functional Selectivity of G Protein-Coupled Receptors is a valuable educational tool and reference source for students and scientists interested in drug development, chemical biology, and GPCR function.

Download or read book NF B Related Genetic Diseases written by Gilles Courtois and published by Springer. This book was released on 2015-12-29 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

Download or read book Normal and Malignant B Cell written by Mourad Aribi and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normal and Malignant B-Cell is a collection of harmonious chapters contributed by different authors. This book sets out to describe the B-cell during different stages of ontogeny and the molecular mechanisms of its antigen receptor diversity. It also discusses the main clinical and etiopathogenic aspects when it is transformed into a malignant cell. The book will be interesting and useful for clinicians, biologists, researchers, teachers, and graduate students of both doctoral and master's degrees in the field of immunology.