Download or read book Novel Insights Into the Pathophysiology of Chagas Cardiomyopathy written by Philipp Stahl and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The protozoan hemoflagellate Trypanosoma cruzi (T. cruzi) is the etiologic agent of the zoonotic Chagas' disease that affects approximately six to seven million people in Central and South America, causing dilated cardiomyopathy and megavisceral disease. Although Chagas' disease is the leading cause of heart failure in Latin America among people living in poverty and places an immense socioeconomic burden on society, it is still currently classified as a neglected tropical disease (NTD). The disease is typically transmitted by reduviid bugs or orally by contaminated food, while the transmission of parasitic organisms by other routes such as blood transfusion, organ transplantation, and transplacental infection is relatively rare. Given the wide cellular tropism infecting virtually all nucleated cells, the protozoan is able to persist asymptomatically for decades until ultimately causing organ-specific symptoms of chronic Chagas' disease such as chronic heart failure. The acute phase of the disease triggers an immune response that often does not restrict the dissemination of the parasite and may cause skin lesions, fever, enlarged lymph nodes, pallor, swelling, and abdominal and chest pain. Despite recent advances in our knowledge about the pathogenesis of this disease, the complex host-parasite interactions are not completely understood and, in particular, the persistence of parasites in host cells for such a long time remains largely undefined. In this book chapter, we focus on the pathophysiology of American trypanosomiasis and emphasize the role of host-specific transcription factors executing antiparasitic immune reactions.
Download or read book Novel Insights Into the Immune Mechanisms Associated With the Pathogenesis of Chagas Disease written by Giovane R. Sousa and published by Frontiers Media SA. This book was released on 2022-06-16 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiomyopathies written by Kaan Kırali and published by BoD – Books on Demand. This book was released on 2017-04-12 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiomyopathies are the most featured cardiac pathologies in the twenty-first century, that threaten public health and burden healthcare budgets. This book is composed of the main topics on pathophysiology, general forms and specific types of cardiomyopathies and it also introduces new research in the field. Specific forms with or without genetic inheritance are discussed separately to attract the readers' attention on these topics. Well-known medical follow-up strategies occur ineffective at the end-stage heart failure, however, new surgical approaches can be an alternative for these patients to get a chance at the last crossroad and to improve their life quality and survival and also to gain or prolong time until possible heart transplantation.
Download or read book Pathophysiology of the Heart written by Gordon Ross and published by . This book was released on 1982 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chagas Disease written by María-Jesús Pinazo Delgado and published by Springer Nature. This book was released on 2020-07-20 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive resource on various aspects of the parasite Trypanosoma cruzi and the neglected tropical disease Chagas disease (American trypanosomiasis), the disorder resulting from infection with the parasite. Topics include the biological description and taxonomy of the parasite, epidemiology and transmission routes, laboratory techniques in use when working with the parasite, as well as diagnostic measures and treatment of Chagas disease. Furthermore, a chapter with life stories of people in contact with the disease in endemic as well as non-endemic countries is included. The book is therefore a valuable source for individuals engaged in basic research as well as patient care and health management related to American trypanosomiasis.
Download or read book American Trypanosomiasis written by Jenny Telleria and published by Elsevier. This book was released on 2010-09-03 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: The host: human and mammalian reservoirs The insect vectors: domestic and sylvatic vectors The causative parasite: Trypanosoma cruzi Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts
Download or read book Compendium on Cardiomyopathies Basics Therapeutics and Perspectives written by Jinfu Yang and published by Bentham Science Publishers. This book was released on 2020-01-28 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compendium on Cardiomyopathies provides an easily readable source of material for practicing physicians, clinicians, cardiologists, intensivists and emergency medicine specialists. It presents an overview of different cardiomyopathies with information known from the past to the present. Chapters cover different kinds of cardiomyopathies: hypertrophic cardiomyopathies, pediatric cardiomyopathies, arrhythmogenic right ventricular cardiomyopathy, inherited cardiomyopathies, Chagas disease, Takotsubo cardiomyopathy and more. Readers will be informed about current research on different aspects of these cardiomyopathies such as etiology, important imaging methods used in diagnosis and treatment, genetics and clinical management. This compendium also introduces the reader to new terms describing groups of cardiomyopathies to enable them to apply modern clinical management principles while treating patients.
Download or read book Cellular and Molecular Pathobiology of Cardiovascular Disease written by Monte Willis and published by Academic Press. This book was released on 2013-12-23 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Download or read book Cardiovascular MRI in Practice written by John Grizzard and published by Springer Science & Business Media. This book was released on 2008-11-03 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular MR imaging has become a robust, clinically useful mod- ity, and the rapid pace of innovation and important information it conveys have attracted many students whose goal is to become adept practitioners. In turn, many excellent textbooks have been written to aid this process. These books are necessary and useful in helping the student learn the underlying pulse sequences used in CMR, as well as the imaging findings in a variety of disorders. However, one of the difficulties inherent in learning CMR from a book is that the printed format is not the ideal medium to d- play the dynamic imaging that comprises a typical CMR case. For instance, it may be difficult to perceive focal areas of wall motion abnormality on serial static pictures, but these abnormalities are often easily seen on cine loops. One might say that trying to learn CMR solely from a standard textbook with illustrations is like trying to learn to drive by looking at snapshots obtained through the windshield of a moving car. The learner needs to see the cardiac motion and decide if it is normal or abnormal; he or she needs to be in the driver’s seat. An additional limitation of the ava- able textbooks on CMR is that while they often have superb illustrations of abnormal findings, these images have been preselected.
Download or read book Evidence Based Cardiology written by Salim Yusuf and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second editionis a ground-breaking clinical text with a strong emphasis on rigorous evidence. Leaders in the field discuss best practice in the light of systematic reviews and randomised control trials, and how best to treat where the information is less clear. Case histories provide intriguing discussions on how to apply the evidence in real life situations. Evidence-based Cardiology also includes free access to the latest evidence, which is automatically posted on a companion website.
Download or read book Dilated Cardiomyopathy written by Gianfranco Sinagra and published by Springer. This book was released on 2019-05-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up. Furthermore, it discusses open issues, such as the apparent healing phenomenon, the early prognosis of arrhythmic events or the use of genetic testing in clinical practice. Offering a multidisciplinary approach for optimizing the clinical management of DCM, this book is an invaluable aid not only for the clinical cardiologists, but for all physicians involved in the care of this challenging disease.
Download or read book Novel Perspectives For The Therapy And Prevention Of Heart Failure written by Eliot Ohlstein and published by Frontiers Media SA. This book was released on 2022-08-26 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chagas Disease written by Jaime Marcelo Altcheh and published by Springer Nature. This book was released on 2019-09-09 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals. This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area. Chapter "Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities" is available open access under a via link.springer.com.
Download or read book Control of Chagas Disease written by World Health Organization and published by World Health Organization. This book was released on 2002-05 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report of a WHO Expert Committee reviews current knowledge of Chagas disease and its pathogenesis discusses the causative parasite the triatomine vectors and the natural reservoirs of infection and considers the epidemiology and incidence trends of the disease. Prevention and control strategies are described as are the various formal initiatives for interruption of disease transmission. The report concludes by identifying priorities for research and offering guidance for the planning implementation and strengthening of national control programmes. ... this book makes an extremely valuable contribution toward understanding Chagas disease and promoting solid prevention and control efforts. It will no doubt be an important addition to the library of anyone student and expert alike with interests in Chagas disease. The authors are to be congratulated on the completion of a work of excellence - an extremely difficult endeavour at a time when our knowledge of vectors parasites and methodologies is expanding so rapidly. - Transactions of the Royal Society of Tropical Medicine and Hygiene
Download or read book Chagas Disease Basic Investigations and Challenges written by Helieh S. Oz and published by . This book was released on 2018 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 11 chapters of significant and updated materials on what we know and what we lack and need in better understanding of Trypanosoma cruzi - a parasite that never dies - and the consequences of Chagas disease as one of the most important neglected parasitic diseases threatening the global health and wellbeing. This book is intended to increase the readers' enthusiasm to explore the four sections of the contents: Section 1 begins with biochemistry, pathophysiology, histo-immunological study, and findings to assist in the diagnosis; Section 2 further investigates the role of vector in propagation of the parasite, the intensity on epidemiology, and the severity on clinical aspects, which help us to be well perceived on the course of disease; Section 3 is seeking beyond modern medicine and what lays in the nature that helps fight against this parasite; and the last section, Section 4, deals with the impacts of public health problem and the control strategies on Chagas disease.
Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.
Download or read book Cardiac MR Imaging An Issue of Magnetic Resonance Imaging Clinics of North America written by Roberto C Cury and published by Elsevier Health Sciences. This book was released on 2019-07-08 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on Cardiac MR Imaging and is edited by Drs. Roberto C. Cury and Clerio Azevedo. Articles will include: The prognostic value of late gadolinium enhancement in non-ischemic heart disease; The role of contrast-enhanced CMR in the assessment of patients with malignant ventricular arrhythmias; Assessment of cardiac sarcoidosis by CMR: comparison with other imaging modalities; The value of T1 mapping techniques in the assessment of non-ischemic cardiomyopathies; Assessment of cardiotoxicity of cancer chemotherapy: The value of cardiac MRI; State-of-the-art quantitative assessment of myocardial ischemia by stress perfusion CMR; T2* mapping techniques: Iron overload assessment and other potential clinical applications; Automated Quantitative Stress Perfusion in a Clinical Routine; Comprehensive assessment of cardiac involvement in muscular dystrophies by cardiac CMR; Assessment of aortic stenosis by CMR: quantification of flow, characterization of myocardial injury, TAVR planning and more; Cardiac MRI at 7.0 Tesla: Reality?; The role of cardiac MRI in the assessment of patients with cardiac amyloidosis; Applications of Cardiac MRI in Electrophysiology: Current Status and Future Needs; and more!
