Download or read book Novel Determinants of the Hematopoietic Microenvironment in Development and Homeostasis written by Olaia Naveiras Torres-Quiroga and published by . This book was released on 2008 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
Download or read book Bone Marrow Niche written by Takashi Nagasawa and published by Springer Nature. This book was released on 2021-12-01 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes recent advances in research on mesenchymal cell populations in the bone marrow. It explores how mesenchymal cells create niches for immune cells in extramedullary organs and it discusses new concepts of lympho-hematopoietic microenvironments. Readers are introduced to the fundamentals of hematopoietic stem cells (HSCs) differentiation to all types of blood cells, including immune cells, in the bone marrow. The book highlights how this process is supported and regulated by the individual microenvironments of stem cells, termed niches. The identity of HSC niches has been subject to longstanding debates. Recent studies identified the population of mesenchymal stem cells as the major cellular component of niches, for hematopoietic stem and progenitor cells (HSPCs) and their candidate developmental origin. Furthermore, candidate cellular niches for immune cells in lymph nodes and adipose and connective tissues were identified. The authors of this volume focus on shared features between those and HSPC niche cells in the bone marrow. Covering latest research results, this book serves as fascinating read for researchers and clinicians in hematology and immunology.
Download or read book Handbook of Benign Hematology written by Martha Pritchett Mims, MD, PhD and published by Springer Publishing Company. This book was released on 2019-12-11 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Benign Hematology is a practical guide to the diagnosis and management of benign hematologic conditions. The book begins with a chapter on normal hematopoiesis and follows with chapters devoted to groups of blood disorders and syndromes including neutrophil disorders, nonmalignant myeloid disorders, bone marrow failure syndromes, myeloproliferative disorders, anemias, iron metabolism disorders, platelet disorders, hemostasis and coagulation defects, and thrombosis. Each disorder subtype covered features a clinical case, an introduction to the condition, details on diagnosis including applicable criteria and lab work needed, key diagnostic dilemmas, prognosis, treatment options, details on clinical trials and emerging clinical strategies, and bulleted key points to highlight clinical pearls and common pitfalls. The final chapters provide best practices for transfusion medicine and a guide to pharmacologic agents and their uses in clinical practice for adult and pediatric patients. The handbook is filled with tables and illustrations which highlight FDA-approved drug information, clinical trials data, hematopathologic characteristics of different disorders, important management criteria and more, making it the ideal handbook for those in practice or for review. The Editors and chapter authors are experienced academic practitioners in the fields of adult and pediatric hematology, pathology, blood banking, and pharmacology. Emphasizing best practices for patient management, this handbook is essential for oncologists, hematologists, trainees, and other practitioners who regularly or increasingly receive referrals to diagnose and treat adults or children with nonmalignant hematologic conditions. Key Features: Includes dozens of clinical cases covering all nonmalignant blood disorders Emphasizes patient management and best practices for disorders seen in adults and children Contains over 30 color images and numerous tables for quick reference Presents important details of all pharmacologic agents used to treat or manage hematologic disorders and their complications Purchase includes access to the ebook for use on most mobile devices or computers
Download or read book Hematopoietic Stem Cell Development written by Isabelle Godin and published by Springer Science & Business Media. This book was released on 2010-05-27 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.
Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2010-12-16 with total page 1203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. - Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology - The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine - New discoveries from leading researchers on restoration of diseased tissues and organs
Download or read book Developmental Hematopoiesis written by Margaret H. Baron and published by . This book was released on 2005-01-01 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the first collection of methods to study embryonic and fetal hematopoiesis in both invertebrate (fruit flies) and vertebrate (frog, fish, mouse, chick, and human) organisms. These state-of-the-art techniques range from the genetic, molecular, and cellular, to cell and embryo explant culture and whole animals, including in vivo imaging. Bioinformatic and functional genomic approaches for studying stem cells and their supportive stromal cells are also discussed.
Download or read book Rodak s Hematology E Book written by Elaine M. Keohane and published by Elsevier Health Sciences. This book was released on 2024-04-15 with total page 1020 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make sure you are thoroughly prepared to work in a clinical laboratory. Rodak's Hematology: Clinical Principles and Applications, 7th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology and hemostasis. This new edition details the parts and functions of the cell; shows how to accurately identify cells; covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins; and simplifies hemostasis and thrombosis concepts and disorders. Easy to follow and understand, this book also covers key topics, including working in the hematology and hemostasis laboratory; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; and laboratory testing of blood cells and body fluid cells. Over 700 full-color illustrations and photomicrographs make it easier for students to visualize hematology concepts and show what they'll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. Content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for students to review the important points in every chapter. Learning objectives begin each chapter and indicate what students should achieve, with review questions appearing at the end. - NEW! Chapter on Patient Safety in Hematology and Hemostasis. - NEW! Section on hematology and hemostasis in transgender populations. - UPDATED! White blood cell chapters are current with the 2022 World Health Organization (WHO) Classification of Haematolymphoid Tumours. - NEW! Changes in laboratory results associated with COVID-19 and other viral infections. - NEW! Content and figures on plasma transport, cell communication, and signal transduction. - NEW! Coverage of CRISPR technology for treatment of hemoglobinopathies and thalassemia. - UPDATED! Major revision of the Automated Blood Cell Analysis chapter.
Download or read book Geriatric Oncology written by Martine Extermann and published by Springer. This book was released on 2020-01-30 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.
Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. - Introduces the MSC-exosome mediated cell-cell communication - Covers the major functional benefits in current MSC-derived exosome studies - Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
Download or read book Cells of the Immune System written by Ota Fuchs and published by BoD – Books on Demand. This book was released on 2020-05-13 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cells of the immune system are lymphocytes (T-cells, B-cells and NK (natural killer) cells), neutrophils, eosinophils, and monocytes/macrophages. This book is an overview of some types of these cells and their role in recognizing and/or reacting against foreign material. The immune system is characterized by collaboration between cells and proteins. The development of all cells of the immune system begins in the bone marrow with a hematopoietic stem cell. Two chapters deal with neutrophils, three chapters with T-cells, four chapters with eosinophils, and other chapters review the immunomodulation of macrophages, the role of transcription factor KLF4 in regulating plasticity of myeloid-derived suppressor cells, immune reconstitution after allogeneic hematopoietic stem cell transplantation, and role of sorption detoxification in the therapy of acute radiation sickness.
Download or read book Hematology written by Leslie E. Silberstein and published by Elsevier Health Sciences. This book was released on 2017-06-14 with total page 2696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field. Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas. Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more. Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies. New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device. Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.
Download or read book Hematology written by Ronald Hoffman and published by Elsevier Health Sciences. This book was released on 2022-10-27 with total page 2886 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource. Covers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume. Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice. Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system. Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs. Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches. Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders. Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders. Presents relevant basic science as background for clinical application in later sections.
Download or read book Stem Cell Biology written by Daniel R. Marshak and published by CSHL Press. This book was released on 2001 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells are the focus of intense interest from a growing, multidisciplinary community of investigators with new tools for isolating and characterizing these elusive cell types. This volume, which features contributions from many of the world's leading laboratories, provides a uniquely broad and authoritative basis for understanding the biology of stem cells and the current excitement about their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their potential for clinical exploitation. It is an essential work of reference for investigators in embryology, hematology, and neurobiology, and their collaborators in the emerging field of regenerative medicine.
Download or read book Fetal and Neonatal Physiology E Book written by Richard Polin and published by Elsevier Health Sciences. This book was released on 2016-05-11 with total page 2381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
Download or read book Hematology E Book written by Leslie E. Silberstein and published by Elsevier Health Sciences. This book was released on 2012-11-05 with total page 2789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematology, 6th Edition encompasses all of the latest scientific knowledge and clinical solutions in the field, equipping you with the expert answers you need to offer your patients the best possible outcomes. Ronald Hoffman, MD, Edward J. Benz, Jr., MD, Leslie E. Silberstein, MD, Helen Heslop, MD, Jeffrey Weitz, MD, John Anastasi, MD, and a host of world-class contributors present the expert, evidence-based guidance you need to make optimal use of the newest diagnostic and therapeutic options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Make confident, effective clinical decisions by consulting the world's most trusted hematology reference. Access the complete contents online at www.expertconsult.com, with a downloadable image collection, regular updates, case studies, patient information sheets, and more. Apply all the latest knowledge on regulation of gene expression, transcription splicing, and RNA metabolism; pediatric transfusion therapy; principles of cell-based gene therapy; allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia and myelodysplastic syndrome in adults; hematology in aging; and much more, thanks to 27 brand-new chapters plus sweeping updates throughout. Find the information you need quickly and easily thanks to a completely reworked organization that better reflects today’s clinical practice. Visualize clinical problems more clearly with new and updated images that reflect the pivotal role of hematopathology in modern practice. Benefit from the experience and fresh perspective of new editor Dr. Jeffrey Weitz, Professor of Medicine at McMaster University School of Medicine and Executive Director of the Thrombosis and Atherosclerosis Research Institute in Ontario.
Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
