Download or read book Novel Approach to the Total Synthesis of Indole Alkaloids Via Cyclopentanoid Intermediates written by Mark Wingfield and published by . This book was released on 1982 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Novel Approach to the Total Synthesis of Corynanthe Indole Alkaloids Via Cyclopentanoid Intermediates written by Mark Wingfield and published by . This book was released on 1986 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Novel Approach to the Total Synthesis of Corynanthe Indole Alkaloids Via Cyclopentanoid Intermediaries written by M. Wingfield and published by . This book was released on 1985 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Indole Alkaloids written by Maliha Uroos and published by Elsevier. This book was released on 2022-02-04 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Indole Alkaloids: Spirooxindole details the multistep synthesis of natural products using schematic diagrams, providing a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. As a volume in the Visual Guides to Natural Product Synthesis series, this book presents the schematic total syntheses of natural products containing a "spirooxindole” core structure. It covers spirooxindole molecules through visual diagrams, highlighting key steps involved in total, formal and semi-syntheses. Sections cover Brevianamide A and B, Citrinadin A and B, Coerulescine and Horsfiline, Elacomine and Isoelacomine, Gelsemine, Paraherquamide A and B, Rynchophylline, Isorynchophylline, and more. Visual layouts provide quick-and- easy access to developed synthetic routes towards the targeted spirooxindoles. Outlines synthetic strategies for natural products bearing a spirooxindole core structure Includes schematic diagrams of multistep synthetic routes, highlighting key steps along the way Describes all routes for the formal synthesis, semi-synthesis and total synthesis of spirooxindole alkaloids
Download or read book Synthesis of Indole Alkaloids written by Reuben Murray White and published by . This book was released on 2019 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Approaches Toward the Total Synthesis of Oroidin Alkaloids written by Apsara K. Herath and published by . This book was released on 2020 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nagelamides and ageliferin are oroidin-derived alkaloids which have gained the attention of the scientific community, because of their significant biological activity as well as the unprecedented structural diversity. Our work is directed toward the development of synthetic methods for the construction of oroidin dimers. Accordingly, this dissertation is composed of two sections; the chapter one provides an overview of the oroidin alkaloids with a particular focus on the nagelamide family and the third chapter describes synthetic studies towards ageliferin. The first part of chapter two focuses on the Palladium-catalyzed Stille cross-coupling reaction for the construction of the main dimeric scaffolds of the nagelamide molecules. First, we describe new methodology to synthesize the iodoimidazole fragment for use in the Stille cross-coupling reaction and subsequent progress in optimizing the yield of Stille reaction. Additional advancement of the synthesis has been achieved via azide installation in allylic and alkyl side chains of the basic framework of nagelamides A and C. A convenient method of dimethylaminosulfonyl group deprotection was reported on these advanced intermediates prior to the installation of pyrrole carboxamide moieties. The second part of chapter two details a novel approach for acylation was developed in azidecontaining imidazole systems using thio acid chemistry providing amides in one step. The reaction conditions were optimized in diverse monomeric imidazole containing-azide systems, and excellent yields of acetamide and benzamide formation were obtained. Interestingly, a newly synthesized pyrrole thio acid offers promising results for the installation of the pyrrole carboxamide moiety in oroidin-derived systems. This chemistry can be employed in the final transformation of nagelamide A and C to install the pyrrole carboxamide moieties, however; the final reaction conditions still require optimization. The third chapter describes a potential intermediate en route to ageliferin which was constructed through an intramolecular Diels-Alder reaction using 4-vinylimidazole tethered to a urazole as the starting material. The Diels-Alder precursor was synthesized through palladium-catalyzed TsujiTrost cross-coupling reaction between t-butyl carbonate protected vinylimidazole and Nphenylurazole in excellent yield. We have explored three different protecting groups (DMAS, Bn, and SEM) on the imidazole nitrogen which can affect both the Diels-Alder reactivity and the electronic nature of the tetrahydrobenzimidazole ring system. For example, this can influence the oxidative rearrangement and introduction of the C2-amino moiety at the later in the synthesis. Further studies are in progress to complete the total synthesis of ageliferin using these advanced intermediates.
Download or read book Part I General Approach to the Total Synthesis of 9 methoxy Substituted Indole Alkaloids written by Jun Ma and published by . This book was released on 2006 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Total Synthesis of 16 17 dihydrosecodine and Related Indole Alkaloids written by Robert A. Farr and published by . This book was released on 1981 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 1988 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Download or read book Metathesis in Natural Product Synthesis written by Janine Cossy and published by John Wiley & Sons. This book was released on 2010-06-28 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diese übersichtlich strukturierte Monographie stellt die Bedeutung der Metathese für die Naturstoffsynthese in den Mittelpunkt der Diskussion. Ausführliche Erläuterungen zu den verschiedenen Typen von Schlüsselreaktionen fügen sich zu einem informativen Gesamtbild zusammen. Mit ausgewählten Synthesevorschriften!
Download or read book The Chemistry of Mycotoxins written by Stefan Bräse and published by Springer Science & Business Media. This book was released on 2013-02-14 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biological activity of mycotoxins ranges from weak and/or sometimes positive effects, such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to strong mutagenic (e. g. aflatoxins, patulin), carcinogenic (e. g. aflatoxins), teratogenic, neurotoxic (e. g. ochratoxins), nephrotoxic (e. g. fumonisins, citrinin), hepatotoxic, and immunotoxic (e. g. ochratoxins, diketopiperazines) activity. Nowadays, many laboratories around the world are specialized in the detection of mycotoxins in food products and contaminated material found in housing. In this volume, a focus on the most important classes of mycotoxins is provided and their chemistry of the last ten years is discussed. In each Section, the individual biological impact is outlined. Sections are arranged according to mycotoxin classes (e. g. aflatoxins) and/or structural classes (e. g. resorcinyl lactones, diketopiperazines). The biology of mycotoxins is also described.
Download or read book The Pauson Khand Reaction written by Ramon Rios Torres and published by John Wiley & Sons. This book was released on 2012-03-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control. The Pauson-Khand Reaction investigates the nature and many variations of this reaction. Topics covered include: the mechanisms of Pauson‐Khand-type reactions non chiral intramolecular and intermolecular versions of Pauson‐Khand reactions asymmetric Pauson‐Khand reaction using chiral auxiliaries the enantioselective Pauson‐Khand reaction Pauson‐Khand reactions catalysed by metals other than cobalt unconventional Pauson‐Khand reactions the Pauson‐Khand reaction in total synthesis Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.
Download or read book Domino Reactions in Organic Synthesis written by Lutz F. Tietze and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.
Download or read book Synthesis and Characterization of Glycosides written by Marco Brito-Arias and published by Springer Nature. This book was released on 2022-04-22 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition is a comprehensive and extended study about the best known approaches for preparing the main types of glycosides, covering the classic and more recent glycosylation reactions used for preparing simple and challenging glycosides currently used as potent antiviral and antineoplastic drugs, or fluorogenic substrates used for enzymatic detection in cell biology. Besides, this new edition provides more examples of the glycosidic methodologies followed for preparing complex glycoconjugates such as glycoproteins and glycosphingolipids and gangliosides used as adjuvants or as synthetic vaccines candidates. Also, additional mechanistic evidence is presented for better understanding of the glycosylation reaction, trying to identify the variables mainly depending on protecting and leaving groups, as well as catalyst and reaction condition which altogether directs the anomeric stereo control. A chapter on the glycoside hydrolysis is included in view of the increasing interest in the use of biomass as a natural and renewable source for obtaining important intermediates or products used in food or valuable materials. The author includes information in the characterization of glycosides section with the aim of giving additional tools for the structural assignment through NMR, X-Ray and mass spectra techniques.
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1987 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
