Download or read book Novel Antibacterial Biomaterials for Medical Applications and Modeling of Drug Release Process written by Vesna Mišković-Stanković and published by . This book was released on 2025 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book provides a comprehensive review of synthesis and physicochemical and biological characterization of novel antibacterial biomaterials produced according to original procedures and aimed at medical applications such as wound dressing, soft and hard tissue implants, drug delivery devices and carriers for cell cultivation. This book is intended for all researchers working in the fields of biomaterials and biomedical engineering, as well as medical professionals, science and engineering graduate students, academics, and industrial researchers"--

Download or read book Novel Antibacterial Biomaterials for Medical Applications and Modeling of Drug Release Process written by Vesna Mišković-Stanković and published by CRC Press. This book was released on 2024-06-12 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of synthesis and physicochemical and biological characterization of novel antibacterial biomaterials produced according to original procedures and aimed at medical applications such as wound dressing, soft and hard tissue implants, drug delivery devices, and carriers for cell cultivation. It is intended for all researchers working in the fields of biomaterials and biomedical engineering, as well as medical professionals, science and engineering graduate students, academics, and industrial researchers. Includes in-depth discussions on synthesis and physicochemical characterization of novel poly vinyl alcohol-based hydrogels aimed at wound dressings and soft tissue implants Explores synthesis and physicochemical characterization of novel bioceramic hydroxyapatite-based coatings on metal surface aimed for hard tissue implants Reviews cytotoxicity and antibacterial activity of novel poly vinyl alcohol-based hydrogels aimed for wound dressing and soft tissue implants Discusses cytotoxicity and antibacterial activity of bioceramic hydroxyapatite-based coatings on metal surface aimed for hard tissue implants Provides original fractional derivative models of drug release process from hydrogels and bioceramic coatings on metal surface and explores diffusion mechanism

Download or read book Antimicrobial Materials for Biomedical Applications written by Abraham J Domb and published by Royal Society of Chemistry. This book was released on 2019-08-02 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the need to combat emerging infectious diseases, research around antimicrobial biomaterials and their applications is booming. This book provides the field with a much-needed fundamental overview of the science, addressing the chemistry of a broad range of biomaterial types, and their applications in the biomedical industry. Materials covered include polymers, from those with inherent antimicrobial activity to those that release antimicrobial agents, antimicrobial ceramics and inorganic compounds, such as metal based antimicrobial additives, and the developing field of biomimetic materials, are discussed. Surfaces, coatings and adhesives are covered, whilst the applications of these antimicrobial materials in biomedical applications, from catheters to orthopaedics, dentistry to ophthalmology, are explored. Edited by international leaders and with contributions from the best in the field, this book is the go-to resource for graduates and researchers in biomaterials science, biomedical engineering, chemical engineering, and materials and polymer chemistry.

Download or read book Advanced Antimicrobial Materials and Applications written by Inamuddin and published by Springer Nature. This book was released on 2020-11-04 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface bio-contamination has become a severe problem that contributes to outbreaks of community acquired and nosocomial infections through contiguous fomite transmission of diseases. Every year, thousands of patients die due to nosocomial infections by pathogens. It is therefore essential to develop novel strategies to prevent or improve the treatment of biomaterial concomitant infections. The concept of antimicrobial materials is becoming increasingly important not only in the hospital and healthcare environments, but also for laboratories, home appliances, and certain industrial applications. Materials are now being developed to prevent the buildup, spread and transfer of harmful microbes, and to dynamically deactivate them. Drawing on research and examples from around the world, this book highlights the latest advances in, and applications of, antibacterial biomaterials for biomedical devices, and focuses on metals with antibacterial coatings/surfaces, antibacterial stainless steels and other commonly used antibacterial materials. It also discusses the role of innovative approaches and provides a comprehensive overview of cutting-edge research on the processing, properties and technologies involved in the development of antimicrobial applications. Given its scope, the book will be of interest to researchers and policymakers, as well as undergraduate and graduate students of biochemistry, microbiology, and environmental chemistry

Download or read book Handbook of Biomaterials for Medical Applications Volume 1 written by Deepa Suhag and published by Springer Nature. This book was released on with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advanced Porous Biomaterials for Drug Delivery Applications written by Mahaveer Kurkuri and published by CRC Press. This book was released on 2022-11-30 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Porous Biomaterials for Drug Delivery Applications probes cutting-edge progress in the application of advanced porous biomaterials in drug delivery fields. These biomaterials offer promise in improving upon the design, cost, and creation of potent novel drug delivery systems. The book focuses on two categories: nature engineered and synthetic advanced porous biomaterials, with a wide range of low-cost porous biomaterial-based systems that have been used for the delivery of diverse drugs through in vitro/in vivo approaches. Details how advanced porous biomaterial-assisted systems improve essential properties in drug delivery applications Explains how advanced porous biomaterials systems are being used and explored to improve overall performances of drug delivery systems in mitigating a variety of diseases Emphasizes major applications in drug delivery such as controlled release, cancer therapy, and targeted delivery, and with focus on oral, topical, and transdermal applications Focuses on both naturally available and synthetic low-cost advanced porous biomaterials and their role in enhancing important parameters in drug delivery applications Accessible to readers with bio and non-bio backgrounds This book is an ideal reference for academics, researchers, and industry professionals in the interdisciplinary fields of biomedicine and biomedical engineering, pharmaceuticals, materials science, and chemistry.

Download or read book Polymeric Biomaterials for Healthcare Applications written by Kokkarachedu Varaprasad and published by Woodhead Publishing. This book was released on 2022-05-07 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Biomaterials for Healthcare Applications details a broad range of polymeric biomaterials, methods of synthesis and preparation, and their various applications in healthcare and biomedicine. The book provides a fundamental overview of polymers and processing technologies to allow clinical scientists to explore the use of these polymers in alternative applications. A wide variety of healthcare applications are covered, including treatment for autoimmune diseases and bacterial infections, tissue engineering, gene delivery, wound dressing, and more. The book provides a core introductory text for clinical and materials scientists new to the area of polymeric biomaterials. This book will prove useful to academics and researchers in materials science, biomedical engineering, clinical science and pharmaceutical science. Covers a broad range of polymeric biomaterials, including chitosan, alginate, cellulose, collagen, synthetic conjugates, and more Details a wide variety of healthcare applications for polymeric biomaterials, such as orthopedic engineering, antibiotics, targeted drug delivery, and more Provides a detailed overview of polymer processing technologies and sterilization considerations

Download or read book Functional Chitosan written by Sougata Jana and published by Springer Nature. This book was released on 2020-03-05 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.

Download or read book Alginate Biomaterial written by Sougata Jana and published by Springer Nature. This book was released on 2023-01-31 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on recent trends of research on alginate-based biomaterials in Drug Delivery strategies and biomedical engineering. It contains the widely used alginate-based biomaterials as micro to nano-controlled drug delivery (oral, ocular delivery, topical delivery, etc.) and its fabrication technology, characterization, and biomedical aspects (such as cancer therapy, tissue engineering, gene delivery, vaccine delivery, enzyme immobilization, wound healing, dental applications, etc.) in a single book. The chapters cover updated information, current research trends, informatics, and all aspects of applications. Alginate is a U.S. Food and Drug Administration (FDA)-approved natural biomaterial and has diverse biomedical applications. In recent years, researchers and scientists are working on the alginate-based drug delivery systems that have been designed and characterized as a matrix, micro to nanocarriers, fibers, composite/scaffolds, etc. Alginate has versatile properties such as biodegradable, biocompatible, nontoxic, and easily available. This book especially highlights both the drug delivery strategies and biomedical engineering aspects such as controlled drug delivery, drug targeting to the site of action, cancer therapy, gene and vaccine delivery, enzyme immobilization, tissue engineering, and regenerative medicine.

Download or read book Functional Biomaterials written by Sougata Jana and published by Springer. This book was released on 2023-03-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Download or read book Development of Novel Biodegradable Antimicrobial Polymers for Biomaterials Applications written by Gregory Lu-Yuen Woo and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacterial infection is a frequent complication associated with the use of medical devices. Antimicrobial agents have been incorporated into or applied directly onto the surfaces of devices to combat infection. This thesis will assess the feasibility of using a novel biodegradable polymer to release antibiotic drugs in response to inflammatory related enzymes. A series of biodegradable drug polymers were synthesized using diisocyanates, oligomeric compounds, and an antibiotic, ciprofloxacin. The drug polymers were characterized by gel permeation chromatography (GPC), and elemental analysis. Biodegradation studies were carried out by incubating the polymers with solutions of cholesterol esterase (CE). Degradation was assessed by high performance liquid chromatography (HPLC), mass spectrometry (MS) and radiolabel release. Subsequently, the activity of the released antibiotic was assessed against a clinical isolate of Pseudomonas aeruginosa. For one of the polymer formulations, the release of ciprofloxacin was approximately two-fold higher in the presence of enzyme as compared to buffer alone. Another formulation using a different diisocyanate showed the release of multiple degradation products. The results of this study suggest that these novel antimicrobial polymers or similar analogs show good potential for use in the control of medical device associated infections.

Download or read book Injectable Biodegradable Carriers for the Delivery of Therapeutic Agents and Tissue Engineering written by Riccardo Levato and published by . This book was released on 2015 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The design of smart biomaterial devices plays a key role to improve the way conventional therapies are being delivered, and to promote the development of new approaches for advanced therapies, such as regenerative medicine and targeted drug release. Injectable biodegradable materials, such as those consisting of suspensions of polymeric particles, are highly versatile devices that can be delivered through minimally-invasive injections. The physic-chemical properties of the particles can be engineered to obtain smart scaffolds for tissue engineering, carriers for drug release and cell therapy. The aim of this Thesis is to develop a novel class of biodegradable and injectable particulate carriers based on polylactic acid (PLA), that are capable to trigger and guide specific responses from the cells and the biological milieu. First, a novel route to fabricate PLA-based microcarriers (MCs) was set and characterized. The production method involved green, non-harmful chemicals and it is easy to scale-up. Such technique allowed tuning MC size and size distribution in the range suitable for drug and cell delivery applications. The favorable regulatory status of the materials and reagents may also be beneficial for the translation of the MCs from bench to bedside. The principles guiding the fabrication procedure can inspire techniques to generate nanocarriers for controlled drug delivery. Recent studies point out the importance of drug-loaded and submicron-sized materials in the treatment of severe clinical conditions, such as persistent biofilm infections. These nanoparticles (NPs) can be endowed with smart functionalities to enhance drug delivery within the biofilm matrix. In this way, NPs encapsulating the antibiotic ciprofloxacin were produced and functionalized with DNase I. The NPs improved the antimicrobial activity of the encapsulated drug and promoted biofilm eradication, targeting and degrading directly the biofilm matrix. On the other hand, larger particles such as MC, display a high surface area for cell expansion. MCs can also deliver cells with therapeutic potential as ¿living drugs¿, ideally in a spatio-temporal controlled fashion. This is especially important, as, in standard cell therapies, direct injection of cells is accompanied by massive cell mortality that renders the treatment ineffective. PLA MCs suitable for Mesenchymal Stromal Cells (MSCs) homing have been produced and modified with different functionalization approaches. The physic-chemical properties of the MCs and bioactive coatings modulated cell adhesion, proliferation, and migratory potential in response to chemokines that regulate MSC tissue localization, like SDF-1a. The results highlight the importance of carriers design to control cell delivery, and provide important guidelines to instruct a new generation of efficient biomaterial carriers. Another exciting application of injectable, cell-laden MCs is to use them as building blocks to fabricate living tissues in vitro. Combining MC technology and bioprinting is an appealing strategy to generate tissues grafts with controlled architectures. The suspension of injectable PLA cell-laden MCs within gelatin-based hydrogels formed an extrudable, composite bioink. MCs acted as mechanical reinforcement for soft gels and as means for cell expansion to encapsulate high cell payload. MSCs were shown to form MC-MSCs aggregates, with enhanced cell-to-cell contact on surface functionalized PLA MCs, and differentiated towards the osteogenic lineage. This result suggests potential applications of MC-MSCs laden bioinks for bone tissue engineering, and the composite bioink is proposed as component to build multimaterial, 3D-printed osteochondral graft models. Taken together, the injectable devices developed in the Thesis constitute promising and highly versatile biomaterial platforms for biomedical applications, and can be employed in a wide array of tissue engineering, and cell and drug delivery strategies.

Download or read book Handbook of Biomaterials for Medical Applications Volume 1 written by Deepa Suhag and published by Springer. This book was released on 2025-02-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Handbook on Biomaterials for Medical Applications: Fundamentals" is a critical monograph that merges advanced technological insights with practical applications in biomedical materials science. It navigates through the intricate blend of theoretical knowledge and real-world medical practices, highlighting the significant roles these materials play in enhancing therapeutic outcomes. Addressing the interdisciplinary nature of the field, the book incorporates perspectives from chemistry, biology, engineering, and clinical medicine. This comprehensive guide covers novel biomaterials, advanced drug delivery systems, innovative tissue engineering, and the emerging field of theranostics, providing a holistic view of how these elements drive medical advancements. This book can be a valuable reference for scholars, researchers, and healthcare practitioners. Its text is richly illustrated with diagrams and tables, facilitating both the understanding and application of complex concepts. With an educational narrative accessible to both experts and beginners, the monograph encourages a passion for innovation and a deep understanding of the transformative potential of multifunctional biomedical materials. It invites readers to explore the confluence of materials science and therapeutic innovation, setting the stage for future breakthroughs in medical science and therapy. It can also be prescribed as a textbook for various graduate and undergraduate courses like tissue engineering and regenerative medicine, nanomedicine, biomedical engineering and biomaterials science and engineering.

Download or read book Emerging Nanomaterials and Nano based Drug Delivery Approaches to Combat Antimicrobial Resistance written by Muthupandian Saravanan and published by Elsevier. This book was released on 2022-06-24 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource. Outlines how to overcome existing traditional approaches to combatting antimicrobial resistance Explains how to apply multiple drug delivery mechanisms (MDR) to the target area in order to better combat antimicrobial resistance Shows how nanomaterials are used as drug carriers in this context

Download or read book Nanostructures for Antimicrobial Therapy written by Anton Ficai and published by Elsevier. This book was released on 2017-05-29 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Download or read book Engineered Biomaterials for Drug delivery written by Amit Kumar Nayak and published by Woodhead Publishing. This book was released on 2023-10-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineering of biomaterials improves the key properties and function of the materials, enabling enhanced performance and efficacy in drug delivery applications. Engineered Biomaterials for Drug Delivery covers a core selection of engineering approaches and methods to optimize materials for drug delivery, including grafting, cross-linking, thiolation, conjugation and functionalization of biomaterials. A wide range of engineered biomaterial types are described, from biopolymers and nanobiomaterials, to metals, ceramics and composites. Biocompatibility, toxicity and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. Engineered Biomaterials for Drug Delivery is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science and pharmacology, chemical engineering and clinical science.

Download or read book Handbook of Bioceramics and Biocomposites written by Iulian Vasile Antoniac and published by Springer. This book was released on 2016-05-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes several current trends in the development of bioceramics and biocomposites for clinical use in the repair, remodelling, and regeneration of bone tissue. Comprehensive coverage of these materials allows fundamental aspects of the science and engineering to be seen in close relation to the clinical performance of dental and orthopaedic implants. Bioceramics and biocomposites appear to be the most dynamic area of materials development for both tissue engineering and implantable medical devices. Almost all medical specialties will continue to benefit from these developments, but especially dentistry and orthopaedics. In this Handbook, leading researchers describe the use of bionanomaterials to create new functionalities when interfaced with biological molecules or structures. Also described are technologies for bioceramics and biocomposites processing in order to fabricate medical devices for clinical use. Another important section of the book is dedicated to tissue regeneration with development of new matrices. A targeted or personalized treatment device reduces drug consumption and treatment expenses, resulting in benefits to the patient and cost reductions for public health systems. This authoritative reference on the state-of-the-art in the development and use of bioceramics and biocomposites can also serve as the basis of instructional course lectures for audiences ranging from advanced undergraduate students to post-graduates in materials science and engineering and biomedical engineering.