Download or read book Normal and Malignant Hematopoiesis written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''An exciting glance at key issues in contemporary hematopoiesis.'' -The Quarterly Review of Biology
Download or read book Modeling Normal and Malignant Hematopoiesis Using Human Pluripotent Stem Cells written by Patrick Joseph Walsh and published by . This book was released on 2011 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Myeloid Progenitors in Normal and Malignant Hematopoiesis written by Thanyaphong Na Nakorn and published by . This book was released on 2002 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epigenetic Regulation of Normal and Malignant Hematopoiesis written by and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interleukin 4 written by Jozef Henricus Jansen and published by . This book was released on 1992 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stress Signaling Heterogeneity in Normal and Malignant Hematopoiesis written by Abdul Rahman Itani and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Smoothened Regulates Normal and Malignant Hematopoiesis written by Claudius Klein and published by . This book was released on 2020* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Hematopoietic Stem Cell Research written by Rosana Pelayo and published by IntechOpen. This book was released on 2012-01-27 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview in our understanding of the biology and therapeutic potential of hematopoietic stem cells, and is aimed at those engaged in stem cell research: undergraduate and postgraduate science students, investigators and clinicians. Starting from fundamental principles in hematopoiesis, Advances in Hematopoietic Stem Cell Research assemble a wealth of information relevant to central mechanisms that may regulate differentiation, and expansion of hematopoietic stem cells in normal conditions and during disease.
Download or read book Textbook of Malignant Hematology written by Laurent Degos and published by CRC Press. This book was released on 2004-12-14 with total page 1492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of this successful title has been fully revised and updated and now includes expanded sections on normal and malignant haematopoiesis, offering a thorough review of the molecular and cellular processes involved in malignancy, developments in diagnostic techniques and treatment, concluding with discussion of treatment of individual diseases, late effects of therapy and supportive care. Short Contents
Download or read book Molecular Dissection of Normal and Malignant Hematopoiesis Identifies Therapeutic Targets in Myeloid Neoplasms written by Daniel Lipka and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Ebf2 in Normal and Malignant Hematopoiesis written by Christoph Hinzen and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transcription Factors written by Katya Ravid and published by John Wiley & Sons. This book was released on 2003-11-04 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Download or read book Functional Consequences of Cohesin Complex Mutations on Normal and Malignant Hematopoiesis written by Claire Mazumdar and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have identified recurrent mutations in all components of the cohesin complex in acute myeloid leukemia and other myeloid malignancies, and, importantly, have shown these mutations to occur early in disease pathogenesis and in pre-leukemic hematopoietic stem cells. Here, we investigate the impact of these mutations on hematopoiesis and demonstrate that introduction of cohesin mutants into normal human hematopoietic stem and progenitor cells (HSPC) results in blocked differentiation and enforcement of stem cell programs both in vitro and in vivo. These effects were cell context dependent, restricted to immature HSPC populations. Cohesin mutants selectively increased chromatin accessibility and likelihood of occupancy at binding sites for transcription factors known to regulate HSPC including ERG, GATA2, and RUNX1 as measured by ATAC-Seq and ChIP-Seq. Furthermore, epistasis experiments showed that silencing of these transcription factors 2in which mutant cohesin impairs hematopoietic differentiation and aberrantly enforces stem cell programs through the modulation of HSPC chromatin accessibility and transcription factor activity.
Download or read book The Role of MicroRNAs in Normal and Malignant Hematopoiesis written by Florian Kuchenbauer and published by . This book was released on 2017* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of DNA Methyltransferases in Normal and Malignant Hematopoiesis written by Staci L. Haney and published by . This book was released on 2016 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA methylation is an epigenetic modification that regulates gene transcription. The addition of a methyl group to cytosine is catalyzed by a family of enzymes known as DNA methyltransferases (Dnmts). The three catalytically active Dnmts in humans and mice are Dnmt1, Dnmt3a, and Dnmt3b. DNA methylation is clinically relevant, as aberrations in the methylation landscape are a hallmark of nearly all human cancers. Cancer methylomes are typically characterized by genome wide hypomethylation and regional specific hypermethylation, both of which have been linked to alterations in gene expression. In order to understand the contribution of epimutations to the development of hematological malignancies we created several mouse models in which one or more Dnmt is deleted in hematopoietic stem cells and all downstream lineages. This allowed us to address the role of individual Dnmts in normal and malignant hematopoiesis. We found that Dnmts contribute to the cancer methylome through both de novo and maintenance methylation, and that activities of individual Dnmts seldom overlap with one another. We identified Dnmt1 as being critical for T cell development and maintenance of the tumor phenotype in T cell lymphomas. Furthermore, we identified Dnmt3a and Dnmt3b as critical tumor suppressor genes in the prevention of chronic lymphocytic leukemia in mice. Collectively, these studies provide insight into the effects of Dnmt deregulation in tumorigenesis.
Download or read book Intrinsic and Extrinsic Regulators of Stem Cell Function in Normal and Malignant Hematopoiesis written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mesenchymal Niche Contribution to Normal and Malignant Hematopoiesis written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
