Download or read book Non Vitamin K Antagonist Oral Anticoagulants Clinical Use Real World Data and Reversal of Anticoagulant Effect written by Özcan Başaran and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice and is associated with a higher risk of thromboembolic events. CHA2DS2VASc score enables identification of those patients with AF who will most benefit from anticoagulation therapy and low-risk patients with AF who do not need any antithrombotic therapy. Antithrombotic drugs especially oral anticoagulants (OACs) are the mainstay of therapy to prevent stroke in patients with AF. Although vitamin K antagonists (VKAs) were the only available drugs for decades, numerous non-vitamin K antagonist oral anticoagulants (NOACs) have been developed and marketed for stroke prevention in recent years. The risk of stroke was reported to decline up to 68 % with OAC therapy, associated with good anticoagulation control with VKAs, assessed by time in therapeutic range (TTR). In low TTR values, VKAs were found to be associated with severe complications, and a minimum TTR of 58 % should be achieved to expect a net benefit from being on OAC therapy. Narrow therapeutic index, drug-drug interactions, and the need for close monitoring are the main disadvantages of VKAs, and management of patients have dramatically improved after the introduction of NOACs. NOACs have a more predictable anticoagulant affect which allows a fixed-dose regimen. The efficacy and safety of NOACs have been shown not only in large randomized controlled clinical trials but also in observational studies. The main advantages of NOACS such as "fixed-dose regimen" and "no need for regular anticoagulant therapy monitoring" may also be the Achilles heel of the use of these agents. Fixed-dose regimen may not be appropriate for elderly, for patients with chronic kidney disease, and for patients using interacting drugs. Adherence to NOAC therapy is another concern as it may be as low as 50 % in the chronic use of cardiovascular drugs, especially if the drug has no apparent affect to the patient. Thus, appropriate use of OACs among non-valvular AF (NVAF) patients is essential for stroke prophylaxis. We intended to review the use of OAC therapy among (NVAF) patients.
Download or read book Anticoagulation Therapy written by Ozcan Basaran and published by BoD – Books on Demand. This book was released on 2016-09-08 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists.
Download or read book Non Vitamin K Antagonist Oral Anticoagulants written by Eduard Shantsila and published by Springer. This book was released on 2015-12-21 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.
Download or read book Treatment of Non vitamin K Antagonist Oral Anticoagulants written by Masaaki Uno and published by Springer. This book was released on 2016-10-31 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes new concepts and strategies for the clinical application of non-vitamin K antagonist oral anticoagulants (NOACs) for stroke. Although vitamin K antagonists have traditionally been used for the prevention of stroke, there are some problems associated with their use, such as the risk of intracranial hemorrhage, the need for dietary restrictions, and individual variability. Recently, NOACs have been introduced as alternatives to traditional anticoagulants and are becoming an option for treating stroke patients around the globe. However, their use is not without risk. Each chapter describes the successful use of NOACs for stroke patients and discusses their future impact from various points of view. The book is primarily written for neurosurgeons and neurologists but is also of interest to cardiologists involved in stroke treatment.
Download or read book Anticoagulation Therapy written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Direct Oral Anticoagulants written by Riccardo Proietti and published by Springer Nature. This book was released on 2021-06-28 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely covers the latest developments in the application of direct oral anticoagulants (DOACs) within cardiovascular medicine. It details the pharmacodynamics and pharmacokinetic mechanisms of DOACs and their application in treating patients with conditions ranging from coronary heart disease through kidney disease and cancer, including their perioperative management. Direct Oral Anticoagulants: From Pharmacology to Clinical Practice systematically describes the underlying mechanisms associated with DOACs and their use to treat a range of conditions and is an indispensable resource for all trainee and practicing physicians in a range of disciplines seeking a concise up-to-date resource on the topic.
Download or read book Oral Anticoagulants written by L. Poller and published by CRC Press. This book was released on 1996-08-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Warfarin and related drugs have been used for over half a century in prevention and treatment of thrombotic disorders. Only recently however has their clinical role been firmly established by randomised studies and their benefit/risk ratio improved by lower dose therapy with improvements in laboratory monitoring. 'Oral Anticoagulants' is the first comprehensive, practical survey of the subject available. An international team of recognised experts provide detailed coverage on the mode of action; clinical pharmodynamics; magnitude and sources of variability in individuals response to oral anticoagulant; methods of individualising dosing regimens; laboratory monitoring; and comparison between the different currently prescribed oral anticoagulants.
Download or read book Anticoagulation Therapy written by Joe F. Lau and published by Springer. This book was released on 2018-04-16 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.
Download or read book Diez Werner written by and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oral Anticoagulation Therapy written by Kathryn Kiser and published by Springer. This book was released on 2017-05-31 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the amount and complexity of information surrounding the the target specific oral anticoagulants a lengthy didactic educational format has the potential to be overwhelming to the reader and difficult to translate and apply to direct patient care. The proposed book will educate clinicians utilizing a series of clinical cases to simultaneously develop the readers’ knowledge base, problem-solving skills, and practically apply their new knowledge to a variety of clinical situations. These will be short focused case presentations that provide critical information and pose questions to the reader at key points in the decision making process. The cases will be relevant to what clinicians will encounter not only on a daily basis, but also reflective of scenarios that clinicians will not encounter regularly, but that they will have to act upon (e.g. a bleeding patient, patient scheduled for elective or emergent procedure, patient with changing renal function, patient on drugs that have a plausible yet unstudied drug interaction with a target specific oral anticoagulant etc). Included in the case studies will be evidence-based discussions (with appropriate references) that provide immediate feedback on the different treatment alternatives that were offered. The case studies will be designed to instruct the reader how to select and effectively utilize the most appropriate agent for a given clinical scenario. They will focus on key features of the target specific oral anticoagulants, what they have in common, how they are unique from each other, as well as illustrating the clinical decision process one should take when selecting an agent or managing a patient already receiving one of the target specific oral agents.
Download or read book Image Guided Interventions E Book written by Kenneth R. Thomson and published by Elsevier Health Sciences. This book was released on 2020-03-13 with total page 1193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised to reflect recent, rapid changes in the field of interventional radiology (IR), Image-Guided Interventions, 3rd Edition, offers comprehensive, narrative coverage of vascular and nonvascular interventional imaging—ideal for IR subspecialists as well as residents and fellows in IR. This award-winning title provides clear guidance from global experts, helping you formulate effective treatment strategies, communicate with patients, avoid complications, and put today’s newest technology to work in your practice. Offers step-by-step instructions on a comprehensive range of image-guided intervention techniques, including discussions of equipment, contrast agents, pharmacologic agents, antiplatelet agents, and classic signs, as well as detailed protocols, algorithms, and SIR guidelines. Includes new chapters on Patient Preparation, Prostate Artery Embolization, Management of Acute Aortic Syndrome, Percutaneous Arterial Venous Fistula Creation, Lymphatic Interventions, Spinal and Paraspinal Nerve Blocks, and more. Employs a newly streamlined format with shorter, more digestible chapters for quicker reference. Integrates new patient care and communication tips throughout to address recent changes in practice. Highlights indications and contraindications for interventional procedures, and provides tables listing the materials and instruments required for each. Features more than 2,300 state-of-the-art images demonstrating IR procedures, full-color illustrations of anatomical structures and landmarks, and video demonstrations online. 2014 BMA Medical Book Awards Highly Commended in Radiology category!
Download or read book Management of Acute Pulmonary Embolism written by Stavros V. Konstantinides and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.
Download or read book Anticoagulant Drugs written by Mojca Božič-Mijovski and published by BoD – Books on Demand. This book was released on 2018-08-29 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.
Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.
Download or read book Mosby s Handbook of Herbs Natural Supplements E Book written by Linda Skidmore-Roth and published by Elsevier Health Sciences. This book was released on 2009-04-27 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Access the most reliable information on herbs and alternative medicines from trusted author, Linda Skidmore-Roth, in Mosby’s Handbook of Herbs and Natural Supplements! Reviewed by nurses and herbalists alike, this authoritative resource presents herb and supplement profiles in a convenient, A-Z format for fast reference. This edition’s updated, streamlined design helps you find information quickly, and a new systematic pregnancy and breastfeeding classification offers the latest guidelines for this special client population. Detailed monographs for 300 commonly used herbal products and natural supplements include vital information on the products you’ll encounter with your clients. Updated references and information from new studies make this a reliable source for herbal content. Alert icons warn you of potentially dangerous reactions that could threaten your clients’ health. Popular Herb, Pregnancy, and Pediatric icons help you find relevant content quickly for common herbs and herbs for special populations. Quick-reference format presents consistent monographs for each herb and makes it easy to find the information you need. Herbal Resource appendix, Drug/Herb Interaction appendix, Pediatric Herbal Use appendix, and a list of abbreviations provide essential resources and expanded herbal material in one convenient spot. A comprehensive index of herbal terms allows you to look up an herb by its common or scientific name, as well as by condition. A pregnancy classification system from the Australian Therapeutic Goods Administration allows you to analyze herbs individually and provides a consistent formula to decide which herbs should be used. Updated content throughout includes the latest uses, actions, dosages, contraindications, side effects/adverse reactions, interactions, pharmacology, alerts, and references. Pediatric Herbal Use appendix covers uses, guidelines, and expanded pediatric and adolescent information for 32 herbs. Drug/Herb Interaction appendix lists known drug and herb interactions for herbs included in the handbook to ensure client safety.
Download or read book Case Studies in Emergency Medicine written by Colin G. Kaide and published by Springer Nature. This book was released on 2019-11-14 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a variety of medical case studies from actual patients presenting to the emergency department. It includes not only typical cases that present to the ED but also less common, yet very important cases that one can't afford to miss. Each chapter begins with a case – or set of cases with typical and atypical aspects – of the disease in question. This is followed by high-value learning points on the condition with introductory/background points, physiology and pathophysiology of the disease, how to make the diagnosis, and finally how to initiate treatment. The cases provide expert discussion with tips and tricks, personal experience with management of each of the cases, and a follow-up description of the outcome of the cases to provide the reader with closure. To supplement each case study, all 67 chapters include a pattern recognition component that identifies the key diagnostic features of the disease discussed. The chapters conclude with a summary of the diagnostic and treatment details of each condition. Using a concise, easy-to-read, bulleted format, the book helps readers to learn, evaluate, adopt new practices, right now (LEARN). Emergency Medicine Case Studies - LEARNing Rounds: Learn, Evaluate, Adopt, Right Now is an essential resource for a variety of emergency medicine clinicians including experienced physicians, residents, physician assistants, nurse practitioners, nurses, and medical students rotating in the emergency department. Finally, this book can be used as a basis for small group discussions, especially in emergency medicine training programs.
