Download or read book Nitric Oxide in Diabetes and Hypertension written by Shiekh gazalla Ayub and published by LAP Lambert Academic Publishing. This book was released on 2015-10-20 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide is one the pivotal molecule released by endothelium and its turnover is vital for proper endothelial function. Various chronic risk factors associated with Type II Diabetes Mellitus and hypertension may disrupt the homeostatic balance in vascular system potentiating endothelial dysfunction. Endothelial dysfunction accompanies all cardiovascular risk factors and presumably plays a prime role in the occurrence of cardiovascular events associated with diabetes and hypertension. Although, it is apparent that NO turnover has a deep influence on the etiology of diabetes and hypertension, much remains to be done to substantiate NO-targeted therapies for the treatment of these disorders. Likewise, a systematic detail of ascertaining the relationship of NO dynamics with such disorders need to be elucidated before NO-targeted therapeutic proposition is considered. Our study is an attempt to quantitate and compare the NO level status in these different pathological conditions and analyse it in relation to the effect of disease.
Download or read book Diabetes and Hypertension written by Samy I. McFarlane and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Download or read book The Role of Nitric Oxide peroxynitrite Imbalance in Diabetes and Salt induced Hypertension written by Salah Alsanussi Mousa Awad and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Nitric Oxide in Type 2 Diabetes written by Asghar Ghasemi and published by Bentham Science Publishers. This book was released on 2022-12-01 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role. This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.
Download or read book Diabetic Dysregulation of Endothelial Glucose Metabolism written by Matthew Brent West and published by . This book was released on 2005 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evident increase in obesity and sedentary lifestyles across the globe is consistent with a rise in the incidence of both non-insulin-dependent diabetes mellitus (type 2 diabetes) and cardiovascular disease (CVD). Type 2 diabetes is a clinically polygenic disease that has become an emergent global problem. Like CVD, diabetes is exaggerated by dyslipidemia, hypertension, obesity, and smoking, and it has been suggested that type 2 diabetes is a cardiovascular disease. Indeed, CVD and diabetes share identical and overlapping risk factors ("common soil hypothesis"). A majority of diabetic complications are a result of both micro and macrovascular changes that either directly or indirectly contribute to these chronic pathologies.
Download or read book Atherosclerosis Hypertension and Diabetes written by Grant N. Pierce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to atherosclerosis, hypertension, and diabetes, three of the most important disease conditions in the world today. Nutritional intervention, cholesterol lowering agents, lipids themselves, particularly oxidized LDL, protein modification by ADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are all discussed in the context of atherosclerotic cardiovascular disease. The hypertension section focuses on factors that may be responsible for high blood pressure, such as genetic predisposition, vascular hyperplasia and remodeling, insulin resistance, neurological aspects such as hypothalamic peptides. Also discussed are the possible contributions of the cellular function of the endothelium, nutrition, kidney dysfunction, leptin, and the brain. Novel routes of drug delivery for treatment of hypertension is also a focus. The risk factors and mechanisms responsible for diabetic vascular and cardiac dysfunction are discussed. Lipid profile changes and fibrinolysis in diabetic patients is detailed, along with adipogenesis, diabetic cardiomyopathy, energy metabolism in the diabetic heart, vanadate as an alternative to insulin, insulin resistance mechanisms, and neurotransmitters as targets for the prevention of cardiovascular disease and diabetes.
Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Download or read book Phytotherapy in the Management of Diabetes and Hypertension written by Mohamed Eddouks and published by Bentham Science Publishers. This book was released on 2012-11-20 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytotherapy in the Management of Diabetes and Hypertension is a good addition to existing volumes detailing knowledge of hyperglycemia therapy. This e-book emphasizes the basic biochemistry behind diabetes mellitus and hypertension, along with the control or remediation of these conditions through a cost effective, safe, easy-going, easy-adaptable method validated by scientific research. This e-book contains 7 chapters dealing with various aspects of these diseases and their Phytotherapy treatment and life style management. Phytotherapy can give patients long term benefits with less or no side effects. Hence, this e-book is an authentic alternative or complementary therapeutic compendium to physicians and patients. This book will also be useful to students, teachers, researchers, clinicians and general readers interested in learning about applied phytotherapy.
Download or read book Diabetes and Cardiovascular Disease written by Michael T. Johnstone and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.
Download or read book Nitric Oxide written by Louis J. Ignarro and published by Academic Press. This book was released on 2000-09-13 with total page 1023 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense
Download or read book Hypertension and Cardiovascular Disease written by Emmanuel A. Andreadis and published by Springer. This book was released on 2016-09-20 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive analysis into individualized patient care, and applying evidence‐based medicine while integrating basic medical knowledge with applied medicine. The Editor and the contributors not only discuss important issues on hypertension management and its deleterious consequences if it is not well‐controlled, but also highlight the important signaling pathways involved in the pathogenesis of hypertensive heart disease and cardiac hypertrophy.
Download or read book Hypertension Insulin Resistance and Nitric Oxide Bioavailability written by Mobin Mohteshamzadeh and published by . This book was released on 2002 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effect of a High fat Refined carbohydrate Diet on Blood Pressure and Nitric Oxide Synthase written by Christian Kenneth Roberts and published by . This book was released on 1999 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effect of Novel Nitric Oxide Releasing Aspirin NCX4016 on the Consequences of Ischaemia and Reperfusion in Rat Models of Hypertension Diabetes and Obesity written by Steven George Burke and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metabolism of Nitric Oxide in Blood in Diabetic Patients written by Paris Brouzos and published by . This book was released on 2009 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pediatric Hypertension written by Joseph Flynn and published by Springer Science & Business Media. This book was released on 2013-06-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
Download or read book New Translational Insights on Metabolic Syndrome Obesity Hypertension Diabetes and beyond written by Camille M. Balarini and published by Frontiers Media SA. This book was released on 2016-08-15 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic syndrome (MetS) can be considered as a clustering of several risk factors such as obesity, hypertension, insulin resistance and dyslipidemia, which could lead to the development of diabetes and cardiovascular diseases (CVD). There are several underlying causes for MetS including overweight, physical inactivity and genetic factors. However, the underlying mechanisms that leads to MetS are still poorly understood. Therefore, the aim of this E-book is to provide a space where researchers holding different backgrounds could shed some light onto the pathophysiology of different risk factors involved in MetS, mostly from translational research worldwide.
