Download or read book New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune Mediated Inflammatory Diseases written by Konstantinos Papamichael and published by Mdpi AG. This book was released on 2023-12-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn's disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID.
Download or read book Biologics in Inflammatory Bowel Disease An issue of Gastroenterology Clinics of North America written by Edward V. Loftus Jr and published by Elsevier Health Sciences. This book was released on 2014-09-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: By the time this issue of Gastroenterology Clinics of North America is released, it will have been 16 years since infliximab was approved by the US Food and Drug Administration for the treatment of moderate to severe Crohn disease. Not only have we come a long way in understanding the efficacy and safety of infliximab, we are beginning to understand how and when to use the drug. Furthermore, as of this writing, we have five other biologic agents approved for either Crohn disease or ulcerative colitis, and there are many more molecules currently in drug development for these indications. In this issue,the Editors have assembled a collection of experts to provide the most cutting-edge information on the status of biologic therapy for inflammatory bowel disease.
Download or read book New Concepts in Inflammatory Bowel Disease written by Batool Mutar Mahdi and published by . This book was released on 2018 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract of unknown origin, which includes Crohn's disease, ulcerative colitis, and inflammatory bowel disease of unclassified type. It is associated with different intestinal and extraintestinal manifestations like different neurological and psychiatric disorders. Histology is an important tool in the diagnosis and prognosis of inflammatory bowel disease and has an increasing part in patients' management. The objective of treatment is to make and keep long-lasting remission by immunosuppressive treatment like corticosteroids, thiopurines, and monoclonal antibodies directed against tumor necrosis factor alpha. Therapeutic drug monitoring of thiopurines by measuring levels of their metabolites has been proposed as a potentially effective tool in optimizing therapy in inflammatory bowel disease. Diets and their components influence microbiota of the intestine, function of the epithelial barrier, immune response, and other factors that have an important role in development and treatment of inflammation in the gut mucosa.
Download or read book New Concepts in Inflammatory Bowel Disease written by Batool Mutar Mahdi and published by BoD – Books on Demand. This book was released on 2018-03-21 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract of unknown origin, which includes Crohn's disease, ulcerative colitis, and inflammatory bowel disease of unclassified type. It is associated with different intestinal and extraintestinal manifestations like different neurological and psychiatric disorders. Histology is an important tool in the diagnosis and prognosis of inflammatory bowel disease and has an increasing part in patients' management. The objective of treatment is to make and keep long-lasting remission by immunosuppressive treatment like corticosteroids, thiopurines, and monoclonal antibodies directed against tumor necrosis factor alpha. Therapeutic drug monitoring of thiopurines by measuring levels of their metabolites has been proposed as a potentially effective tool in optimizing therapy in inflammatory bowel disease. Diets and their components influence microbiota of the intestine, function of the epithelial barrier, immune response, and other factors that have an important role in development and treatment of inflammation in the gut mucosa.
Download or read book Therapeutic Advances in Inflammatory Bowel Disease Current Therapies and Future Directions written by Giulia Roda and published by Frontiers Media SA. This book was released on 2023-10-23 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammatory bowel diseases (IBD), are chronic and progressive diseases. Long-term complications are demolition surgery and colon-rectal cancer (CRC). A treat-to-target approach aims to modify the natural course of these diseases. Targets are pre-defined therapeutic goals demonstrated to prevent end-organ disfunction and disability in the long-term period. According to the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) indications, mucosal healing (MH) and clinical remission are the main targets in IBDs. Recently, the concept of remission and evidence on new targets included histological remission and transmural healing as future new targets. It remains controversial whether achieving these targets is associated with significantly better long-term disease outcomes. In this Research Topic, we aim to systematically review current evidence and future perspectives on therapeutic targets in IBD including mucosal and transmural healing.
Download or read book Biologics in Inflammatory Bowel Disease written by Scott Plevy and published by OUP USA. This book was released on 2012-10 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologics in Inflammatory Bowel Disease is a practical guide to the safe administration of biological agents to treat inflammatory gastrointestinal illnesses. This ultraconcise and practical volume focuses on tumour necrosis factor (TNF) blocking therapy (TNF blocker), and important new class of biologic therapy indicated for the treatment of several rheumatic and other auto-immune disorders, including Crohn's disease and ulcerative colitis.
Download or read book Alternatives in the Management of Inflammatory Bowel Disease written by Adriaan Volkers and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This thesis consists of clinical research on optimization of the management of inflammatory bowel diseases (IBD) by exploring alternatives for monitoring and treatment of IBD. Furthermore, research was conducted on the implications of SARS-CoV-2 for patients with various immune-mediated inflammatory diseases (IMID), including IBD.One aspect of the investigation involved assessing therapy response in Crohn's disease (CD) through pan-enteric capsule endoscopy (Pan-CE), enabling observation of the entire small intestine and colon. Pan-CE demonstrated its efficacy in measuring changes in endoscopic disease activity among CD patients. Additionally, four faecal biomarkers of intestinal inflammation were compared in paediatric Crohn's disease cases: faecal calprotectin (FCP), chitinase 3-like-1 protein (CHI3L1), S100A12, and osteoprotegerin (OPG). Among these biomarkers, FCP proved to be the most suitable indicator of clinical and endoscopic disease activity in children with CD. In another study, a novel POCT (point-of-care testing) device was validated for measuring concentrations of infliximab, adalimumab, and CRP in capillary blood obtained through finger-prick, as well as FCP levels in stool samples. A randomized controlled trial (RCT) compared placebo to mercaptopurine, with mercaptopurine dosing guided by therapeutic drug monitoring. Mercaptopurine was more effective, as after one year of treatment, a significantly higher number of patients on mercaptopurine achieved clinical, endoscopic, and histological remission. Subsequently, a switch from intravenous vedolizumab maintenance treatment to subcutaneous vedolizumab injections was investigated. Vedolizumab concentration in the blood increased after the transition from infusions to vedolizumab injections, with a correlation between lower disease activity and higher serum drug levels. Utilizing data from a comprehensive observational study on SARS-CoV-2 in immune-mediated inflammatory diseases, the long-term humoral immune response was explored in patients with confirmed previous SARS-CoV-2 infection. Patients treated with anti-TNF agents (including infliximab or adalimumab) had a lower seropositivity rate following a prior infection. Approximately one-quarter of patients reported increased IMID activity, resulting in treatment intensification in only two percent of these cases."--
Download or read book Treatment of Inflammatory Bowel Disease with Biologics written by Adam S. Cheifetz and published by Springer. This book was released on 2017-11-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a concise yet comprehensive overview of the use of biologics for the treatment of Crohn’s disease and ulcerative colitis. The volume details how best to utilize these medications in order to optimize their efficacy and safety, as well as how to understand, recognize, and treat complications that may arise from using biologics to treat IBD. The text also focuses on new data, novel biologics, and biosimilars of this rapidly expanding field. Written by experts in the field, Treatment of Inflammatory Bowel Disease with Biologics is a valuable resource for gastroenterologists, allied health professionals, fellows, and trainees who treat patients with inflammatory bowel disease.
Download or read book Induction of immune tolerance Addressing unmet medical need in immune mediated diseases and immune responses to biologics written by Amy Rosenberg and published by Frontiers Media SA. This book was released on 2023-09-25 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunogenicity of Proteins Used as Therapeutics written by Amy Rosenberg and published by Frontiers Media SA. This book was released on 2020-12-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Susan Richards is an employee of Sanofi and owns stock in the corporation. Topic Editor Bernard Maillere declares economic support from pharmaceutical companies (Novartis, Sanofi, and UCB) in the frame of collaborations aiming to evaluate the recognition by human T cells of therapeutic proteins and antibodies.
Download or read book Crohn s Disease and Ulcerative Colitis written by Daniel C. Baumgart and published by Springer. This book was released on 2017-03-01 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.
Download or read book Right Heart Pathology written by Silviu Ionel Dumitrescu and published by Springer. This book was released on 2018-05-31 with total page 935 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the management of right heart diseases, incorporating etiology, physiopathology, prevention, diagnosis and treatment. The frequency of this pathology has increased in recent years, while techniques for its treatment have evolved. This book therefore represents a complete, detailed and updated presentation of this pathology, reviewing the expanded treatment options while considering the management of patients in detail. Right Heart Pathology: From Mechanism to Management provides a comprehensive insight into right heart pathology, current diagnostic methods, treatments and postsurgical management. Written by experienced cardiologists and cardiovascular surgeons who have addressed significant issues in this topic area, it represents the essential reference in this specialty.
Download or read book Autoimmune Bullous Diseases written by Müzeyyen Gönül and published by BoD – Books on Demand. This book was released on 2018-05-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune bullous diseases are a group of rare skin diseases characterized by intraepidermal and subepidermal bullae formations due to autoantibodies directed against the structural proteins of the epidermis or the dermal-epidermal junction. Early and correct diagnosis and adequate treatment of autoimmune bullous diseases are important as they cause morbidity and mortality in the affected patients. This book, which gives detailed information about autoimmune bullous diseases, has two sections and nine chapters with sixteen contributing authors. The first section describes the structure and tasks of desmosomes and basement membrane zone, which consist of the major antigens of skin integrity targeted by autoantibodies. The second section is about the epidemiology, etiopathogenesis, mucocutaneous, histopathologic and laboratory findings, and therapy of autoimmune bullous diseases.
Download or read book Therapeutic Monoclonal Antibodies written by Zhiqiang An and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Download or read book Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-12-10 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.
Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Download or read book Biomarkers in Inflammatory Bowel Diseases written by Nik Sheng Ding and published by Springer. This book was released on 2019-05-13 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.
