Download or read book Neurophenotypes written by Vinoth Jagaroo and published by Springer. This book was released on 2017-02-24 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in ‘biomarkers’ seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics. A host of ‘omics’ disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further. They have also made more tractable the complex mappings of genotypes to phenotypes – genome-to-phenome mapping – to which the concept of a biomarker is central. Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems. Neural and cognitive phenomics are considered a necessary complement to genomics of the brain. Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail. Such developments are defining a new era of brain science. And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions – that facilitate brain-behavioral alignment in an omics operating environment. This volume explores the topic of markers framed around the constructs of cognitive and neural systems. ‘Neurophenotype’ is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework – and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks. In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain. The topic is critically important to psychiatry and neuropsychology: Neurophenotypes offer a ‘format’ and a ‘language’ by which psychiatry and neuropsychology can be in step with the brain sciences. They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement. Topics covered in the volume include: Brain and cognition in the omics era Phenomics, connectomics, and Research Domain Criteria Circuit-based neurophenotypes, and complications posed by non-gene regulated factors The legacy of the endophenotype concept – its utility and limitations Various potential neurophenotypes of relevance to clinical neuroscience, including Response Inhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and Reward Deficiency, Face Perception, and Language Phenotypes Dynamic (electrophysiological) and computational neurophenotypes The challenge of a cultural shift for psychiatry and neuropsychology The volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.
Download or read book Neuroscience of Social Stress written by Klaus A. Miczek and published by Springer Nature. This book was released on 2022-06-06 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social stress has emerged as a research front in the neurosciences, and this volume highlights recent insights in brain mechanisms and methodological advances. The topics range from the evolutionary origins of coping with social challenges to neural mechanism-driven focus on novel treatment targets. The parallel presentation of work with animal models and human subjects is bound to be useful to a broad research community.
Download or read book Advanced Neuroimaging Methods in Brain Disorders written by Jurong Ding and published by Frontiers Media SA. This book was released on 2022-05-05 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Behavioral and Neural Genetics of Zebrafish written by Robert T. Gerlai and published by Academic Press. This book was released on 2020-04-03 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Download or read book The Neuroscience of Pain Anesthetics and Analgesics written by Rajkumar Rajendram and published by Academic Press. This book was released on 2021-11-30 with total page 1742 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia. The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. Includes content on the features and assessments of pain, anesthesia and analgesia Provides a mini-dictionary of terms and summary points that succinctly encapsulate each chapter Covers a broad range of topics related to the neuroscience of analgesics and anesthetics Helps readers navigate key areas for research and further clinical recommendations Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain
Download or read book The world according to zebrafish How neural circuits generate behaviour written by Gonzalo G. De Polavieja and published by Frontiers E-books. This book was released on 2014-11-07 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how the brain functions is one of the most ambitious current scientific goals. This challenge will only be accomplish by a multidisciplinary approach involving genetics, molecular biology, optics, ethology, neurobiology and mathematics and using tractable model systems. The zebrafish larva is a transparent genetically tractable small vertebrate, ideal for the combination state-of-the- art imaging techniques (e.g. two-photon scanning microscopy, single-plane illumination microscopy, spatial light modulator microscopy and lightfield microscopy), bioluminiscence and optogenetics to monitor and manipulate neuronal activity from single specific neurons up to the entire brain, in an intact behaving organism. Furthermore, the zebrafish model offers large and increasing collection of mutant and transgenic lines modelling human brain diseases. With these advantages in hand, the zebrafish larva became in the recent years, a novel animal model to study neuronal circuits and behaviour, taking us closer than ever before to understand how the brain controls behaviour.
Download or read book Transgenic Neuroscience Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-04-03 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.
Download or read book Foundations of Neuroscience written by Marcus Jacobson and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author makes a unique contribution to the field by discussing the history and philosophy of the neurosciences, and then developing critical approaches which integrate techniques, theory, and ethics. Taken as a whole, Jacobson's work will provide a coherent and humane framework for future research programs. The paperback edition of this highly successful text, first published in 1993, is now available! The author brings the ethics of neuroscience into a closer relationship with empirical research. Covering the field's history, philosophy, theories, and techniques, this volume provides the necessary moral and ethical framework to evaluate neuroscience research.
Download or read book Affective Cognitive and Social Neuroscience New Knowledge in Normal Aging Minor and Major Neurocognitive Disorders written by Rosalba Morese and published by Frontiers Media SA. This book was released on 2022-03-21 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book What Can Neuroscience Learn from Contemplative Practices written by Zoran Josipovic and published by Frontiers Media SA. This book was released on 2016-09-22 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: A recent wave of brain research has advanced our understanding of the neural mechanisms of conscious states, contents and functions. A host of questions remain to be explored, as shown by lively debates between models of higher vs. lower-order aspects of consciousness, as well as global vs. local models. (Baars 2007; Block, 2009; Dennett and Cohen, 2011; Lau and Rosenthal, 2011). Over some twenty-five centuries the contemplative traditions have also developed explicit descriptions and taxonomies of the mind, to interpret experiences that are often reported in contemplative practices (Radhakrishnan & Moore, 1967; Rinbochay & Naper, 1981). These traditional descriptions sometimes converge on current scientific debates, such as the question of conceptual vs. non-conceptual consciousness; reflexivity or “self-knowing” associated with consciousness; the sense of self and consciousness; and aspects of consciousness that are said to continue during sleep. These real or claimed aspects of consciousness have not been fully integrated into scientific models so far. This Research Topic in Consciousness Research aims to provide a forum for theoretical proposals, new empirical findings, integrative literature reviews, and methodological improvements inspired by meditation-based models. We include a broad array of topics, including but not limited to: replicable findings from a variety of systematic mental practices; changes in brain functioning and organization that can be attributed to such practices; their effects on adaptation and neural plasticity; measurable effects on perception, cognition, affect and self-referential processes. We include contributions that address the question of causal attribution. Many published studies are correlational in nature, because of the inherent difficulty of conducting longitudinal experiments based on a major lifestyle decision, such as the decision to commit to a mental practice over a period of years. We also feature clinical and case studies, integrative syntheses and significant opinion articles.
Download or read book The Oxford Handbook of Cultural Neuroscience and Global Mental Health written by Joan Y. Chiao and published by Oxford University Press. This book was released on 2022-02-28 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Oxford Handbook of Cultural Neuroscience and Global Mental Health provides a substantive and in-depth overview of the study of cultural neuroscience and global mental health. Theory, methods and evidence-based practices are reviewed and integrated across themes that identify ethical, scientific, and health care issues for distinct populations across nations. The international research collaboration in the field of cultural neuroscience and global mental health provides research and training opportunities for global mental health researchers. Future research and training in the field seeks the achievement of the amelioration of disease and fulfillment of the goal to alleviate the unmet societal needs due to the global burden of disease"--
Download or read book Handbook of Medical Neuropsychology written by Carol L. Armstrong and published by Springer Nature. This book was released on 2019-09-03 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: This ambitious and important second edition of the Handbook of Medical Neuropsychology takes an in-depth approach to the medical conditions and methods of neurorehabilitation. Comprehensive in scope and highly detailed in its coverage, the second edition, like the first, characterizes the effects of disease and the impact of interventions in the current state of advanced medicine at a level appropriate both for researchers and for clinicians. Featuring the most up-to-date information and quantitative research on cognitive neuroscience of autism, HIV/AIDS, cancer, head injury, respiratory diseases, endocrine diseases, early birth injury, dementia, and other disorders, the book handles theory, historical background, practical considerations, and controversial areas with evidence based disease indicators, clinical expertise, and real-world insight. It seeks to critique diagnostic and assessment tools specific to disorders. The new chapters in this inclusive second edition reflect the changes in prominent problems found in the clinic and provide worthy insights for research investigation in their review of: Substance use disorders. Nutrition in neurocognition and mental health. Hypothyroidism and Hashimoto’s thyroiditis. Traumatic brain injury in very early childhood. Cognitive functioning in asthma. The role of mindfulness in neurorehabilitation. The Handbook of Medical Neuropsychology, 2nd Edition continues to be an essential resource for the neuropsychology clinician, researcher, practitioner or graduate student. It will be stimulating and relevant reading for years to come.
Download or read book Brain and Somatization Symptoms in Psychiatric Disorders written by Wenbin Guo and published by Frontiers Media SA. This book was released on 2019-07-11 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cerebral Cortex Development written by Koh-ichi Nagata and published by Springer Nature. This book was released on with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Early Detection of Neurological Disorders Using Machine Learning Systems written by Paul, Sudip and published by IGI Global. This book was released on 2019-06-28 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: While doctors and physicians are more than capable of detecting diseases of the brain, the most agile human mind cannot compete with the processing power of modern technology. Utilizing algorithmic systems in healthcare in this way may provide a way to treat neurological diseases before they happen. Early Detection of Neurological Disorders Using Machine Learning Systems provides innovative insights into implementing smart systems to detect neurological diseases at a faster rate than by normal means. The topics included in this book are artificial intelligence, data analysis, and biomedical informatics. It is designed for clinicians, doctors, neurologists, physiotherapists, neurorehabilitation specialists, scholars, academics, and students interested in topics centered on biomedical engineering, bio-electronics, medical electronics, physiology, neurosciences, life sciences, and physics.
Download or read book Impulsivity written by Jeffrey R. Stevens and published by Springer. This book was released on 2017-03-29 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the 64th volume in the prestigious Nebraska Series on Motivation, this book focuses on impulsivity, a multi-faceted concept that encompasses such phenomena as the inability to wait, a tendency to act without forethought, insensitivity to consequences, and/or an inability to inhibit inappropriate behaviors. Due to this multi-faceted nature, it plays a critical role in a number of key behavioral problems, including pathological gambling, overeating, addiction, adolescent risk-taking, spread of sexually transmitted diseases, criminal behavior, financial decision making, and environmental attitudes. This broad and interdisciplinary scope has historically resulted in separate subfields studying impulsivity in relative isolation from one another. Therefore, a central achievement of this volume is to convey an integrative exploration of impulsivity. To provide a comprehensive and cohesive understanding of impulsivity, this volume brings together eminent scholars and rising researchers from different domains (developmental psychology, neuroscience, animal cognition, anthropology, addiction science), who use different techniques (behavioral assays, imaging, endocrinology, genetics). Moreover, it includes perspectives and analyses from the two primary types of impulsivity: impulsive choice (or decision making) and impulsive action (or disinhibition). The authors present expert analyses of topics such as delayed gratification, discounting models, and adaptive foraging decisions. Leveraging breadth of coverage and renowned scholarship, Impulsivity: How Time and Risk Influence Decision Making advances our understanding of this complex topic and sheds light on novel research directions and potential future collaborations.
Download or read book Textbook of Autism Spectrum Disorders Second Edition written by Eric Hollander, M.D. and published by American Psychiatric Pub. This book was released on 2022-03-15 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 40 years after the official recognition of infantile autism in DSM-III, advances continue to be made in our understanding of the possible causes, assessment and evaluation, and treatment of autism spectrum disorder (ASD). With contributions by dozens of experts in the field, this second edition of the Textbook of Autism Spectrum Disorders has been updated to reflect the latest research in ASD. Unrivaled in its thoroughness, this volume discusses issues of assessment and evaluation; examines the etiology of ASD and its recognized associations with other medical conditions; analyzes standard and experimental treatments; and delves into social policy issues pertinent to individuals with ASD and those who treat them. With summary points in each chapter and copious lists of recommended readings, this is an indispensable resource for psychiatrists, psychologists, neurologists, social workers, speech therapists, educators, and all others in the continuum of care.
