Download or read book Neuronal Morphogenesis written by Kazuhito Toyooka and published by Springer Nature. This book was released on with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuronal Morphogenesis written by Kazuhito Toyooka and published by Humana. This book was released on 2024-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details molecular mechanisms that are involved in neuronal morphogenesis, and methods for analyzing these mechanisms. Chapters detail analyzing neuronal morphology in vitro and in vivo using a variety of model systems, including rodents and human induced pluripotent stem cells (hiPSCs). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuronal Morphogenesis: Methods and Protocols aims to be suitable for a wide range of readers interested in the mechanisms of neuronal morphology and related neurological disorders.
Download or read book Genetic Analysis of Neuronal Morphogenesis in Vivo written by Neal T. Sweeney and published by . This book was released on 2006 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proper dendritic branching is required for neuronal function. Although a number of genes that regulate dendritic branching have recently been identified, the mechanisms by which these genes control morphogenesis remain unknown. As many genes are expressed in multiple tissues and at multiple developmental time points, it is important to determine the specific cell-autonomous roles for a particular gene in dendritic branching, independent of pleiotropic effects.
Download or read book Signaling Mechanisms Regulating Neuronal Morphogenesis in the Cerebellar Cortex written by Parizad Maheyar Bilimoria and published by . This book was released on 2010 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Connecting Form and Function Recent Advances in Understanding Dendrite Morphogenesis and Plasticity written by Quan Yuan and published by Frontiers Media SA. This book was released on 2022-03-03 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuronal Cytoskeleton written by Hirokawa and published by CRC-Press. This book was released on 1994-01-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Download or read book Transcriptional Regulations of Neuronal Morphogenesis written by Brice Gaudilliere and published by . This book was released on 2005 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Branching Morphogenesis written by Jamie Davies and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular and Molecular Biology of Neuronal Development written by Ira Black and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Download or read book Microtubule Dynamics in Neuronal Morphogenesis written by Melissa Eng and published by . This book was released on 2016 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules in neurons provide structural stability, and also provide a transport route for cellular cargo carried by motor proteins. Exactly how microtubules are organized and maintained in neurons is not clear, but microtubule organizing centers (MTOCs) in neurons are not required as in non-neuronal cells. Assembly of microtubules within neurons is a major factor that affects neuronal morphology, and is regulated by tubulin availability and other nucleating factors. Maintenance of microtubules is determined in large part by post-translational modifications (PTMs), and regulation of disassembly factors. Consequences of perturbed microtubule dynamics include failure to specify the axon and dendrite of neurons, and can lead to neurological defects due to failed neuronal migration. Inhibited microtubule dynamics in neurons also lead to morphological defects and dampened synaptic plasticity. This review discusses the current state of knowledge regarding the effect of microtubule dynamics on neuronal morphogenesis.
Download or read book Morphogenesis of the Brain in Staged Rhesus Monkey Embryos written by Agnes Antoinette Marie Gribnau and published by Springer. This book was released on 1985 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Slit Robo Signaling in Neuronal Morphogenesis written by Jennifer Elizabeth Round and published by . This book was released on 2009 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Orienting and Organizing Neuronal Morphogenesis in the Retina written by Owen Myles Randlett and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Axon Guidance Receptor Expression and Activity During Neuronal Morphogenesis written by Celine Santiago and published by . This book was released on 2016 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors expressed on the surface of neurons during development direct cell migration, axon guidance, dendrite morphogenesis, and synapse formation by responding to cues in the neuron’s environment. The expression levels and the activity of cell surface receptors must be tightly controlled for a neuron to acquire its unique identity. Transcriptional mechanisms are essential in this process, and many studies have identified requirements for specific transcription factors during the different steps of neural circuit assembly. However, the downstream effectors by which most of these factors control morphology and connectivity remain unknown. In Chapter 1, I highlight recent work that elucidated functional relationships between transcription factors and the cellular effectors through which they regulate neural morphogenesis and synaptogenesis in multiple model systems. In Chapters 2 and 3, I present data demonstrating that the homeodomain transcription factors Hb9 and Islet control motor axon guidance in Drosophila embryos through distinct effectors: Hb9 regulates the (Roundabout) 2 receptor in a subset of motor neurons, while Islet acts in the same cells to regulate the Frazzled/DCC receptor. Genetic rescue experiments indicate that these relationships are functionally important for the guidance of motor axons to their muscle targets. In addition, Islet regulates motor neuron dendrite targeting in the central nervous system (CNS) through Frazzled, demonstrating how an individual transcription factor can control multiple aspects of neuronal connectivity through the same effector. In Chapter 4, I characterize a non-canonical function for the Robo2 receptor during midline crossing, and present data suggesting that this activity requires Robo2 to be expressed in midline cells, providing an example of how mechanisms that regulate guidance receptor gene expression are key to regulating receptor function and nervous system formation. In Chapter 5, I explore the implications of these findings, and propose future directions of research to build upon them.
Download or read book Mosaic Analysis of Neurogenesis and Neuronal Morphogenesis in Drosophila Learning and Memory Center Mushroom Bodies written by Sijun Zhu and published by . This book was released on 2005 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Wiring the Nervous System Mechanisms of Axonal and Dendritic Remodelling in Health and Disease written by Tracy S. Tran and published by CRC Press. This book was released on 2024-01-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines recent key findings on the mechanisms of axonal and dendritic remodeling in different model organisms. Each chapter is contributed by a panel of experts in their respective subfields of neurosciences, to provide and discuss the latest discoveries ranging from neuronal morphogenesis during development, experience-dependent structural plasticity, to neuronal degeneration, regeneration, and pathologies in neurological disorders. The process of neuronal remodeling, specifically their axons and dendrites, is essential for the proper wiring of the nervous system during early development and continues during postnatal ages to shape the pattern of synaptic connections throughout the life of the organism, including humans. Over recent years, substantial progress has been made in our understanding of the cellular and molecular mechanisms that control neuronal remodeling. In addition, there is accumulating evidence demonstrating how the nervous system could remodel in response to injury and in pathological conditions. Topics discussed in the book include: Axonal degeneration during development and in pathological or disease conditions Neuronal morphogenesis (axons and dendrites) Experience-dependent structural plasticity to synaptogenesis Dendrite degeneration and regeneration
