Download or read book Neuromuscular Junctions in Drosophila written by and published by Academic Press. This book was released on 1999-04-29 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach.This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories. Key Features* Synthesizes the genetic approaches used to study synaptic development and function at the neuromuscular junction, using flies as a model system* Covers major recent advances in muscle development, pathfinding, synapse maturation and plasticity, exo- and endocytosis, and ion channel function* Written in clear language that is easily understandable to readers not already familiar with fruit fly research* Includes numerous diagrams and extensive reference lists

Download or read book The Fly Neuromuscular Junction Structure and Function written by Vivian Budnik and published by Elsevier. This book was released on 2006-11-02 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Drosophila larval neuromuscular junction (NMJ) has become one of the most powerful model systems to ask key neurobiological questions. This synapse is unparalleled by its accessibility, its simplicity, and the ability to manipulate genes important for synapse development and function. Its synapses have properties shared by many organisms including humans. The vast majority of genes that when mutated cause congenital disorders of the nervous system in humans, are present in the fruit fly genome, and fly models of human disorders are available. Thus, this preparation is a powerful tool to understand the normal function of these genes. This book reviews outstanding work by recognized leaders in the fields of Drosophila cellular neurogenetics including developmental neurobiology, mechanisms of synaptic function, and experience dependent changes at synapses. The book also includes step-by-step protocols to study the cellular biology of the NMJ, making it a vital resource for researchers beginning their investigations with this system, for those who are training students and postdoctoral fellows in this area, or simply as a general reference material for neuroscientists and neuroscience professors in general. * Provides a synthesis of the main topics in modern neurogenetics* Includes step-by-step protocols for the use of the Drosophila NMJ system in neurobiology lab research* Offers genetic approaches to study synapse development and function*

Download or read book Mechanisms Underlying Rapid Activity dependent Structural Plasticity at Drosophila Neuromuscular Junctions written by Zachary David Piccioli and published by . This book was released on 2014 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Drosophila neuromuscular junction (NMJ) is capable of rapidly budding new presynaptic varicosities over the course of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we characterized this dynamic process and demonstrate that rapid bouton budding requires retrograde BMP signaling and local alteration in the presynaptic actin cytoskeleton. BMP acts during development to provide competence for rapid synaptic growth by regulating the levels of the Rho GEF trio, a transcriptional output of BMP-Smad signaling. In a parallel pathway, we find that the BMP type 11 receptor Wit signals through the effector protein LIM domain kinasel (Limk) to regulate bouton budding. Limk interfaces with structural plasticity by controlling the activity of the actin depolymerizing protein Cofilin. Expression of constitutively active or inactive Cofilin in motor neurons demonstrates that increased Cofilin activity promotes rapid bouton formation in response to elevated synaptic activity. Correspondingly, overexpression of Limk, which inhibits Cofilin, inhibits bouton budding. Live imaging of the presynaptic F-actin cytoskeleton reveals that activity-dependent bouton addition is accompanied by formation of new F-actin puncta at sites of synaptic growth. Pharmacological disruption of actin turnover inhibits bouton budding, indicating local changes in the actin cytoskeleton at preexisting boutons precede new budding events. We propose that developmental BMP signaling potentiates NMJs for rapid activity-dependent structural plasticity that is achieved by muscle release of retrograde signals that regulate local presynaptic actin cytoskeletal dynamics.

Download or read book A Genetic Analysis of Synaptic Plasticity at the Neuromuscular Junction in Drosophila written by Sophie Ann Petersen and published by . This book was released on 1998 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanisms Controlling the Formation and Growth of Synapses at the Neuromuscular Junction of Drosophila Melanogaster written by Karen Marie Zito and published by . This book was released on 1998 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Laminin a Regulates Synaptic Plasticity at Drosophila Neuromuscular Junctions written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book In Vivo Imaging of Long term Changes in the Drosophila Neuromuscular Junction written by Tobias M. Rasse and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulation of Synaptic Strength at the Drosophila Neuromuscular Junction written by Robin Wanomi Ball and published by . This book was released on 2007 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synaptic Physiology of the Developing Drosophila Neuromuscular Junction written by Robert Johannes Kittel and published by . This book was released on 2006 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Heterogeneous Transmission at the Drosophila Larval Neuromuscular Junction Revealed by Single bouton Optical Imaging written by Giovanna Guerrero and published by . This book was released on 2004 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Drosophila Neuromuscular Junction as a Model System to Study the Molecular Mechanisms of Neurodevelopment and Synaptic Degeneration written by Petra Füger and published by . This book was released on 2012 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Mechanisms that Regulate Synaptic Efficacy at the Drosophila Neuromuscular Junction written by Stephanie D. Albin and published by . This book was released on 2006 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular mechanisms underlying the retrograde control of presynaptic neurotransmitter release at the NMJ are not well understood. Here we describe the identification of the first known inhibitor of synaptic homeostasis. Identification of the pathways through which this inhibitor act may eventually lead to a greater understanding of the mechanisms that regulate homeostasis.

Download or read book Par6 Functions in Synaptic Growth at the Drosophila Neuromuscular Junction written by Stephanie A. Moeckel Cole and published by . This book was released on 2004 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exocytosis and Endocytosis written by Andrei I. Ivanov and published by Springer Science & Business Media. This book was released on 2008 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.

Download or read book Molecular and Phenomenological Characterization of Synaptic Homeostasis at the Drosophila Neuromuscular Junction written by Kurt W. Marek and published by . This book was released on 2004 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Development of Drosophila Neuromuscular Junction written by Hao Li and published by . This book was released on 2001 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Wnt Signaling in Drosophila Neuromuscular Junctions written by Anne-Marie Lüchtenborg and published by . This book was released on 2015 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thèse. Biologie. Médecine. 2015