Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Download or read book Neurologic Stem Cell Surgery written by Jeffrey N. Weiss and published by Springer. This book was released on 2021-06-18 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a concise how-to of successfully treating previously poorly or untreatable neurologic conditions with stem cell therapies. The text examines the IRB approved protocols of NEST (Neurologic Bone Marrow Derived Stem Cell Treatment Study), SCiExVr (Stem Cell Spinal Cord Injury Exoskeleton and Virtual Reality Treatment Study), and ACIST (Alzheimer’s and Cognitive Impairment Stem Cell Treatment Study). The discussion focuses on the protocols and informed consents and may be used as a template for specialists to develop clinical trials utilizing stem cell based therapy. Other potential noninvasive treatments for brain injury are also discussed. Neurologic Stem Cell Surgery, the sister text to the recently published Retinal and Optic Nerve Stem Cell Surgery, is an invaluable reference for all physicians with an interest in the development of stem cell based treatments.
Download or read book Cell Therapy Stem Cells and Brain Repair written by Cyndy D. Davis and published by Springer Science & Business Media. This book was released on 2007-11-09 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.
Download or read book Stem Cell based Therapy for Neurodegenerative Diseases written by Fabin Han and published by Springer Nature. This book was released on 2020-10-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the state-of-the-art in stem-cell-based therapies for neurodegenerative diseases, and highlights advances in both animal models and clinical trials. It comprehensively discusses most neurodegenerative diseases, including such as Parkinson's, Alzheimer's and Huntington’s diseases, amyotrophic sclerosis, multiple sclerosis, muscular dystrophy and retinal degeneration, in which stem cells could potentially be used for therapy in the future. It also addresses the challenges and problems relating to the translation of stem-cell-based therapies into treatments. As such, the book will appeal to research scientists, physicians, graduate students, and medical professionals in the field of stem cells, neuroscience, neurology, neurorestoratology and major neurological disorders.
Download or read book Cell Therapy Against Cerebral Stroke written by Kiyohiro Houkin and published by Springer. This book was released on 2017-01-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.
Download or read book Progenitor Cell Therapy for Neurological Injury written by Charles S. Cox, Jr. and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.
Download or read book Neurological Regeneration written by Phuc Van Pham and published by Springer. This book was released on 2017-01-16 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable resource explores the regenerative potential of stem cells in the nervous system, with a focus on clinical applications. The expertly authored chapters discuss cell-based therapies for spinal cord injury and regeneration, traumatic brain injury, glioblastoma, Parkinson's Disease, ischemic stroke, cell banking, human embryonic stem cells and related concerns, harvesting of adipose tissue, and more. These topics are contextualized within a discussion of future directions of these therapies. Neurological Regeneration, part of Springer’s Stem Cells in Clinical Applications series, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, neurology, regenerative medicine or tissue engineering.
Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Download or read book Stem Cells and Neurodegenerative Diseases written by Laurent Lescaudron and published by CRC Press. This book was released on 2014-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the potential of stem cells for ameliorating the quality of life of patients with neurological and neurodegenerative diseases. It discusses results of pre-clinical investigations and case studies on the effects of stem cell transplantation on cell death, as well as to promote/stimulate neuroprotection after brain and spinal cord injury through trophic support, cell replacement and remyelination. The book covers the maintenance of the balance between stem cells and their progenitors within their niche, both under normal and degenerative processes and with ischemic stroke, multiple sclerosis, and brain tumor.
Download or read book Guide to Ophthalmic and Neurologic Stem Cell Treatments written by Jeffrey Weiss and published by Createspace Independent Publishing Platform. This book was released on 2016-08-11 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Stem Cell Ophthalmology Treatment Study, SCOTS, is the largest Institutional Review Board (IRB) approved ophthalmology study registered with the NIH (www.ClinicalTrials.gov Identifier NCT01920867). Jeffrey Weiss, M.D. is the Principal Investigator and Steven Levy M.D. is the Study Director. Discoveries made during SCOTS lead to the development of the Neurologic Stem Cell Treatment Study, NEST. NEST is IRB approved and registered with NIH (www.ClinicalTrials.gov Identifier NCT02795052).
Download or read book Human Neural Stem Cells written by Leonora Buzanska and published by Springer. This book was released on 2018-09-12 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Download or read book Stem Cell Therapy for Vascular Diseases written by Tulio Pinho Navarro and published by Springer Nature. This book was released on 2020-11-05 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.
Download or read book Bone marrow stem cell therapy for stroke written by Kunlin Jin and published by Springer. This book was released on 2016-12-13 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.
Download or read book Retinal and Optic Nerve Stem Cell Surgery written by Jeffrey N. Weiss and published by Springer Nature. This book was released on 2020-11-19 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a concise how-to of successfully treating previously deemed "untreatable" retinal and optic nerve conditions with stem cell therapies. Based on the results of 11 years of experience treating approximately 600 patients, this text will serve as a template for others to develop similar stem cell based treatments in their specialty. Author, Jeffrey N. Weiss, MD is specifically poised to offer dependable insight on stem cell surgery for both the retina and the optic nerve, having performed the first retinal stem cell surgery in 2010, with Institutional Review Board (IRB) approved studies that are registered with the National Institute of Health (NIH), and listed on ClinicalTrials.gov. Featuring all original work from Dr. Jeffrey Weiss's specialization in stem cell ophthalmology, this book is primarily written for ophthalmologists, but structured so that specialists across disciplines can take the model presented and create their own studies and clinical trials using stem cell therapies.
Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Download or read book Hematopoietic Stem Cell Transplantation for Neurologic Diseases written by and published by Elsevier. This book was released on 2024-08-05 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. Reviews immunological mechanisms of HSCT and CNS autoimmunity Identifies neurological diseases showing treatment efficacy with HSCT Includes MS, myasthenia gravis, neuromyelitis optica, and more Covers early and late side effects of HSCT
Download or read book Physical Disabilities written by Uner Tan and published by BoD – Books on Demand. This book was released on 2017-06-14 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, Physical Disabilities - Therapeutic Implications, presents reports on a wide range of areas in the field of neurobiological disabilities, including movement disorders (Uner Tan syndrome, genetic and environmental influences, chronic brain damage, stroke, and pediatric disabilities) related to physical and stem cell therapy. Studies are presented from researchers around the world, looking at aspects as wide-ranging as the genetics, wheelchair, and robotics behind the conditions to new and innovative therapeutic approaches.
