Download or read book Nanostructured Biomaterials for Regenerative Medicine written by Vincenzo Guarino and published by Woodhead Publishing. This book was released on 2019-10-05 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured Biomaterials for Regenerative Medicine focuses on the definition of new trends for the design of biomaterials for biomedical applications. It includes the ex novo synthesis as well as technological strategies to manipulate them into appropriate two-dimensional (2D) and three-dimensional (3D) forms, in order to impart all the main physical, chemical, structural and biological properties requested to achieve desired clinical efficacy. This book aims at offering a concise overview of innovative platforms based on nanostructured biomaterials as a function of their chemical nature - established by a consolidated material classification i.e., polymer, ceramics and metals. For each class, emerging bioinspired systems with rapid expansion in the biomedical research area and fabricated via new enabling technologies will be proposed for the use in tissue repair/regeneration and nanomedicine. This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine. - Classifies materials into three classes for comprehensive discussion - Discusses design techniques to create innovative nanostructured biomaterials - Looks at enabling technologies and strategies for emerging applications

Download or read book Nanoengineered Biomaterials for Regenerative Medicine written by Masoud Mozafari and published by Elsevier. This book was released on 2018-09-17 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoengineered Biomaterials for Regenerative Medicine showcases the advances that have taken place in recent years as an increasing number of nanoengineered biomaterials have been targeted to various organ tissues. The book systematically explores how nanoengineered biomaterials are used in different aspects of regenerative medicine, including bone regeneration, brain tissue reconstruction and kidney repair. It is a valuable reference resource for scientists working in biomaterials science who want to learn more about how nanoengineered materials are practically applied in regenerative medicine. Nanoengineered biomaterials have gained particular focus due to their many advantages over conventional techniques for tissue repair. As a wide range of biomaterials and nanotechnology techniques have been examined for the regeneration of tissues, this book highlights the discussions and advancements made. - Provides a digestible reference source for surgeons and physicians who want to learn more on nanoengineered biomaterials and their use in effective medical treatments - Offers systematic coverage on how nanoengineered biomaterials are used for different types of medicine - Assesses the benefits and drawbacks of the use of bioengineered nanomaterials in different areas of regenerative medicine

Download or read book Nanotechnology in Tissue Engineering and Regenerative Medicine written by Ketul Popat and published by CRC Press. This book was released on 2010-11-22 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although nanotechnology applied to medicine has a potentially huge impact on drug delivery and tissue engineering, significant challenges need to be resolved before clinically viable nanomedicine or nanobiomedicine therapies will be available. Skillfully edited, with contributions from an expert panel of researchers, Nanotechnology in Tissue Engine

Download or read book New Trends in Smart Nanostructured Biomaterials in Health Sciences written by Gil Goncalves and published by Elsevier. This book was released on 2022-10-07 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Trends in Smart Nanostructured Biomaterials in Health Sciences provides guidance on the design and synthesis of nanostructured smart biomaterials, as well as the resultant therapeutic effects and associated biomedical applications of these novel materials. The book provides readers with a deeper understanding of these novel biomaterials and aids them in making informed decisions when selecting appropriate materials for tissue engineering and cancer therapy applications. It will be of specific interest to materials scientists, biomedical engineers, oncological scientists, tissue engineers and those working in regenerative medicine. Nanostructured smart materials have the special ability to respond to changes in the cell microenvironment, allowing for robust, biocompatible and rapidly adaptable, therapeutic and restorative action against a range of ailments. These materials are thus ideal candidates for use in tissue engineering and cancer therapy due to the varying nature of the cell microenvironment between persons, tissues and cancers. This book covers the design, synthesis, unique properties and application of smart biomaterials in these two key topic areas of tissue engineering and cancer therapeutics. - Presents an overview of how smart biomaterials respond to changes in physiological factors and exogeneous stimuli and their impact in modern medicine - Provides readers with the basis for designing, processing and characterizing advanced smart biomaterials - Guides the reader through the mechanisms of tissue repair and cancer therapeutics by exploring the most relevant features of smart nanostructured materials

Download or read book Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology written by Hari Singh Nalwa and published by . This book was released on 2005 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: - The first reference work ever published on nanostructured biomaterials and their applications. - A unique source of in-depth knowledge of recent advances in applications of nanostructured biomaterials. Most up-to-date emerging aspects of nanobiomaterials and their applications in the field of nanotechnology. - Contains 33 state-of-the-art chapters written by over 70 internationally renowned experts from 10 countries. - About 5,000 bibliographic citations and hundreds of illustrations, figures, tables, chemical structures and equations.

Download or read book Nanostructured Materials for Tissue Engineering written by Arijit Mondal and published by Elsevier. This book was released on 2023-08-28 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured Materials for Tissue Engineering introduces the key properties and approaches involved in using nanostructured materials in tissue engineering, including functionalization, nanotechnology-based regenerative techniques, toxicological and biocompatible aspects. A broad range of nanomaterial types are covered, from polymer scaffolds and nanocomposites to gold nanoparticles and quantum dots. This book aids the reader in materials selection, as well as matching to the best applications, including bone, skin, pulmonary or neurological tissue engineering. Users will find this book to be an up-to-date review on this fast-changing field that is ideal for materials scientists, tissue engineers, biomedical engineers, and pharmaceutical scientists. - Covers the most recent advances in this fast-moving field, including all key aspects from properties and functionalization to materials selection and application in tissue engineering - Reviews a variety of nanomaterials and their benefits, including polymeric, gold and carbon nanoparticles - Explores a range of tissue engineering applications, such as cardiovascular therapies, skin repair and regeneration, and diabetes management

Download or read book Nanostructured Biomaterials for Tissue Regeneration and Repair written by Primana Punnakitikashem and published by . This book was released on 2019 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured materials have been explored in biomedical field especially in tissue engineering over a past decade. This type of material can be processed into biomaterial scaffolds; revealed many advantages to be used in human living system such as restoring, healing, replacing and improving the function of interested tissues or organs. In this work, nanostructured materials were synthesized as a nanofibrous scaffold or nanoparticles, which were characterized and tested for their biofunctions in the regeneration of blood vessels, lung and skin tissues. Firstly, biodegradable polyurethane nanofibrous scaffolds with dipyramole were electrospun to create a vascular graft, and results demonstrated that this nanofibrous scaffold matched the native artery mechanical strength, reduced the platelet deposition, improved blood compatibility, supported endothelial cell formation and inhibited the proliferation of smooth muscle cells. Next, biodegradable polylactic-glycolic acid nanoparticles were fabricated and then coated with porcine lung extracellular matrix to maximize the nanoparticle deposition on the alveolar epithelial cells. These nanoparticles also show that they were cytocompatible with alveolar type I epithelial cells and facilitated the cellular retention/uptake. Preliminary studies of electrospun nanofibrous polyurethane scaffold incorporated with nanoparticles loaded with anti-microbial peptide and/or antibiotics for wound healing application demonstrated these nanostructured materials could be used to prevent bacterial infection and suggest their potential in skin wound healing applications. Results from this research suggest that the biomaterials either in the nanofiber or nanoparticle structures could be used for regeneration of various tissue organs such as blood vessels and skins, and for protein (growth factors) or gene therapy (cDNA plasmids) delivery to facilitate lung regeneration. Hence, the nanostructured biomaterials would have high potential to be applied for tissue regeneration to manage diseased and damaged tissues/organs for human healthcare.

Download or read book Nano Biomaterials for the Delivery of Therapeutic and Biological Cues for Regenerative Medicine written by Silvia Minardi and published by Frontiers Media SA. This book was released on 2022-02-21 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Nanostructured Cellulose based Biomaterials written by Neftali L V Carreño and published by Springer. This book was released on 2017-05-16 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the advances on nanostructured celullose from different obtaining forms: natural plants and bacterial microorganisms. It gives the reader an introduction of cellulose focusing in nanosize particles, its potential applications and future perspectives. The potential use of cellulose in the biomedical field is highlighted.

Download or read book Nanobiomaterials written by Roger Narayan and published by Woodhead Publishing. This book was released on 2017-09-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined. - Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials - Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials - Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials

Download or read book Nanoengineering Materials for Biomedical Uses written by Emilio I. Alarcon and published by Springer Nature. This book was released on 2019-11-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills the gap between fundamental and applied research in the use of nanomaterials in biomedical applications, covering the most relevant areas, such as the fundamental concepts of the preparation of nanostructures and regulatory requirements for their safe use in biomedical devices. It also critically discusses what has been achieved in the field, and what needs to be urgently addressed and reviews the state-of-the-art medical uses of nanomaterials for treating damaged organs and tissues. Combining the expertise of clinical researchers working in the field of tissue engineering and novel materials, the book explores the main topics regarding the characterization of materials, specific organ-oriented biomaterials and their applications, as well as regulations and safety. Further, it also examines recent advances, difficulties, and clinical requirements in terms of human bone, cornea, heart, skin and the nervous system, allowing readers to gain a clear and comprehensive understanding of current nanomaterial use in biomedical applications and devices, together with the challenges and future trends. This book is a valuable tool for multidisciplinary scientists and experts interested in fundamental concepts and synthetic routes for preparing nanomaterials. It is also of interest to students and researchers involved in cross-disciplinary research in nanomaterials for clinical applications and offers practical insights for clinicians as well as engineers and materials scientists working in nanoengineering.

Download or read book Nanostructured Biomaterials for Overcoming Biological Barriers written by Maria Jose Alonso and published by Royal Society of Chemistry. This book was released on 2012 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a critical overview of the advances being made toward overcoming biological barriers through the contribution of nanosciences and nanotechnologies to solve the problems of many current drugs and vaccines.

Download or read book Nanomaterials for Regenerative Medicine written by Ayse Begum Tekinay and published by Springer Nature. This book was released on 2019-12-13 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a broad range of therapeutic applications of nanomaterials that are used for regenerative medicine applications, including neural regeneration, cartilage regeneration, wound healing, dental regeneration and implants, and immunomodulation. Chapters are contributed by leading experts in the field and cover concepts for developing materials for medicine as well as requirements for potential clinical uses. Nanomaterials for Regenerative Medicine also provides the requirements for the design of optimal nanomaterials for regenerative medicine and covers the most recent approaches in nanomaterial design. It is ideal for graduate students and researchers in chemistry, biology, materials science, medicine, and life sciences.

Download or read book Engineering Micro and Nanostructured Biomaterials for Cell and Tissue Engineering written by Benjamin Li-Ping Lee and published by . This book was released on 2014 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering has emerged as a well-investigated research area that aims to ultimately create biological substitutes, ranging from skin replacement to artificial blood vessels, for regenerative medicine applications. It is a multidisciplinary field that integrates knowledge and advancements from biology, materials, chemistry, and many others. Although the goal of tissue engineering is to engineer tissues with structure and function that closely mimic those of native tissues for not only diagnostic and drug testing applications but also repair and replacement of diseased and injured tissues, it provides in-depth understanding of tissue development and morphogenesis, including the intricate biological systems in the body that together operate to direct growth, repair, and death. The general approach of tissue engineering is to use cells, biomaterials, bioactive molecules, or a combination thereof to best recapitulate the properties of native tissues and reconstitute function. Specifically, biomaterial scaffolds play a key role in that their main function is to serving as a basis to interact with and support cells, promoting their attachment and migration while providing a porous and biomimetic microenvironment for mass transport and integration of bioactive factors. Therefore, in order to fabricate implantable scaffolds with properties that emulate the natural extracellular matrix (ECM) in terms of structure and organization, we utilize and implement electrospinning technology. Electrospinning is a versatile technique with immense potential to create cell-instructive scaffolds possessing ECM-like fibrous structures. Because of the ability to tune scaffold structure with respect to physical (i.e. geometry and mechanical properties) and chemical (i.e. retention and presentation of bioactive molecules) features, electrospun scaffolds, which are made from synthetic, natural, or a combination of the two polymers, have demonstrated functional success in an array of tissue engineering applications. In fact, the fibrous network, especially in the nanoscale, possesses high surface-area-to-volume ratio that is favorable for surface modifications to facilitate cell attachment as well as immobilization and covalent conjugation of bioactive molecules. However, one major shortcoming of electrospun scaffolds as a result of such densely packed network of fibers is their small pore size, limiting cell infiltration and tissue ingrowth essential for desired angiogenesis and tissue integration. Thus, electrospun scaffolds with dense fibrous structure and small pore size have not had enormous success in the regeneration of large, more complex tissues that require abundant vascularization and mass transport of oxygen and nutrients. In this dissertation, we attempt to address both the physical and chemical elements of electrospun scaffolds as we engineer novel ways to modulate their structural features and surface chemistry for their utilization in different cell and tissue engineering applications. We focus primarily on micro- and nanostructures, topographical cues, and chemical modifications and their role in enhancing cell infiltration and promoting better tissue integration in terms of angiogenesis in and overall functional performance of implanted scaffolds as well as vascular graft. Specifically, we detail the employment of an ultrafast, femtosecond (FS) laser system as a promising post-fabrication technology to pattern structural features (i.e. through-holes) that influence cell behavior and improve the integration electrospun scaffolds in vivo. We also demonstrate that changes in biophysical factors, such as increasing pore size and porosity via incorporation and removal of sacrificial fibers from composite scaffolds, can not only improve cell infiltration but more importantly regulate stem cell differentiation. Lastly, we show that we can fabricate small-diameter, nanofibrous vascular graft made of Carbosil®, a commercially available polycarbonate-urethane (PCU), via electrospinning and subsequently manipulate its surface properties through plasma treatment and reductive amination to effectively end-point immobilize heparin to reduce surface thrombogenicity while enhancing bioactivity and short-term in vivo performance. In summary, we offer novel design and fabrication of electrospun scaffolds with large pore size and highly porous structure, and vascular grafts with tailored surface chemistry and bioactivity optimal for their biological performance. We demonstrate through our studies that physical and chemical features of not only electrospun scaffolds but implantable biomaterials in general can be engineered and manipulated using post-fabrication processing (i.e. FS laser and tunable surface chemistry) and unique fabrication approaches (i.e. multiple polymers with sacrificial components). Only with ample vascularization and tissue integration will such biomaterial scaffolds regenerate native tissue function and demonstrate success in both simple, such as skin substitutes, as well as complicated, such as artificial heart, tissues and organs for applications in regenerative medicine.

Download or read book Bionanocomposites in Tissue Engineering and Regenerative Medicine written by Shakeel Ahmed and published by Woodhead Publishing. This book was released on 2021-06-03 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bionanocomposites in Tissue Engineering and Regenerative Medicine explores novel uses of these in tissue engineering and regenerative medicine. This book offers an interdisplinary approach, combining chemical, biomedical engineering, materials science and pharmacological aspects of the characterization, synthesis and application of bionanocomposites. Chapters cover a broad selection of bionanocomposites including chitosan, alginate and more, which are utilized in tissue engineering, wound healing, bone repair, drug formulation, cancer therapy, drug delivery, cartilage regeneration and dental implants. Additional sections of Bionanocomposites in Tissue Engineering and Regenerative Medicine discuss, in detail, the safety aspects and circular economy of bionanocomposites – offering an insight into the commercial and industrial aspects of these important materials. Bionanocomposites in Tissue Engineering and Regenerative Medicine will prove a highly useful text for for those in the fields of biomedical engineering, chemistry, pharmaceutics and materials science, both in academia and industrial R&D groups. - Each bionanocomposite type is covered individually, providing specific and detailed information for each material - Covers a range of tissue engineering and regenerative medicine applications, from dental and bone engineering to cancer therapy - Offers an integrated approach, with contributions from authors across a variety of related disciplines, including biomedical engineering, chemistry and materials science

Download or read book Nanotechnology and Regenerative Engineering written by Cato T. Laurencin and published by CRC Press. This book was released on 2017-11-22 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology and regenerative engineering have emerged to the forefront as the most versatile and innovative technologies to foster novel therapeutic techniques and strategies of the twenty-first century. The first edition of Nanotechnology and Tissue Engineering: The Scaffold was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition, renamed Nanotechnology and Regenerative Engineering: The Scaffold, provides a thorough update to the existing material, bringing together these two unique areas to give a perspective of the emerging therapeutic strategies for a wide audience. New coverage includes: Updated discussion of the importance of scaffolds in tissue engineering Exploration of cellular interactions at the nanoscale Complete range of fabrication processes capable of developing nanostructured scaffolds for regenerative engineering Applications of nanostructured scaffolds for neural, skin, cardiovascular, and musculoskeletal regenerative engineering FDA approval process of nanostructure scaffolds Products based on nanostructured scaffolds Due to the unique and tissue-mimic properties of the nanostructured scaffolds, the past five years have seen a tremendous growth in nanostructured materials for biological applications. The revised work presents the current state-of-the-art developments in nanostructured scaffolds for regenerative engineering.

Download or read book Biomaterials in Regenerative Medicine written by Leszek A. Dobrzański and published by BoD – Books on Demand. This book was released on 2018-02-14 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Biomaterials in Regenerative Medicine is addressed to the engineers and mainly medical practitioners as well as scientists and PhD degree students. The book indicates the progress in research and in the implementation of the ever-new biomaterials for the application of the advanced types of prosthesis, implants, scaffolds and implant-scaffolds including personalised ones. The book presents a theoretical approach to the synergy of technical, biological and medical sciences concerning materials and technologies used for medical and dental implantable devices and on metallic biomaterials. The essential contents of the book are 16 case studies provided in each of the chapters, comprehensively describing the authors' accomplishments of numerous teams from different countries across the world in advanced research areas relating to the biomaterials applied in regenerative medicine and dentistry. The detailed information collected in the book, mainly deriving from own and original research and R