Download or read book Nano and Cell Mechanics written by Horacio D. Espinosa and published by John Wiley & Sons. This book was released on 2012-12-12 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in nano and cell mechanics has received much attention from the scientific community as a result of society needs and government initiatives to accelerate developments in materials, manufacturing, electronics, medicine and healthcare, energy, and the environment. Engineers and scientists are currently engaging in increasingly complex scientific problems that require interdisciplinary approaches. In this regard, studies in this field draw from fundamentals in atomistic scale phenomena, biology, statistical and continuum mechanics, and multiscale modeling and experimentation. As a result, contributions in these areas are spread over a large number of specialized journals, which prompted the Editors to assemble this book. Nano and Cell Mechanics: Fundamentals and Frontiers brings together many of the new developments in the field for the first time, and covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. Key features: • Provides an overview of recent advances in nano and cell mechanics. • Covers experimental, analytical, and computational tools used to investigate biological and nanoscale phenomena. • Covers fundamentals and frontiers in mechanics to accelerate developments in nano- and bio-technologies. • Presents multiscale-multiphysics modeling and experimentation techniques. • Examines applications in materials, manufacturing, electronics, medicine and healthcare. Nano and Cell Mechanics: Fundamentals and Frontiers is written by internationally recognized experts in theoretical and applied mechanics, applied physics, chemistry, and biology. It is an invaluable reference for graduate students of nano- and bio-technologies, researchers in academia and industry who are working in nano and cell mechanics, and practitioners who are interested in learning about the latest analysis tools. The book can also serve as a text for graduate courses in theoretical and applied mechanics, mechanical engineering, materials science, and applied physics.
Download or read book Cell Mechanics and Tumor Development written by Ronald L. Huston and published by . This book was released on 2020 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Magnetic Nanoparticles and Cell Mechanics written by Federica Crippa and published by . This book was released on 2018 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanics of Biological Systems and Materials Micro and Nanomechanics Research Applications written by Jacob Notbohm and published by Springer Nature. This book was released on 2021-03-26 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanics of Biological Systems & Micro-and Nanomechanics, Volume 5 of the Proceedings of the 2020 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fifth volume of seven from the Conference, brings together contributions to important areas of research and engineering. The collection presents early findings and case studies on a wide range of topics, including: Cell Mechanics & Traumatic Brain Injury Micromechanical Testing Adhesion and Fracture MEMS Devices and Technology Nano-scale Deformation Mechanisms 1D & 2D Materials Tribology & Wear Research and Applications in Progress
Download or read book Trends in Nanoscale Mechanics written by Vasyl Michael Harik and published by Springer Science & Business Media. This book was released on 2003-11-30 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: An outstanding feature of this book is a collection of state-of-the-art reviews written by leading researchers in the nanomechanics of carbon nanotubes, nanocrystalline materials, biomechanics and polymer nanocomposites. The structure and properties of carbon nanotubes, polycrystalline metals, and coatings are discussed in great details. The book is an exceptional resource on multi-scale modelling of metals, nanocomposites, MEMS materials and biomedical applications. An extensive bibliography concerning all these topics is included. Highlights on bio-materials, MEMS, and the latest multi-scale methods (e.g., molecular dynamics and Monte Carlo) are presented. Numerous illustrations of inter-atomic potentials, nanotube deformation and fracture, grain rotation and growth in solids, ceramic coating structures, blood flows and cell adhesion are discussed. This book provides a comprehensive review of latest developments in the analysis of mechanical phenomena in nanotechnology and bio-nanotechnology.
Download or read book Mechanics of Biological Systems Micro and Nanomechanics Volume 4 written by Martha Grady and published by Springer. This book was released on 2018-10-01 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanics of Biological Systems & Micro-and Nanomechanics, Volume 4 of the Proceedings of the 2018 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fourth volume of eight from the Conference, brings together contributions to important areas of research and engineering. The collection presents early findings and case studies on a wide range of topics, including: Cell Mechanics & Traumatic Brain Injury Micromechanical Testing Adhesion and Fracture MEMS Devices and Technology Nano-scale Deformation Mechanisms 1D & 2D Materials Tribology & Wear Research and Applications in Progress
Download or read book Single cell Mechanics Provides a Sensitive Quantitative and Cell Geometry Independent Means for Investigating Protein and Nanoparticle cell Interactions written by Christopher Charles Zimmer and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental factors can profoundly affect the mechanical compliance and adhesion of living cells. This work explores the in vitro measurement and quantification of the mechanical compliance of individual cells interacting with: a metastable protein, zinc oxide (ZnO) and silicon dioxide (SiO2) nanoparticles (NPs), as well as the effects of in vitro focal adhesion formation on the single-cell mechanics of fibroblasts. In the first system, atomic force microscopy (AFM) based single-cell compression was found to be sufficiently sensitive to measure and quantify interactions between neuronal type cells and A[beta]42 protein, a principal component of plaque found in the brains of Alzheimer's disease patients. Cellular membrane Young's modulus, osmotic pressure change, and change in intracellular ion concentration were extracted. Of the three forms of A[beta]42 protein investigated including monomer, oligomer, and fibrillar, it was found that the oligomer had the strongest effect on cell mechanics by increasing membrane stiffness. This result is consistent with the known cytotoxicity of the oligomer. In another investigation, human aortic endothelial cells (HAECs) were exposed to ZnO and SiO2 NPs at 10 [microgram]/ml and 50 [microgram]/ml concentrations having previously been shown to induce inflammation and become cytotoxic in a dose dependent manner. By using single-cell compression, it was found that ZnO NPs induced measurable cell swelling and stiffening likely due to osmotic pressure increase and lipid peroxidation which crosslinks lipids within the membrane. At the higher concentration, a sub-population developed which showed significant morphological alteration and was mechanically softer under load, possibly due to significant lipid degradation. At low concentration, SiO2 NPs had no effect on cell mechanics. However, at higher concentration a sub-population of cells became stiffened. Three time points associated with three stages of focal adhesion formation were investigated by AFM, cell compression, and laser scanning confocal microscopy (LSCM). A new single-cell compression methodology was devised in order to measure and compare force vs. three-dimensional deformation of cells undergoing adhesion. Global cell stiffening took place correlating with increasing actin filament alignment and growth as seen with LSCM. AFM imaging revealed a transition from membrane decorated dot to rod-like structures as focal adhesion progressed.
Download or read book Integrative Mechanobiology written by Yu Sun and published by Cambridge University Press. This book was released on 2015-11-12 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts describe state-of-the-art micro-nano techniques for cell mechanobiology and introduce the most recent advances in the field.
Download or read book Nano Comes to Life written by Sonia Contera and published by Princeton University Press. This book was released on 2021-11-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Increasingly, scientists are gaining control over matter at the nanometer scale. Spearheaded by physical scientists operating at the interfaces of physics and biology (such as the author herself), advances in nanoscience and technology are transforming how we think about life and treat human health. This is due to a convergence of size. To do medicine, one must understand and be able to reach the nanoscale environment of healthy cells in tissues and organs, as well as other nano-sized building blocks that constitute a living organism, such as proteins and DNA. The ground-breaking advances being made at the frontiers of nanoscience and -technology, specifically in the areas of biology and medicine, are the subject of this short, popular-level book. Chapter 1 describes how nanotechnology and quantitative methods in biology are progressively being deployed to embrace life in all its multiscale, hierarchical intricacy and multiplicity. Chapters 2 through 4 review how bioinspired and biomimetic nanostructures and nanomachines are being created and integrated into strategies aimed at solving specific medical problems. In particular, Chapter 2 summarizes how scientists are seeking to build artificial nanostructures using both biological molecules and the organizational principles of biology. Chapter 3 gives an account of how nanotechnology is being used to develop drug-delivery strategies that specifically target cancer cells and tumors to improve the efficacy of current cancer chemotherapies. Chapter 4 reviews the science of one of the most potentially transformative scientific fields: tissue engineering. In a concluding chapter (Chapter 5), Contera reviews how nanotechnology, biology, and medicine will continue fusing with other sciences and technologies - incorporating more mathematical and computational modelling, as well as AI and robotics. Nanoscale devices will be used to learn biology; and biology will be used to inspire increasingly sophisticated "transmaterial" devices that mimic some of the characteristics of biology and incorporate new features that are not available in the biological world. The effects on human health and longevity will be profound. In a more personal epilogue, Contera describes the crossroads at which we find ourselves. Accessing our own biology evokes a mixture of possibility and dread. However, Contera maintains that we can create a positive transmaterial world for the benefit of humankind, and she describes ways in which scientists are proactively engaging with the public, politicians, industry, and entrepreneurs, as well as the media and the arts, to communicate the power and risks of new advances and to influence the ways in which new technologies will affect our future"--
Download or read book Cytoskeletal Mechanics written by Mohammad R. K. Mofrad and published by Cambridge University Press. This book was released on 2006-09-04 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a full spectrum of views on current approaches to modeling cell mechanics. The authors come from the biophysics, bioengineering and physical chemistry communities and each joins the discussion with a unique perspective on biological systems. Consequently, the approaches range from finite element methods commonly used in continuum mechanics to models of the cytoskeleton as a cross-linked polymer network to models of glassy materials and gels. Studies reflect both the static, instantaneous nature of the structure, as well as its dynamic nature due to polymerization and the full array of biological processes. While it is unlikely that a single unifying approach will evolve from this diversity, it is the hope that a better appreciation of the various perspectives will lead to a highly coordinated approach to exploring the essential problems and better discussions among investigators with differing views.
Download or read book The World of Nano Biomechanics written by Atsushi Ikai and published by Elsevier. This book was released on 2016-11-18 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations. Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities. The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis. Explains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work on small-scale biological samples Presents recent developments of force-based biosensing Includes novel applications of nano-biomechanics to the medical field
Download or read book Mechanics of Biological Systems written by Seungman Park and published by Morgan & Claypool Publishers. This book was released on 2019-11-06 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.
Download or read book Nano Comes to Life written by Sonia Contera and published by Princeton University Press. This book was released on 2019-11-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nanotechnology revolution that will transform human health and longevity Nano Comes to Life opens a window onto the nanoscale—the infinitesimal realm of proteins and DNA where physics and cellular and molecular biology meet—and introduces readers to the rapidly evolving nanotechnologies that are allowing us to manipulate the very building blocks of life. Sonia Contera gives an insider's perspective on this new frontier, revealing how nanotechnology enables a new kind of multidisciplinary science that is poised to give us control over our own biology, our health, and our lives. Drawing on her perspective as one of today's leading researchers in the field, Contera describes the exciting ways in which nanotechnology makes it possible to understand, interact with, and manipulate biology—such as by designing and building artificial structures and even machines at the nanoscale using DNA, proteins, and other biological molecules as materials. In turn, nanotechnology is revolutionizing medicine in ways that will have profound effects on our health and longevity, from nanoscale machines that can target individual cancer cells and deliver drugs more effectively, to nanoantibiotics that can fight resistant bacteria, to the engineering of tissues and organs for research, drug discovery, and transplantation. The future will bring about the continued fusion of nanotechnology with biology, physics, medicine, and cutting-edge fields like robotics and artificial intelligence, ushering us into a new "transmaterial era." As we contemplate the power, advantages, and risks of accessing and manipulating our own biology, Contera offers insight and hope that we may all share in the benefits of this revolutionary research.
Download or read book Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms written by Xinyu Liu and published by Academic Press. This book was released on 2021-08-14 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms provides a comprehensive introduction to the state-of-the-art micro and nano systems that have recently been developed and applied to biophysical studies of cells and small organisms. These micro and nano systems span from microelectromechanical systems (MEMS) and microfluidic devices to robotic micro-nanomanipulation systems. These biophysical studies range from cell mechanics to the neural science of worms and Drosophila. This book will help readers understand the fundamentals surrounding the development of these tools and teach them the most recent advances in cellular and organismal biophysics enabled by these technologies. Comprehensive coverage of micro and nano-system technology and application to biophysical studies of cells and small organisms. Highlights the most recent advances in cellular and organismal biophysics enabled by micro and nano systems. Insightful outlook on future directions and trends in each chapter covering a sub-area of the book topic.
Download or read book Cell Mechanics And Tumor Development written by Ronald L Huston and published by World Scientific. This book was released on 2020-02-18 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this book is on centrioles — small organelles adjacent to the nucleus in all human and animal (eucaryotic) cells. It provides the findings and critical analyses of over 750 articles written in this century.In addition to centrioles, the topics include: centrosomes, chromosomes, microtubules and kinetochores, cell division and duplication, and tumor development. The book also includes discussions on centriole dynamics and electromagnetics effects. It concludes with a chapter on centriole errors — particularly cells with supernumerary centrioles.The book is intended for students, scholars, and researchers studying and working in the field of nuclear mechanics. In addition to the book content, it provides a guide for literature investigation.
Download or read book Nano Opto mechanical Characterization of Neuron Membrane Mechanics Under Cellular Growth and Differentiation written by Ashwini Gopal and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Mechanics written by Yu-Li Wang and published by Academic Press. This book was released on 2007-07-05 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell mechanics is the field of study that looks at how cells detect, modify, and respond to the physical properties of the cell environment. Cells communicate with each other through chemical and physical signals which are involved in a range of process from embryogenesis and wound healing to pathological conditions such as cancerous invasion. Similar principles are also likely to be critical for success in regenerative medicine. Cell mechanics is thus central to understanding these principles. As cell mechanics draws from the fields of biology, chemistry, physics, engineering, and mathematics, this book aims not only to provide a collection of research methods, but also to develop a common language among scientists who share the interest in cell mechanics but enter the field with diverse backgrounds. To this end all of the contributing authors have sought to explain in plain language the nature of the biological problems, the rationale for the approaches, in addition to the methods themselves. In addition, to balance practical utility against conceptual advances, Cell Mechanics has intentionally included both chapters that provide detailed recipes and those that emphasize basic principles. Presents a distinctive emphasis on matrix mechanics and their interplay with cell functions Includes highly significant topics relevant to basic and translational research, as well as tissue engineering Emphasizes mechanical input and output of cells
