Download or read book Myeloproliferative Neoplasms Biology and Treatment written by and published by Frontiers Media SA. This book was released on 2024-04-10 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) - including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PM) - are clonal stem cell disorders characterized by acquired activating mutations which result in an excessive production of red blood cells, platelets, and neutrophils. Recent advances in the understanding of the molecular biology and genomics of MPNs have led to the development of novel targeted treatment approaches; however, the high rate of life-threatening vascular events and the high risk of disease progression with myelofibrotic and leukemic transformation continue to present challenges in the management of MPNs. Thereby, there remains a need for novel treatment strategies. Recently, research has revealed a role for clonal hematopoiesis, driver mutations and inflammation in thrombosis risk, which may provide a basis for novel thrombosis-prevention strategies.
Download or read book Myeloproliferative Neoplasms written by Srdan Verstovsek and published by Springer Science & Business Media. This book was released on 2010-10-17 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms. Utilizing current World Health Organization nomenclature, classification, and diagnostic criteria, international experts have assembled to convey the most up-to-date knowledge in this rapidly evolving field. The opening chapters cover the diagnosis and classification, genetics, cytogenetic findings, and prognostic factors of MPNs. Further chapters explore therapies specific to the different disease entities, including polycythemia vera, essential thrombocytopenia, myelofibrosis, and eosinophilic disorders, and mastocytosis. Unique areas of discussion include JAK2 inhibitor therapy, hematopoietic stem cell transplantation, and blastic transformation. A valuable reference for practicing hematologists, this forefront book enriches our understanding of recent discoveries and their impact on conventional and investigational treatments.
Download or read book Myeloproliferative Disorders written by Richard T. Silver and published by CRC Press. This book was released on 2007-10-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the recent discovery of JAK2 mutations in myeloproliferative disorders, medical science has taken a revolutionary stride forward toward understanding the pathogenesis of these diseases. This new advancement translates not only to a more rapid and reliable diagnosis, but also allows groundbreaking research into the development of new therapeuti
Download or read book Cellular and Molecular Aspects of Myeloproliferative Neoplasms Part B written by and published by Academic Press. This book was released on 2022-02-11 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part B, Volume 366 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Sections cover Genetic and Sex predisposition to MPN, Transcriptional configurations of Myeloproliferative Neoplasms, Inhibitors and therapeutic targets of MPN, Mutational landscape of blast-phase myeloproliferative neoplasm (MPN-BP) and antecedent MPN, and Lessons from Mouse model of MPN, Lab tests for MPN. - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists from international sources - Offers a wide range of perspectives on specific subjects
Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Download or read book Cellular and Molecular Aspects of Myeloproliferative Neoplasms Part A written by and published by Academic Press. This book was released on 2021-10-29 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Aspects of Myeloproliferative Neoplasms - Part A, Volume 365 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release include MPN a continuum of different disease entities, Bone marrow microenvironment of MPN, Extramedullary hemopoiesis in MPN, The JAK2 mutation, Calreticulin mutations in myeloproliferative neoplasms, and Cytogenetic abnormalities and non-driver mutations in MPN. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists and drawn from international sources - Offers a wide range of perspectives on specific subjects
Download or read book New Perspectives in the Biology and Treatment of Myeloproliferative Disorders written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Myeloproliferative Neoplasms written by Tiziano Barbui and published by Springer Science & Business Media. This book was released on 2012-01-10 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on three of the main categories of myeloproliferative neoplasm: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Relevant laboratory and clinical advances are comprehensively covered, and great emphasis is placed on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
Download or read book New Perspectives in the Biology and Treatment of Myeloproliferative Disorders written by Craig M. Kessler and published by . This book was released on 2004 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chronic Myeloproliferative Disorders written by Tariq Mughal and published by CRC Press. This book was released on 2008-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the new classification of chronic myeloproliferative disorders, and the rise of interest in molecularly targeted therapies, this timely text brings together international experts on the topic to discuss the current technologies and their implications for the treatment of patients. This title comprehensively covers chronic myeloid leukemia and Ph-negative chronic myeloproliferative disorders and is an essential resource for all practitioners in Hematologic Oncology.
Download or read book Fast Facts Myeloproliferative Neoplasms written by Ruben A. Mesa and published by Karger Medical and Scientific Publishers. This book was released on 2019 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: * Essential thrombocythemia (ET) - characterized by increased platelet count * Polycythemia vera (PV) - characterized by excessive production of red blood cells * Primary myelofibrosis - a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.
Download or read book Myeloproliferative Neoplasms An Issue of Hematology Oncology Clinics of North America written by John Mascarenhas and published by Elsevier Health Sciences. This book was released on 2021-02-27 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include—but are not limited to— Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.
Download or read book Molecular Basis of Chronic Myeloproliferative Disorders written by H.L. Pahl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first description of Philadelphia chromosome-negative chronic myeloproliferative disorders more than 100 years ago, the diagnosis and therapy of these conditions have been based primarily on clinical experience and judgement. Until recently very little was known about the molecular basis of these diseases. In order to spark research in this area basic scientists and clinicians from various parts of the world have contributed to this volume, the first of its kind to put together the current knowledge. The book deals with the new WHO classification of these disorders, novel aspects of diagnostic pathology, the search for disease-relevant genes utilizing molecular biology and proteomic techniques, the description of the roles of PVR-1 and VHL genes for polycythemias and the discovery of the gene mutation responsible for the idiopathic hypereosinophilic syndrome. A chapter on anagrelide, an important novel drug for the treatment of primary thrombocythemia, is included.
Download or read book Myeloproliferative Neoplasms written by Tiziano Barbui and published by Springer. This book was released on 2016-08-23 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on three of the main categories of myeloproliferative neoplasm: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Relevant laboratory and clinical advances are comprehensively covered, and great emphasis is placed on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
Download or read book Living Well with a Myeloproliferative Neoplasm MPN written by Gowin Krisstina and published by Spry Publishing. This book was released on 2019-02-14 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: The journey through a diagnosis of MPN is different for each person and there is no road map that will work for everyone. In her book, LIVING WELL with a Myeloproliferative Neoplasm, Dr. Krisstina Gowin provides an essential guide to treatment options and symptom management, while helping patients and their caregivers take an informed and active role in getting quality care, communicating with their healthcare team, and developing a support system. As importantly, she addresses all aspects of the patient—body, mind, psychosocial and spiritual health—promoting overall wellness in bodies already challenged by disease. By following Dr. Gowin’s integrative approach— combining traditional and complementary therapies—MPN patients can get started on a path to living the best life possible every day. -- Gowin
Download or read book Oxford Specialist Handbook Myeloproliferative Neoplasms written by Tariq I. Mughal and published by Oxford University Press. This book was released on 2020-09-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of myeloproliferative neoplasms (MPN) disorders, a group of clonal haematological malignancies characterized by excessive accumulation of one or more myeloid cell lineages, has grown considerably over the past four decades. Myeloproliferative Neoplasms offers a detailed evidence-based guide to MPNs in an easily accessible format, structured to facilitate learning specialist information by presenting core information in 'bite size' chunks. Each chapter summarises the state-of-the art preclinical and clinical knowledge, and its impact on the clinical management of patients with MPNs. This practical guide, written by experts in the field, is essential reading for oncologists, haematologists, and other health care professionals interested in the field of MPNs.
Download or read book Molecular Biology of Hematopoiesis 5 written by Nader G. Abraham and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Molecular Biology of Hematopoiesis is dedicated to John W. Adam son, M. D. , Tadamitsu Kishimoto, M. D. , Robert C. Gallo, M. D. , Arthur W. Nienhuis, M. D. , and Franco Mandelli, M. D. , for their contributions in developing an overall view of the state-of-the-art knowledge in the field of hematopoiesis. Richard Champlin, among other renowned clinicians, presented updated information on stem cells and T-cell depletion for bone marrow transplant. A clinical update on thrombopoietin was presented by Pamela Hunt of Amgen and by Kenneth Kaushansky. Arthur Nienhuis' and Katherine Turner's contribu tions to our current knowledge and advances in the fields of growth factors and gene transfer were also recognized during the 9th Symposium on Molecular Biology of Hematopoiesis in Genoa. The chapters cover such diverse areas as preclinical and clinical updates on growth factors and positive and negative regulatory molecules. "Advances in Leukemia: Mechanism and Treatment by Interferon" was presented by Professor Sante Tura. Readers will find presentation of exciting advances that have occurred in the area of hematopoiesis. The elucidation of gene structures of key growth factor proteins such as IL-12 and IL-II will lead to new insights and new approaches in understanding the regulation of hematopoiesis, as well as application of new growth factors.
