Download or read book Multi spectral Confocal Microendoscope for In vivo Imaging PHD written by Andrew Robert Rouse and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endoscopic Microscopy written by and published by . This book was released on 2007 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Integrated Multi Spectral Fluorescence Confocal Microendoscope and Spectral Domain Optical Coherence Tomography Imaging System for Tissue Screening written by Houssine Makhlouf and published by . This book was released on 2011 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: A multi-modality imaging system intended for clinical utilization has been developed. It is constructed around an existing fiber-bundle-based fluorescence confocal microendoscope. Additional imaging modalities have been implemented to expand the capabilities of the system and improve the accuracy of disease diagnosis. A multi-spectral mode of operation is one such modality. It acquires fluorescence images of a biological sample across a spectral range of sensitivity and explores the collected image data at any specified wavelength within that spectral range. Cellular structures can be differentiated according to their spectral properties. The relative distribution and concentration of the different cellular structures can potentially provide useful pathologic information about the imaged tissue. A spectral-domain optical coherence tomography (SDOCT) modality is another imaging technique integrated into the system. It provides a cross-sectional imaging perspective that is comparable to microscopic images obtained from histology slides and complementary to the en face view obtained from the confocal imaging modality. The imaging system uses a parallelized architecture (fiber-optic bundle, line of illumination) to increase the data acquisition speed. A one-dimensional scan is needed to capture 2D images in the confocal modality or a 3D data cube (two spatial dimensions and one spectral dimension) in the multi-spectral mode of operation. No scanning is required to capture a 2D OCT image. The fiber-bundle design is particularly critical for the SDOCT modality as it paves the way to novel fast endoscopic OCT imaging that has a high potential for translation into the clinic. The integrated multi-modality imaging system can readily switch between different imaging modalities, which will make it a powerful diagnostic tool in a clinical environment. It can provide valuable information about the morphology, the spectral and biochemical features, and the macroscopic architecture of tissue. It is believed that fast and accurate disease diagnosis can potentially be made based on all these characteristics.
Download or read book Optical Microendoscopy for Imaging Cells Lying Deep Within Live Tissue written by Robert Juson Barretto and published by Stanford University. This book was released on 2010 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical microendoscopy is an emerging modality for imaging in live subjects. Using gradient refractive index (GRIN) microlenses, microendoscopy enables subcellular-resolution imaging in deep tissues that are inaccessible by traditional imaging techniques. We present a platform of methods and technologies that build upon GRIN microendoscopy: 1) miniaturized microscopes for imaging in awake, behaving animals, 2) methods for imaging contractile dynamics in the muscles of animal and human subjects, 3) chronic brain preparations that allow for longitudinal examinations of subcellular neuronal features and disease progression, and 4) novel microendoscope probes whose imaging capabilities approach that of standard water-immersion microscope objectives. When combined with the broad sets of available fluorescent reporters, and minimally invasive surgical preparations, the work described in this dissertation enables sophisticated experimental designs for probing how cellular char- acteristics may underlie or explain behavior, in models of both healthy and diseased states.
Download or read book Design of Confocal Microendscopy for Fallopian Tube Imaging and Detection of Esophageal Cancer written by Tzu-Yu Wu and published by . This book was released on 2015 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents several major developments related to a fluorescence confocal microendoscope technology that can provide instantaneous cellular level images from selected depths of tissue inside the human body. The confocal microendoscope systems discussed employ fiber-optic based imaging catheters coupled to custom built slit-scan confocal microscopes. One major new development involves the design, development, and testing of a new flexible confocal microgastroscope (CMG) system for imaging the esophagus. This new system has the potential to aid in the early detection of esophageal cancer. It consists of a new optical scan unit mounted on an endoscopy cart and a new flexible catheter that can be inserted through the instrument channel of a commercial gastroscope. The CMG system has higher spatial resolution and larger field of view than the previous generation clinical confocal microendoscopes in our lab. In addition, the new CMG system can be operated over a greater wavelength range than its predecessor. Central to the CMG system is the design, construction, and testing of a new distal miniature objective that enables high-quality microendoscopy. The miniature objective, built with all glass spherical surfaces, achieves diffraction-limited performance over a 486 to 1000 nm spectral range. The wide achromatic range of this lens allows the CMG system to be used with a variety of contrast agents including agents in the NIR region. In addition, the new miniature objective can be mounted on existing confocal microendoscopes in our lab such as the ovarian clinical confocal microlaparoscope and our laboratory based experimental system. Finally, a new confocal microlaparoscope with an articulating catheter capable of imaging inside the distal portion of fallopian tubes is presented. This instrument is intended to allow the detection of early stage ovarian cancer originating inside the fallopian tube. The new microlaparoscope is compatible with 5 mm trocars and includes a thin 2.2 mm diameter articulating distal tip consisting of a bare fiber bundle and an automated dye delivery system. The distal tip of this new endoscope can be articulated through simple wrist movements and locked in place at a given angle if desired. The thin distal tip and the ability to control the angle of the tip provide the size and flexibility needed to image inside the curved and delicate structures of the fallopian tube. Preliminary imaging results from the new CMG system, the achromatized miniature objective, and the new articulating confocal microlaparoscope are presented to demonstrate the performance and the potential of each system towards the overall goal of in vivo imaging and disease diagnosis.
Download or read book Biomedical Optical Imaging Technologies written by Rongguang Liang and published by Springer Science & Business Media. This book was released on 2012-09-21 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.
Download or read book Multimodal Multispectral Optical Endoscopic Imaging for Biomedical Applications written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proceedings of Three dimensional and Multidimensional Microscopy written by Carol J. Cogswell and published by Society of Photo Optical. This book was released on 1998 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: A study of three-dimensional and multidimensional microscopy. The first part reviews image acquisition and processing, covering topics such as optical instrumentation and biological measurement. The second part looks at interpretation and automation, and covers multispectral imaging.
Download or read book Ultra narrowband Multispectral Imaging written by Janis Spigulis and published by . This book was released on 2025 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book provides insight into an unconventional modality of imaging where several spectral images are captured by a single snapshot under multi-laser illumination, ensuring high-speed imaging within extremely narrow spectral bands. This method has three distinct advantages, if compared to common commercial multispectral imaging systems - considerably improved spectral selectivity (or colour sensitivity) of imaging, avoided motion artefacts in the spectral image sets, and simpler/faster image processing as integrals over the spectral bands of imaging are replaced by numbers of the fixed working wavelengths. The basic principles and progress in this field are reviewed, focusing on applications for human skin diagnostics and printed forgery detection. The designs of ten different lab-developed prototypes that implement this method are described, along with results of their laboratory, clinical and/or forensic tests. This research leads to the development of new equipment and protocols for better skin diagnostics and the advanced detection of money, document, and artwork forgeries. Chapter 1 explains the basics of spectral imaging, including the main principles of multispectral and hyperspectral imaging. Chapter 2 introduces the snapshot multi-spectral-line imaging (SMSLI) method, focusing on lasers as multi-wavelength illumination sources. Chapter 3 describes multi-laser illumination designs while Chapter 4 presents main specifications of the lab-assembled prototype devices implementing such designs. Results of the test measurements confirming applicability of the developed solutions for analysis/mapping of colour pigments in clinical diagnostics and forgery detection are discussed in Chapters 5 and 6, respectively. This will be a valuable reference for laser and imaging professionals, photonics researchers and engineers, clinicians (dermatologists, plastic surgeons, oncologists), forensic experts, and students of physics, chemistry, biology, medicine, and engineering"--
Download or read book Laser Multi spectral Confocal Microscopy for Structured Illumination Imaging written by Abhilash Sukumari and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Confocal laser scanning microscopy is a powerful and well-established technique with a wide range of applications. Structured illumination microscopy is a technique to extend the spatial resolution by a factor of two or potentially more beyond Abbe’s microscopy limit by using patterned illumination light. Certain aspects of each technique can be combined to give a new approach with advantageous features of each. Theoretical work has been done to demonstrate the applicability of SIM principle to CLSM. This research focuses on experimental investigation and developing a state-of-the-art instrumentation that can be deployed to demonstrate this concept. Research challenges are expected for all aspects of the proposed work. The anticipated ultimate impact of this research is a new feature that can be added to existing and future CLSM systems that can double the spatial resolution of these systems. Given the large number of existing CLSM for numerous applications, this feature may have a substantial commercial market.
Download or read book Miniature Dual Axes Confocal Microscope for Real Time In Vivo Imaging written by Wibool Piyawattanametha and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Miniature Dual Axes Confocal Microscope for Real Time In Vivo Imaging.
Download or read book Hyperspectral Microscope for in Vivo Imaging of Microstructures and Cells in Tissues written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: An optical hyperspectral/multimodal imaging method and apparatus is utilized to provide high signal sensitivity for implementation of various optical imaging approaches. Such a system utilizes long working distance microscope objectives so as to enable off-axis illumination of predetermined tissue thereby allowing for excitation at any optical wavelength, simplifies design, reduces required optical elements, significantly reduces spectral noise from the optical elements and allows for fast image acquisition enabling high quality imaging in-vivo. Such a technology provides a means of detecting disease at the single cell level such as cancer, precancer, ischemic, traumatic or other type of injury, infection, or other diseases or conditions causing alterations in cells and tissue micro structures.
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Download or read book Imaging in Photodynamic Therapy written by Michael R. Hamblin and published by CRC Press. This book was released on 2017-02-03 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the broad field of cellular, molecular, preclinical, and clinical imaging either associated with or combined with photodynamic therapy (PDT). It showcases how this approach is used clinically for cancer, infections, and diseases characterized by unwanted tissue such as atherosclerosis or blindness. Because the photosensitizers are also fluorescent, the book also addresses various imaging systems such as confocal microscopy and small animal imaging systems, and highlights how they have been used to follow and optimize treatment, and to answer important mechanistic questions. Chapters also discuss how imaging has made important contributions to clinical outcomes in skin, bladder, and brain cancers, as well as in the development of theranostic agents for detection and treatment of disease. This book provides a resource for physicians and research scientists in cell biology, microscopy, optics, molecular imaging, oncology, and drug discovery.
Download or read book MATLAB written by Kelly Bennett and published by BoD – Books on Demand. This book was released on 2014-09-08 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: MATLAB is an indispensable asset for scientists, researchers, and engineers. The richness of the MATLAB computational environment combined with an integrated development environment (IDE) and straightforward interface, toolkits, and simulation and modeling capabilities, creates a research and development tool that has no equal. From quick code prototyping to full blown deployable applications, MATLAB stands as a de facto development language and environment serving the technical needs of a wide range of users. As a collection of diverse applications, each book chapter presents a novel application and use of MATLAB for a specific result.
Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Download or read book The Maxillary Sinus written by James A. Duncavage and published by Thieme. This book was released on 2011-01-01 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive multimedia reference for the care of maxillary sinus problems This user-friendly reference and accompanying DVDs, authored by a team of internationally recognized experts, present the latest treatment options for the maxillary sinus, including a detailed analysis of the effectiveness of different surgical techniques and how best to successfully apply them. After an overview of embryology, surgical anatomy, and imaging, concise chapters guide the reader through the full range of pathologic conditions. The accompanying DVDs feature over three hours of state-of-the-art endoscopic surgical footage covering every technique cited in the text. Features: More than 70 step-by-step narrated endoscopic videos - each cross-referenced to a specific location in the book High-resolution radiographs and numerous full-color photographs that aid understanding of key principles Learning from a Difficult Case section in which experts share their personal experiences on complex topics, such as recurring maxillary sinus inverted papilloma and transmaxillary approaches to the pterygopalatine space A "Pearls" table with handy tips in every chapter The Maxillary Sinus: Medical and Surgical Management fills the current gap in maxillary sinus literature with clear, accessible coverage that makes this book the ideal choice for fellows, residents, and practicing physicians in rhinology and otolaryngology-head and neck surgery.
