Download or read book Multiscale Modeling of Cardiac Electrophysiology Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment written by Mathias Wilhelms and published by KIT Scientific Publishing. This book was released on 2014-05-22 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Download or read book A Multi scale Computational Investigation of Cardiac Electrophysiology and Arrhythmias in Acute Ischaemia written by and published by . This book was released on 2014 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiscale Cohort Modeling of Atrial Electrophysiology Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms written by Nagel, Claudia and published by KIT Scientific Publishing. This book was released on 2023-04-24 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.
Download or read book Multi Scale Computational Cardiology written by Ling Xia and published by Frontiers Media SA. This book was released on 2022-03-07 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mathematical Cardiac Electrophysiology written by Piero Colli Franzone and published by Springer. This book was released on 2014-10-30 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.
Download or read book Multi Scale Cardiac Electrophysiology written by Kevin Patrick Vincent and published by . This book was released on 2016 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac arrhythmias are a major source of morbidity, mortality, and healthcare cost in the United States. Arrhythmias are inherently multi-scale phenomena where cellular and subcellular abnormalities result in pathological impulse propagation. The failure of clinical therapies to sufficiently prevent or terminate arrhythmias is due, in part, to a lack of understanding of the underlying mechanisms. Integrating experimental results across spatial and temporal scales using computation modeling presents an important paradigm for investigating arrhythmia mechanisms. In this dissertation, computational modeling and experimental data at the subcellular, cellular, and tissue scales are used together to gain insight in to mechanisms of arrhythmias for clinically relevant cardiac diseases. On the cellular and subcellular scale, the ability of caveolin-3 to modulate action potential duration through ion channel regulation was investigated using action potential models to interpreting ion channel data. Two examples are presented in Chapter 2. In the first example, a mouse ventricular action potential model is able to link changes in Kv4.3 channel expression to observed QT shortening from the electrocardiogram of caveolin-3-overexpressing mice. The second example parameterizes ionic currents in a human ventricular action potential model with patch clamp data from ion channels co-expressed with Long QT Syndrome causing mutations in caveolin-3. The results identify slowed calcium-dependent inactivation of the L-type calcium channel as an potentially arrhythmogenic mechanisms. Integrating the subcellular, cellular, and tissue scales for multi-scale cardiac electrophysiology modeling presents numerical, computational, and physiological challenges. Chapter 3 examines these numerical challenges and presents a new high order finite element method to potentially reduce computational expense. This multi-scale electrophysiology solver is used to investigate the behavior of electrical rotors in the human atria in Chapter 4. Specifically, discontinuities in the fiber architecture of the right atria are shown to anchor rotors. Transgenic mouse models present a unique ability investigate genome effects on the tissue scale. The final two chapters provide literature reviews aimed towards future work investigating triggered arrhythmia mechanisms. Chapter 5 reviews the mechanisms of CaMKII mediated afterdepolarization in cardiac disease. Finally, Chapter 6 provides a detailed methodological review of Langendorff perfusion and optical mapping of ex-vivo transgenic mouse hearts.
Download or read book Mathematical Cardiac Electrophysiology written by Piero Colli Franzone and published by Springer. This book was released on 2014-11-02 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.
Download or read book Josephson s Clinical Cardiac Electrophysiology written by Callans, David and published by Lippincott Williams & Wilkins. This book was released on 2023-09-19 with total page 2034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widely regarded as the premier text in this complex field, Josephson’s Clinical Cardiac Electrophysiology, Seventh Edition, provides a thorough understanding of the mechanisms of cardiac arrhythmias and the therapeutic interventions used to treat them. Dr. David J. Callans, personally chosen and trained by Dr. Mark Josephson, provides expert clinical insights and superb illustrations that highlight proven approaches and methods. With its strong focus on physiologic investigation and its role in clinical decision making, this comprehensive text is a must-have reference for cardiology fellows, electrophysiologists, and others in the EP lab.
Download or read book Cardiac Electrophysiology in Clinical Practice written by David T. Huang and published by Springer Nature. This book was released on 2024-01-01 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensively updated edition is a practical guide to the clinical diagnosis and treatment of cardiac arrhythmias that meets the needs of this highly specialized, complex and growing field of cardiology. As understanding of the evaluation of treatment of arrhythmias continues to advance at a rapid pace, learning and understanding the principles of electrophysiology in order to provide the best possible treatments for patients can be a daunting task. With a scientific, practical and multi-disciplinary approach, Cardiac Electrophysiology in Clinical Practice establishes the foundation of the subject and provides a concise illustrative approach to facilitate and enhance understanding. It is designed to be accessible to serve as an introduction to electrophysiology, but advanced enough to serve as a guide for experienced practitioners. Electrophysiology students of all levels, including residents, fellows, mid-level providers, nurses, technologists, primary care providers, cardiologists and electrophysiologists will find value in these pages.
Download or read book Introduction to Computational Cardiology written by Boris Ja. Kogan and published by Springer Science & Business Media. This book was released on 2009-12-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Computational Cardiology provides a comprehensive, in-depth treatment of the fundamental concepts and research challenges involved in the mathematical modeling and computer simulation of dynamical processes in the heart, under normal and pathological conditions. About this textbook: - Presents descriptions of models used in both biology and medicine for discovering the mechanisms of heart function and dysfunction on several physiological scales across different species. - Provides several examples throughout the textbook and exercises at the end which facilitate understanding of basic concepts and introduces, for implementation, treated problems to parallel supercomputers. Introduction to Computational Cardiology serves as a secondary textbook or reference book for advanced-level students in computer science, electrical engineering, biomedical engineering, and cardiac electrophysiology. It is also suitable for researchers employing mathematical modeling and computer simulations of biomedical problems.
Download or read book Personalized Multi Scale Modeling of the Atria Heterogeneities Fiber Architecture Hemodialysis and Ablation Therapy written by Martin Wolfgang Krüger and published by KIT Scientific Publishing. This book was released on 2014-05-22 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book targets three fields of computational multi-scale cardiac modeling. First, advanced models of the cellular atrial electrophysiology and fiber orientation are introduced. Second, novel methods to create patient-specific models of the atria are described. Third, applications of personalized models in basic research and clinical practice are presented. The results mark an important step towards the patient-specific model-based atrial fibrillation diagnosis, understanding and treatment.
Download or read book An Essential Introduction To Cardiac Electrophysiology written by Kenneth T Macleod and published by World Scientific Publishing Company. This book was released on 2013-11-14 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides undergraduate and postgraduate students with an accessible and comprehensive overview of the fascinating area of cardiac electrophysiology. Using plain language and well-designed illustrations, it attempts to overcome the preconceptions of the subject as difficult to approach, given the complexity of intricate electrical cellular processes within the human heart. Based on lectures presented to intercalating BSc medical students, this book has been designed with the undergraduate in mind, but offers enough scope to be worthwhile at the postgraduate level.Readers of this book will feel more confident and at ease with electrical concepts and the important physiological mechanisms that govern the initiation and regulation of the heartbeat. This volume intends to bridge that difficult region between basic undergraduate lecture notes and original papers in an approachable way. It will be useful to students studying medicine, physiology, pharmacology, pharmacy and biology, particularly where their curricula includes not only cardiac physiology, but also neurobiology and muscle physiology.
Download or read book Cardiac Electrophysiology 2 An Advanced Visual Guide for Nurses Techs and Fellows written by Paul D. Purves and published by Cardiotext Publishing. This book was released on 2014-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Essential Visual Guide to Cardiac Electrophysiology Following the bestselling Cardiac Electrophysiology: A Visual Guide for Nurses, Techs, and Fellows, this book builds upon the basic concepts of electrophysiology introduced in the first volume and guides the reader to a more in-depth understanding of cardiac electrophysiology by working through commonly encountered scenarios in the EP lab. 45 full-page landscape, high-quality color intracardiac tracings are presented as “every-day” observations and unknowns, followed by annotated tracings and discussions that emphasize a systematic approach to the interpretation of EP tracings. Authored by a team of experts, Cardiac Electrophysiology: An ADVANCED Visual Guide for Nurses, Techs, and Fellows is an invaluable resource, providing superb guidance in developing the knowledge and skills required to practice clinical cardiac electrophysiology.
Download or read book Cardiac Electrophysiology written by Milind G. Parikh and published by Springer Nature. This book was released on 2022-02-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive review of clinical cardiac electrophysiology in a question and answer format. Chapters contain over 200 questions divided into 9 chapters, each organized by cardiac electrophysiology topic. Each question is followed by the correct answer with a detailed explanation along with references for further reading. Important concepts are highlighted and supported by over 200 illustrations and high resolution images. The book addresses a broad range of topics that are important when studying for the initial certification or recertification of the clinical cardiac electrophysiology board examination. It is also highly relevant for daily clinical practice in cardiology and cardiac electrophysiology. Topics covered in the book include: Review of basic and clinical cardiac electrophysiology principles associated with cardiac arrhythmias The evaluation and management of patients with cardiac rhythm disorders Review of pharmacologic and nonpharmacologic therapies for the treatment of arrhythmias Clinical indications, fundamental principles and electrical characteristics of implantable cardiac electronic devices such as pacemakers and defibrillators Clinical, electrocardiographic, and electrophysiologic characteristics of specific cardiac arrhythmia syndromes Cardiac Electrophysiology Board Review is a must-have resource for cardiology and cardiac electrophysiology trainees as well as attending physicians preparing for the certification or recertification examination. It may also be a useful guide for cardiologists, cardiac electrophysiologists and all clinicians who wish to further their understanding of heart rhythm disorders.
Download or read book Handbook of Cardiac Electrophysiology written by Andrea Natale and published by CRC Press. This book was released on 2007-05-30 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first practical, user-friendly guide to the theory and practice of a routinely used technique, this new manual provides the specialist in training with a thorough grounding in the equipment, procedures, and clinical findings with which clinicians need to be familiar.Conceived as an alternative to the large and expensive texts aimed at specialis
Download or read book Clinical Cardiac Electrophysiology in Clinical Practice written by David T. Huang, MD and published by Springer. This book was released on 2014-12-01 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Electrophysiology (EP) is a highly specialized, complex and growing field of cardiology. As understanding of the evaluation of treatment of arrhythmias continues to advance, learning and understanding the principles of EP in order to provide the best possible treatments for patients can be a daunting task. The Manual of Clinical Cardiac Electrophysiology is a guide to the clinical diagnosis and treatment of cardiac arrhythmias that meets this need. With a scientific, practical, and multi-disciplinary approach, the book establishes the foundation of the cardiac electrophysiology and provides multimedia illustrations to facilitate and enhance understanding. These illustrations will come directly from real case studies, to provide an authentic look at each principle of EP. Since the world of EP moves so fast, and arrhythmias are diagnosed and treated in real time, it is often difficult to learn EP from static texts, images and diagrams. This book is designed to be accessible enough to serve as an introduction to EP, but advanced enough to serve as a guide for experienced practitioners. EP students of all levels, including medical students, residents, fellows, mid-level providers, nurses, technologist, primary care providers, cardiologists and electrophysiologists will find value in the Manual of Clinical Cardiac Electrophysiology.
Download or read book Understanding Clinical Cardiac Electrophysiology written by Peter Spector and published by John Wiley & Sons. This book was released on 2016-05-16 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fast paced world of clinical training, students are often inundated with the what of electrophysiology without the why. This new text is designed to tell the story of electrophysiology so that the seemingly disparate myriad observations of clinical practice come into focus as a cohesive and predictable whole. Presents a unique, conceptually-guided approach to understanding the movement of electrical current through the heart, the impact of various disease states and the positive effect of treatment Reviews electrophysiologic principles and the analytic tools which, when combined with a firm grasp of EP mechanisms, allow the reader to think through any situation Presents the mathematics necessary for the practice of cardiac electrophysiology in an accessible and understandable manner Contains accompanying video clips, including computer simulations showing the flow of electrical current through the heart, which help explain and visualise concepts discussed in the text Includes helpful chapter summaries and full color illustrations aid comprehension
