Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Download or read book Gel Forming and Soluble Mucins written by Joseph Z. Zaretsky and published by Bentham Science Publishers. This book was released on 2013-03-18 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucins are glycoproteins that are expressed in cells of different types and fulfill multiple functions that determine participation of these proteins in such processes as signal transduction, regulation of gene expression, cell proliferation, embryogenesis, cell differentiation, immunity, apoptosis and cancer development. This E-book series on mucins presents critical reviews on modern data concerning structures and functions of mucins, their roles in cell physiology and pathology as well as molecular aspects of therapy of mucin-associated diseases. Mucins are represented by two types of molecules: secreted mucins and membrane-bound (receptor) mucins. This e-book series represents a unique attempt to describe the molecular nature of mucin multifunctionality in separate volumes. Chapters in each volume demonstrate the central role of mucins as connectors and regulators of different signaling pathways and their participation metastatic processes. Clinical aspects of mucins, such as their role as diagnostic markers as well as possible applications in mucin-based immuno- and gene-therapies are also discussed. This is the first volume of the series. This volume introduces readers to the general properties of mucins, followed by chapters on specific variants of gel-forming and soluble mucins. The volume concludes with information on the functions of secreted mucins.

Download or read book Biopolymers for Biomedical and Biotechnological Applications written by Bernd H. A. Rehm and published by John Wiley & Sons. This book was released on 2020-12-01 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides insight into biopolymers, their physicochemical properties, and their biomedical and biotechnological applications This comprehensive book is a one-stop reference for the production, modifications, and assessment of biopolymers. It highlights the technical and methodological advancements in introducing biopolymers, their study, and promoted applications. "Biopolymers for Biomedical and Biotechnological Applications" begins with a general overview of biopolymers, properties, and biocompatibility. It then provides in-depth information in three dedicated sections: Biopolymers through Bioengineering and Biotechnology Venues; Polymeric Biomaterials with Wide Applications; and Biopolymers for Specific Applications. Chapters cover: advances in biocompatibility; advanced microbial polysaccharides; microbial cell factories for biomanufacturing of polysaccharides; exploitation of exopolysaccharides from lactic acid bacteria; and the new biopolymer for biomedical application called nanocellulose. Advances in mucin biopolymer research are presented, along with those in the synthesis of fibrous proteins and their applications. The book looks at microbial polyhydroxyalkanoates (PHAs), as well as natural and synthetic biopolymers in drug delivery and tissue engineering. It finishes with a chapter on the current state and applications of, and future trends in, biopolymers in regenerative medicine. * Offers a complete and thorough treatment of biopolymers from synthesis strategies and physiochemical properties to applications in industrial and medical biotechnology * Discusses the most attracted biopolymers with wide and specific applications * Takes a systematic approach to the field which allows readers to grasp and implement strategies for biomedical and biotechnological applications "Biopolymers for Biomedical and Biotechnological Applications" appeals to biotechnologists, bioengineers, and polymer chemists, as well as to those working in the biotechnological industry and institutes.

Download or read book Mucins Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mucins—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Mucins in a compact format. The editors have built Mucins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mucins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Mucins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Mucins written by Michael A. McGuckin and published by Humana Press. This book was released on 2012-01-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial mucins are large complex cell surface and secreted glycoproteins produced by mucosal epithelial cells. In, Mucins: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study Mucins. These include methods and techniques for the best approaches to analysing each specific area of mucin biochemistry, physiology and biophysics before providing individual detailed experimental protocols together with troubleshooting and interpretation tips. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mucins: Methods and Protocols is designed to be a useful resource for those entering the mucin field and to facilitate those already studying mucins to broaden their experimental approaches to understanding mucosal biology.

Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students

Download or read book Glycoprotein Methods and Protocols written by Anthony P. Corfield and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mucins (mucus glycoproteins) have long been a complex corner of glycoprotein biology. While dramatic advances in the separation, structural an- ysis, biosynthesis, and degradation have marked the progress in general glycop- tein understanding, the mucins have lagged behind. The reasons for this lack of progress have always been clear and are only now being resolved. The mucins are very large molecules; they are difficult to separate from other molecules present in mucosal secretions or membranes; they are often degraded owing to natural protective functions or to isolation methodology and their peptide and oligos- charide structures are varied and complex. Understanding these molecules has demanded progress in several major areas. Isolation techniques that protect the intact mucins and allow dissociation from other adsorbed but discrete molecules needed to be developed and accepted by all researchers in the field. Improved methods for the study of very large molecules with regard to their aggregation and polymerization were also needed. Structural analysis of the peptide domains and the multitude of oligosaccharide chains was required for smaller sample sizes, for multiple samples, and in shorter time. In view of these problems it is perhaps not surprising that the mucins have remained a dilemma, of obvious biological importance and interest, but very difficult to analyze.

Download or read book Low Abundance Proteome Discovery written by Egisto Boschetti and published by Newnes. This book was released on 2013-03-26 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Low-Abundance Proteome Discovery addresses the most critical challenge in biomarker discovery and progress: the identification of low-abundance proteins. The book describes an original strategy developed by the authors that permits the detection of protein species typically found in very low abundance and that may yield valuable clues to future discoveries. Known as combinatorial peptide ligand libraries, these new methodologies are one of the hottest topics related to the study of proteomics and have applications in medical diagnostics, food quality, and plant analysis. The book is written for university and industry scientists starting proteomic studies of complex matrices (e.g., biological fluids, biopsies, recalcitrant plant tissues, foodstuff, and beverage analysis), researchers doing wet chemistry, and graduate-level students in the areas of analytical and biochemistry, biology, and genetics. - Covers methodologies for enhancing the visibility of low-abundance proteins which, until now, has been the biggest challenge in biomarker progress - Includes detailed protocols that address real-life needs in laboratory practice - Addresses all applications, including human disease, food and beverage safety, and the discovery of new proteins/peptides of importance in nutraceutics - Compiles the research and analytic protocols of the two scientists who are credited with the discovery of these landmark methodologies, also known as combinatorial peptide ligand libraries, for the identification of low-abundance proteins

Download or read book Oral Delivery of Insulin written by T.A. Sonia and published by Elsevier. This book was released on 2014-12-11 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. - Presents an overview of Diabetes Mellitus - Includes a discussion of various strategies and techniques adopted for oral delivery of insulin - Presents an update of research in the field

Download or read book Studies of Salivary Mucin and Its Quantitative Determination written by James Masanaga Inouye and published by . This book was released on 1924 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Airway Mucus written by D. F. Rogers and published by . This book was released on 1997-09-23 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lacrimal Gland Tear Film and Dry Eye Syndromes 2 written by David A. Sullivan and published by Springer Science & Business Media. This book was released on 1998 with total page 1090 pages. Available in PDF, EPUB and Kindle. Book excerpt: Harvard Medical School, Boston, MA. Proceedings of the Second International Conference on the Lacrimal Gland, Tear Film, and Dry Eye Syndromes, held November 16-19, 1996, at the Southampton Princess Resort, Bermuda. DNLM: Lacrimal Apparatus--congresses.

Download or read book The Epithelial Mucins Structure Function Roles In Cancer And Inflammatory Diseases written by Isabelle Van Seuningen and published by . This book was released on 2008-01-01 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the Mucin World During life, our body has to maintain a balance to preserve tissue integrity and vital functions. This balance is defined by the term homeostasis, which results from equilibrium between cell proliferation and cell death (apoptosis). Each mucosa possesses a complex architectural organization that is specific for the organ or tissue and that serves the biological functions of that particular organ or tissue. Maintenance of epithelial homeostasis and protection of underlying tissues is controlled by several molecules and more particularly by mucus, the first line of defense. The mucus creates an interface between the outside milieu (lumen) and the underlying epithelium, thereby protecting the epithelium against various aggressions such as pollutants, pH, bacterial/viral products, parasites, bile salts, inflammatory cells and products, proteases, etc (Figure 1). Mucus is composed of water, proteins (mucins being the major protein component), and ions. Variations of these three components will have a direct impact on the rheological properties of mucus (viscosity, fluidity, adhesiveness and elasticity). Mucins are secreted by specialized cells, the goblet cells located at the surface of the epithelium, or mucus cells of the glands. In healthy adult mucins have a cell- and tissue-specific pattern of expression (Figure 1). The general term of mucin, has become more confusing over the past few years, not only to the general reader but also to the mucineers , with the description and attribution of the name MUC to molecules that are not mucins. Mucins were initially described as high molecular weight secreted glycoproteins responsible for the rheological properties of mucus. Their peptidic structure was characterized by a high content in serine (Ser), threonine (Thr) and proline (Pro) residues, contained within a central domain that bears hundreds of oligosaccharidic chains in the mature molecule of mucin [1]. The sugar moiety of mucins represents 50-80 % of the weight of the molecule. With the identification of the first mucin by molecular biologists in the 90's, MUC1, mucineers were a bit disappointed as its structure did not fit with the mucin standard described by biochemists in the 70's. The weight of MUC1 was relatively small and it was a transmembrane protein, only the Ser/Thr/Pro rich extracellular glycosylated central domain was present. The discovery and characterization of many more mucin genes thereafter quickly brought up the issue of a mucin classification and the definition of what is a mucin? At the present time, we reached MUC21 and two major classes of mucins have been defined: the secreted mucins and the membrane-bound mucins. For extensive reviews about mucin classification see references [2-5]. The characterization of the mucin genes and of the peptides encoded by these genes led to a better understanding of their genetic regulation, to the production of new molecular tools (specific antibodies, nucleic probes) and more recently to the generation of knockout (KO) mouse models. From these studies new important roles for both secreted and membrane-bound mucins have emerged. It is hypothesized that MUC2 may play a role of tumour suppressor gene in colorectal carcinogenesis, whereas MUC1 and MUC4, the best characterized membrane-bound mucins at this time, were demonstrated to interfere with tumour cell properties such as migration, proliferation, invasion, survival but also cell adhesion and escape from the immune system. Epithelial cancers constitute a problem of public health. Indeed, 90% of tumours develop from epithelial cells with a secretory function and notably with a mucus secretory function. Each mucosa is characterized by a specific profile of mucin gene expression, this profile being also specific for the cell types found in the mucosa. Moreover, gradients of mucin expression exist between epithelial surface cells and submucosal glands. Finally, qualitative and quantitative abnormalities in mucin gene expression are often associated with the prognosis of the tumour (good or bad). The sugar moiety is also modified in cancer with a decrease in number and length of oligosaccharidic chains allowing expression of cryptic epitopes as well as tumour-associated antigens, which are presently used as diagnostic biomarkers in several cancers (CA15.3, CA19.9, CA125). All these data made clinicians consider mucins as potent tumour markers for diagnostic and/or prognostic purposes but also to classify tumours. Mucins are also considered as potent new therapeutic targets in mucosal biology, in malignant and inflammatory diseases of the epithelial tissues (Figure 1). Before describing the different chapters of this book, I will talk about the debated issue of mucin classification among mucin specialists and present the way we see it at this time. We only consider mucins those that are expressed and synthesized by epithelial cells. Mucins expressed by other cell types (endothelial cells, brain cells, melanoma cells), which often are very small molecules and only membrane-bound, the so-called mucin-like , will not be discussed in this book. I. The secreted mucins The family of secreted mucins includes gel-forming mucins MUC2, MUC5AC, MUC5B, MUC6, and MUC19. Their main function is to participate in mucus formation by forming a tridimensional network in which other peptides are entangled and interact with mucins and to protect underlying epithelia against various injuries (inflammation, bacteria, virus, pollutants, pH, etc). Recently, however, the knocking down of Muc2 in mice showed that secreted mucins may play a role in tumourigenesis, as Muc2 KO mice developed intestinal tumours [6]. In the coming years, generation of KO mice for the other members of the mucin family will undoubtedly provide additional critical information as to whether they are also implicated in tumourigenesis. MUC7 and MUC9 are two secreted mucins, smaller in size and they do not polymerise to form a gel. Currently, structural information on the secreted mucin MUC8 to classify it as gel-forming or not, is lacking. Figure 1. Regulation of mucin gene expression and pathophysiology of the epithelium. II. The membrane-bound mucins The family of membrane-bound mucins includes MUC1, MUC3A/3B, MUC4, MUC12, MUC13, MUC15, MUC16, MUC17, MUC20 and now MUC21. Among them the best characterized are MUC1 and MUC4. MUC1 and MUC4 transmembrane mucins are highly glycosylated proteins with an extended rigid extracellular domain that confer them a role of molecular sensors between the extracellular milieu and the epithelial cell. Passage of information to the cell (inflammatory products, growth factors, viral or bacterial exoproducts, pH variation, bile, pollutants, cytotoxic and anti-cancer drugs) is thus depending on the quantity and quality of mucins present at the cell surface. These membrane mucins are also ligands for receptors of growth factors (MUC1-ErbBs, MUC4-ErbB2). They participate in cell signalling, influence cell proliferation, tumour progression, tumour cell morphology, or cell polarity, and mediate cell escape from immune surveillance. Moreover, over-expression of membrane-bound mucins in numerous cancers is often associated with a poor prognosis. Finally, ability to be cleaved, secreted and participate in mucus formation make these mucins an important component of mucus and epithelial defense as well. A better understanding of the molecular mechanisms governing mucin expression is thus mandatory if one wants to assign direct roles to mucins in carcinogenesis and better understand their influence on the biological properties of tumour cells. The studies aiming at deciphering the signalling pathways will allow the design of therapeutic molecules with the ultimate goal to restore a normal mucus secretion and/or to modulate their expression at the cell surface. Moreover, availability of specific antibodies toward the peptidic part of the different mucins will be a major advance to use mucins as diagnostic and/or prognostic indicators. The use of mucin promoters in gene-based therapy is also being evaluated and may provide new tools in these approaches to treat cancer. This book will focus on the recent advances about the biology of both secreted and membrane-bound mucins and more particularly on the description of their key roles in carcinogenesis either as tumour promoters or tumour-suppressor genes, as biomarkers and potent therapeutic targets. Future directions for research on mucin biology in cancer (gene-based, immuno-based, or even glyco-based) will be discussed. The first two chapters are devoted to the genetic and peptidic structures of the secreted gel-forming (chapter I) and membrane-bound (chapter II) mucins. In these chapters the potential roles and biological functions of the structural domains of mucins, the conservation of the structures compared with their animal counterparts, as well as the structure and regulation of the promoters of the genes encoding membrane-bound mucins will be discussed. A previous review described the structure and regulation of the promoters of the genes encoding secreted gel-forming mucins [7]. The mucins are large O-glycoproteins carrying hundreds of oligosaccharidic chains with important structural and biological functions. For that reason, the next two chapters are dealing with the biosynthesis of mucin glycan chains and the different enzymes involved in that process (chapter III) and the structure of the sugar chains (chapter IV). In that chapter, authors focused on tumour-associated antigens (TAAs) born by mucins, the functions of TAAs in bacterial/viral-host interactions, as diagnostic and/or prognostic factors but also as targets in vaccine therapies. As mentioned in the beginning of this introduction, mucins as well as their genes show altered patterns of expression in many epithelial cancers, with variations during the carcinogenetic sequence, that are tissue- and cell-specific. Interestingly, these alterations are also observed in inflammatory diseases of the epithelium (Figure 1). In each case, these variations have critical and often detrimental effects on epithelium homeostasis since mucins are critical for epithelial defense and protection. In cancer these changes modify the biological activity of mucins (more particularly of membrane-bound mucins), thereby influencing tumour proliferation and progression as well as metastasis. Moreover, mucin expression may be seen before cytodifferentiation during embryonic and foetal development or concomitant to cytodifferentiation. The regulatory mechanisms underlying these patterns of expression during development, usually silent in healthy adult but often reactivated in disease, are important to understand as some mucin genes show oncofoetal type patterns of expression in cancers (chapter V). Moreover, next to alterations of their regulation at the transcriptional level mucin genes are also regulated at the epigenetic level and we discuss these relatively recent results in chapter VI. Following these two chapters, we describe expression and regulation of mucins in healthy and pathological epithelium of the lung (chapters VII, VIII, and IX), the oesophagus (chapter X), the gastro-intestinal tract (chapters XI and XII), the pancreas and hepato-biliary tract (chapter XIII), and of the uro-genital tract (chapter XIV). In these chapters, authors describe the most recent studies dealing with therapies targeting mucins or mucin genes aiming at controlling mucus secretion, goblet cell differentiation or cancer cell behaviour, which in the end should help treat cancers or inflammatory diseases. Mucin expression and targeting in breast cancer are not discussed in this book as excellent reviews by expert groups are available [8-10]. The last chapter of this book (chapter XV) is a description of clinical studies that analyzed mucin expression in epithelial cancers and correlated it to clinicopathological parameters in order to evaluate their potential role and/or their value as diagnostic and/or prognostic factors in epithelial cancers. Results are often controversial and bring about issues such as the size of cohorts, sampling techniques, immunohistochemical methods, and more importantly specificity of the antibodies (glycan- or peptidic-based) used to detect mucins. In conclusion, I want to insist on the great variety of mucin molecules that exist in the human body and on their conservation throughout evolution, which indicates their importance both in normal development and survival of the body. However, that great diversity is still not well-understood as to why so many mucins? Why such a cell- and tissue-specificity? Why such alterations in cancers and inflammatory diseases of the epithelium? Despite an increasing amount of studies since the characterization of mucin gene promoters and regulatory regions much more work is needed to understand the regulatory mechanisms and signalling pathways responsible for mucin expression. The recent development of new techniques to apprehend gene regulation in vivo (small interfering RNA, small hairpin RNA interference) and the discovery of miRNA, a world that has yet to be explored regarding mucins, should help in that regard. The development of animal models suited for mucin studies will with no doubts bring invaluable information that we need, to better define the biological role of mucins in vivo. Only Muc1 and Muc2 deficient mice have been published so far. These mouse models have not only brought new information about the role of these two mucins in cancer but also raised new questions; for instance is development of tumours in Muc2 KO mice a cause or consequence of Muc2 absence? These models also confirmed the existence of a non negligible system of redundancy in the world of mucins, which still need to be deciphered and explained. Development of biological tools, especially specific antibodies towards human but also rodent mucins, remains a great challenge. Unfortunately too many publications published these past years with commercial antibodies that are not specific or well-defined were accepted for publication and do not bring clarity in that instance. Mucins as diagnostic and/or prognostic factors? The answer to this question is still pending. Some hope may come from epigenetic detection of methylated forms of mucin genes in biological fluids using pyrosequencing. Establishment of glyco-signatures in cancer diagnosis is also a very active field at this time and mucins are in the first line [11]. What about mucins as biomarkers? Lots of studies by clinicians have already shown that mucins are used to classify tumours but in the future gene expression profiling (genomics, proteomics, epigenomics, glycomics, metabolomics) studies will certainly bring more information and faith as to whether mucin genes and their translational products may be considered as reliable biomarkers in cancers and be included in molecular signatures that will in the future be the criteria to define tumours and improve patient management. References 1. Roussel, P., Lamblin, G., Lhermitte, M., Houdret, N., Lafitte, J. J., Perini, J. M., Klein, A. and Scharfman, A. 1988, Biochimie, 70(11), 1471-82. 2. Hollingsworth, M. A. and Swanson, B. J. 2004, Nat Rev Cancer, 4(1), 45-60. 3. Moniaux, N., Escande, F., Porchet, N., Aubert, J. P. and Batra, S. K. 2001, Front Biosci, 6, D1192-206. 4. Dekker, J., Rossen, J. W., Buller, H. A. and Einerhand, A. W. 2002, Trends Biochem Sci, 27(3), 126-31. 5. Porchet, N. and Aubert, J. P. 2004, Med Sci (Paris), 20(5), 569-74. 6. Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K. and Augenlicht, L. 2002, Science, 295(5560), 1726-9. 7. Van Seuningen, I., Pigny, P., Perrais, M., Porchet, N. and Aubert, J. P. 2001, Front Biosci, 6, D1216-34. 8. Carraway, K. L., Ramsauer, V. P. and Carraway, C. A. 2005, J Cell Biochem, 96(5), 914-26. 9. Taylor-Papadimitriou, J., Burchell, J. M., Plunkett, T., Graham, R., Correa, I., Miles, D. and Smith, M. 2002, J Mammary Gland Biol Neoplasia, 7(2), 209-21. 10. Gendler, S. J. 2001, J Mammary Gland Biol Neoplasia, 6(3), 339-53. 11. Willyard, C. 2007, Nat Med, 13(11), 1267.

Download or read book Mucins in Normal and Diseased Airways written by Hans Werner Hovenberg and published by . This book was released on 1996 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Marine Cosmeceuticals written by Se-Kwon Kim and published by CRC Press. This book was released on 2016-04-19 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Cosmeceuticals: Trends and Prospects is a consolidated overview of the marine environment as a productive source of novel cosmeceuticals. It accumulates the latest research in this field from around the globe, highlighting the potential of marine micro and macro flora and fauna as effective agents for the development of novel cosmeceuticals.

Download or read book Marine Pharmacognosy written by Se-Kwon Kim and published by CRC Press. This book was released on 2012-12-06 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse and abundant, marine-derived bioactive compounds offer a plethora of pharmacologically active agents with the potential to produce valuable therapeutic entities. Marine-derived organisms, including some macroalgae, microalgae, blue-green algae, invertebrates, and vertebrates—valued in traditional Chinese medicine since ancient times—are now recognized as rich sources of pharmaceutically active compounds. These factors, coupled with the growing need for novel bioactives for the treatment of severe human diseases such as cancer, diabetes, microbial infections, and inflammatory processes, has brought marine pharmaceuticals to the forefront of pharmacology. Marine Pharmacognosy: Trends and Applications provides a comprehensive account of marine-derived bioactive pharmaceuticals and their potential health benefits, including antioxidant, anticancer, antiviral, anticoagulant, antidiabetic, antiallergy, anti-inflammatory, antihypertensive, antibacterial, and radioprotective activities. Moreover, it discusses the sources, isolation and purification, chemistry, functionality interactions, applications, and industrial features of a variety of marine-derived pharmaceuticals. Marine pharmacognosy is a dynamic field that has been systematically investigated over the last 50 years, and the number of publications and patents are increasing every year. Bringing together a global team of experts, Marine Pharmacognosy: Trends and Applications reviews current research on marine-derived bioactive compounds and provides insight into future research on their potential as pharmacologically active agents.

Download or read book Quick Reference Handbook for Surgical Pathologists written by Natasha Rekhtman, MD, PhD and published by Springer. This book was released on 2019-05-07 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a compilation of high-yield, at-a-glance summaries in quick reference format for various topics that are frequently encountered by pathologists in the daily practice or on the boards. The focus is not organ-based histologic criteria, but rather everything else that goes into pathologic diagnoses but is difficult to keep committed to memory. The emphasis is on immunohistochemistry, special stains, grading systems, molecular markers, tumor syndromes, and helpful clinical references. Also included are morphologic summaries that encompass high-yield material cutting across all organ systems, such as an illustrated guide for microorganisms, tumor differentials, and an illustrated glossary of pathologic descriptors. The book has a unique format in that the information is presented primarily in tables and diagrams accompanied by brief and to-the-point explanatory text. The guiding principle was to boil the information down to the essentials but with just enough commentary to be accessible to a newcomer to pathology and to serve as a quick reference to a practicing pathologist. In the 7 years since its initial publication, there have been considerable advances in surgical pathology, particularly immunohistochemical stains, molecular diagnostics, and histologic grading schemes. In the second edition, the content has been thoroughly updated to incorporate these developments, while retaining the overall scope and concise format of the first edition. In addition, the reader will find summaries for many new topics as well as multiple new cartoon illustrations and diagrams.