Download or read book Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition EMT and Fibrosis Volume II written by Cecilia Battistelli and published by Frontiers Media SA. This book was released on 2022-10-17 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition EMT and Fibrosis written by Cecilia Battistelli and published by Frontiers Media SA. This book was released on 2020-02-10 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epithelial mesenchymal Transitions New Advances in Development Fibrosis and Cancer written by Erik W. Thompson and published by . This book was released on 2010-12-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue represents a progression through signaling processes, development, fibrosis and cancer, illustrating common underlying mechanisms and highlighting the growing recognition of therapeutic possibilities. Novel molecular pathways are shown in the context of known regulators, and many articles offer specific insights into therapeutic targeting. Not surprisingly, several articles relate to the signaling pathways activated by the common anchor transforming growth factor (TGF)-beta in relation to epithelial-mesenchymal transition (EMT). A number of new mechanisms with therapeutic implications are described, specifically the interplay between the non-Smad PI3 kinase-Akt-mTOR axis and EMT-associated invasion in response to TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced EMT, the cooperativity between oncostatin M, hepatocyte growth factor and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and periostin in developmental EMT associated with gastrulation and palate fusion, respectively. Collectively, the issue presents the full spectrum of interest in EMT today.
Download or read book Molecular Mechanism in Epithelial Mesenchymal Transition EMT and Fibrosis written by Sabrina Lisi and published by . This book was released on 2024-03-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue of the International Journal of Molecular Sciences (IJMS), entitled "Molecular Mechanism in Epithelial-Mesenchymal Transition (EMT) and Fibrosis", collected 15 original research papers (5 reviews and 10 articles) written by a panel of experts from different countries who highlight recent advances in the EMT process. Navigating the complex field of EMT, this Special Issue introduces the current understanding of the underlying mechanisms of EMT in the evolution and progression of fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis. Overall, the 15 scientific articles in this Special Issue of the International Journal of Molecular Sciences provide valuable insights into the complex mechanisms governing the EMT process linked to fibrosis and have highlighted the potential of novel therapeutic strategies. In the last few years, the field of EMT has shown considerable promise, and there is still much to be learned. As our understanding continues to grow, we hope that this Special Issue serves as a catalyst for further research and innovation in this developing field.
Download or read book The Epithelial to Mesenchymal Transition EMT in Cancer written by Joëlle Roche and published by MDPI. This book was released on 2018-04-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Download or read book New insights into renal fibrosis and therapeutic effects of natural products volume II written by Dan-Qian Chen and published by Frontiers Media SA. This book was released on 2023-04-19 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Renal Fibrosis Mechanisms and Therapies written by Bi-Cheng Liu and published by Springer. This book was released on 2019-08-09 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
Download or read book Molecular Mechanisms in Chronic Kidney Disease written by Claudia Torino and published by Frontiers Media SA. This book was released on 2021-09-02 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Damage Associated Molecular Patterns in Human Diseases written by Walter Gottlieb Land and published by Springer Nature. This book was released on 2020-09-19 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a continuance of the topic: “DAMPs in Human Diseases”, the basics of which were described in a first volume by the same author. This second volume presents our current understanding of the impact of sterile stress/injury-induced innate immune responses on the etiopathogenesis of human diseases by focusing on those diseases that are pathogenetically dominated by DAMPs, i.e., on polytrauma, various solid organ injuries (brain, lung, kidney, liver), atherosclerosis, and cerebro-cardiovascular diseases. Our growing understanding of the pathogenetic function of activating DAMPs and suppressive DAMPs (“SAMPs”) is used as a point of departure to explore how these molecules can be used as biomarkers to extend and improve current diagnostic and prognostic modalities. Moreover, this new knowledge about the pathogenetic function of DAMPs and SAMPs is taken as a sound and plausible reason for discussing their implications for present and future treatment of the diseases addressed here. In this context, the focus is on the potential of DAMPs as future therapeutic targets and SAMPs as future therapeutics, applied in strict compliance with safety precautions, as also recommended in this work. The book is intended for professionals from all medical and paramedical disciplines who are interested in applying innovative data from inflammation and immunity research to clinical practice. The readership will include practitioners and clinicians working in the broad field of acute and chronic inflammatory/fibrotic diseases, in particular, traumatologists and intensivists; neurologists and neurosurgeons; cardiologists and cardiac surgeons; pulmonologists and thoracic surgeons; vascular surgeons; nephrologists; gastroenterologists and hepatologists; and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses
Download or read book Targeting Cell Survival Pathways to Enhance Response to Chemotherapy written by and published by Academic Press. This book was released on 2018-03-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials
Download or read book Fibrosis Etiology Pathophysiology Measurements and Therapy written by Yuxia Zhao and published by Frontiers Media SA. This book was released on 2023-06-01 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma Volume 2 written by Ganji Purnachandra Nagaraju and published by Academic Press. This book was released on 2022-04-02 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theranostics and Precision Medicine for the Management of Hepatocellular Carcinoma, Volume Two: Diagnosis, Therapeutic Targets and Molecular Mechanisms for Hepatocellular Carcinoma Progression provides comprehensive information about ongoing research and clinical data surrounding liver cancer. The book presents detailed descriptions about diagnostics and therapeutic options for easy understanding, with a focus on precision medicine approaches to improve treatment outcomes. The volume discusses topics such as computational approaches for identification of biomarkers, enzymes and pathways of HCC, circulating and epigenetic biomarkers, drug resistance, metabolic pathways, and small molecule-target therapies. In addition, it discusses immunotherapies, immune check point inhibitors and nanotechnology-based therapies. This book is a valuable resource for cancer researchers, oncologists, graduate students, hepathologists and members of biomedical research who need to understand more about liver cancer to apply in their research work or clinical setting. Provides detailed information on traditional and novel diagnostic tools for hepatocellular carcinoma Discusses promising targeted therapies, both available and in development, explaining the best option to use for specific cases Brings recent findings in immunotherapies, immune checkpoint inhibitors and nanotechnology-based therapeutic approaches for treatment of HCC
Download or read book Diabetic Kidney Disease Routes to drug development pharmacology and underlying molecular mechanisms written by Swayam Prakash Srivastava and published by Frontiers Media SA. This book was released on 2023-09-08 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epithelial mesanchymal Interactions written by Raul Fleischmajer (ed) and published by . This book was released on 1968 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diabetic Nephropathy written by Joris J. Roelofs and published by Springer. This book was released on 2018-10-29 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the most up-to-date research on diabetic nephropathy and the current understanding of its pathogenesis, clinical features and socio-economic developments. Written by leading experts in the field, it provides a comprehensive synthesis of clinical and pathophysiological aspects from a mechanism-based point of view, and reviews evidence-based treatment modalities for the prevention and management of diabetic nephropathy. In addition, closely related areas such as diabesity, diabetic eye disease and macrovascular involvement in diabetes are addressed. Diabetic Nephropathy will be of interest for nephrologists, diabetologists, internists, transplant physicians, public health professionals, basic scientists, geneticists, epidemiologists, pathologists, and molecular and cell biologists working in the field of diabetes and its complications.
Download or read book The Molecular Mechanisms of Chronic Inflammation Development written by Masaaki Murakami and published by Frontiers E-books. This book was released on with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation is critical for the development of many complex diseases and disorders including autoimmune diseases, metabolic syndrome, neurodegenerative diseases, cancers, and cardiovascular diseases. Inflammation comes as two types: chronic inflammation, which can be defined as a dysregulated form of inflammation, and acute inflammation, which can defined as a regulated form. Because of its special role in the aforementioned diseases, establishing methods to control chronic inflammation is important for developing cures and treatments. One challenge for this purpose has been the ability to distinguish chronic and acute inflammation based on molecular biology diagnostics. Thus, this Research Topic is focused on articles that can shed some new light on the molecular mechanisms responsible for the development of chronic inflammation and its related conditions.
Download or read book Chronic Liver Disease New Targets and New Mechanisms written by Jinhang Gao and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
