Download or read book Molecular Mechanism of Peptide Binding to Major Histocompatibility Complex Class I Molecules in the Cellular Context written by Esam Abualrous and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Mechanism of Major Histocompatibility Complex Class I Peptide Binding and Exchange written by Ankur Saikia and published by . This book was released on 2022 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of the Cellular Processes that Generate Peptides for Major Histocompatibility Complex Class I Molecules written by Thomas Francis Serwold and published by . This book was released on 2000 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book MHC Ligands and Peptide Motifs written by Hans-Georg Rammensee and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is centered on a comprehensive list of MHC peptide motifs and ligands as known to date, together with selected T cell epitopes, arranged in an easy-to-read fashion. This information is put into context by chapters on MHC gene organization, MHC structure, T cell epitope prediction, antigen processing and T cell responses. In addition, the book provides a great deal of complementary information: amino acid sequences of MHC class I alpha1 and alpha2 domains and of class II alpha1 and beta1 domains, the established or predicted composition and specificity of MHC pockets, notes on MHC nomenclature including old assignments and reference to useful internet addresses. A handy reference manual that should be helpful for all those dealing with MHC-associated peptides.
Download or read book Antigen Processing and Presentation written by Robert Edward Humphreys and published by . This book was released on 1994 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the few volumes dedicated to antigen processing, this unique text is not only especially current but also valuable for its description of petentially "hot" areas with its "Future Directions" sections. * Current, important topics covered by this text include: Processing and presentation of foreign and self protein antigens to T lymphocytes Intracellular assembley and transport of MHC proteins Regulation of the assembley and expression of processed antigen-MHC complexes
Download or read book Kinetic and Structural Analysis of Class II MHC peptide Complexes written by Michael N. Liang and published by . This book was released on 1997 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A History of Modern Immunology written by Zoltan A. Nagy and published by Academic Press. This book was released on 2013-10-11 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. - Contains the history of major breakthroughs in immunology featured with authenticity and insider details - Gives an insight into personal aspects of the players in the history of immunology - Enables the reader to recognize and select data of heuristic value which elucidate important facets of the immune system - Provides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune system - Gives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine
Download or read book Analysis of Peptide Binding to MHC Class I Molecules and the Function of Tapasin During the Binding Process written by Florian Sieker and published by . This book was released on 2008 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: MHC class I molecules play an important role in the adaptive immune response of mammalian immune systems. Class I molecules are loaded with antigenic peptides inside the endoplasmatic reticulum. After binding a high affinity peptide they are transported to the cell surface where their peptide cargo can be inspected by T-cells. In case the peptide cargo is recognized to be antigenic the T-cell will induce apoptosis of the infected cell. Despite their large structural similarity class I molecules differ in their dependence on tapasin. Tapasin is a chaperone protein and a part of the loading complex which is responsible for facilitating the binding of class I molecules and high affinity peptides. Several studies already revealed that even MHC molecules with almost identical sequences show great differences in their dependence on tapasin. Here I focus on two HLA-B alleles B*4402 and B*4405, respectively. The two alleles differ only at position 116 where the tapasin-dependent allele B*4402 carries an aspartate while the independent allele has a tyrosine. Although there are quite a number of hints for the function of tapasin the mode of action is still not known so far. Here, the difference between the two almost identical alleles was investigated to get an insight into the functioning of tapasin. Molecular dynamics simulations were performed to analyze the binding groove of MHC class I alleles which differ significantly in their tapasin-dependence with a high spatial and time resolution. Results suggested that one possible function of tapasin lies in stabilizing the alpha-2-1-helix which is next to the C-terminus of a bound peptide and near a proposed tapasin binding region at position 134.
Download or read book Pioneer Round of Translation Supplies Peptides for Major Histocompatibility Complex Class I Presentation written by Keling Chen and published by . This book was released on 2013 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytotoxic T cells monitor MHC class I complexes on antigen presenting cells for the potential presence of any non-self peptides that could derive from viral infection or cancerous cells. Effective immune surveillance requires that MHC class I molecules display a peptide repertoire on the surface representing all cellular proteins. This ensures that foreign antigens from all sources are presented. How the peptide repertoire can be comprehensive despite the large differences in abundance and stability of individual proteins is not known. The pioneer round of translation is the first round of translation that occurs on newly spliced mRNA. It is associated with nonsense-mediated decay of mRNAs, allowing cells to detect and eliminate the aberrant mRNAs containing premature stop codons. We showed here that the peptide presentation by MHC I molecules was strongly influenced by the pioneer round of translation. Inhibition of the pioneer round of translation by knockdown of CBP80, a nuclear cap-binding protein, reduced peptide presentation by MHC class I molecules on the cell surface without affecting global protein synthesis. On the other hand, introduction of premature stop codons changed mRNA stability without affecting peptide presentation by MHC I on the cell surface. In addition, intronless mRNAs bypassing the pioneer round of translation resulted in reduced MHC I presentation on the cell surface. Furthermore, knockdown of CBP80 led to the deficiency of the cytosolic peptides delivered by the transporter associated with antigen processing (TAP) for the MHC class I pathway. Together, these findings highlight the importance of the pioneer round of translation in deriving peptides to generate a comprehensive display of virtually all endogenous proteins for the immune surveillance.
Download or read book Primary Immunodeficiency Diseases written by Hans D. Ochs and published by . This book was released on 2007 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
Download or read book The HLA FactsBook written by Steven G.E. Marsh and published by Elsevier. This book was released on 1999-12-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists Up-to-date, complete listing of HLA alleles Invaluable reference resource for immunologists, geneticists, and cell biologists Combines both structural and functional information, which has never been compiled in a single reference book previously Serological specificity of allotypes Identity of material sequenced including ethnic origin Database accession numbers Population distribution Peptide binding specificities T cell epitopes Amino acid sequences of allotypes Key references
Download or read book The Influence of Tapasin on MHC Class I peptide Interaction written by Praveen Pudiavettil Tayakuniyil and published by . This book was released on 2009 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since peptide-empty MHC class I molecules at the cell surface would be inefficient and probably dangerous for cells, class I molecules must select peptides with dissociation rates that are sufficiently slow to allow survival of the peptide-class I complex during the transit to the cell surface and for some time thereafter. Elliott and collaborators have shown that class I molecules, however, first bind low-affinity peptides in the ER and later exchange them for high-affinity ones before leaving for the Golgi apparatus (Williams et al., 2002). This process, termed peptide editing, depends on the class I - specific assembly factor, tapasin, which binds directly to class I molecules in the ER. How does tapasin work? Based on our molecular dynamics simulations (Zacharias and Springer, 2004), we hypothesize that it may bind to and deform the peptide binding site of class I molecules by moving one flexible helix away from the peptide. As a consequence, some of the hydrogen bonds between the class I molecule and the peptide backbone may break and reduce the affinity between peptide and class I molecule. This would lead to a rapid dissociation of low-affinity peptides from the class I molecule. As a conclusion, this hypothesis predicts that tapasin universally decreases the affinity of class I molecules for peptide ligands. Since it is difficult to recreate the entire class I loading complex with purified proteins (it contains several other chaperones), we are investigating peptide binding to class I molecules in the lumen of isolated microsomal membranes in the presence and absence of tapasin. Class I molecules are transcribed, translated, and translocated in vitro. Peptide is then added to the microsomes, and peptide-class I complexes are precipitated by conformation-specific antibodies. We have observed that tapasin mediates the binding of high-affinity peptide to MHC class I molecules in the ER by accelerating dissociation of low-affinity peptides.
Download or read book Indoor Allergens written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.
