Download or read book Molecular Force Sensors written by Rachel Bender and published by American Chemical Society. This book was released on 2022-03-09 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular force sensors are a powerful tool for studying the mechanics of cells. These sensors not only provide information on the general mechanical behavior of cells but also can help elucidate the mechanical markers of disease formation and progression. For example, can we use cell mechanics as a biomarker to diagnose cancer? What are the mechanics associated with immune system function? Can cell mechanics be used to better understand the effect of drug treatments? The number of available questions in the field of mechanobiology is endless. After reading this e-book, you will be equipped with the information needed to begin designing your own molecular force sensors, and to begin answering the multitude of questions surrounding cell mechanobiology.
Download or read book Stromal Signaling in Cancer written by and published by Academic Press. This book was released on 2022-04-20 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stromal Signaling in Cancer, Volume 154 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics surrounding cancer research. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Advances in Cancer Research series - Updated release includes the latest information on Stromal Signaling in Cancer
Download or read book Molecular Sensors and Nanodevices written by John X. J. Zhang and published by Academic Press. This book was released on 2018-11-19 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical Engineering, Second Edition is designed to be used as a foundational text, aimed at graduates, advanced undergraduates, early-career engineers and clinicians. The book presents the essential principles of molecular sensors, including theories, fabrication techniques and reviews. In addition, important devices and recently, highly-cited research outcomes are also cited. This differentiates the book from other titles on the market whose primary focus is more research-oriented and aimed at more of a niche market. - Covers the fundamental principles of device engineering and molecular sensing, sensor theories and applications in biomedical science and engineering - Introduces nano/micro fabrication techniques, including MEMS, bioMEMS, microTAS and nanomaterials science that are essential in the miniaturization of versatile molecular sensors - Explores applications of nanomaterials and biomaterials, including proteins, DNAs, nanoparticles, quantum dots, nanotubes/wires and graphene in biomedicine
Download or read book The Cytoskeleton in T Cell Migration and Activation written by Jerome Delon and published by Frontiers Media SA. This book was released on 2022-11-16 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanobiology written by Ronen Zaidel-Bar and published by Springer Nature. This book was released on 2023-01-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book collects methodologies exploring mechanobiology, the involvement of mechanical forces in cell fate specification and in controlling single and collective cell behaviors such as directed migration, morphogenesis, wound healing, and the immune response. The volume features methods to quantify the mechanical properties of cells and adhesion proteins, to expose cells to external mechanical forces, to quantitatively characterize mechano-responses at various scales, to measure forces applied by cells on the extracellular matrix, as well as chapters on force measurement inside cells, probing cell signaling and gene expression in response to force, and biophysical modeling of cell shape and protein dynamics. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary material and reagents, step-by-step and readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Mechanobiology: Methods and Protocols aims to provide meaningful tools for cell and developmental biologists approaching the study of cell and tissue dynamics from a mechanobiological perspective, molecular biologists interested in the effects of force on proteins, as well as for cancer biologists and biophysicists.
Download or read book Functional Tactile Sensors written by Ye Zhou and published by Woodhead Publishing. This book was released on 2021-01-20 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional Tactile Sensors: Materials, Devices and Integrations focuses on the subject of novel materials design and device integration of tactile sensors for functional applications. The book addresses the design, materials characteristics, device operation principles, specialized device application and mechanisms of the latest reported tactile sensors. The emphasis of the book lies in the materials science aspects of tactile sensors—understanding the relationship between material properties and device performance. It will be an ideal resource for researchers working in materials science, engineering and physics. - Includes the latest advances and recent developments in tactile sensors for artificial intelligence applications - Reviews the relationship between materials properties and device performance - Addresses materials and device design strategies for targeted sensing applications
Download or read book Vascular Engineering written by Kazuo Tanishita and published by Springer. This book was released on 2016-03-17 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
Download or read book Cellular Mechanics and Biophysics written by Claudia Tanja Mierke and published by Springer Nature. This book was released on 2020-10-30 with total page 919 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the mechanical properties of cells, discussing the basic concepts and processes in the fields of immunology, biology, and biochemistry. It introduces and explains state-of-the-art biophysical methods and examines the role of mechanical properties in the cell/protein interaction with the connective tissue microenvironment. The book presents a unique perspective on cellular mechanics and biophysics by combining the mechanical, biological, physical, biochemical, medical, and immunological views, highlighting the importance of the mechanical properties of cells and biophysical measurement methods. The book guides readers through the complex and growing field of cellular mechanics and biophysics, connecting and discussing research findings from different fields such as biology, cell biology, immunology, physics, and medicine. Featuring suggestions for further reading throughout and addressing a wide selection of biophysical topics, this book is an indispensable guide for graduate and advanced undergraduate students in the fields of cellular mechanics and biophysics.
Download or read book Gas Sensors written by Sher Bahadar Khan and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the applications of nanomaterials in the fabrication of gas sensors. It covers recent developments of different materials used to design gas sensors, such as conducting polymers, semiconductors, as well as layered and nanosized materials. The widespread applications of various gas sensors for the detection of toxic gases are also discussed. The book provides a concise but thorough coverage of nanomaterials applications and utilization in gas sensors. In addition, it overviews recent developments in and the fabrication of gas sensors and their attributes for a broad audience, including beginners, graduate students, and specialists in both academic and industrial sectors.
Download or read book Mechanical Unfolding Response of Proteins written by Ionel Popa and published by American Chemical Society. This book was released on 2023-06-16 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanical Unfolding Response of Proteins is a thermodynamically motivated overview of when, why, and how proteins respond to mechanical perturbations and the experimental techniques used to probe single protein biophysics. Relative newcomers to the field (new graduate students), and those starting from a biological background hoping for an introduction to the physics behind protein behavior, will benefit from reading this primer.
Download or read book Thermal Sensors written by León Islas and published by Academic Press. This book was released on 2014-10-28 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume presents an up to date presentation of current knowledge and problems in the field of thermal receptors. This is a rapidly evolving research area and the book contains important contributions from some of the leaders in the field. - Written by leading experts - Contains original material, both textual and illustrative, that should become a very relevant reference material - The material is presented in a very comprehensive manner - Both researchers in the field and general readers should find relevant and up-to-date information
Download or read book Mechanobiology written by Glen L. Niebur and published by Elsevier. This book was released on 2019-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology: From Molecular Sensing to Disease will provide a review of the current state of understanding of mechanobiology and its role in health and disease. It covers: Current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli, A review of diseases that with known or purported mechanobiological underpinnings; The role of mechanobiology in tissue engineering and regenerative medicine; Experimental methods to capture mechanobiological phenomena; Computational models in mechanobiology. - Presents our current understanding of the main molecular pathways by which cells sense and respond to mechanical stimuli - Provides a review of diseases with known or purported mechanobiological underpinnings - Includes the role of mechanobiology in tissue engineering and regenerative medicine - Covers experimental methods to capture mechanobiological phenomena
Download or read book The Influence of Substrate Elasticity and Shear Rate on Human Blood Platelet Contraction written by Jana Hanke and published by Göttingen University Press. This book was released on 2018 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human blood platelets are small, anucleate cell fragments that are important for the life-saving mechanism of haemostasis, i.e. the process to prevent a haemorrhage. Upon injury, blood platelets adhere to the exposed extra-cellular matrix and spread, clot and contract to close the wound. This process has to work reliably in a multitude of different environments, including surrounding tissues of various stiffnesses as well as the exposure of different shear flows due to blood circulation. In the present work, the reaction of human blood platelets to such environments is reported. Specifically, the spatial and temporal contraction behaviour of platelets and its variation is studied in response to elastic substrates within the stiffness range of 19 kPa to 83 kPa and shear rates between 14 s^(-1) and 33 s^(-1), corresponding to shear rates as found in larger veins. To be able to visualise and analyse the contraction of the platelets, time-resolved traction force microscopy was employed together with a specifically tailored differential particle image velocimetry method and a microfluidic system. It was found that platelets exhibit very dynamic contractile behaviour as well as comparatively high forces in the light of their small size. The experimental results showed that platelets are not mechanosensitive within the studied stiffness or shear rate ranges. This was observed both in the spatial and temporal force development as well as the final spread area reached by the platelets. The force was, instead, depending on the spread area. By modelling the cell as an elastic, actively contracting disc and fitting this model to the dependency of the force on the area for data collected on various stiffnesses, it was concluded that due to their small size, platelets are only mechanosenstive to substrates of at least one order of magnitude softer than used here. Under flow conditions, it was shown that platelets do indeed adapt to the direction of the flow. Here, the preferred orientation of the contraction in comparison to the flow direction changed from 45° for the lower flow rates to roughly 90° for the highest shear rate. To understand this result, the stress distribution on the platelets’ surface under flow was simulated, demonstrating the highest stress to be found roughly at 90°. Hence, the reported orientation of the contraction is accounted for by the reduction of stress on the force-transmitting network of the platelet connected to the underlying substrate. In conclusion, platelets are mechanoinsensitive to a multitude of different environments, indicating an ‘all-or-nothing’ response to such cues.
Download or read book Tip Based Nanofabrication written by Ampere A. Tseng and published by Springer Science & Business Media. This book was released on 2011-07-25 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanofabrication is critical to the realization of potential benefits in the field of electronics, bioengineering and material science. One enabling technology in nanofabrication is Tip-Based Nanofabrication, which makes use of functionalized micro-cantilevers with nanoscale tips. Tip-Based Nanofabrication: Fundamentals and Applications discusses the development of cantilevered nanotips and how they evolved from scanning probe microscopy and are able to manipulate environments at nanoscale on substrates generating different nanoscale patterns and structures. Also covered are the advantages of ultra-high resolution capability, how to use tip based nanofabrication technology as a tool in the manufacturing of nanoscale structures, single-probe tip technologies, multiple-probe tip methodology, 3-D modeling using tip based nanofabrication and the latest in imaging technology.
Download or read book Cardiac Mechano Electric Coupling and Arrhythmias written by Peter Kohl and published by OUP Oxford. This book was released on 2011-08-25 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction. Information is grouped into logical sections, from molecular mechanisms, to cell, tissue and whole organ responses, right through to patient-based observations and insight emerging from clinical trials. The information provided carefully highlights both consensus insight and current shortcomings in our understanding of cardiac mechano-electric coupling. The book has been thoroughly revised and expanded since publication of the first edition in 2005, extensively updated to reflect recent developments in the field, and now offers a more balanced view of mechano-electrical interactions in the heart and develops a more clinical focus. Written with the practising cardiologist and junior doctor in mind, it offers interesting new insight for the established physician with an interest in cardiac arrhythmogenesis and heart rhythm management.
Download or read book Molecular Architectonics written by Takuji Ogawa and published by Springer. This book was released on 2017-07-06 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book draws on the main themes covered during the International Workshop on Molecular Architectonics which took place in Shiretoko, Japan from August 3 to 6, 2015. The concepts and results explored in this book relate to the term “molecular architectonics” which stands for electronic, optical and information-processing functions being orchestrated by molecular assemblies. This area is defined as the third stage of single-molecule electronics and builds on stage one, where measurements were performed on single-molecule layered films, and stage two, the resulting quantitative analyses. In this work, experts come together to write about the most important aspects of molecular architectonics. This interdisciplinary, visionary and unique book is of interest to scientists working on electronic materials, surface science and information processing sciences using noise and fluctuation.
Download or read book Biomechanics in Oncology written by Cheng Dong and published by Springer. This book was released on 2018-10-27 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
