Download or read book Modified Cascade Impactor written by University of Rochester and published by . This book was released on 194? with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Production Design of the Modified Cascade Impactor written by S. Laskin and published by . This book was released on 1950 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cascade Impactor Network written by Robert E. Lee and published by . This book was released on 1972 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cascade Impactor written by James P. Lodge and published by Amer Industrial Hygiene Assn. This book was released on 1986 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Procedures for Cascade Impactor written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design and calibration of an improved cascade impactor for size analysis of aerosols written by and published by . This book was released on 1957 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book WADC Technical Report written by United States. Wright Air Development Division and published by . This book was released on 1956 with total page 1746 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Good Cascade Impactor Practices AIM and EDA for Orally Inhaled Products written by Terrence P. Tougas and published by Springer Science & Business Media. This book was released on 2013-04-10 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this publication is to introduce a new, simpler and more effective way in which to interpret pharmaceutical aerosol particle size data from orally inhaled products (OIPs). Currently, the compendial and regulatory requirements dictate the need for measurements by full resolution multi-stage cascade impactor (CI), a process that is demanding for the operator, time consuming, prone to experimental error, and challenging for method transfers from one laboratory to another. Furthermore, we shall show that the current practice of reducing information from mass-weighted aerodynamic particle size distribution (APSD) measurements through the use of CI stage groupings is not the most effective decision-making tool for OIP quality control (QC) in comparison with newly introduced, mutually-independent efficient data analysis (EDA) metrics that can be derived either from full resolution or abbreviated impactor measurements (AIM).

Download or read book Development of a Cascade Impactor System for Sampling 0 02 to 20 Micron Diameter Particles written by and published by . This book was released on 1978 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Field Evaluation of a Personal Cascade Impactor Sampler PCIS written by Manisha Singh and published by . This book was released on 2003 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cascade Impactor Sampling and Data Analysis written by Lodge Jr JP Ed and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characteristics of a Perforated Plate Cascade Impactor written by Douglas Gray (C.) and published by . This book was released on 1974 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Andersen Personal Cascade Impactor Performance with Toner Dust written by Rita J. White and published by . This book was released on 1991 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stage Response of an Andersen Cascade Impactor to Monodisperse Droplets written by D. J. Rader and published by . This book was released on 1989 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cascade impactor network written by Robert E. Lee and published by . This book was released on 1972 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Influence of Electrostatic Charge Upon the Deposition Behavior of Pharmaceutical Aerosols Within Cascade Impactors written by Megha Mohan and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cascade impactors, routinely used for in vitro particle size characterization of pharmaceutical aerosols, are calibrated using dilute, charge-neutralized, monodisperse aerosols. But pharmaceutical aerosols are known to generate concentrated, inherently charged, polydisperse aerosol clouds. A computational model of the Andersen Cascade Impactor (ACI) suggested that the presence of charge on aerosol particles may influence their deposition within the ACI, but experimental validation of the model is warranted. This dissertation investigates the influence of electrostatic charge upon the deposition behavior of aerosols within cascade impactors, to address the impact of charge on particle size characterization. The influence of applied charge upon the deposition pattern and aerodynamic particle size distribution (APSD) of commercially available pressurized metered dose inhalers (pMDIs) within the Electrical Low Pressure Impactor (ELPI) was examined. Electrostatic properties were modified using an external voltage source in conjunction with the ELPI corona charger and observed to be dependent on the formulation and device packaging. Induced artificial charge on the aerosol particles influenced the deposition pattern within the impactor, but did not result in a significant change in the apparent APSD. An experimental apparatus capable of producing charge neutralized and charged aerosol, with targeted deposition on the CFD predicted "charge sensitive" ACI stages, was developed. In vitro results were observed to be in partial agreement with the CFD predictions. While charge influenced the deposition pattern in the ACI with increased deposition observed in the charger and on the upper stages of the ACI, it did not influence the apparent APSD of the aerosol. Electrostatic charge effects on deposition behavior within cascade impactors were delineated with respect to space charge and image charge effects by investigating the influence of impactor grounding, particle size, stage coating and loading. While the deposition pattern within the ACI was influenced by charge, only stage coating and stage loading resulted in a small, significant difference in the apparent APSD, which may not be practically relevant due to the variability associated with in vitro aerosol testing. Similar trends were observed in the deposition behavior of charge neutralized and charged aerosol within an abbreviated ACI system compared to the full resolution ACI.

Download or read book Advanced Data Inversion Applied to Cascade Impactor Data written by Eric Jayjock and published by . This book was released on 2011 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, there is a lack of an FDA approved bio-equivalence test for generic aerosol drug products. The prime candidate for such a test is a device known as the cascade impactor. The cascade impactor uses a momentum-based impaction mechanism to classify incoming aerosols into different size bins. As the deposition of an aerosol in the lung is also driven by a momentum-based impaction, in principle, the cascade impactor is expected to be ideally suited for the task. In practice the cascade impactor has been limited by a major shortcoming: it does not sharply divide incoming aerosol into various size bins. To make impactors as accurate as possible, the current development methodology uses data from computational fluid dynamics (CFD) models to produce stages with maximally sharp cut-off sizes. However, these models do not account for the propensity for solid particles to rebound off the collection plate. As a result, cascade impactors have fairly straight impaction curves, but these curves come at the cost of increased variability. It is hypothesized that a superior impactor could be created by eliminating particle bounce, and then developing methods to accurately recover the data for the non-ideal impactor stage performance. In this work, tools are developed to help make such a device a reality. First, two inference-based inversion techniques, maximum entropy and fisher information, are formulated for use with the cascade impactor and tested with a model Andersen Cascade Impactor. Both techniques are shown to be capable of recovering accurate distributions from non-ideal impactors. The maximum entropy technique is found to be mathematically less complex, but also less accurate. The fisher information technique demonstrated superior accuracy, but it is much more mathematically complex and difficult to implement. For both inversion techniques, the relationship between neighboring impactor stages is found to be important to the accuracy of the inversion technique. In the second part, the ability of CFD tools to predict the impactor curve shape was tested. It was found that this approach lead to an over prediction of the sharpness of the impactor curves.