Download or read book Models for Prostate Cancer Pcbr written by Daniel Murphy and published by . This book was released on 1980-03 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Prostate Cancer Model Systems Molecular and Cellular Mechanisms Early Detection and Therapies written by Tanya I. Stoyanova and published by Frontiers Media SA. This book was released on 2022-08-08 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumor Immunotherapy in the RM 1 Mouse Model of Prostate Cancer written by Julieanne Francine Grant and published by . This book was released on 2007 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most frequently diagnosed noncutaneous cancer among men and a leading cause of cancer deaths. No curative treatment exists for hormone resistant prostate cancer, but immunotherapy has the potential to prevent disease recurrences and to destroy metastases. We investigated the efficacy of immunotherapy in the RM-1 model of prostate cancer. RM-1 cells are aggressive, non-immunogenic mouse prostate cancer cells that express very little MHC I, similar to many human prostate cancers. Our goal was to develop a whole cell tumor vaccine that would generate a protective T cell-dependent antitumor response.
Download or read book Defeating Prostate Cancer written by National Cancer Institute (U.S.). Prostate Cancer Progress Review Group and published by . This book was released on 1998 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stem Cells and Prostate Cancer written by Scott D. Cramer and published by Springer Science & Business Media. This book was released on 2013-04-12 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent evidence demonstrates that normal prostate tissue contains stem cells. There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells. Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer. The purpose of this book is to explore the role of stem cells in prostate cancer, which is becoming an increasingly hot trend in cancer research.
Download or read book A Micro Simulation Model of the Benefits and Costs of Prostate Cancer Screening and Treatment written by and published by . This book was released on 2002 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: This idea development award developed a micro-simulation model of prostate cancer screening and treatment. As described in our initial proposal, we developed an detailed model of the natural history, screening, and treatment of prostate cancer organized around a Markov model that incorporated true stage and grade of tumor, misclassification of tumors that generates discrepancies between clinical and true stage, and other innovative features that had been neglected in prior models. We also extended the model to account for persistent heterogeneity that would not be adequately modeled by usual Markov models. We also did a detailed structured literature review to estimate key parameters of our model and developed new techniques to estimate the parameters of the natural history model by fitting it to aggregate and individual-level data from the SEER program. Our baseline analysis suggests that screening and treatment will increase life expectancy but decrease quality-adjusted life expectancy. Potential gains are largest in men ages SO-70 and when undiagnosed cancer creates substantial anxiety. We published a paper based on some initial analyses of treatment patterns, have a main cost-effectiveness manuscript in progress, and received ROl funding from the National Cancer Institute to further extend this work.
Download or read book Prostate Cancer written by Philippe E. Spiess and published by BoD – Books on Demand. This book was released on 2011-11-25 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present textbook highlights many of the exciting discoveries made in the diagnosis and treatment of prostate cancer over the past decade. International thought leaders have contributed to this effort providing a comprehensive and state-of-the art review of the signaling pathways and genetic alterations essential in prostate cancer. This work provides an essential resource for healthcare professionals and scientists dedicated to this field. This textbook is dedicated to the efforts and advances made by our scientific community, realizing we have much to learn in striving to some day in the not too distant future cure this disease particularly among those with an aggressive tumor biology.
Download or read book Optimizing Local Therapy for High Risk Prostate Cancer Evidence and Emerging Options written by Timothy Showalter and published by Frontiers Media SA. This book was released on 2020-10-30 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Prostate Cancer written by Chawnshang Chang and published by World Scientific. This book was released on 2005 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the second leading cause of death in men and its progression is highly dependent on androgens and androgen receptors. However, even with treatment, eventually most prostate cancers progress. Studies of the mechanisms behind this progression leads to advances in treatments for androgen-related diseases. Our book discusses recent prostate cancer research which include the following topics: immunotherapy and chemotherapy; radiation, gene, hormonal, and androgen ablation therapies; basic mechanisms behind prostate cancer growth; how mechanisms can be used to treat prostate cancer; and research in newly developed mouse model systems. This book should be of interest as both a study guide and research reference to students, basic scientists, and clinicians.
Download or read book Development of a Transgenic Stem Cell Model of Prostate Cancer written by Robert E. Reiter and published by . This book was released on 1999 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall goal of our proposal is to develop a new transgenic model of prostate cancer by targeting transformation to prostatic basal cells using the prostate stem cell antigen promoter (PSCA). A 9kb region upstream of the PSCA coding sequence was isolated and demonstrated to drive prostat-specific expression in vitro. This region was subsequently tested in vivo using a GFP reporter construct. Analysis of the PSCA promoter-GFP transgenic mice have demonstrated relatively prostate-specific expression of GFP. GFP expression in these mice is regulated developmentally, with prominent expression localized to the ductal tips of the prostate. Promoter activity appears to be androgen responsive and androgen independent. The PSCA promoter can drive target gene expression to the prostate of mice. Expression is restricted to a subset of prostatic cells, potentially the progenitor cells of the prostate. We are currently using this promoter to create new transgenic models of prostate cancer.
Download or read book Development and Characterization of an in Vitro Model of Prostate Cancer Progression written by Colin R. Soares and published by . This book was released on 2002 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Prostate Cancer written by Sam S. Chang and published by Springer. This book was released on 2018-05-10 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most frequent genitourinary malignancy that garners significant medical and media attention. Over the past decade significant new discoveries have been made that have enabled substantial improvements in screening, diagnosis and management of this disease. Importantly, there has been constant evolution of the best way to treat these patients. This text will provide a single, comprehensive reference source that incorporates all the latest information regarding prostate cancer. It will serve as an easy reference source for researchers, clinicians, individuals in training, allied health professionals and medical students regarding prostate cancer by focusing on the controversial points of debate. New data regarding PSA screening, prostate cancer biomarkers, diagnostic evaluation techniques, surveillance protocols, and treatment interventions for localized and more advanced disease will be discussed. Gaps in current knowledge and areas for future research will be highlighted. Ongoing important clinical trials which could imminently yield significant new knowledge will be discussed. Uniquely to all of the above will be the clinical scenario-based format of this text. For the practicing physician, the prostate cancer screening and treatment situations will hopefully become better understood. We will incorporate key educational concepts in the framework of patient situations with evidence-based discussions of screening, diagnosis, evaluation, and therapeutic management. To provide even more insight, we plan on a comment section from leaders in the field that will be more “opinion-based” allowing the reader to get access to experienced physicians’ thought processes and practice patterns. All chapters will be authored by experts in their respective fields and incorporate original figures and illustrations to the extent possible. We anticipate that this book will quickly become the ready reference source for professionals and students in various fields with an interest in the management of a complex and multifaceted disease such as prostate cancer. The book will be comprehensive and encompass the entire the spectrum of prostate cancer. The information will be presented in a succinct and easily understandable manner so as to appeal to both scientists and clinicians.
Download or read book Prostate Cancer New Horizons in Research and Treatment written by Michael L. Cher and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the pace of research in prostate cancer has increased dramatically. Creative ideas in combination with new and emerging technologies have led to an explosion of discovery. These types of advances in prostate cancer research presage an era of new treatment strategies based on an understanding of the cellular and molecular mechanisms of disease. In creating this book, we aimed to cover a broad "bench to bedside" research spectrum ranging from: genetic, molecular and cellular analyses to epidemiological studies, refinements in local treatment strategies and new biologically based non-hormonal treatments for systemic disease. Researchers and clinicians will find in this book a group of timely and clinically relevant chapters on prostate cancer research and treatment.
Download or read book The Exploration and Computations of Mathematical Models of Intermittent Treatment for Prostate Cancer written by Alacia Voth and published by . This book was released on 2012 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer written by Donald S. Coffey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings emanate from the Second Prouts Neck Conference on prostate cancer held on October 17-19, 1986, the theme of which was treat ment, with focus on current issues and future research that is needed to answer critical questions related to optimal management of the various stages of prostate cancer. The objective was to reveal the most crucial problems impeding progress and to crystallize the combined multidisci plinary input generated by the conference into focused concepts or recommendations for presentation to the National Cancer Institute (NCI) , with the ultimate intent of targeting research to address the priority issues identified. In organizing the workshop, every effort was made to maintain a multidisciplinary balance among nationally renowned authorities on prostate cancer. Thus, leading surgeons, radiation and medical onco logists and biostatisticians were in equal presence. While there were spirited exchanges with careful scrutiny and critique of all data pre sented, there was a common belief that the challenge of prostate cancer would be best approached in this multidisciplinary Organ Systems-oriented fashion. During the course of the conference, it became apparent to all present that major nomenclature and procedural barriers have made it generally difficult, and frequently impossible, to compare results of clinical research.
Download or read book Adenocarcinoma of the Prostate written by Andrew W. Bruce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.
Download or read book Development of Internet Accessible Prediction Models for Prostate Cancer Diagnosis Treatment and Follow Up written by and published by . This book was released on 2003 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of the development of Internet-accessible prediction models is to enhance the diagnosis accuracy, treatment efficacy and prognosis for patients with carcinoma of prostate cancer (CaP). On the basis of the established tools (Oracle database, Internet-accessible data collection applications, and program packages for data retrieval and standardization) in the first year of the support, the roles of a set of variables (race/ethnicity, diagnostic age, labs, delayed treatment interval, treatment types, early and late hormonal therapy, etc.) on the outcome of CaP patients were analyzed. The results show that delayed surgery over 3 months post diagnosis would impact the outcome of patients with high risk disease (submitted to J Urol). Early hormonal therapy can delay clinical metastasis only in men with high risk disease (J Urol, in press). Race, percentage of cancer positive cores over total biopsy cores, surgical margin status and seminal vesicle invasion are independent prognostic variables for men with intermediate risk disease (submitted to J Urol). Race plays an important role in tumor volume and spatial distribution based on 3 dimensional reconstructed models with radical prostatectomy specimens (submitted to J Urol). Post- treatment PSA doubling time
