Download or read book Modeling of Electrophysiology and Tension Development in the Human Heart written by Gunnar Seemann and published by . This book was released on 2005 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modeling of electrophysiology and tension development in the human heart written by and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehension of the beating of the human heart is important for cardiac research and will improve many clinical applications. Simulations based on models describing cardiac electro-mechanics can acquire insights into this behavior. This work focuses on the mathematical reconstruction of electrophysiology, excitation conduction, and tension development in the human heart on the cellular and the tissue level. The tissue models represent accurate anatomical shapes of the atria and the ventricles and incorporate electrophysiological heterogeneity and anisotropic conduction. The simulations comprehend the physiological behavior of the ventricles and of the atrium including the sinoatrial node as well as pathological cases like ventricular and atrial fibrillation and genetic defects in ionic channels.
Download or read book Computational Cardiology written by Frank B. Sachse and published by Springer. This book was released on 2005-01-12 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to computer-based modeling in cardiology, by taking an educational point of view, and by summarizing knowledge from several, commonly considered delimited areas of cardiac research in a consistent way. First, the foundations and numerical techniques from mathematics are provided, with a particular focus on the finite element and finite differences methods. Then, the theory of electric fields and continuum mechanics is introduced with respect to numerical calculations in anisotropic biological media. In addition to the presentation of digital image processing techniques, the following chapters deal with particular aspects of cardiac modeling: cardiac anatomy, cardiac electro physiology, cardiac mechanics, modeling of cardiac electro mechanics. This book was written for researchers in modeling and cardiology, for clinical cardiologists, and for advanced students.
Download or read book Modeling Human Atrial Patho Electrophysiology from Ion Channels to ECG Substrates Pharmacology Vulnerability and P Waves written by Loewe, Axel and published by KIT Scientific Publishing. This book was released on 2016-08-03 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.
Download or read book Cardiac Electrophysiology Methods and Models written by Daniel C. Sigg and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.
Download or read book Multiscale Modeling of Cardiac Electrophysiology Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment written by Mathias Wilhelms and published by KIT Scientific Publishing. This book was released on 2014-05-22 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Download or read book Functional Imaging and Modeling of the Heart written by Alejandro F. Frangi and published by Springer Science & Business Media. This book was released on 2005-05-31 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the Third International Workshop on Functional Imaging and Modeling of the Heart, FIMH 2005, held in Barcelona, Spain in June 2005. The 47 revised full papers presented were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on modeling of the heart: anatomy extraction and description; electro-physiology and electro- and magnetography; modeling of the cardiac mechanisms and functions; and cardiac motion estimation.
Download or read book Multiscale Modeling of the Ventricles written by David Urs Josef Keller and published by KIT Scientific Publishing. This book was released on 2014-08-22 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is focused on different aspects within the loop of multiscale modeling: On the cellular level, effects of adrenergic regulation and the Long-QT syndrome have been investigated.On the organ level, a model for the excitation conduction system was developed and the role of electrophysiological heterogeneities was analyzed.On the torso level a dynamic model of a deforming heart was created and the effects of tissue conductivities on the solution of the forward problem were evaluated
Download or read book Mathematically Modelling the Electrical Activity of the Heart written by Andrew J. Pullan and published by World Scientific. This book was released on 2005 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book on modelling the electrical activity of the heart is an attempt to describe continuum based modelling of cardiac electrical activity from the cell level to the body surface (the forward problem), and back again (the inverse problem). Background anatomy and physiology is covered briefly to provide a suitable context for understanding the detailed modelling that is presented herein. The questions of what is mathematical modelling and why one would want to use mathematical modelling are addressed to give some perspective to the philosophy behind our approach. Our view of mathematical modelling is broad ? it is not simply about obtaining a solution to a set of mathematical equations, but includes some material on aspects such as experimental and clinical validation.
Download or read book Introduction to Computational Cardiology written by Boris Ja. Kogan and published by Springer Science & Business Media. This book was released on 2009-12-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Computational Cardiology provides a comprehensive, in-depth treatment of the fundamental concepts and research challenges involved in the mathematical modeling and computer simulation of dynamical processes in the heart, under normal and pathological conditions. About this textbook: - Presents descriptions of models used in both biology and medicine for discovering the mechanisms of heart function and dysfunction on several physiological scales across different species. - Provides several examples throughout the textbook and exercises at the end which facilitate understanding of basic concepts and introduces, for implementation, treated problems to parallel supercomputers. Introduction to Computational Cardiology serves as a secondary textbook or reference book for advanced-level students in computer science, electrical engineering, biomedical engineering, and cardiac electrophysiology. It is also suitable for researchers employing mathematical modeling and computer simulations of biomedical problems.
Download or read book Modified Mass spring System for Physically Based Deformation Modeling written by Oussama Jarrousse and published by KIT Scientific Publishing. This book was released on 2014-09 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass-spring systems are considered the simplest and most intuitive of all deformable models. They are computationally efficient, and can handle large deformations with ease. But they suffer several intrinsic limitations. In this book a modified mass-spring system for physically based deformation modeling that addresses the limitations and solves them elegantly is presented. Several implementations in modeling breast mechanics, heart mechanics and for elastic images registration are presented.
Download or read book Personalized Multi Scale Modeling of the Atria Heterogeneities Fiber Architecture Hemodialysis and Ablation Therapy written by Martin Wolfgang Krüger and published by KIT Scientific Publishing. This book was released on 2014-05-22 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book targets three fields of computational multi-scale cardiac modeling. First, advanced models of the cellular atrial electrophysiology and fiber orientation are introduced. Second, novel methods to create patient-specific models of the atria are described. Third, applications of personalized models in basic research and clinical practice are presented. The results mark an important step towards the patient-specific model-based atrial fibrillation diagnosis, understanding and treatment.
Download or read book ECG Based Analysis of the Ventricular Repolarisation in the Human Heart written by Baas, Tobias and published by KIT Scientific Publishing. This book was released on 2012-08-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: ECG recordings provide diagnostic relevant information on the de- and repolarisation sequences of the heart. A modification of the repolarisation sequence is assumed to cause Torsades de Pointes. Especially drug induced effects on the repolarisation processes are in focus, since some non-cardiac drugs have been associated with sudden cardiac death in the 1990s.The analysis of the ventricular repolarisation using a set of parameters depicting the morphology of the T-wave is introduced in this work. Therefore, new methods of fully automatic patient-specific QRS detection, beat classification and precise T-wave delineation are presented. Using these methods, medical studies are investigated regarding the modification of the T-wave by different compounds. Also the impact of the heart rate on the morphology of the T-wave is part of this research.The reliable identification of ventricular ectopic beats allows an analysis of the influence of these beats on subsequent heart beats. It turned out that the morphology of subsequent heart beats can significantly be changed. This might give new information on the proarrythmical risk of ventricular ectopic beats.
Download or read book Formation of Intracardiac Electrograms under Physiological and Pathological Conditions written by Keller, Matthias and published by KIT Scientific Publishing. This book was released on 2014-09-09 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents methods to advance electrophysiological simulations of intracardiac electrograms (IEGM). An experimental setup is introduced, which combines electrical measurements of extracellular potentials with a method for optical acquisition of the transmembrane voltage in-vitro. Thereby, intracardiac electrograms can be recorded under defined conditions. Using experimental and clinical signals, detailed simulations of IEGMs are parametrized, which can support clinical diagnosis.
Download or read book Characterizing Cardiac Electrophysiology during Radiofrequency Ablation An Integrative Ex vivo In silico and In vivo Approach written by Pollnow, Stefan and published by KIT Scientific Publishing. This book was released on 2019-04-23 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computer Simulation and Experimental Assessment of Cardiac Electrophysiology written by Nathalie Virag and published by Blackwell Publishing. This book was released on 2001-12-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading edge look at the dynamic field of computer modeling of cardiac electrophysiology. This book is among the first to give a comprehensive overview of the promising and rapidly growing field of computer modeling of the heart. The success of this new field strongly depends on the establishment of multidisciplinary exchanges of information. Accordingly, scientists from different horizons, including clinicians, basic electrophysiologists, engineers, and mathematicians, have all contributed to this succinct work. The book's aim is to show how computer modeling can help us to understand the mechanisms of cardiac arrhythmia and to develop new therapeutic strategies. In addition to computer simulation results, it presents the corresponding experimental data, efficiently gathering in one book research work on simulation and experiments on humans and animals. Electrophysiologists, cardiologists, biomedical engineers, biophysicists, and others interested in the field of computer modeling of cardiac electrophysiology, will all benefit from this current, dynamic review.
Download or read book Personalized Modeling of Cardiac Electrophysiology written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
