Download or read book Introduction to Population Pharmacokinetic Pharmacodynamic Analysis with Nonlinear Mixed Effects Models written by Joel S. Owen and published by John Wiley & Sons. This book was released on 2014-07-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a user-friendly, hands-on introduction to the Nonlinear Mixed Effects Modeling (NONMEM) system, the most powerful tool for pharmacokinetic / pharmacodynamic analysis. • Introduces requisite background to using Nonlinear Mixed Effects Modeling (NONMEM), covering data requirements, model building and evaluation, and quality control aspects • Provides examples of nonlinear modeling concepts and estimation basics with discussion on the model building process and applications of empirical Bayesian estimates in the drug development environment • Includes detailed chapters on data set structure, developing control streams for modeling and simulation, model applications, interpretation of NONMEM output and results, and quality control • Has datasets, programming code, and practice exercises with solutions, available on a supplementary website
Download or read book Model Building for Nonlinear Mixed Effects Models written by Jose C. Pinheiro and published by . This book was released on 1995 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mixed Effects Models in S and S PLUS written by José Pinheiro and published by Springer Science & Business Media. This book was released on 2006-05-17 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the theory and application of linear and nonlinear mixed-effects models in the analysis of grouped data, such as longitudinal data, repeated measures, and multilevel data. The authors present a unified model-building strategy for both models and apply this to the analysis of over 20 real datasets from a wide variety of areas, including pharmacokinetics, agriculture, and manufacturing. Much emphasis is placed on the use of graphical displays at the various phases of the model-building process, starting with exploratory plots of the data and concluding with diagnostic plots to assess the adequacy of a fitted model. The NLME library for analyzing mixed-effects models in S and S-PLUS, developed by the authors, provides the underlying software for implementing the methods presented. This balanced mix of real data examples, modeling software, and theory makes the book a useful reference for practitioners who use, or intend to use, mixed-effects models in their data analyses. It can also be used as a text for a one-semester graduate-level applied course.
Download or read book Covariate model building in nonlinear mixed effects models written by Jakob Ribbing and published by . This book was released on 2007 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mixed Effects Models for Complex Data written by Lang Wu and published by CRC Press. This book was released on 2009-11-11 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.
Download or read book Mixed Effects Models for the Population Approach written by Marc Lavielle and published by CRC Press. This book was released on 2014-07-14 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wide-Ranging Coverage of Parametric Modeling in Linear and Nonlinear Mixed Effects ModelsMixed Effects Models for the Population Approach: Models, Tasks, Methods and Tools presents a rigorous framework for describing, implementing, and using mixed effects models. With these models, readers can perform parameter estimation and modeling across a whol
Download or read book Robust Mixed Model Analysis written by Jiang Jiming and published by World Scientific. This book was released on 2019-04-10 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mixed-effects models have found broad applications in various fields. As a result, the interest in learning and using these models is rapidly growing. On the other hand, some of these models, such as the linear mixed models and generalized linear mixed models, are highly parametric, involving distributional assumptions that may not be satisfied in real-life problems. Therefore, it is important, from a practical standpoint, that the methods of inference about these models are robust to violation of model assumptions. Fortunately, there is a full scale of methods currently available that are robust in certain aspects. Learning about these methods is essential for the practice of mixed-effects models.This research monograph provides a comprehensive account of methods of mixed model analysis that are robust in various aspects, such as to violation of model assumptions, or to outliers. It is suitable as a reference book for a practitioner who uses the mixed-effects models, and a researcher who studies these models. It can also be treated as a graduate text for a course on mixed-effects models and their applications.
Download or read book Nonlinear Models for Repeated Measurement Data written by Marie Davidian and published by Routledge. This book was released on 2017-11-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
Download or read book Pharmacokinetic Pharmacodynamic Modeling and Simulation written by Peter L. Bonate and published by Springer Science & Business Media. This book was released on 2011-07-01 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.
Download or read book Mixed Models written by Eugene Demidenko and published by John Wiley & Sons. This book was released on 2013-08-05 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition “This book will serve to greatly complement the growing number of texts dealing with mixed models, and I highly recommend including it in one’s personal library.” —Journal of the American Statistical Association Mixed modeling is a crucial area of statistics, enabling the analysis of clustered and longitudinal data. Mixed Models: Theory and Applications with R, Second Edition fills a gap in existing literature between mathematical and applied statistical books by presenting a powerful examination of mixed model theory and application with special attention given to the implementation in R. The new edition provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as nontraditional applications, such as regrowth curves, shapes, and images. The book features the latest topics in statistics including modeling of complex clustered or longitudinal data, modeling data with multiple sources of variation, modeling biological variety and heterogeneity, Healthy Akaike Information Criterion (HAIC), parameter multidimensionality, and statistics of image processing. Mixed Models: Theory and Applications with R, Second Edition features unique applications of mixed model methodology, as well as: Comprehensive theoretical discussions illustrated by examples and figures Over 300 exercises, end-of-section problems, updated data sets, and R subroutines Problems and extended projects requiring simulations in R intended to reinforce material Summaries of major results and general points of discussion at the end of each chapter Open problems in mixed modeling methodology, which can be used as the basis for research or PhD dissertations Ideal for graduate-level courses in mixed statistical modeling, the book is also an excellent reference for professionals in a range of fields, including cancer research, computer science, and engineering.
Download or read book Linear Mixed Effects Models Using R written by Andrzej Gałecki and published by Springer Science & Business Media. This book was released on 2013-02-05 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Linear mixed-effects models (LMMs) are an important class of statistical models that can be used to analyze correlated data. Such data are encountered in a variety of fields including biostatistics, public health, psychometrics, educational measurement, and sociology. This book aims to support a wide range of uses for the models by applied researchers in those and other fields by providing state-of-the-art descriptions of the implementation of LMMs in R. To help readers to get familiar with the features of the models and the details of carrying them out in R, the book includes a review of the most important theoretical concepts of the models. The presentation connects theory, software and applications. It is built up incrementally, starting with a summary of the concepts underlying simpler classes of linear models like the classical regression model, and carrying them forward to LMMs. A similar step-by-step approach is used to describe the R tools for LMMs. All the classes of linear models presented in the book are illustrated using real-life data. The book also introduces several novel R tools for LMMs, including new class of variance-covariance structure for random-effects, methods for influence diagnostics and for power calculations. They are included into an R package that should assist the readers in applying these and other methods presented in this text.
Download or read book The Chemical Basis of Growth and Senescence written by Thorburn Brailsford Robertson and published by . This book was released on 1923 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Methods for Functional Regression and Nonlinear Mixed effects Models with Applications to PET Data written by Yakuan Chen and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Simulations are conducted to compare the power of detecting group effect in both rate parameters and summarized measures of tests based on both NLS and NLME models. We apply our NLME approach to clinical PET data to illustrate the model building procedure.
Download or read book Mixed Effects Models in S and S PLUS written by José C. Pinheiro and published by Springer Science & Business Media. This book was released on 2009-04-15 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: R, linear models, random, fixed, data, analysis, fit.
Download or read book Growth Modeling written by Kevin J. Grimm and published by Guilford Publications. This book was released on 2016-10-17 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth models are among the core methods for analyzing how and when people change. Discussing both structural equation and multilevel modeling approaches, this book leads readers step by step through applying each model to longitudinal data to answer particular research questions. It demonstrates cutting-edge ways to describe linear and nonlinear change patterns, examine within-person and between-person differences in change, study change in latent variables, identify leading and lagging indicators of change, evaluate co-occurring patterns of change across multiple variables, and more. User-friendly features include real data examples, code (for Mplus or NLMIXED in SAS, and OpenMx or nlme in R), discussion of the output, and interpretation of each model's results. User-Friendly Features *Real, worked-through longitudinal data examples serving as illustrations in each chapter. *Script boxes that provide code for fitting the models to example data and facilitate application to the reader's own data. *"Important Considerations" sections offering caveats, warnings, and recommendations for the use of specific models. *Companion website supplying datasets and syntax for the book's examples, along with additional code in SAS/R for linear mixed-effects modeling.
Download or read book Linear and Nonlinear Models for the Analysis of Repeated Measurements written by Edward Vonesh and published by CRC Press. This book was released on 1996-11-01 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrates the latest theory, methodology and applications related to the design and analysis of repeated measurement. The text covers a broad range of topics, including the analysis of repeated measures design, general crossover designs, and linear and nonlinear regression models. It also contains a 3.5 IBM compatible disk, with software to implement immediately the techniques.
Download or read book Asymptotic Analysis of Mixed Effects Models written by Jiming Jiang and published by CRC Press. This book was released on 2017-09-19 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Large sample techniques are fundamental to all fields of statistics. Mixed effects models, including linear mixed models, generalized linear mixed models, non-linear mixed effects models, and non-parametric mixed effects models are complex models, yet, these models are extensively used in practice. This monograph provides a comprehensive account of asymptotic analysis of mixed effects models. The monograph is suitable for researchers and graduate students who wish to learn about asymptotic tools and research problems in mixed effects models. It may also be used as a reference book for a graduate-level course on mixed effects models, or asymptotic analysis.
