Download or read book Meet M M written by Pat Ross and published by Penguin. This book was released on 1997-10-01 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mandy and Mimi are best friends. They look alike, have the same tooth missing, and they're also neighbors--which means fun is never far away. But one day everything goes wrong. They argue about what games to play, how to play them, and even where to play! Mimi storms upstairs to apartment 3B, while Mandy sulks at home in 2B. Can M and M find a way to meet halfway? "Fast, funny, and crisis-ridden."--Publishers Weekly

Download or read book Biomarkers and Clinical Indicators in Motor Neuron Disease written by Pierre-Francois Pradat and published by Frontiers Media SA. This book was released on 2020-01-24 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biomarkers and Pathogenesis of Alpha Synuclein in Parkinson s Disease written by Pingyi Xu and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Applications of Herbal Medicine to Control Chronic Kidney Disease written by Jianping Chen and published by Frontiers Media SA. This book was released on 2021-10-21 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Neuromodulation Treatment of Parkinson s Disease and Aging Related Movement Disorders written by Kailiang Wang and published by Frontiers Media SA. This book was released on 2024-04-22 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by progressive motor disability with a spectrum of non-motor symptoms. Similar to Parkinson's disease, essential tremor, dystonia, Huntington's disease, and other aging-related movement disorders are widespread in the elderly with relatively unideal medicine-treatment effects. In recent years, deep brain stimulation (DBS) has been established as an effective treatment for PD and other aging-related movement disorders, especially with motor symptoms. However, there are still many problems to be solved in research work and clinical practice in this field. For example, it is unclear regarding the most effective stimulation targets or the underlying mechanism of DBS. And it is still unknown how to choose the optimal targets among STN, GPi, PSA, VIM, etc, or if we could choose the nerve fiber for stimulation besides the nuclei, And despite wearable sensors could be a powerful tool for the digital evaluation of movement disorders or provide the feedback biomarkers for DBS, the closed-loop biomarkers for DBS are still lacking. Furthermore, apart from PD, the DBS treatment in gene-related dystonia, Huntington's disease, and other movement disorders also needs to be further explored.

Download or read book Marek s Disease written by Fred Davison and published by Elsevier. This book was released on 2004-06-30 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marek's disease is a form of cancer of poultry caused by an important herpesvirus (MDV). It continues to be a threat to poultry health and welfare and worldwide losses are estimated to be US$ 1 billion annually. Marek's Disease provides a timely review of the problems of Marek's disease with descriptions of the complex viral life cycle, how MDV targets different types of white blood cells, and details of the virus structure, its genes and proteins. - The multiplicity of factors contributing to susceptibility is explored in detail - Vaccination - the problems arising from current vaccination strategies and how these can be improved and made sustainable in future - The lessons learned in the control of MD over the past 30 years, and how we can use MD as a model for other animal and human diseases is discussed

Download or read book Molecular Components of Store Operated Calcium Entry in Health and Disease written by Joanna Gruszczynska-Biegala and published by Frontiers Media SA. This book was released on 2021-12-01 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Molecular Biology of Neurological Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Download or read book Alzheimer s Disease and Dementia in Down Syndrome and Intellectual Disabilities written by Vee P. Prasher and published by Radcliffe Publishing. This book was released on 2005 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basic aim of this book is to help carers and professionals living or working with adults with intellectual disability to understand further Alzheimer's disease and other forms of dementia.

Download or read book Parkinson s Disease Second Edition written by Ronald F. Pfeiffer and published by CRC Press. This book was released on 2012-10-09 with total page 1335 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, and aspects of the pathophysiology, pathogenesis, and treatment of PD.

Download or read book Molecular Links Between Mitochondrial Damage and Parkinson s Disease and Related Disorders written by Yuzuru Imai and published by Frontiers Media SA. This book was released on 2021-09-28 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Alzheimer s Disease Challenge Volume II written by Mohammad Amjad Kamal and published by Frontiers Media SA. This book was released on 2024-04-15 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the success of Volume I of this Research Topic, we are pleased to announce the launch of Volume II: “The Alzheimer's Disease Challenge”. The repeated failure of clinical trials on the amyloid-based medications and the pessimistic calculations of Alzheimer's disease cost burden for the next few decades present a severe challenge to humankind with severe social implications. In recent years, several alternative diagnostic and treatment procedures have been presented to treat and manage Alzheimer’s disease as it has been nearly impossible to suggest a holistic solution. Several revelations in human biology have highlighted the multiparametric character of the disease. Besides the amyloid aggregation and neurofibrillary tangles that result in Aβ toxicity and tau phosphorylation, processes such as Gene Mutations, Proteins Misfolding, Brain Biochemical and Histopathological Changes, Behavioral Changes, Nutrition and Metabolism Alterations, and Autonomic Dysfunctions due to Central Nervous System dysregulations are common signs and probably early diagnostic biomarkers in most of the Alzheimer's classification categories.

Download or read book The Impact of Systems Medicine on Human Health and Disease written by Adil Mardinoglu and published by Frontiers Media SA. This book was released on 2017-03-24 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex disorders including obesity, diabetes, fatty liver disease, cardiovascular disease and cancer are results from a combination of genetic, environmental and lifestyle factors. The prevalence of such disorders has increased dramatically in the last two decades and there is an urgent need for the development of new prognostic tools for the treatment of such diseases. However, this requires a deep understanding of the underlying molecular mechanisms involved in the occurrence of the diseases. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models as well as the developed tools can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects.

Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1974 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book U S Government Research Reports written by and published by . This book was released on 1962-10 with total page 1330 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chagas disease novel drug targets and treatments written by Vilma G. Duschak and published by Frontiers Media SA. This book was released on 2023-06-22 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neurophysiology in Alzheimer s Disease and Dementia written by Davide Vito Moretti and published by Frontiers Media SA. This book was released on 2016-09-06 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease (AD) and dementia are the most common neurodegenerative disorder. Since the number of individuals with AD and dementia is expected to increase considerably in the near future, reliable treatment and diagnosis are critical. EEG and neurophysiological technique could be used as a cost-effective screening tool for early detection and diagnosis in the Mild Cognitive Impairment (MCI) stage. The aim in neurophysiology research is to develop signal processing methods that improve the specificity for diagnosing dementia; we wish to discover signal features that not only significantly differ in AD patients, but also allow us to reliably separate AD patients and control subjects. This approach is valuable for clinical purposes (as diagnostic tool for dementia), and it also more fundamentally contributes to a better understanding of brain dynamics of MCI patients. Finally, the development of neurophysiological biomarker could be useful in monitoring pharmacological treatments. The main focus of this special issue will be on the most recent developments and ideas in the field of EEG and neurophysiology which will enable us to extract features that improve the specificity for diagnosing AD and dementia.