Download or read book Methods of Discovery written by Andrew Delano Abbott and published by W W Norton & Company Incorporated. This book was released on 2004 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abbott helps social science students discover what questions to ask. This exciting book is not about habits and the mechanics of doing social science research, but about habits of thinking that enable students to use those mechanics in new ways, by coming up with new ideas and combining them more effectively with old ones. Abbott organizes his book around general methodological moves, and uses examples from throughout the social sciences to show how these moves can open new lines of thinking. In each chapter, he covers several moves and their reverses (if these exist), discussing particular examples of the move as well as its logical and theoretical structure. Often he goes on to propose applications of the move in a wide variety of empirical settings. The basic aim of Methods of Discovery is to offer readers a new way of thinking about directions for their research and new ways to imagine information relevant to their research problems. Methods of Discovery is part of the Contemporary Societies series.
Download or read book Drug Discovery Strategies and Methods written by Alexandros Makriyannis and published by CRC Press. This book was released on 2003-11-04 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery of new pharmaceutical candidates including the use of cutting-edge techniques utilized in drug design and development. It considers key elements in the drug design cycle ranging from appropriateness of targets and disease models to compound characterization, safety, and efficacy and the role of protein crystallography in structure-based drug design.
Download or read book Models of Discovery written by Herbert A. Simon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: We respect Herbert A. Simon as an established leader of empirical and logical analysis in the human sciences while we happily think of him as also the loner; of course he works with many colleagues but none can match him. He has been writing fruitfully and steadily for four decades in many fields, among them psychology, logic, decision theory, economics, computer science, management, production engineering, information and control theory, operations research, confirmation theory, and we must have omitted several. With all of them, he is at once the technical scientist and the philosophical critic and analyst. When writing of decisions and actions, he is at the interface of philosophy of science, decision theory, philosophy of the specific social sciences, and inventory theory (itself, for him, at the interface of economic theory, production engineering and information theory). When writing on causality, he is at the interface of methodology, metaphysics, logic and philosophy of physics, systems theory, and so on. Not that the interdisciplinary is his orthodoxy; we are delighted that he has chosen to include in this book both his early and little-appreciated treatment of straightforward philosophy of physics - the axioms of Newtonian mechanics, and also his fine papers on pure confirmation theory.
Download or read book Continuous Discovery Habits written by Teresa Torres and published by Product Talk LLC. This book was released on 2021-05-19 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: "If you haven't had the good fortune to be coached by a strong leader or product coach, this book can help fill that gap and set you on the path to success." - Marty Cagan How do you know that you are making a product or service that your customers want? How do you ensure that you are improving it over time? How do you guarantee that your team is creating value for your customers in a way that creates value for your business? In this book, you'll learn a structured and sustainable approach to continuous discovery that will help you answer each of these questions, giving you the confidence to act while also preparing you to be wrong. You'll learn to balance action with doubt so that you can get started without being blindsided by what you don't get right. If you want to discover products that customers love-that also deliver business results-this book is for you.
Download or read book Chance Discovery written by Yukio Ohsawa and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chance discovery means discovering chances - the breaking points in systems, the marketing windows in business, etc. It involves determining the significance of some piece of information about an event and then using this new knowledge in decision making. The techniques developed combine data mining methods for finding rare but important events with knowledge management, groupware, and social psychology. The reader will find many applications, such as finding information on the Internet, recognizing changes in customer behavior, detecting the first signs of an imminent earthquake, etc. This first book dedicated to chance discovery covers the state of the art in the theory and methods and examines typical scenarios, and it thus appeals to researchers working on new techniques and algorithms and also to professionals dealing with real-world applications.
Download or read book Screening written by Angela Dean and published by Springer Science & Business Media. This book was released on 2006-07-28 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of discovery in science and technology may require investigation of a large number of features, such as factors, genes or molecules. In Screening, statistically designed experiments and analyses of the resulting data sets are used to identify efficiently the few features that determine key properties of the system under study. This book brings together accounts by leading international experts that are essential reading for those working in fields such as industrial quality improvement, engineering research and development, genetic and medical screening, drug discovery, and computer simulation of manufacturing systems or economic models. Our aim is to promote cross-fertilization of ideas and methods through detailed explanations, a variety of examples and extensive references. Topics cover both physical and computer simulated experiments. They include screening methods for detecting factors that affect the value of a response or its variability, and for choosing between various different response models. Screening for disease in blood samples, for genes linked to a disease and for new compounds in the search for effective drugs are also described. Statistical techniques include Bayesian and frequentist methods of data analysis, algorithmic methods for both the design and analysis of experiments, and the construction of fractional factorial designs and orthogonal arrays. The material is accessible to graduate and research statisticians, and to engineers and chemists with a working knowledge of statistical ideas and techniques. It will be of interest to practitioners and researchers who wish to learn about useful methodologies from within their own area as well as methodologies that can be translated from one area to another.
Download or read book Model Rules of Professional Conduct written by American Bar Association. House of Delegates and published by American Bar Association. This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Model Rules of Professional Conduct provides an up-to-date resource for information on legal ethics. Federal, state and local courts in all jurisdictions look to the Rules for guidance in solving lawyer malpractice cases, disciplinary actions, disqualification issues, sanctions questions and much more. In this volume, black-letter Rules of Professional Conduct are followed by numbered Comments that explain each Rule's purpose and provide suggestions for its practical application. The Rules will help you identify proper conduct in a variety of given situations, review those instances where discretionary action is possible, and define the nature of the relationship between you and your clients, colleagues and the courts.
Download or read book Modern Methods of Drug Discovery written by Alexander Hillisch and published by Birkhäuser. This book was released on 2012-11-28 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach in the 1970s and 1980s, high-throughput screening and structure-based design are now major players among a multitude of methods used in drug discov ery. Quite often, companies favor one of these relatively new approaches over the other, e.g., screening over rational design, or vice versa, but we believe that an intelligent and concerted use of several or all methods currently available to drug discovery will be more successful in the medium term. What has changed most significantly in the past few years is the time available for identifying new chemical entities. Because of the high costs of drug discovery projects, pressure for maximum success in the shortest possible time is higher than ever. In addition, the multidisciplinary character of the field is much more pronounced today than it used to be. As a consequence, researchers and project managers in the pharmaceutical industry should have a solid knowledge of the more important methods available to drug discovery, because it is the rapidly and intelligently combined use of these which will determine the success or failure of preclinical projects.
Download or read book Target Discovery and Validation written by Alleyn T. Plowright and published by John Wiley & Sons. This book was released on 2020-02-18 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.
Download or read book Synthetic Methods in Drug Discovery written by David C. Blakemore and published by Royal Society of Chemistry. This book was released on 2016 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
Download or read book Causation in Science and the Methods of Scientific Discovery written by Rani Lill Anjum and published by Oxford University Press, USA. This book was released on 2018-10-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Causation is the main foundation upon which the possibility of science rests. Without causation, there would be no scientific understanding, explanation, prediction, nor application in new technologies. How we discover causal connections is no easy matter, however. Causation often lies hiddenfrom view and it is vital that we adopt the right methods for uncovering it. The choice of methods will inevitably reflect what one takes causation to be, making an accurate account of causation an even more pressing matter. This enquiry informs the correct norms for an empirical study of the world. In Causation in Science and the Methods of Scientific Discovery, Rani Lill Anjum and Stephen Mumford propose nine new norms of scientific discovery. A number of existing methodological and philosophical orthodoxies are challenged as they argue that progress in science is being held back by an overlysimplistic philosophy of causation.
Download or read book Scientific Discovery in the Social Sciences written by Mark Addis and published by Springer Nature. This book was released on 2019-09-12 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers selected papers exploring issues arising from scientific discovery in the social sciences. It features a range of disciplines including behavioural sciences, computer science, finance, and statistics with an emphasis on philosophy. The first of the three parts examines methods of social scientific discovery. Chapters investigate the nature of causal analysis, philosophical issues around scale development in behavioural science research, imagination in social scientific practice, and relationships between paradigms of inquiry and scientific fraud. The next part considers the practice of social science discovery. Chapters discuss the lack of genuine scientific discovery in finance where hypotheses concern the cheapness of securities, the logic of scientific discovery in macroeconomics, and the nature of that what discovery with the Solidarity movement as a case study. The final part covers formalising theories in social science. Chapters analyse the abstract model theory of institutions as a way of representing the structure of scientific theories, the semi-automatic generation of cognitive science theories, and computational process models in the social sciences. The volume offers a unique perspective on scientific discovery in the social sciences. It will engage scholars and students with a multidisciplinary interest in the philosophy of science and social science.
Download or read book Reinventing Discovery written by Michael Nielsen and published by Princeton University Press. This book was released on 2020-04-07 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Reinventing Discovery argues that we are in the early days of the most dramatic change in how science is done in more than 300 years. This change is being driven by new online tools, which are transforming and radically accelerating scientific discovery"--
Download or read book Data Mining Methods for Knowledge Discovery written by Krzysztof J. Cios and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Mining Methods for Knowledge Discovery provides an introduction to the data mining methods that are frequently used in the process of knowledge discovery. This book first elaborates on the fundamentals of each of the data mining methods: rough sets, Bayesian analysis, fuzzy sets, genetic algorithms, machine learning, neural networks, and preprocessing techniques. The book then goes on to thoroughly discuss these methods in the setting of the overall process of knowledge discovery. Numerous illustrative examples and experimental findings are also included. Each chapter comes with an extensive bibliography. Data Mining Methods for Knowledge Discovery is intended for senior undergraduate and graduate students, as well as a broad audience of professionals in computer and information sciences, medical informatics, and business information systems.
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Download or read book California Deposition and Discovery Practice written by J. N. DeMeo and published by . This book was released on 2011 with total page 1338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Federal Criminal Discovery written by Robert M. Cary and published by American Bar Association. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Federal Criminal Discovery thoroughly covers each of the different methods of discovery available to the parties in federal criminal cases. It serves as an invaluable resource for judges, academics, prosecutors, and defense lawyers by providing an exhaustive discussion on the statutory and constitutional bases for discovery, and by covering the existing law fairly while examining both sides of the issues.
