Download or read book Metabolic Inhibitors V1 written by R Hochster and published by Elsevier. This book was released on 2012-12-02 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic Inhibitors: A Comprehensive Treatise, Volume I focuses on the properties of inhibitors of metabolic processes or enzyme systems. The book explores a wide range of substances that interfere with (and usually retard) metabolic and enzymic processes, emphasizing the inhibitor rather than the metabolic or enzymic system that is affected. Organized into 15 chapters, this volume begins with a historical overview of research on the mode of action of biological inhibitors, touching on the principle of competitive inhibition by structural analogues. The book then turns to the concept of a competitive enzymic relationship by growth inhibitory analogues and their corresponding amino acids; the metabolic inhibitory effects of polypeptides and proteins; and the use of pentoses as analogues in carbohydrate metabolism. The reader is also introduced to the metabolic inhibitory effects of fatty acids; the intermediary metabolism of phospholipids; and the inhibition of purine and pyrimidine analogues. The remaining chapters discuss the role of nucleic acids and nucleoproteins in the regulation of cellular metabolism and the inhibition of amino acid decarboxylases, cholesterol, and steroid biosynthesis. This book will be of value to biochemists, advanced students, medical research workers, and research workers in the various fields of biological chemistry, as well as those working in the microbiological, botanical, and other agricultural fields.
Download or read book Risk Assessment for Chemicals in Drinking Water written by Robert A. Howd and published by John Wiley & Sons. This book was released on 2007-11-09 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference on state-of-the-art risk assessment methodologies for drinking water Risk Assessment for Chemicals in Drinking Water discusses the major steps and goals in risk assessments and suggests ways to improve the methodologies and accuracy, while consolidating up-to-date information on the current principles and practices in one authoritative reference. After an enlightening overview of risk assessment practices and regulatory guidelines, it: Includes descriptions of the use of variability analysis, exposure analysis, physiologically based pharmacokinetics, and modeling for both cancer and non-cancer endpoints Describes the practices of major organizations, including the U.S. EPA, Health Canada, World Health Organization, and California Office of Environmental Health Hazard Assessment Includes complete chapters on risk assessment for essential nutrients, arsenic, chloroform, and perchlorate Explains how to address susceptible sub-populations, including the elderly and infants and children, in risk assessments Covers the potential of using genomic and proteomic screens Addresses recent advances, emerging issues, and future challenges With contributions and perspectives from leading scientists, this is the definitive resource for health and environmental scientists, toxicologists, risk assessors and managers, regulators, consultants, and other professionals responsible for the safety of drinking water.
Download or read book FDA Medical Library Periodicals Holdings List written by United States. Food and Drug Administration. Medical Library and published by . This book was released on 1978 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inhibitors of Purine Metabolism written by Edward B. Skibo and published by . This book was released on 1980 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enzyme and Metabolic Inhibitors written by John Leyden Webb and published by . This book was released on 1963 with total page 1056 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Water Contamination and Health written by Rhoda G.M. Wang and published by CRC Press. This book was released on 2020-08-26 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines every potential means of exposure to water contaminants, provides in-depth discussions on toxicology, and explains up-to-date techniques for evaluating human health risk. It develops a methodology for assessing the cumulative absorbed dose of contaminants through all routes of exposure, including ingestion, inhalation and dermal. Federal and state efforts to monitor and treat water are examined.
Download or read book The Mycoplasmas V1 written by M.F. Barile and published by Elsevier. This book was released on 2012-12-02 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mycoplasmas, Volume I: Cell Biology is a volume of a comprehensive three-volume series encompassing various facets of mycoplasmology, emphasizing outstanding developments made in the field. This volume deals specifically with the cell biology of the mycoplasmas. This book focuses on problems regarding mycoplasma classification, phylogenetics, and relatedness to wall-covered bacteria; their unique molecular biology, energy metabolism, transport mechanisms, antigenic structure, and membrane biochemistry. The characterization, ultrastructure, and molecular biology of the mycoplasmaviruses, as well as the special properties of several groups of mycoplasmas, such as Ureaplasma, Acholeplasma, Thermoplasma, and Anaeroplasma, are also described. This book will serve as a standard reference work for mycoplasmologists, as well as for other interested microbiologists, cellular and molecular biologists, membrane biochemists, clinicians, veterinarians, plant pathologists, and entomologists.
Download or read book Regulation of Phosphate and Mineral Metabolism written by Shaul G. Massry and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: We are pleased to present to our readers the Proceedings of the Fifth International Workshop on Phosphate and Other Minerals which was held in New York City, New York, U.S.A during September 23-27,1981. It was hosted by Joseph M. Letteri, M.D., Professor of Medicine at the State University of New York at Stonybrook School of Medicine, and Chief, Division of Nephrology, Nassau County Medical Center. As in the previous Workshops, this meeting provided an oppor tunity for interested scientists from interrelated fields, including nephrology, endocrinology, physiology, biochemistry and nutrition, to get together and discuss the recent advances in the field of phosphate and mineral metabolism. There were 29 invited presenta tions by leading scientists and 40 oral and 90 poster presentations selected from over 250 abstracts submitted to the Organizing Committee. The Workshop was attended by 250 scientists from 14 countries including Austria, Australia, Canada, Denmark, England, France, Germany, Holland, Israel, Italy, Japan, Sweden, and the United States of America. The Sixth International Workshop on Phosphate and Other Minerals will be held during June 24-26, 1983 in Verona, Italy. It will be hosted by Professor Giuseppe Maschio, Director, Division of Nephrology, Istituti Ospitalieri, Verona, Italy. The theme of this coming Workshop will continue to focus on the pathophysiology of phosphate homeostasis and the metabolism of other minerals.
Download or read book Diabetes Related Literature Index by Authors and by Key Words In the Title written by and published by . This book was released on 1962 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Metabolism in Drug Design and Development written by Donglu Zhang and published by John Wiley & Sons. This book was released on 2007-11-16 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Download or read book From Metabolite to Metabolism to Metabolon written by Earl R. Stadtman and published by Elsevier. This book was released on 2014-06-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Cellular Regulation, Volume 33: From Metabolite, to Metabolism, to Metabolon is a collection of articles on the study of the machinery of the living cell. The book is also a tribute to Paul Srere, an eminent biochemist, on the occasion of his sixty-fifth birthday. The book contains contributions written by students, postdoctoral fellows, and biochemists within Paul Srere's broad sphere of influence. The text provides articles that discuss topics on cellular infrastructure and metabolic organization; how carbohydrates cross the lipid membrane of bacterial cells; and macromolecular processes. The structural aspects of citrate biochemistry; the electron transport systems; nucleotide biosynthesis; enzyme organization and the direction of metabolic flow; and bioengineering applications are tackled as well. Biochemists, cytologists, and cell biologists will find the book very insightful.
Download or read book Metabolism and Respiration written by David D. Davies and published by Elsevier. This book was released on 2014-05-10 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biochemistry of Plants: A Comprehensive Treatise, Volume 2: Metabolism and Respiration is a collection of articles that is largely concerned with the area of intermediary metabolism. This volume contains papers that discuss topics on the production of active C1 groups, photorespiration and the effect of light on respiration. Respiration and related metabolic activity in wounded and infected tissues, the respiration and senescence of plant organs, the effect of temperature on respiration and the assessment of the contributions of metabolic pathways to plant respiration are likewise covered. Biochemists and botanists will find the book highly useful.
Download or read book Enzyme and Transporter Based Drug Drug Interactions written by K. Sandy Pang and published by Springer Science & Business Media. This book was released on 2009-12-17 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.
Download or read book FDA Medical Library Serials Holdings List written by Sylvia A. Bullock and published by . This book was released on 1995 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Anticancer Drugs written by William B. Pratt and published by Oxford University Press, USA. This book was released on 1994 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an up-to-date review of the pharmacology, mechanisms of action, development of resistance, and toxicity of cancer chemotherapeutic agents. A rationale for their clinical use, based on cancer cell biology, is given for each class of drugs.
Download or read book Purine and Pyrimidine Metabolism in Man IX written by Andrea Griesmacher and published by Springer Science & Business Media. This book was released on 1998 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presented at the joint symposium held in Gmunden, Austria in June 1997 (and dedicated to the memory of Andre deVries), these 164 papers are relevant to research interests in molecular biology, biochemical pharmacology, biochemistry, developmental biology, immunology, epidemiology, and clinical applications. Topics are presented in 13 sections: gout, adenosine workshop, inborn errors of purine and pyrimidine (PP) metabolism, regulation and enzymes of PP metabolism, NMR in study of purines and energy metabolism, mutations, effects of hypoxia, free radicals, or reperfusion injury on purine, purines and signal transduction, hot research areas, immuomodulations by PP, PP in cell differentiation, the impact of PP on therapeutic strategies, and miscellaneous topics. Israel is the venue for 2000.
Download or read book Mass Spectrometry in Drug Metabolism and Disposition written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2011-03-16 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.
