Download or read book Mechanistic Investigations Into the Thermal C C Bond Forming Cyclization of Metal Pyridine Enamide Complexes and the Synthesis and Reactivity of Cationic and Neutral Iron IV Alkylidene Complexes written by Brian Lindley and published by . This book was released on 2016 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of first row transition metal pyridine-enamide complexes has been synthesized. In the course of reactivity studies, it was discovered that heating a solution of the cobalt bis(pyridine-enamide) pyridine adduct resulted in intraligand CC coupling to form an indolamide ligand. Control experiments with the corresponding lithium pyridine-enamide afforded the same indolamide. In order to probe the mechanism of cyclization, deuterium labeling experiments for the lithium pyridineenamide compound were conducted. Careful kinetics measurements supported a mechanism consisting of reversible hydrogen transfer followed by rate-determining CC bond formation, in accord with computational results. Iron(II) complexes bearing cyclometalated benzyldialkylphosphine ligands were synthesized via a salt metathesis approach by treating FeCl2(PMe3)2 with two equivalents of (2-lithiobenzyl)diphenyl- and (2-lithiobenzyl)dicyclohexylphosphine reagents. For the phenyl derivative, a 6-coordinate diamagnetic complex containing two chelating phosphine ligands and two trimethylphosphine ligands was obtained. Contrarily, for the cyclohexyl derivative, a 5-coordinate complex containing two chelating phosphines and one molecule of trimethylphosphine was obtained. This compound is paramagnetic with an S = 1 ground state. Efforts to synthesize Fe(IV) alkylidenes by treating these Fe(II) complexes with diphenyldiazomethane were ultimately unsuccessful. An iron(II) vinyl complex was synthesized by reaction of cis-Me2Fe(PMe3)4 with a 2-propynylaniline benzylidene ligand. Protonation of this complex with [H(OEt2)2]BArF4 (BArF4 = B(3,5-(CF3)2C6H3)4) gave access to a cationic Fe(IV) alkylidene complex. By treating this complex with different anionic nucleophiles, a rare series of neutral Fe(IV) alkylidene complexes was obtained. In addition, treatment of the cationic alkylidene complex with MeMgCl afforded a novel Fe(IV) methyl complex. Attempts at catalyzing olefin metathesis with both the cationic and neutral alkylidene complexes proved unsuccessful, likely due to recalcitrant phosphine dissociation and the sterics at the alkylidene carbon.
Download or read book Enantioselective C C Bond Forming Reactions written by and published by Elsevier. This book was released on 2023-12-01 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enantioselective C-C Bond Forming Reactions: From Metal Complex-, Organo-, and Bio-catalyzed Perspectives, Volume 73 in the Advances in Catalysis series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as An introduction to Chirality, Metal-catalyzed stereoselective C-C-bond forming reactions, Enantioselective C-C bond forming reactions promoted by organocatalysts based on unnatural amino acid derivatives, Enantioselective C-C bond formation in complex multicatalytic system, Gold-based multicatalytic systems for enantioselective C-C Bond forming reactions, Novel enzymatic tools for C-C bond formation through the development of new-to-nature biocatalysis, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Advances in Catalysis serials Updated release includes the latest information in the field
Download or read book Investigations of the Synthesis and Reactivity of Chiral at iron Benzylidene Complexes written by Robert Craig Buck and published by . This book was released on 1987 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbon Carbon Bond Formation written by Lisa Kaithland Burke and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photochemical transformations have sparked great interest among synthetic chemists for their effective carbon-carbon bond formation abilities. Photochemical reactions follow a mechanistic pathway that allows them to access high-energy intermediates that would be forbidden under thermal conditions. For over a century, UV light has been commonly used in photoreactions and have proved very successful in C-C bond formation. However, UV light catalyzed reactions have short-lived, highly reactive excited states and can decompose large molecules. In recent decades, scientists have focused their attention on using lower energy visible light for C-C bond formation reactions. Recent reports have shown the application of transition metal photocatalysts in various visible light irradiated systems to be effective in forming cyclobutane C-C bond via transition metal catalyzed [2+2] photocycloadditions. This research focuses on the energy transfer between ruthenium and iridium polypyridine complexes and oxazinone photosubstrates, which has been previously reported to undergo [2+2] cycloaddition of the alkenes in UV light. [2+2] cycloaddition was observed only in the presence of the iridium catalyst and not at all with the ruthenium catalyst. Further research into the triplet state energies of our photosubstrates will be conducted.
Download or read book Olefin Polymerization written by Walter Kaminsky and published by Wiley-VCH. This book was released on 2006-08-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an enormous velocity, olefin polymerization has expanded to one of the most significant fields in polymers since the first industrial use about 50 years ago. In 2005, 100 million tons of polyolefins were produced - the biggest part was catalyzed by metallorganic compounds. The Hamburg Macromolecular Symposium 2005 with the title "Olefin Polymerization" involved topics such as new catalysts and cocatalysts, kinetics, mechanism and polymer reaction engineering, synthesis of special polymers, and characterization of polyolefins. The conference combined scientists from different disciplines to discuss latest research results of polymers and to offer each other the possibility of cooperation. This is reflected in this volume, which contains invited lectures and selected posters presented at the symposium.
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Download or read book Zinc Catalysis written by Stephan Enthaler and published by John Wiley & Sons. This book was released on 2015-04-27 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap in the market for comprehensive coverage of this hot topic, this timely book covers a wide range of organic transformations, e. g. reductions of unsaturated compounds, oxidation reactions, Friedel-Crafts reactions, hydroamination reactions, depolymerizations, transformations of carbon dioxide, oxidative coupling reactions, as well as C-C, C-N, and C-O bond formation reactions. A chapter on the application of zinc catalysts in total synthesis is also included. With its aim of stimulating further research and discussion in the field, this is a valuable reference for professionals in academia and industry wishing to learn about the latest developments.
Download or read book The Organometallic Chemistry of the Transition Metals written by Robert H. Crabtree and published by John Wiley & Sons. This book was released on 2005-06-14 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and expanded to reflect recent advances, this Fourth Edition of the classic text provides students and professional chemists with an excellent introduction to the principles and general properties of organometallic compounds, as well as including practical information on reaction mechanisms and detailed descriptions of contemporary applications.
Download or read book Enantioselective Titanium catalysed Transformations written by Helene Pellissier and published by World Scientific. This book was released on 2016-01-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral titanium complexes are low-cost, low-toxicity and high-efficiency catalysts. Impressive progress on enantioselective titanium-catalysed transformations has been achieved in the past seven years, with exciting new discoveries ranging from basic reactions to novel methodologies. Despite this, the field has not been substantially reviewed since 2008.This book contains up to date research and covers all types of enantioselective transformations using chiral titanium catalysts. It illustrates the economic, health, and environmental benefits of chiral titanium catalysts, showing the types of highly enantioselective reactions that they are able to induce are unlimited.Work presented here is aimed at researchers in organic and catalytic chemistry, and has been carefully curated to encourage future research possibilities.
Download or read book Hydrogen Transfer Reactions written by Gabriela Guillena and published by Springer. This book was released on 2016-09-27 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
Download or read book Applications of Transition Metal Catalysis in Drug Discovery and Development written by Matthew L. Crawley and published by John Wiley & Sons. This book was released on 2012-05-14 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.
Download or read book Homogeneous Catalysts written by John C. Chadwick and published by John Wiley & Sons. This book was released on 2011-06-09 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book to illuminate this important aspect of chemical synthesis improves the lifetime of catalysts, thus reducing material and saving energy, costs and waste. The international panel of expert authors describes the studies that have been conducted concerning the way homogeneous catalysts decompose, and the differences between homogeneous and heterogeneous catalysts. The result is a ready reference for organic, catalytic, polymer and complex chemists, as well as those working in industry and with/on organometallics.
Download or read book Handbook of Organopalladium Chemistry for Organic Synthesis written by Ei-ichi Negishi and published by John Wiley & Sons. This book was released on 2003-11-24 with total page 1657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Download or read book Asymmetric Synthesis of Three Membered Rings written by Hélène Pellissier and published by John Wiley & Sons. This book was released on 2017-06-19 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Download or read book Modern Reduction Methods written by Pher G. Andersson and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its comprehensive overview of modern reduction methods, this book features high quality contributions allowing readers to find reliable solutions quickly and easily. The monograph treats the reduction of carbonyles, alkenes, imines and alkynes, as well as reductive aminations and cross and heck couplings, before finishing off with sections on kinetic resolutions and hydrogenolysis. An indispensable lab companion for every chemist.
Download or read book Strategic Applications of Named Reactions in Organic Synthesis written by Laszlo Kurti and published by Elsevier. This book was released on 2005-04-29 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples* An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools* Extensive index quickly locates information using words found in text and drawings
