Download or read book Mechanisms of Adiponectin Action written by Tania Fiaschi and published by MDPI. This book was released on 2019-07-26 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.
Download or read book Mechanisms of Adiponectin Action written by Tania Fiaschi and published by . This book was released on 2019 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue “Mechanisms of Adiponectin Action” highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.
Download or read book Mechanisms of Adiponectin Action written by and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The adipokine adiponectin is very concentrated in plasma, and decreased levels of adiponectin are associated with pathological conditions such as obesity, diabetes, cardiovascular diseases, and metabolic syndrome. When produced in its full-length form, adiponectin self-associates to generate multimeric complexes. The full-length form of adiponectin can be cleaved by the globular form of elastase that is produced locally, and the resulting biological effects are exerted in a paracrine or autocrine manner. The different forms of adiponectin bind to specific receptors consisting of two G-protein-independent, seven-transmembrane-spanning receptors, called AdipoR1 and AdipoR2, while T-cadherin has been identified as a potential receptor for high molecular weight complexes of adiponectin. Adiponectin exerts a key role in cellular metabolism, regulating glucose levels as well as fatty acid breakdown. However, its biological effects are heterogeneous, involving multiple target tissues. The Special Issue "Mechanisms of Adiponectin Action" highlights the pleiotropic role of this hormone through 3 research articles and 7 reviews. These papers focus on the recent knowledge regarding adiponectin in different target tissues, both in healthy and in diseased conditions.
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Download or read book Polycystic Ovary Syndrome written by Andrea Dunaif and published by Springer Science & Business Media. This book was released on 2008-01-12 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.
Download or read book Hyperandrogenism in Women written by R. Pasquali and published by Karger Medical and Scientific Publishers. This book was released on 2019-09-09 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding of androgen excess and its impact on several conditions. Topics include development of adipose tissue in females, insulin sensitivity, congenital adrenal hyperplasia, and Cushing’s disease/syndrome. There is also a discussion of PCOS with emphasis on in utero origins and specific genetic and epigenetic factors. This book provides a wealth of relevant information for every endocrinologist and gynecologist who wants to broaden their knowledge of androgens in various conditions.
Download or read book Epicardial Adipose Tissue written by Gianluca Iacobellis and published by Springer Nature. This book was released on 2020-03-25 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first authoritative and comprehensive volume dedicated to epicardial adipose tissue (EAT). It provides an up-to-date and highly illustrated synopsis of the anatomical, biomolecular, genetic, imaging features, and clinical applications of EAT and its role in cardiovascular disease. It relays to the reader a contemporary view of the emerging interplay between the heart and adiposity-related diseases. In addition, this volume discusses the clinical implications and therapeutic targets of EAT in atrial fibrillation, heart failure and coronary artery disease. Comprehensive yet focused, Epicardial Adipose Tissue: From Cell to Clinic is an essential resource for physicians, residents, fellows, and medical students in cardiology, endocrinology, primary care, and health promotion and disease prevention.
Download or read book Obesity and Lipotoxicity written by Ayse Basak Engin and published by Springer. This book was released on 2017-06-05 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
Download or read book Obesity and Gynecology written by Tahir A. Mahmood and published by Elsevier. This book was released on 2020-06-11 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obesity and Gynecology, Second Edition, presents updated chapters on a variety of topics, ranging from adolescent obesity, contraception, assisted reproduction and sexual dysfunction, to bariatric surgery and improving semen parameters. The prevalence of obesity in men and women continues to dramatically increase around the world. Obesity presents specific challenges in relation to male and female infertility and general gynecology. Patients who are obese require specific considerations and knowledge. Presents an essential reference on the significant risks of obesity related to contraception, male and female infertility, and general gynecology Builds foundational knowledge, showing how obesity relates to general gynecology, including menstrual disorders, breasts cancer, menopause and sexual dysfunction Assembles critically evaluated chapters that focus on obesity and gynecology to meet the practical needs of gynecologists, endocrinologists and general practitioners
Download or read book The ASMBS Textbook of Bariatric Surgery written by Ninh T. Nguyen and published by Springer Nature. This book was released on 2019-10-16 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fully updated 2nd edition of this textbook continues to serve as a comprehensive guide for information dealing with the ever-evolving field of bariatric surgery. The chapters are written by experts in the field and include the most up-to-date information, including new sections on quality in bariatric surgery, endoscopic surgery, and management of bariatric complications. This new edition continues to cover the basic considerations for bariatric surgery, the currently accepted procedures, outcomes of bariatric surgery including long-term weight loss, improvement and resolution of comorbidities, and improvement in quality of life. Other special emphasis is given to the topics of metabolic surgery and surgery for patients with lower BMI. In addition, new endoscopic bariatric procedures including the gastric balloons, endoscopic revisional procedures, and newer pharmacotherapy for obesity are reviewed. The ASMBS Textbook of Bariatric Surgery Second Edition will continue to be a leading source of scientific information for surgeons, physicians, residents, students, and integrated health members today and for years to come.
Download or read book Anti diabetes and Anti obesity Medicinal Plants and Phytochemicals written by Bashar Saad and published by Springer. This book was released on 2017-05-11 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity. The side effects and safety of herbal-derived anti-diabetic and anti-obesity phytochemicals are detailed in depth, and the text has a strong focus on current and future trends in anti-diabetic medicinal plants. This unique and comprehensive text is the only current book on the market focusing exclusively on medicinal plants used to combat obesity and diabetes. An introductory chapter focuses on diabetes and obesity and introduces the major causes and main treatments of this increasing epidemic in modern society. Readers are then introduced to medicinal plants, including details on their therapeutic aspects, plus side effects and safety. Following chapters focus on anti-diabetic and anti-obesity medicinal plants, as well as phytogenic natural products in the treatment of each. The text closes by focusing on present and future trends and challenges in these medicinal plants. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals: Safety, Efficacy, and Action Mechanisms is a much-needed and truly original work, finally presenting in one place all the necessary information on medicinal plants used in conjunction with obesity and diabetes prevention.
Download or read book Gestational Diabetes During and After Pregnancy written by Catherine Kim and published by Springer Science & Business Media. This book was released on 2014-01-02 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gestational Diabetes Mellitus is becoming an increasingly prevalent disease as obesity and other chronic diseases are on the rise. It requires careful and informed clinical management as the care received during pregnancy affects not only perinatal health but the risk of developing type 2 diabetes even decades into the future, in both the mother and the child.From epidemiology and pathophysiology to diagnosis and management, covering recent breakthroughs in research and up-to-date developments in clinical practice, Gestational Diabetes During and After Pregnancy offers the reader a comprehensive and current look at Gestational Diabetes. Anyone involved in the research, public health or clinical aspects of Gestational Diabetes will find this volume a valuable aid in consolidating all recent developments regarding this disease.
Download or read book Adipose Tissue in Health and Disease written by Todd Leff and published by John Wiley & Sons. This book was released on 2010-03-19 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.
Download or read book Inflammation and Atherosclerosis written by Georg Wick and published by Springer Science & Business Media. This book was released on 2011-12-03 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 150 years that hallmarks of inflammation can be observed in the wall of atherosclerotic vessels. It was, however, not clear if this inflammation is the cause or the consequence of atherogenesis. More recently, it has become evident that inflammation mediated both by innate and adaptive immunity is instrumental even in the earliest stages of the development of atherosclerotic lesions, i.e., that it plays an important pathogenetic role. In this volume, international experts in the field discuss the pathogenetic, diagnostic, preventive and possible therapeutic relevance of inflammation in atherogenesis. This book is intended for researchers and physicians in the fields of vascular biology, immunology and atherosclerosis.
Download or read book Gestational Diabetes written by A. Lapolla and published by Karger Medical and Scientific Publishers. This book was released on 2019-12-19 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus, one of the most prevalent complications during pregnancy, can cause a range of problems for women and their developing babies. The number of types of diabetes during pregnancy has dramatically increased worldwide in recent years. Obesity is a very common risk factor for the development of GDM and type 2 diabetes. To prevent birth defects and other health problems, optimal healthcare before and during pregnancy is mandatory. To reach this goal, a multidisciplinary approach is of major importance. This book presents the latest knowledge on the physiopathology, diagnosis, autoimmunity, genetics, omics, and management and treatment of diabetic pregnancy. Renowned healthcare professionals and academic experts provide insights into the complexity of diabetic pregnancy, its treatment, and pregnancy complications. This is a comprehensive overview of the clinical characteristics of pregnancy-related type 1 and 2 diabetes as well as of gestational diabetes. It is a must-read for everyone involved in the monitoring of diabetes during pregnancy.
Download or read book Gut Hormones written by Stephen Robert Bloom and published by . This book was released on 1978 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scientific Principles of Adipose Stem Cells written by Lauren Kokai and published by Elsevier. This book was released on 2021-08-25 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Principles of Adipose Stem Cells provides readers with in depth and expert knowledge on adipose stem cells in regards to developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties and clinical insights into applications in regenerative medicine. Written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and are seeking advanced information on adipose stem cells. Topics covered include basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, additional sections are devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications. Given the broad applications for which ASCs are used, as well as the interest in basic ASC science, Scientific Principles of Adipose Stem Cells transcends an audience of plastic surgeons and provides valuable and expert knowledge in developmental and cell biology appealing to basic scientists in a variety of fields. Information on cell manufacturing and commercialization, FDA regulations and ASC exosomes which appeal to those working in industry and applications of ASCs in cutting edge tissue engineering applications such as microphysiologic systems and/or bioreactors, are also included. These new technologies have important applications in drug discovery and for studying genetically modified ASCs.
