Download or read book Mechanisms in Fibre Carcinogenesis written by Robert C. Brown and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Editors are sorry that the production of this volume was delayed by the ill health of one of them and we hope that this does not detract from the value of the con tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.
Download or read book Mechanisms of Fibre Carcinogenesis written by A. B. Kane and published by International Agency for Research on Cancer (I A R C). This book was released on 1996 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposure and interactions with other carcinogens. The relevance of mechanistic data from in vitro and in vivo assays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.
Download or read book Mechanisms of Carcinogenesis written by Elizabeth K. Weisburger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski.
Download or read book Natural Metal Fiber and Macromolecular Carcinogens written by Yin-Tak Woo and published by Academic Press. This book was released on 2013-10-22 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carcinogenic effect of osmotic imbalance in tissue microenvironment, as well as of spontaneous malignant transformation occurring in cell cultures in vitro. Studies on tumor induction and carcinogenesis modification by nonviral nucleic acids, by nucleases, proteases, histones, and by antigenic stimulation as well as by antibodies are also considered. The book further tackles tumor-released factors as possible modifiers of carcinogenesis. The text will prove invaluable to chemists and people involved in cancer research.
Download or read book Mechanisms of Genotoxicity and Carcinogenesis of Mineral Fibres written by Soterios A. Kyrtopoulos and published by . This book was released on 2004 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Mechanisms by which Dietary Fibre Influences the Early Events of Colon Carcinogenesis written by Cynthia Sui Ming Wong and published by . This book was released on 2001 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Man made Vitreous Fibres written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2002 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 9-16 October 2001."
Download or read book Mechanisms of Chemical Carcinogenesis written by D. E. Hathway and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.
Download or read book Mechanisms of Fibre Carcinogenesis written by A. B. Kane and published by International Agency for Research on Cancer (I A R C). This book was released on 1996 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The result of a meeting held at IARC early in 1996, this volume provides a thorough and up-to-date synthesis of the mechanisms of fibre carcinogenesis. A consensus document assesses the strengths, weaknesses and gaps in the data concerning fibre characterization and genotoxicity, fibre-related cell proliferation and activation, gene expression, animal models, mixed dust exposure and interactions with other carcinogens. The relevance of mechanistic data from in vitro and in vivo assays to the evaluation of fibre carcinogenicity are also discussed. Authored review papers, also published in this volume, provide the background material for much of the discussion.
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Diet Nutrition And Cancer written by National Research Council and published by Legare Street Press. This book was released on 2022-10-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Download or read book Cellular and Molecular Aspects of Fiber Carcinogenesis written by Curtis C. Harris and published by CSHL Press. This book was released on 1991 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Airborne fibers have long been recognized as a major health hazard in certain industries and exposure to fibers in the general environment may also cause adverse effects such as cancer, in particular, mesothelioma. Asbestos is the best-known fiber carcinogen and, in the construction industry, is being widely replaced by substitute materials. Yet to perform properly, these materials must physically resemble asbestos. Does this mean that they too are hazardous? In this volume, invited experts in cell and tumor biology review the processes of cell division and the influence of fibers upon them. The biology of tumors and other diseases of the lung is discussed in some detail and in several papers the molecular basis of malignant transformation in mesothelioma cells is considered. These contributions combine to give the book a unique, scientific slant on an important environmental issue. It will interest research scientists investigating carcinogenesis and the biology of cell division, thoracic physicians, public health specialists, and those concerned with environmental control policy.
Download or read book Antimutagenesis and Anticarcinogenesis Mechanisms III written by Giorgio Bronzetti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lifestyle, in any part of the world, is associated with the occurrence of major chronic diseases, including coronary heart disease, hypertension, and stroke; many distinct types of cancer; and adult onset diabetes (11,22,70,75). One important element of lifestyle is tobacco use, which appreciably increases the risk of a number of chronic diseases (21). Other lifestyle factors relate to nutritional traditions, alcohol use, and exercise (11,30,58,60,70,71). The underlying evidence is, in part, based on the evidence of specific diseases in relation to dietary habits in a given geographic region, as well as changes in such disease occurrences in migrant populations from a low risk to a high risk area, and vice versa (25,42). Populations that customarily consume fruits and vegetables and also whole grain cereal products generally have a lower risk of cardiovascular diseases and specific types of cancer than populations with a lower intake of such foods, everything else being equal (63). In the last few years, research has provided mechanistic explanations as to the reasons for the protective effects of specific foods. This paper will emphasize the mechanisms whereby cancer risks are reduced by dietary modification.
Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles
Download or read book Chemical Induction of Cancer written by Joseph C. Arcos and published by . This book was released on 1968 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Risk Factors and Mechanisms in Carcinogenesis written by and published by . This book was released on 1990 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tumour Site Concordance and Mechanisms of Carcinogenesis written by Robert A. Baan and published by International Agency for Research on Cancer. This book was released on 2019-05-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment.
