Download or read book Mathematical Methods for Analysis of a Complex Disease written by F. C. Hoppensteadt and published by American Mathematical Soc.. This book was released on 2011-09-23 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex diseases involve most aspects of population biology, including genetics, demographics, epidemiology, and ecology. Mathematical methods, including differential, difference, and integral equations, numerical analysis, and random processes, have been used effectively in all of these areas. The aim of this book is to provide sufficient background in such mathematical and computational methods to enable the reader to better understand complex systems in biology, medicine, and the life sciences. It introduces concepts in mathematics to study population phenomena with the goal of describing complicated aspects of a disease, such as malaria, involving several species. The book is based on a graduate course in computational biology and applied mathematics taught at the Courant Institute of Mathematical Sciences in fall 2010. The mathematical level is kept to essentially advanced undergraduate mathematics, and the results in the book are intended to provide readers with tools for performing more in-depth analysis of population phenomena.
Download or read book Mathematical Methods for Analysis of a Complex Disease written by Frank Charles Hoppensteadt and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex diseases involve most aspects of population biology, including genetics, demographics, epidemiology, and ecology. Mathematical methods, including differential, difference, and integral equations, numerical analysis, and random processes, have been used effectively in all of these areas. The aim of this book is to provide sufficient background in such mathematical and computational methods to enable the reader to better understand complex systems in biology, medicine, and the life sciences. It introduces concepts in mathematics to study population phenomena with the goal of describing c.
Download or read book Mathematical Tools for Understanding Infectious Disease Dynamics written by Odo Diekmann and published by Princeton University Press. This book was released on 2013 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how to translate biological assumptions into mathematics to construct useful and consistent models, and how to use the biological interpretation and mathematical reasoning to analyze these models. It shows how to relate models to data through statistical inference, and how to gain important insights into infectious disease dynamics by translating mathematical results back to biology.
Download or read book Mathematical Methods in Immunology written by Jerome Kenneth Percus and published by American Mathematical Soc.. This book was released on 2012 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Any organism, to survive, must use a variety of defense mechanisms. A relatively recent evolutionary development is that of the adaptive immune system, carried to a quite sophisticated level by mammals. The complexity of this system calls for its encapsulation by mathematical models, and this book aims at the associated description and analysis. In the process, it introduces tools that should be in the armory of any current or aspiring applied mathematician, in the context of, arguably, the most effective system nature has devised to protect an organism from its manifold invisible enemies.
Download or read book Mathematical Methods of Electromagnetic Theory written by Kurt O. Friedrichs and published by American Mathematical Soc.. This book was released on 2014-11-12 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a mathematically precise but intuitive introduction to classical electromagnetic theory and wave propagation, with a brief introduction to special relativity. While written in a distinctive, modern style, Friedrichs manages to convey the physical intuition and 19th century basis of the equations, with an emphasis on conservation laws. Particularly striking features of the book include: (a) a mathematically rigorous derivation of the interaction of electromagnetic waves with matter, (b) a straightforward explanation of how to use variational principles to solve problems in electro- and magnetostatics, and (c) a thorough discussion of the central importance of the conservation of charge. It is suitable for advanced undergraduate students in mathematics and physics with a background in advanced calculus and linear algebra, as well as mechanics and electromagnetics at an undergraduate level. Apart from minor corrections to the text, the notation was updated in this edition to follow the conventions of modern vector calculus. Titles in this series are co-published with the Courant Institute of Mathematical Sciences at New York University.
Download or read book Analysis of Complex Diseases written by Guanyu Wang, PhD and published by CRC Press. This book was released on 2013-12-18 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complex disease involves many etiological and risk factors operating at multiple levels—molecular, cellular, organismal, and environmental. The incidence of such diseases as cancer, obesity, and diabetes are increasing in occurrence, urging us to think fundamentally and use a broader perspective to identify their connection and revolutionize treatments. The understanding of biological data derived from studying diseases can be enhanced by theories and mathematical models, which clarify the big picture and help to reveal the overarching mechanisms that govern complex biological phenomena. Focusing on diseases related to cellular energy metabolism, such as cancer and diabetes, Analysis of Complex Diseases: A Mathematical Perspective presents a holistic approach for illuminating the molecular mechanisms of these diseases and the evolutionary underpinning of their simultaneous epidemics. Using mathematics to identify patterns of deviation from normality, or the healthy state—spanning multiple levels from molecules to the organism—the author identifies a range of dynamical behaviors that correspond to either cellular physiology or pathology. He uses the information from multiple levels in order to develop a unified theory, which includes the discovery that certain diseases may stem from well-evolved, useful mechanisms activated in the wrong context. This book is divided into three parts. Part I focuses on the organismal level to describe normal physiology and how the body as a whole meets its functional requirements. Part II addresses the subcellular, molecular level to elucidate the organizing principles of cellular biomolecules to meet the demands of the organism. Part III examines complex diseases by combining information from the organismal level and the molecular level, offering a paradigm that can be extended to the study of other categories of diseases.
Download or read book Mathematical Models in Developmental Biology written by Jerome K. Percus and published by American Mathematical Soc.. This book was released on 2015-06-19 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The path from relatively unstructured egg to full organism is one of the most fascinating trajectories in the biological sciences. Its complexity calls for a very high level of organization, with an array of subprocesses in constant communication with each other. These notes introduce an interleaved set of mathematical models representative of research in the last few decades, as well as the techniques that have been developed for their solution. Such models offer an effective way of incorporating reliable data in a concise form, provide an approach complementary to the techniques of molecular biology, and help to inform and direct future research. Titles in this series are co-published with the Courant Institute of Mathematical Sciences at New York University.
Download or read book Computational Methods in Predicting Complex Disease Associated Genes and Environmental Factors written by Yudong Cai and published by Frontiers Media SA. This book was released on 2021-06-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lattice Models and Conformal Field Theory written by Franck Gabriel and published by American Mathematical Society, Courant Institute of Mathematical Sciences at New York University. This book was released on 2024-08-23 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the mathematical ideas connecting Statistical Mechanics and Conformal Field Theory (CFT). Building advanced structures on top of more elementary ones, the authors map out a well-posed road from simple lattice models to CFTs. Structured in two parts, the book begins by exploring several two-dimensional lattice models, their phase transitions, and their conjectural connection with CFT. Through these lattice models and their local fields, the fundamental ideas and results of two-dimensional CFTs emerge, with a special emphasis on the Unitary Minimal Models of CFT. Delving into the delicate ideas that lead to the classification of these CFTs, the authors discuss the assumptions on the lattice models whose scaling limits are described by CFTs. This produces a probabilistic rather than an axiomatic or algebraic definition of CFTs. Suitable for graduate students and researchers in mathematics and physics, Lattice Models and Conformal Field Theory introduces the ideas at the core of Statistical Field Theory. Assuming only undergraduate probability and complex analysis, the authors carefully motivate every argument and assumption made. Concrete examples and exercises allow readers to check their progress throughout.
Download or read book Algebraic and Discrete Mathematical Methods for Modern Biology written by Raina Robeva and published by Academic Press. This book was released on 2015-05-09 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. - Examines significant questions in modern biology and their mathematical treatments - Presents important mathematical concepts and tools in the context of essential biology - Features material of interest to students in both mathematics and biology - Presents chapters in modular format so coverage need not follow the Table of Contents - Introduces projects appropriate for undergraduate research - Utilizes freely accessible software for visualization, simulation, and analysis in modern biology - Requires no calculus as a prerequisite - Provides a complete Solutions Manual - Features a companion website with supplementary resources
Download or read book Harmonic Analysis written by S.R.S. Varadhan and published by American Mathematical Society. This book was released on 2022-05-01 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Harmonic Analysis is an important tool that plays a vital role in many areas of mathematics as well as applications. It studies functions by decomposing them into components that are special functions. A prime example is decomposing a periodic function into a linear combination of sines and cosines. The subject is vast, and this book covers only the selection of topics that was dealt with in the course given at the Courant Institute in 2000 and 2019. These include standard topics like Fourier series and Fourier transforms of functions, as well as issues of convergence of Abel, Feier, and Poisson sums. At a slightly more advanced level the book studies convolutions with singular integrals, fractional derivatives, Sobolev spaces, embedding theorems, Hardy spaces, and BMO. Applications to elliptic partial differential equations and prediction theory are explored. Some space is devoted to harmonic analysis on compact non-Abelian groups and their representations, including some details about two groups: the permutation group and SO(3). The text contains exercises at the end of most chapters and is suitable for advanced undergraduate students as well as first- or second-year graduate students specializing in the areas of analysis, PDE, probability or applied mathematics.
Download or read book Linear Algebra II written by Frederick P. Greenleaf and published by American Mathematical Soc.. This book was released on 2020-05-06 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the second of two volumes on linear algebra for graduate students in mathematics, the sciences, and economics, who have: a prior undergraduate course in the subject; a basic understanding of matrix algebra; and some proficiency with mathematical proofs. Both volumes have been used for several years in a one-year course sequence, Linear Algebra I and II, offered at New York University's Courant Institute. The first three chapters of this second volume round out the coverage of traditional linear algebra topics: generalized eigenspaces, further applications of Jordan form, as well as bilinear, quadratic, and multilinear forms. The final two chapters are different, being more or less self-contained accounts of special topics that explore more advanced aspects of modern algebra: tensor fields, manifolds, and vector calculus in Chapter 4 and matrix Lie groups in Chapter 5. The reader can choose to pursue either chapter. Both deal with vast topics in contemporary mathematics. They include historical commentary on how modern views evolved, as well as examples from geometry and the physical sciences in which these topics are important. The book provides a nice and varied selection of exercises; examples are well-crafted and provide a clear understanding of the methods involved.
Download or read book Linear Algebra I written by Frederick P. Greenleaf and published by American Mathematical Soc.. This book was released on 2019-01-30 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of two volumes on linear algebra for graduate students in mathematics, the sciences, and economics, who have: a prior undergraduate course in the subject; a basic understanding of matrix algebra; and some proficiency with mathematical proofs. Proofs are emphasized and the overall objective is to understand the structure of linear operators as the key to solving problems in which they arise. This first volume re-examines basic notions of linear algebra: vector spaces, linear operators, duality, determinants, diagonalization, and inner product spaces, giving an overview of linear algebra with sufficient mathematical precision for advanced use of the subject. This book provides a nice and varied selection of exercises; examples are well-crafted and provide a clear understanding of the methods involved. New notions are well motivated and interdisciplinary connections are often provided, to give a more intuitive and complete vision of linear algebra. Computational aspects are fully covered, but the study of linear operators remains the focus of study in this book.
Download or read book Medical Biostatistics for Complex Diseases written by Frank Emmert-Streib and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of highly valuable statistical and computational approaches designed for developing powerful methods to analyze large-scale high-throughput data derived from studies of complex diseases. Such diseases include cancer and cardiovascular disease, and constitute the major health challenges in industrialized countries. They are characterized by the systems properties of gene networks and their interrelations, instead of individual genes, whose malfunctioning manifests in pathological phenotypes, thus making the analysis of the resulting large data sets particularly challenging. This is why novel approaches are needed to tackle this problem efficiently on a systems level. Written by computational biologists and biostatisticians, this book is an invaluable resource for a large number of researchers working on basic but also applied aspects of biomedical data analysis emphasizing the pathway level.
Download or read book Metastability and Markov State Models in Molecular Dynamics written by Christof Schütte and published by American Mathematical Soc.. This book was released on 2013-12-26 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications in modern biotechnology and molecular medicine often require simulation of biomolecular systems in atomic representation with immense length and timescales that are far beyond the capacity of computer power currently available. As a consequence, there is an increasing need for reduced models that describe the relevant dynamical properties while at the same time being less complex. In this book the authors exploit the existence of metastable sets for constructing such a reduced molecular dynamics model, the so-called Markov state model (MSM), with good approximation properties on the long timescales. With its many examples and illustrations, this book is addressed to graduate students, mathematicians, and practical computational scientists wanting an overview of the mathematical background for the ever-increasing research activity on how to construct MSMs for very different molecular systems ranging from peptides to proteins, from RNA to DNA, and via molecular sensors to molecular aggregation. This book bridges the gap between mathematical research on molecular dynamics and its practical use for realistic molecular systems by providing readers with tools for performing in-depth analysis of simulation and data-analysis methods. Titles in this series are co-published with the Courant Institute of Mathematical Sciences at New York University.
Download or read book Mathematical Analysis and Numerical Methods written by Aliaa Burqan and published by Springer Nature. This book was released on with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
