Download or read book Mast Cells and Cardiovascular Disease written by Jacob Joseph and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although initially thought to be a deleterious influence on tissue repair and remodelling, recent studies have shown the versatility of the mast cell in modulating tissue responses in a beneficial as well as an adverse manner. Hence it is clear that understanding mast cell biology in the context of normal and abnormal tissue repair and remodelling will be crucial to preventing and treating cardiovascular disease. This book brings together world-renowned scientists in the field of mast cell biology to present the current knowledge regarding the role of these enigmatic cells in cardiovascular disease, and innovative research approaches to tackle this field of cardiovascular investigation.
Download or read book Cardioimmunology Inflammation and Immunity in Cardiovascular Disease written by Mohamed Boutjdir and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mast Cells written by Guha Krishnaswamy and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells. These methods take advantage of the latest advances in molecular biology, technology, and information science. They include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis.
Download or read book Inflammation and Angiogenesis written by Domenico Ribatti and published by Springer. This book was released on 2017-11-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.
Download or read book Advances in Mast Cell Physiology and Mast Cell Driven Diseases written by Carlo Pucillo and published by Frontiers Media SA. This book was released on 2023-11-22 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast cells (MCs) are tissue-resident, innate immune cells with heterogenous phenotypes imprinted by cytokines, growth factors, and other stimuli in their immediate microenvironment. Populating tissues in several waves including during fetal development, in adults bone marrow-derived progenitor cells circulate in the blood and migrate and differentiate into mature MCs in tissue. MCs are abundantly present in the skin and mucosal tissues but can be found in virtually all organs often increasing in numbers during inflammation. MCs are key effectors in IgE-associated immune responses, including allergic disorders and associated protective immune responses. They release a variety of mediators acting on immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. MCs, via the expression of numerous other receptors, can be triggered by many other stimuli including TLR ligands, complement, and neuropeptides etc. Playing a protective role in parasitic, bacterial, and viral infections but also venom and toxin neutralization, MCs are best known for their role in the pathogenesis of allergic diseases. Several lines of evidence have implicated MCs in the development of autoimmune diseases and a whole variety of chronic inflammatory disorders, including cardiovascular diseases, urticaria, mastocytosis, and several cancers. The manifestations of MC-driven disease are considered to be a consequence of an inappropriate activation of MC immune responses which have evolved to protect the body against a host of pathogens and perhaps toxins.
Download or read book Mast Cells written by Guha Krishnaswamy and published by . This book was released on with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mast cell, long implicated in causing allergic reactions, may also be involved in many other disease processes, including cancer, heart disease, parasitic disease, atherosclerosis, asthma, and arthritis. In Mast Cells: Methods and Protocols, hands-on experts describe in detail their best techniques for the isolation, culture, and study of both activation and signaling in human mast cells. These readily reproducible methods take advantage of the latest advances in molecular biology, technology, and information science. The techniques provide a sound base of methodology for mast cell research and include methods for the identification of mast cells, the development of mast cells in vitro, the study of mast cell signaling and gene expression, and the measurement of mast cell expression of inflammatory mediators. Additional chapters cover methods for studying mast cell interactions with other cell types (endothelial cells, fibroblasts, and B cells), the roles of mast cells in host defense, and mast cell apoptosis. A survey of mast cell biology offers insight into its history and the implications for adaptive immunity. The protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and highly practical, Mast Cells: Methods and Protocols provides mast cell researchers with reproducible accounts of basic and advanced molecular and cellular techniques used in studying this fascinating, multifunctional cell.
Download or read book Sympathetic Nerves and Mast Cells in Ischemic Heart Disease written by Federico Corti and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effect of Fluvastatin on Mast Cell Function written by Elizabeth Motunrayo Kolawole and published by . This book was released on 2014 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluvastatin, the HMG-CoA reductase inhibitor known for its role in the treatment of hypercholesterolemia and cardiovascular disease, has more recently been shown to play a role in the immune response. Given the critical role that mast cells play in allergy and inflammatory diseases such as asthma, which effects one third of America's population, we assessed the effect of fluvastatin on mast cell and basophils function. We demonstrate that fluvastatin downregulated IgE-mediated cytokine production. Additionally, in vivo studies showed that fluvastatin suppressed IgE-mediated anaphylaxis. Interestingly, the effects of fluvastatin showed dependence on genetic background, as C57BL/6 mast cells were sensitive, while 129/Sv mast cells were resistant to fluvastatin. Characterizing the role of fluvastatin on mast cells may prove to be therapeutically important.
Download or read book The Tissue Mast Cells in Relation to Coronary Artery Disease written by Ariela Pomerance and published by . This book was released on 1958 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Never Bet Against Occam written by Lawrence B. Afrin and published by Sisters Media, LLC. This book was released on 2016 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2008 Dr. Afrin started coming to understand that a newly recognized type of mast cell disease, now called mast cell activation syndrome (MCAS), was the underlying diagnosis in many patients he was seeing who were each suffering large assortments -- quite different from one patient to the next -- of chronic multisystem inflammatory illnesses of unclear cause. Dr. Afrin soon gained experience that MCAS is far more prevalent than the only mast cell disease previously known to medicine (the rare disease of mastocytosis) and that most MCAS patients, once accurately diagnosed, can eventually find significantly helpful medications targeted at the disease. The frequency and magnitude of the improvements Dr. Afrin has seen -- even the relief that comes from finally having a unifying diagnosis other than "psychosomatism" -- have spurred him to focus in this area, not only tending to the needs of his patients but also pursuing research to advance our understanding of the disease and helping to educate other professionals who in turn can help even more of the many people who have long been suffering not only the symptoms of the disease but also the natural concern of not understanding why one would be so "unlucky" to have acquired so many medical problems. As it turns out, such patients are not so unlucky and truly have just one root issue (and a very common one at that), which has the biological capability to develop, directly or indirectly, into most or all of their previously diagnosed problems. There is a great deal yet to learn about this, but even with just the present very limited understanding, the opportunity to diagnose and help patients with MCAS seems to be enormous and Dr. Afrin felt a description of the disease, written for the general public, might help lead some MCAS patients on a journey to diagnosis and improvement sooner rather than later. Dr. Afrin hopes this book will help people who might have, or do have, MCAS. A portion of the proceeds of purchases of this book will go to support research and education in this area.
Download or read book Mast Cell Biology written by Alasdair M. Gilfillan and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.
Download or read book Mast Cells and Basophils written by Gianni Marone and published by Academic Press. This book was released on 2000-05-25 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Download or read book Arteriogenesis written by Wolfgang Schaper and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizes the research activities of Germany’s Nauheim Institute of the Max Planck Society and its group of investigators both past and present, in the field of collateral artery growth. Incorporates a multidisciplinary in vivo approach to the study of arteriogenesis that includes molecular approaches with classical physiology and immunohistochemistry. Full color throughout and well illustrated.
Download or read book The Mast Cell written by Jack Pepys and published by . This book was released on 1979 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mast Cells written by Michael R. Hughes and published by Humana. This book was released on 2016-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells: Methods and Protocols, Second Edition expands upon the previous edition with current, detailed reviews that cover topics of interest to mast cell neophytes and cognoscenti alike. With new chapters on methods for the enumeration of tissue mast cells and isolation of mature mast cells and mast cell progenitors from mammalian tissues, Danio rerio (zebrafish) model in the study of mast cell development and function, the functions of mast cells in human health and disease and methods for the isolation, methods for the investigation of the molecular mechanisms of mast cell activation and their effector functions, assays for the detection and analysis of mast cell secretory and cell surface phenotype and, mast cell activation state, and experimental mouse models of disease that have been deemed useful for the assessment of mast cell functions in the regulation of innate and adaptive immune response in cancer, tissue fibrosis, auto-inflammation and allergic disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mast Cells: Methods and Protocols, Second Edition provides a sampler of useful methods and techniques in the further study of mast cell biology.
Download or read book Mast Cells written by David B. Murray and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resident mast cells are uniquely positioned in multiple organ systems at either the tissue and/or external environment or located near nerve endings and/or blood vessels. These locations allow the mast cell to serve as a sentinel and thus play a critical role in not only inflammatory situations to promote recruitment and infiltration of other immune cells, but also homeostatic maintenance. Although mast cells have several conserved characteristics, the authors provide evidence that the micro-environment influenced differences in the phenotype of tissue-specific mast cells, control the various responses to injury, inflammation and remodelling. This book brings together the work from experts across multiple tissue/organ systems and inflammatory causes (viral, bacterial, and auto-immune) to present the most up to date knowledge regarding the role of mast cells in these regulatory and disease events.
Download or read book Novel Mechanisms of Cardioprotection written by Noel Yan-ki Chan and published by . This book was released on 2012 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the leading cause of death in the United States. According to the American Heart Association, 33.6% of all deaths in 2007 were caused by cardiovascular disease. Sympathetic overactivity, accompanied by excessive norepinephrine release is a recognized cause of cardiac dysfunction in myocardial ischemia, congestive heart failure and hypertension. Thus, elucidating new mechanisms for the control of norepinephrine release in the heart is of foremost importance. Chapter 1 seeks to determine the putative mechanisms of an unsuspected proadrenergic property of cardiac natriuretic peptides, characterized by increased norepinephrine release. Cardiac natriuretic peptides are usually considered cardioprotective. Yet, recent clinical heart failure trials with recombinant brain natriuretic peptide failed to prove it. Hence, the norepinephrine-releasing property of natriuretic peptides may well oppose their anticipated benefits. Chapter 2 aims to identify a novel cardioprotective anti-renin-angiotensin system paradigm of ischemic preconditioning, i.e., prevention of reperfusion arrhythmias by inhibition of local renin release from cardiac mast cells via aldehyde dehydrogenase activation. Cardiac mast cells are found in close proximity to vessels and nerves. They are considered deleterious since they are known to synthesize, store, and release a wide variety of proinflammatory and vasoactive mediators, including renin. Renin released by ischemia/reperfusion from cardiac mast cells activates a local reninangiotensin system (RAS). Locally formed angiotensin II enhances norepinephrine release from cardiac sympathetic nerves and elicits reperfusion arrhythmias. This study uncovers novel basic mechanisms of pharmacological cardioprotection: the detoxification of reactive aldehydes and reactive oxygen species in ischemia/reperfusion by increasing the catalytic activity of mitochondrial aldehyde dehydrogenase type 2, thus alleviating the dysfunctional consequences of RAS activation in the heart. The goal of Chapter 3 is to determine whether histamine H 3 -receptors afford cardioprotection in ischemia/reperfusion by counteracting the angiotensin AT 1 -receptor-mediated stimulation of neuronal Na + /H + exchanger (NHE). In severe myocardial ischemia, H 3 -receptor activation affords cardioprotection by preventing excessive norepinephrine release and arrhythmias; pivotal to this action, is the inhibition of NHE. My study uncovers an additional cardioprotective effect of H 3 -receptor activation: opposition of the deleterious effects of locally formed angiotensin II, not only by inhibiting NHE, but also by reducing the expression of angiotensin AT 1 -receptor in cardiac sympathetic neurons. Although there have been significant advances in the therapy of cardiovascular disease in recent decades, there is still a major unmet need for better therapies for many patients with these illnesses. Accordingly, my studies will foster the design of new agents to enable safe and effective treatment to cure cardiovascular disease.
