Download or read book Management of Hereditary Colorectal Cancer written by Jose G. Guillem and published by Springer Nature. This book was released on 2020-04-02 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive review of the clinical management of hereditary colorectal cancer. The text focuses on six distinct patient groups: patients with early age-of-onset colorectal cancer and adenomas, patients with hamartomatous colorectal polyps, patients afflicted with familial adenomatous polyposis (FAP), patients with attenuated familial adenomatous polyposis (AFAP), patients with MYH associated polyposis (MAP), and patients afflicted with lynch syndrome (LS). Each chapter illustrates how clinicians utilize current technologies in genetic testing, pathological review, and endoscopic, surgical, and chemotherapeutic/immunotherapeutic approaches to manage these patient groups. Topics such as the timing of genetic testing, endoscopic screening and surveillance, prophylactic surgical options and chemo-preventive interventions are also discussed in concise yet precise detail. Written by experts in their fields, Management of Hereditary Colorectal Cancer: A Multidisciplinary Approach is a valuable and timely resource for gastroenterologists, surgeons, genetic counselors, medical oncologists, psychologists, and any health caregivers involved with the management of patients and families afflicted with a hereditary form of colorectal cancer.
Download or read book Hereditary Colorectal Cancer written by Miguel A. Rodriguez-Bigas and published by Springer Science & Business Media. This book was released on 2010-09-10 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
Download or read book Hereditary Colorectal Cancer written by Laura Valle and published by Springer. This book was released on 2018-05-04 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Download or read book Hereditary Colorectal Cancer written by Joji Utsunomiya and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.
Download or read book Genetics of Colorectal Cancer written by John D. Potter and published by Springer. This book was released on 2008-12-08 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Download or read book Recent Advances in the Treatment of Colorectal Cancer written by Hideyuki Ishida and published by Springer. This book was released on 2018-12-31 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the latest indications and techniques for various endoscopic and surgical colorectal cancer treatments, discussing not only on the standard lymph node dissection technique, but also on laparoscopic and robotic surgery. It particularly focuses on the treatment of rectal cancer, with chapters on radiation therapy and sphincter preservation, which is analyzed from Asian perspectives that differ from those of Western treatment. Further, it presents the results of combining chemotherapy and oral drugs, as well as the treatment of hereditary cancer using next-generation sequencing for genetic diagnosis. Edited by surgeons who have pioneered the research and treatment of colorectal cancer, Recent Advances in the Treatment of Colorectal Cancer presents extensive information for clinicians such as endoscopic surgeons, colorectal surgeons, as well as oncologists and researchers specializing in this field. Providing a foundation for new ideas, it enables advanced surgeons to further develop their skills and offers thought-provoking, instructive and informative reading for residents, students and medical staff.
Download or read book Hereditary and Familial Colorectal Cancer written by Éanna Ryan and published by Cambridge Scholars Publishing. This book was released on 2022-10-17 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the historical context of colorectal cancer predisposition syndromes and the latest knowledge relating to each of the known hereditary colorectal cancer predisposition syndromes. There is a particular focus on the management of each of these syndromes in turn, including medical and surgical management, cancer surveillance, and screening recommendations. It also explores the workings of specialised hereditary and familial cancer clinics from the perspectives of the various clinicians involved in the running of the service. Multidisciplinary management, universal tumour screening, risk estimation, the obtaining and use of genetic information, and appropriate high-risk population screening and surveillance are also discussed, as are future developments and how these may relate to this exciting and evolving field.
Download or read book Genetics of Colorectal Cancer for Clinical Practice written by Fred H. Menko and published by Springer Science & Business Media. This book was released on 1993-07-31 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is a collective term for a heterogeneous group of diseases. In a large proportion of cases, the condition is attributable to genetic predisposition. Those directly involved in the treatment of patients with cancer of the large bowel are confronted to an increasing degree with the genetic aspects of the disease. In familial and hereditary forms of the disorder periodic screening of the close relatives of the patients can in principle prevent disease and death from colorectal cancer. Presymptomatic diagnosis by means of DNA technology is now possible in many cases of familial adenomatous polyposis. Genetic diagnosis will be increasingly important for the identification of high-risk groups. This book summarizes those aspects of the genetics of colorectal cancer that are important for clinical pracice. It has been stated that clinicians can contribute to the goal of reducing mortality from cancer by asking each patient about his or her family history of cancer. The aim of this book is to provide a guideline for the management of those situations in which the family history of colorectal cancer is found to be positive.
Download or read book Cancer Family written by C. Richard Boland, MD and published by AuthorHouse. This book was released on 2015-08-30 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is 1946, and a young man stares out his third-story apartment window. He has returned from the war with metastatic cancer and assumes he will die, leaving his wife and infant daughter behind. Instead, he lives another twenty-four years, raising a family of four children, before he succumbs to a second colon cancer. His son, the author, recognizes that there is a hereditary cancer syndrome in the family and resolves to solve the problem as a medical researcher. Eventually, hereditary colorectal cancer is recognized as a medical entity, and multiple genes responsible for this hereditary condition are isolated. However, the mutation responsible in the author’s family escaped detection. In 2001, his laboratory identifies the mutation responsible for the problem and develops a specific test for the family. This permits the mutation carriers to obtain life-saving care, altering the natural history of the disease for his family and others.
Download or read book DNA Alterations in Lynch Syndrome written by Matjaž Vogelsang and published by Springer. This book was released on 2013-05-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate. An estimated 37,000 of diagnosed colorectal cancer cases worldwide are attributed to Lynch syndrome each year. Intensive cancer screening, with early initiation and frequent follow-up, can reduce colorectal cancer incidence and mortality in LS patients. This book provides an up-to-date overview on the genetic and epigenetic basis of Lynch syndrome. It evaluates clinical features of the disease and critically comments on molecular tools available for identifying mutations responsible for Lynch syndrome; in addition the importance of functional assays that can help clarify the clinical nature of identified mutations is also discussed. The book also focuses on challenges in genetic counselling of at-risk individuals and discusses related ethical issues. The purpose of the book is to give a concise knowledge base for the broader scientific and medical community, including genetic counselors, in order to improve awareness on the potential impact that the diagnosis of LS has on treatment, management and surveillance of LS patients.
Download or read book The ASCRS Textbook of Colon and Rectal Surgery written by Scott R. Steele and published by Springer. This book was released on 2016-03-24 with total page 1269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition text provides a completely revised and updated new version of this unique, modern, practical text that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert colorectal surgeons caring for patients with complex problems–whether they result from underlying colorectal disease or from complications arising from previous surgical therapy. The format follows that of both a “how to” manual as well as an algorithm-based guide to allow the reader to understand the thought process behind the proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides a narrative by the author on his/her operative technical details and perioperative “tips and tricks” that they utilize in the management of these complex surgical challenges. Distinctive to this book, is the reliance on experts in the field including past presidents of the ASCRS, as well as multiple other national and internationally recognized surgeons, to lend their personal insight into situations where data may be more sparse, but individual and collective experience is paramount to making sound decisions and thereby optimizing patient outcomes. The text includes chapters on the assessment of risk and methods utilized to minimize perioperative complications. In addition, it incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Moreover, the technical challenges of managing complications resulting from the original or subsequent operations is addressed. The underlying focus throughout the text is on providing pragmatic and understandable solutions that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems. However, it also goes beyond the technical aspects of colorectal surgery and includes special sections highlighting the essence of a surgeon; covering aspects involving the medical-legal, ethical, and economic challenges confronting surgeons. Throughout the text, each author provides an ongoing narrative of his/her individual surgical techniques along with illustrations and diagrams to “personally” take the reader through the crucial steps of the procedure, and key points of patient care inherent to that topic. Additionally, where appropriate, links to online videos give the reader an up-front look into technical aspects of colorectal surgery.
Download or read book Colorectal Cancer Screening written by Joseph Anderson, MD and published by Springer Science & Business Media. This book was released on 2011-04-23 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal Cancer Screening provides a complete overview of colorectal cancer screening, from epidemiology and molecular abnormalities, to the latest screening techniques such as stool DNA and FIT, Computerized Tomography (CT) Colonography, High Definition Colonoscopes and Narrow Band Imaging. As the text is devoted entirely to CRC screening, it features many facts, principles, guidelines and figures related to screening in an easy access format. This volume provides a complete guide to colorectal cancer screening which will be informative to the subspecialist as well as the primary care practitioner. It represents the only text that provides this up to date information about a subject that is continually changing. For the primary practitioner, information on the guidelines for screening as well as increasing patient participation is presentedd. For the subspecialist, information regarding the latest imaging techniques as well as flat adenomas and chromoendoscopy are covered. The section on the molecular changes in CRC will appeal to both groups. The text includes up to date information about colorectal screening that encompasses the entire spectrum of the topic and features photographs of polyps as well as diagrams of the morphology of polyps as well as photographs of CT colonography images. Algorithms are presented for all the suggested guidelines. Chapters are devoted to patient participation in screening and risk factors as well as new imaging technology. This useful volume explains the rationale behind screening for CRC. In addition, it covers the different screening options as well as the performance characteristics, when available in the literature, for each test. This volume will be used by the sub specialists who perform screening tests as well as primary care practitioners who refer patients to be screened for colorectal cancer.
Download or read book Current Trends in Cancer Management written by Liliana Streba and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques.
Download or read book Recent Progress in Colorectal Cancer written by Francesco Paolo Rossini and published by . This book was released on 1992 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The biology and management of high risk groups for colorectal cancer is the overall thrust of this book. This includes an in-depth discussion of individuals with adenomatous polyps, dietary risk factors, familial adenomatous polyposis, inflammatory bowel disease, and hereditary non polyposis colorectal cancer. The relationship of sporadic colorectal cancer (CRC) to known inherited syndromes is explored in-depth. A major focus of the book is the exciting new developments in CRC. This is exceedingly complex, commensurate with its extant heterogeneity. This book surveys virtually all varieties of sporadic, familial and hereditary forms of CRC. In each of these disorders, the pathology, natural history, genetics, and molecular genetics (when known) are discussed. Surveillance and management programs, including chemopreventive strategies when applicable, are emphasized. Discussions about hereditary CRC registries, including their logistics and the precautions required for insuring confidentiality are described.This book provides useful clinical and research guidelines for primary care physicians, general and colorectal surgeons, gastroenterologists, pathologists, epidemiologists and cancer geneticists.
Download or read book Inherited Cancer Syndromes written by C. Neal Ellis and published by Springer Science & Business Media. This book was released on 2010-10-29 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Inherited Cancer Syndromes incorporates new genetic markers data with the clinical utility and practicality of the first edition.
Download or read book Cancer associated Genodermatoses written by Henry T. Lynch and published by John Wiley & Sons. This book was released on 1982 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Colon Cancer written by Ethan D. and published by Shuttle Systems. This book was released on 2024-03-11 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Embark on an empowering journey of understanding with "Colon Cancer: A Comprehensive Resource for Patients and Families." This pivotal book serves as a beacon of knowledge and support for anyone affected by colon cancer, providing vital information that spans from the basics of the disease to the complexities of treatment and beyond. Understanding Colon CancerBegin with an introduction to what colon cancer is, accompanied by important statistics that shed light on its prevalence. Learn about the risk factors you can control and the preventive measures that can be taken to reduce the likelihood of developing this disease. Anatomy of the DiseaseGain insights into the structure and function of the colon and understand the biological processes by which colon cancer develops, allowing for a better grasp of the diagnosis you or your loved one may be facing. Identifying Colon CancerDiscover the various types of colon cancer and the importance of early detection through regular screening. This book guides you through the methods used for screening and helps interpret the results, providing a clear path toward timely and accurate diagnosis. Genetic Factors and Family HistoryUncover the role of genetics in colon cancer, including how family history influences risk and the options available for genetic testing. Learn about the syndromes that increase susceptibility and how to navigate these hereditary concerns. Navigating Treatment OptionsExplore the comprehensive treatment landscape, from the surgical removal of tumors to the application of chemotherapy and radiation therapy. Innovative treatments like targeted therapy and immunotherapy are also discussed, offering hope through the latest advancements. Day-to-Day LivingAddress the challenges of daily life with colon cancer, including nutrition, exercise, and managing side effects. This book provides practical advice for maintaining quality of life during and after treatment. Emotional and Social SupportAcknowledge the emotional toll of colon cancer and the importance of a strong support system. The book offers resources for emotional support and advice for caregivers on managing the complex role they play. Advanced Care PlanningConfront the difficult topics of palliative care and end-of-life decisions with compassion and understanding. Find guidance on pain management, hospice care, and how to approach these sensitive subjects with dignity. Innovation and the FutureStay informed about the latest research and emerging treatments in colon cancer, with insights into how patient participation can drive progress in the fight against this disease. Prevention and AdvocacyConclude with actionable advice on prevention and learn about the efforts being made in advocacy and public health to combat colon cancer. "Colon Cancer: A Comprehensive Resource for Patients and Families" is more than just a book; it's a companion for those facing the journey through colon cancer. It's an essential tool for patients, families, caregivers, and advocates alike, providing the knowledge and support needed to navigate this challenging path.
